247
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Pharmacoeconomic analysis of paricalcitol and calcitriol in the treatment of secondary hyperparathyroidism in haemodialysis: impact of hospitalisations and survival

, PharmD MBA, , MD, , PharmD MS, , MD, , MD & , MD MPH
Pages 393-409 | Accepted 24 Aug 2007, Published online: 28 Oct 2008

References

  • U.S. Renal Data System. USRDS 2004 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2004
  • Bricker NS, Slatopolsky E, Reiss E, et al. Calcium, phosphorus and bone in renal disease and transplantation. Archives of Internal Medicine 1969; 123: 543–553
  • De Boer IH, Gorodetskaya I, Young B, et al. The severity of secondary hyperparathyroidism in chronic renal insufficiency is GFR-dependent, race-dependent, and associated with cardiovascular disease. Journal of the American Society of Nephrology 2002; 13: 2762–2769
  • Sherrard DJ, Hercz G, Pei Y, et al. The spectrum of bone disease in end-stage renal failure—an evolving disorder. Kidney International 1993; 43: 436–442
  • Coco M, Rush H. Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone. American Journal of Kidney Diseases 2000; 36: 1115–1121
  • Rix M, Andreassen H, Eskildsen P, et al. Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic kidney failure. Kidney International 1999; 56: 1084–1093
  • Tsuchihashi K, Takizawa H, Torii T, et al. Hypoparathyroidism potentiates the cardiovascular complications through disturbed calcium metabolism. Possible risk of vitamin D analog administration in dialysis patients with end-stage renal disease. Nephron 2000; 84: 13–20
  • Goodman W, Goldin J, Kuizon BD, et al. Coronary artery calcification in young adults with end-stage renal disease who are undergoing dialysis. New England Journal of Medicine 2000; 342: 1478–1483
  • Andress DL. Vitamin D in chronic kidney disease: a systemic role for selective vitamin D receptor activation. Kidney International 2006; 69: 33–43
  • Silver J, Russell J, Sherwood LM. Regulation by vitamin D metabolites of messenger RNA for preparathyroid hormone in isolated bovine parathyroid cells. Proceedings of the National Academy of Sciences USA 1985; 82: 4270–4273
  • Ramirez JA, Emmett M, White MG, et al. The absorption of dietary phosphorus and calcium in hemodialysis patients. Kidney International 1986; 30: 753–759
  • Block GA, Port FK. Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendations for a change in management. American Journal of Kidney Diseases 2000; 35: 1226–1235
  • Finch JL, Brown AJ, Slatopolsky E. Differential effects of 1,25-dihydroxy-vitamin D3 and 19-nor-1,25-dihydroxy-vitamin D2 on calcium and phosphorus resorption in bone. Journal of the American Society of Nephrology 1999; 10: 980–985
  • Brown AJ, Finch J, Slatopolsky E. Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport. Journal of Laboratory and Clinical Medicine 2002; 139: 279–284
  • Martin K, Gonzalez E, Gellens M, et al. 19-Nor-1-α-25-dihydroxyvitamin D2 (paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis. Journal of the American Society of Nephrology 1998; 9: 1427–1432
  • Goldenberg MM. Paricalcitol, a new agent for the management of secondary hyperparathyroidism in patients undergoing chronic renal dialysis. Clinical Therapeutics 1999; 21: 432–441
  • Lindberg J, Martin KJ, Gonzalez EA, et al. A long-term, multicenter study of the efficacy and safety of paricalcitol in end-stage renal disease. Clinical Nephrology 2001; 56: 315–323
  • Slatopolsky E, Cozzolino M, Finch JL. Differential effects of 19-nor-1,25-(OH)(2)D(2) and 1alpha-hydroxyvitamin D(2) on calcium and phosphorus in normal and uremic rats. Kidney International 2002; 62: 1277–1284
  • Nakane M, Fey TA, Dixon DB, et al. Differential effects of vitamin D analogs on bone formation and resorption. Journal of Steroid Biochemistry and Molecular Biology 2006; 98: 72–77
  • Teng M, Wolf M, Ofsthun N, et al. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. Journal of the American Society of Nephrology 2005; 16: 1115–1125
  • Dobrez DG, Mathes A, Amdahl M, et al. Paricalcitol-treated patients experience improved hospitalization outcomes compared with calcitriol-treated patients in real-world clinical settings. Nephrology, Dialysis, Transplantation 2004; 19: 1174–1181
  • Teng M, Wolf M, Lowrie E, et al. Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. New England Journal of Medicine 2003; 349: 446–456
  • Sprague SM, Llach F, Amdahl M, et al. Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism. Kidney International 2003; 63: 1483–1490
  • Llach F, Yudd M. Paricalcitol in dialysis patients with calcitriol-resistant secondary hyperparathyroidism. American Journal of Kidney Diseases 2001; 38((Suppl. 5))S45–S50
  • Mittman N, Khanna R, Rani S, et al. Paricalcitol therapy for secondary hyperparathyroidism in patients on maintenance hemodialysis previously treated with calcitriol: a single-center crossover study. Kidney International Supplement 2006, (104): S64–S67
  • Summary of 2005 Physician Schedule Final Rule. Available at: http://www.aapgpa.org/advocacy/1104_hpa_summary.pdf [accessed 7 June 2007].
  • 2006 The DRG Handbook. Comparative Clinical and Financial Benchmarks, Solucient, LLC
  • Marx SE, Brown MD, Ashraf T, et al. Evaluation of annualized dosing ratio of paricalcitol to calcitriol in hemodialysis patients. Journal of the American Society of Nephrology 2004; 15: 862A
  • United States Department of Labor. Available at: http://www.bls.gov/ro5/cpimpls.htm [accessed 17 October 2006].
  • Healthcare Cost & Utilization Project 2004 National Statistics—Principal Diagnosis Only. Available at: http://hcup.ahrq.gov/HCUPnet.jsp [accessed 16 October 2006].
  • Wolf M, Teng M, Thadhani R. Paricalcitol, calcitriol and survival of patients undergoing hemodialysis. New England Journal of Medicine 2003; 349: 1771–1772
  • Berger ML, Bingefors K, Hedblom EC, et al. Health care cost, quality, and outcomes. International Society for Pharmacoeconomics and Outcomes Research 2003; 241
  • Eastman RC, Javitt JC, Herman WH. Model of complications of NIDDM. II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of normoglycemia. Diabetes Care 1997; 20: 735–744
  • Diabetes Control and Complications Trial Research Group. Lifetime benefits and costs of intensive therapy as practiced in the Diabetes Control and Complications Trial. Journal of the American Medical Association 1996; 276: 1409–1415
  • Kiberd BA, Jindal KK. Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation. British Medical Journal 1995; 311: 1595–1599
  • Lawrence WF, Grist TM, Brazy PC. Magnetic resonance angiography in progressive renal failure: a technology assessment. American Journal of Kidney Diseases 1995; 25: 701–709
  • Harvard CEA Registry. Standardizing the methods and practices of cost-effectiveness analysis. Available at: http://www.hcra.harvard.ede/pdf/preferecescores.pdf [accessed 11 Feb 2005].
  • Robbins JD, Kim JJ, Zdon G, et al. Resource use and patient care associated with chronic kidney disease in a managed care setting. Journal of Managed Care Pharmacy 2003; 9: 238–447
  • United States Renal Data System. Cardiovascular report. Available at: http://www.usrds.org/adr.htm [accessed 20 May 2005].
  • St Peter WL, Khan SS, Ebben JP, et al. Chronic kidney disease. The distribution of healthcare dollars. Kidney International 2004; 66: 313–321
  • Drueke TB. Aspects of cardiovascular burden in pre-dialysis patients. Nephron 2000; 85((Suppl. 1))9–14
  • Capomolla S, Febo O, Ceresa M, et al. Cost/utility ratio in chronic heart failure: comparison between heart failure management program delivered by day-hospital and usual care. Journal of the American College of Cardiology 2002; 40: 1259–1266
  • Trentori F, Hunt WC, Stidley CA, et al. Mortality risk among hemodialysis patients receiving different vitamin D analogs. Kidney International 2006; 70: 1858–1856
  • Kalantar-Zadeh K, Juwae N, Regidor DL, et al. Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients. Kidney International 2006; 70: 771–780
  • Drummond MF, Davies L. Economic analysis alongside clinical trials. Revisiting the methodological issues. International Journal of Technology Assessment in Health Care 1991; 7: 561–573

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.