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Original Article

Cost-utility of fingolimod compared with dimethyl fumarate in highly active relapsing-remitting multiple sclerosis (RRMS) in England

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Pages 874-885 | Accepted 27 May 2015, Published online: 01 Jul 2015

References

  • Nylander A, Hafler DA. Multiple sclerosis. J Clin Invest 2012;122:1180-8
  • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46:907-11
  • Tremlett H, Zhu F, Petkau J, et al. Natural, innate improvements in multiple sclerosis disability. Mult Scler 2012;18:1412-21
  • Kingwell E, Marriott JJ, Jette N, et al. Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurol 2013;13:128
  • Mackenzie IS, Morant SV, Bloomfield GA, et al. Incidence and prevalence of multiple sclerosis in the UK 1990–2010: a descriptive study in the General Practice Research Database. J Neurol Neurosurg Psychiatry 2014;85:76-84
  • Kobelt G, Berg J, Lindgren P, et al. Costs and quality of life of patients with multiple sclerosis in Europe. J Neurol Neurosurg Psychiatry 2006;77:918-26
  • McCrone P, Heslin M, Knapp M, et al. Multiple sclerosis in the UK: service use, costs, quality of life and disability. Pharmacoeconomics 2008;26:847-60
  • Kamm CP, Uitdehaag BM, Polman CH. Multiple sclerosis: Current knowledge and future outlook. Eur Neurol 2014;72:132-41
  • electronic Medicines Compendium (eMC). TYSABRI 300 mg concentrate for solution for infusion, 2013. https://www.medicines.org.uk/emc/medicine/18447. Accessed September 8, 2014
  • electronic Medicines Compendium (eMC). Gilenya 0.5mg hard capsules, 2014. http://www.medicines.org.uk/emc/medicine/24443/SPC/. Accessed September 8, 2014
  • Kappos L, Radue E, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401
  • Calabresi PA, Radue EW, Goodin D, et al. Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Neurol 2014;13:545-56
  • Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-15
  • O’Connor P, Wolinsky JS, Confavreux C, et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med 2011;365:1293-303
  • Confavreux C, O’Connor P, Comi G, et al. Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol 2014;13:247-56
  • Vermersch P, Czlonkowska A, Grimaldi LM, et al. Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: a randomised, controlled phase 3 trial. Mult Scler 2014;20:705-16
  • Gold R, Kappos L, Arnold DL, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 2012;367:1098-107
  • Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med 2012;367:1087-97
  • Zhang X, Hay JW, Niu X. Cost effectiveness of fingolimod, teriflunomide, dimethyl fumarate and intramuscular interferon-beta in relapsing-remitting multiple sclerosis. CNS drugs 2015;29:71–81
  • National Institute for Health and Care Excellence. Fingolimod for the treatment of highly active relapsing–remitting multiple sclerosis (TA254). London, UK: NICE; 2012
  • electronic Medicines Compendium (eMC). Tecfidera 240 mg gastro-resistant hard capsules, 2014. http://www.medicines.org.uk/emc/medicine/28592. Accessed August 27, 2014
  • electronic Medicines Compendium (eMC). AUBAGIO 14 mg film-coated tablets, 2014. http://www.medicines.org.uk/emc/medicine/28533. Accessed September 22, 2014
  • National Institute for Health and Care Excellence. Teriflunomide for treating relapsing–remitting multiple sclerosis (TA303). London, UK: NICE; 2014
  • National Institute for Health and Care Excellence. Dimethyl fumarate for treating relapsing–remitting multiple sclerosis (TA320). London, UK: NICE; 2014
  • Bergvall N, Sfikas N, Chin P, et al. Efficacy of fingolimod in pre-treated patients with disease activity: Pooled analyses of FREEDOMS and FREEDOMS II (P3.174). Neurology 2014;82(10 Supplement):P3.174
  • European Medicines Agency. Tecfidera: EPAR - Public assessment report. London, UK: EMA; 2013
  • European Medicines Agency. Gilenya-H-C-2202-II-21: EPAR - Assessment Report - Variation. London, UK: EMA; 2014
  • Boggild M, Palace J, Barton P, et al. Multiple sclerosis risk sharing scheme: two year results of clinical cohort study with historical comparator. BMJ 2009;339:b4677
  • National Institute for Health and Care Excellence (NICE). Guide to the methods of technology appraisal. NICE; 2013 http://www.nice.org.uk/article/pmg9/chapter/Foreword. Accessed October 10, 2014
  • Biogen Idec Ltd. Natalizumab (Tysabri®) for the treatment of adults with highly active relapsing remitting multiple sclerosis. Manufacturer submission of evidence to NICE. London, UK: National Institute for Health and Clinical Excellence: TA127; 2007
  • Biogen Idec Ltd. Dimethyl fumarate for the treatment of adult patients with relapsing remitting multiple sclerosis. Manufacturer submission of evidence. London, UK: National Institute for Health and Care Excellence: TA320; 2013
  • Genzyme. Alemtuzumab for the treatment of relapsing remitting multiple sclerosis in adults. Manufacturer submission of evidence. London, UK: National Institute for Health and Care Excellence: TA312; 2013
  • Genzyme. Teriflunomide for the treatment of relapsing-remitting multiple sclerosis in adults. Manufacturer submission of evidence. London, UK: National Institute for Health and Care Excellence: TA303; 2013
  • Novartis Pharmaceuticals UK Ltd. Fingolimod for the treatment of relapsing-remitting multiple sclerosis in adults. Manufacturer submission of evidence. London, UK: National Institute for Health and Clinical Excellence: TA254; 2011
  • School of Health and Related Research (ScHARR). Cost effectiveness of beta interferons and glatiramer acetate in the management of multiple sclerosis. London, UK: National Institute for Clinical Excellence: TA32; 2001
  • Office for National Statistics. England and Wales, interim life tables, 1980–82 to 2010–2012, 2013. http://www.ons.gov.uk/ons/rel/lifetables/interim-life-tables/2010-2012/rft-ew.xls. Accessed October 22, 2014
  • Pokorski RJ. Long-term survival experience of patients with multiple sclerosis. J Insur Med 1997;29:101-6
  • Sadovnick AD, Ebers GC, Wilson RW, et al. Life expectancy in patients attending multiple sclerosis clinics. Neurology 1992;42:991
  • Weinshenker BG, Bass B, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989;112(Pt 1):133-46
  • Association of British Neurologists. Guidelines for prescribing in multiple sclerosis. London, UK: Association of British Neurologists; 2009
  • Barendregt JJ. The half-cycle correction: banish rather than explain it. Med Decis Making 2009;29:500-2
  • NHS. National Schedule of Reference Costs 2013–14 for NHS trusts and NHS foundation trusts. London, UK: NHS; 2014
  • NHS. NHS Tariff 2013–14. London, UK: NHS; 2014
  • Curtis L. PSSRU unit costs of health and social care. Personal Social Services Research Unit: Canterbury, UK; 2014
  • Tyas D, Kerrigan J, Russell N, et al. The distribution of the cost of multiple sclerosis in the UK: how do costs vary by illness severity? Value Health 2007;10:386-9
  • Orme M, Kerrigan J, Tyas D. The effect of disease, functional status, and relapses on the utility of people with multiple sclerosis in the UK. Value Health 2007;10:54-60
  • EuroQoL. Basic infromation on how tp use EQ-5D questionare. Rotterdam, The Netherlands: EuroQoL; 2009
  • Palace J, Bregenzer T, Tremlett H, et al. UK multiple sclerosis risk-sharing scheme: a new natural history dataset and an improved Markov model. BMJ Open 2014;4:e004073
  • European Medicines Agency. Clinical investigation of medicinal products for the treatment of multiple sclerosis. London, UK: EMA; 2012
  • Bergvall N, Lahoz R, Nazareth T, et al. Persistence with fingolimod versus dimethyl fumarate in patients with multiple sclerosis: a retrospective analysis using US open and closed data sources. Poster presented at the Joint ECTRIMS/ACTRIMS meeting, September 10–13, 2014, Boston, MA. 2014:P289
  • Cohn S, Bermel RA, Hara-Cleaver C, et al. Comparative Tolerability and Efficacy of Dimethyl Fumarate And Fingolimod in Multiple Sclerosis. Poster presented at the Joint ECTRIMS/ACTRIMS meeting, September 10–13, 2014, Boston, MA, USA. 2014. p 300
  • Cohen JA, von Rosenstiel P, Gottschalk R, et al. Long-term safety of fingolimod: interim evaluation of data from the LONGTERMS trial. Poster presented at the 66th American Academy of Neurology Annual Meeting, April 26–May 3, 2014, Philadelphia, PA. 2014. p 2.210
  • Espallargues M, Czoski-Murray CJ, Bansback NJ, et al. The impact of age-related macular degeneration on health status utility values. Invest Ophthalmol Vis Sci 2005;46:4016-23
  • Petrou S, Hockley C. An investigation into the empirical validity of the EQ-5D and SF-6D based on hypothetical preferences in a general population. Health Econ 2005;14:1169-89
  • Currie CJ, McEwan P, Peters JR, et al. The routine collation of health outcomes data from hospital treated subjects in the Health Outcomes Data Repository (HODaR): descriptive analysis from the first 20,000 subjects. Value Health 2005;8:581-90
  • Lloyd A, Nafees B, Narewska J, et al. Health state utilities for metastatic breast cancer. Br J Cancer 2006;95:683-90

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