Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes

References

• Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377:2115–26.
   Google Scholar
• Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR. Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest. 1995;96:2859–69.
   PubMed Web of Science ®Google Scholar
• Squires GR, Okouneff S, Ionescu M, Poole AR. The pathobiol-ogy of focal lesion development in aging human articular carti-lage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum. 2003;48:1261–70.
   PubMed Web of Science ®Google Scholar
• Takacs-Buia L, Iordachel C, Efimov N, Caloianu M, Montreuil J, Bratosin D. Pathogenesis of osteoarthritis: chondrocyte replica-tive senescence or apoptosis? Cytom B Clin Cytom. 2008;74:356–62.
   PubMed Web of Science ®Google Scholar
• Dai SM, Shan ZZ, Nakamura H, Masuko-Hongo K, Kato T, Nishioka K, et al. Catabolic stress induces features of chondro-cyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. Arthritis Rheum. 2006;54: 818–31.
   Google Scholar
• Yudoh K, Nguyen T, Nakamura H, Hongo-Masuko K, Kato T, Nishioka K. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res 'Ther. 2005;7:R380–91.
   Google Scholar
• Martin JA, Buckwalter JA. Telomere erosion and senescence in human articular cartilage chondrocytes. J Gerontol A Biol Sci Med Sci. 2001;56:B172–9.
   PubMed Web of Science ®Google Scholar
• Piera-Velazquez S, Jimenez SA, Stokes D. Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum. 2002;46:683–93.
   Google Scholar
• Hong CE, Lyu SY. Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes. Immune Netw. 2011;11:42–9.
   PubMedGoogle Scholar
• Kong JH, Song KH, Woo JK, Park MH, Rhee MH, Choi C, et al. Ginsenoside Rpl from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells. Plant Foods Hum Nutr. 2011;66:298–305.
   PubMed Web of Science ®Google Scholar
• Liu DH, Chen YM, Liu Y, Hao BS, Zhou B, Wu L, et al. Rbl protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox status. Biol Pharm Bull. 2011;34:1072–7.
   PubMed Web of Science ®Google Scholar
• Lee KT, Jung TW, Lee HJ, Kim SG, Shin YS, Whang WK. The antidiabetic effect of ginsenoside Rb2 via activation of AMPK. Arch Pharm Res. 2011;34:1201–8.
   PubMed Web of Science ®Google Scholar
• Price JS, Waters JG, Darrah C, Pennington C, Edwards DR, Done11 ST, et al. The role of chondrocyte senescence in osteo-arthritis. Aging Cell. 2002;1:57–65.
   Google Scholar
• Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995;92: 9363–7.
   PubMed Web of Science ®Google Scholar
• Aurich M, Poole AR, Reiner A, Mollenhauer C, Margulis A, Kuettner KE, et al. Matrix homeostasis in aging normal human ankle cartilage. Arthritis Rheum. 2002;46:2903–10.
   PubMed Web of Science ®Google Scholar
• Loeser RF. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthr Carta. 2009;17:971–9.
   PubMed Web of Science ®Google Scholar
• Shin JS, Park N, Ra J, Kim Y, Shin M, Hong M, et al. Panax ginseng C.A. Meyer modulates the levels of MMP3 in S12 murine articular cartilage cell line. J Ethnopharmacol. 2009;124: 397–403.
   Google Scholar
• Ishikawa T, Nishigaki F, Miyata S, Hirayama Y, Minoura K, Imanishi J, et al. Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metallopro-teinase inhibitor, FR255031. Br J Pharmacol. 2005;144:133–43.
   PubMed Web of Science ®Google Scholar
• Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, et al. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest. 2001;107:35–44.
   PubMed Web of Science ®Google Scholar
• Forsyth CB, Cole A, Murphy G, Bienias JL, Im HJ, Loeser RF Jr. Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli. J Gerontol A Biol Sci Med Sci. 2005;60: 1118–24.
   Google Scholar
• Wu W, Billinghurst RC, Pidoux I, Antoniou J, Zukor D, Tanzer M, et al. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum. 2002;46:2087–94.
   PubMed Web of Science ®Google Scholar
• Kim KR, Chung TY, Shin H, Son SH, Park KK, Choi JH, et al. Red ginseng saponin extract attenuates murine collagen-induced arthritis by reducing pro-inflammatory responses and matrix metalloproteinase-3 expression. Biol Pharm Bull. 2010;33: 604–10.
   PubMed Web of Science ®Google Scholar
• Lee WM, Kim SD, Park MH, Cho JY, Park H.T, Seo GS, et al. Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP. J Pharm Phar-macol. 2008;60: 1531–6.
   Google Scholar
• Hien TT, Kim ND, Pokharel YR, Oh SJ, Lee MY, Kong KW. Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase. Toxicol Appl Phar-macol. 2010.
   Google Scholar
• Martin JA, Klingelhutz AJ, Moussavi-Harami F, Buckwalter JA. Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence. J Gerontol A Biol Sci Med Sci. 2004;59:324–37.
   Google Scholar
• Nicholson IP, Gault EA, Foote CG, Nasir L, Bennett D. Human telomerase reverse transcriptase (hTERT) extends the lifespan of canine chondrocytes in vitro without inducing neoplastic trans-formation. Vet J. 2007;174:570–6.
   Google Scholar
• Sutipompalangkul W, Morales NP, Charoencholvanich K, Hamroongroj T. Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteo-arthritis. Int J Rheum Dis. 2009;12:324–8.
   PubMed Web of Science ®Google Scholar
• Regan EA, Bowler RP, Crapo JD. Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with mac-roscopically intact cartilage and subacute injury. Osteoarthr Carta. 2008;16:515–21.
   Google Scholar
• Keum YS, Han SS, Chun KS, Park KK, Park JH, Lee SK, et al. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat Res. 2003;523–524:75–85.
   Google Scholar
• Zhang D, Yasuda T, Yu Y, Zheng P, Kawabata T, Ma Y, et al. Ginseng extract scavenges hydroxyl radical and protects unsat-urated fatty acids from decomposition caused by iron-mediated lipid peroxidation. Free Radic Biol Med. 1996;20:145–50.
   PubMed Web of Science ®Google Scholar
• Kim CS, Park JB, Kim KJ, Chang SJ, Ryoo SW, Jeon BH. Effect of Korea red ginseng on cerebral blood flow and superoxide production. Acta Pharmacol Sin. 2002;23:1152–6.
   PubMed Web of Science ®Google Scholar
• Kim YK, Guo Q, Packer L. Free radical scavenging activity of red ginseng aqueous extracts. Toxicology. 2002;172:149–56.
   Google Scholar
• Kang KS, Yokozawa T, Kim HY, Park JH. Study on the nitric oxide scavenging effects of ginseng and its compounds. J Agric Food Chem. 2006;54:2558–62.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Zheng X, Jiang J, Thou H, Hu P. Determination of ginsenoside Rg3 in human plasma and urine by high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878: 2266–73.
   Google Scholar