144
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Modelling the economic impact of recombinant activated Factor VII and activated prothrombin-complex concentrate in the treatment of a mild to moderate bleed in adults with inhibitors to clotting Factors VIII and IX at a comprehensive care centre in the UK

&
Pages 51-64 | Accepted 25 Apr 2002, Published online: 02 Dec 2008

References

  • Colvin BT, Hay CRM, Hill FGH et al. The incidence of Factor VIII inhibitors in the UK, 1990-93. British Journal of Haematology 1995; 89: 908–910.
  • Lusher JM. Early treatment with recombinant Factor VIIa results in greater efficacy with less product. European Journal of Haematology 1998; 61 (Suppl. 63): 7–10.
  • Lusher JM. Recombinant activated Factor VII for treatment of intramuscular haemorrhages: a comparison of early versus late treatment. Blood Coagulation and Fibrinolysis 1998; 9 (Suppl. 1): S111–S114.
  • Santagostino E, Gringeri A, Mannucci PM. Home treatment with recombinant activated Factor VII in patients with Factor VIII inhibitors: the advantages of early intervention. British Journal of Haematology 1999; 104: 22–26.
  • Key NS, on behalf of the US rFVIIa Home Therapy Study Group. Efficacy of recombinant activated Factor VII when administered in the home to control joint, muscle, and mucocutaneous bleeds in haemophilia patients with inhibitors. Blood Coagulation and Fibrinolysis 1998; 9 (Suppl. 1): S153.
  • English PJ, Sheppard EM, Wensley RT. Factor VIII inhibitor bypassing activity. Lancet 1976; 2: 207.
  • Kurczynski EM, Penner JA. Activated prothrombin concentrate for patients with Factor VIII inhibitors. New England Journal of Medicine 1974; 291: 164.
  • Pollock A, Lewis, MJ. Factor VIII inhibitor bypassing activity. Lancet 1976; 2: 43.
  • Stenbjerg S, Jørgensen J. Activated F IX concentrate (aPCC) used in the treatment of haemophilic patients with antibody to F VIII. Acta Medica Scandinavica 1978; 203: 471–476
  • Sjamsoedin LJM, Heijnen L, Mauser- Bunschoten EP et al. The effect of activated prothrombin-complex concentrate (aPCC) on joint and muscle bleeding in patients with haemophilia A and antibodies to Factor VIII. New England Journal of Medicine 1981; 305: 717–721.
  • Hilgartner MW, Knatterud GL and the aPCC Study Group. The use of Factor eight inhibitor by-passing activity (aPCC Immuno) product for treatment of bleeding episodes in haemophiliacs with inhibitors. Blood 1983; 61: 36–40.
  • Hilgartner M, Aledort L, Andes A, Gill J, and the members of the aPCC Study Group. Efficacy and safety of vapor- heated anti-inhibitor coagulant complex in haemophilia patients. Transfusion 1990; 30: 626–630.
  • Negrier C, Goudemand J, Sultan Y, Bertrand M, Rothschild C, Lauroua P and the members of the French aPCC study group. Multicenter retrospective study on the utilisation of aPCC in France in patients with Factor VIII and Factor IX inhibitors. Thrombosis and Haemostasis 1997; 77: 1113–1119.
  • Negrier C, Lee M et al. The aPCC-VH survey: Initial findings from a world-wide surveillance study. Haemophilia 2000; 6 (Suppl. 1): 279–314.
  • Hay CRM, Lozier JN et al. Safety profile of porcine factor VIII and its use as hospital and home therapy for patients with haemophilia A and inhibitors. The results of an international survey. Thrombosis and Haemostasis 1996; 75: 25–29.
  • Stewart AJ, Hanley JP, Ludlam CA. Safety, efficacy and cost-effectiveness of home therapy with recombinant activated Factor VII in a patient with severe haemophilia A and an anti-Factor VIII inhibitor. Blood Coagulation and Fibrinolysis 1998; 9 (Suppl. 1): S93–S95.
  • Guest JF, Odeyemi IAO. Economic impact of recombinant activated Factor VII compared to activated prothrombin- complex concentrate in the home treatment of a minor bleed in haemophilia patients with high titre high responding inhibitors to coagulation Factors VIII and IX. Presented at the American Society for Hematology Annual Meeting, 2000 (Abstract No. 1883).
  • Fink A, Kosecoff J et al. Consensus methods: Characteristics and guidelines for use. American Journal of Public Health 1984; 74: 979–983.
  • Netten A, Dennett J, Knight J. Unit costs of health and social care 1999. University of Kent, Canterbury. Personnel Social Services Research Unit, 1999.
  • Monthly Index of Medical Specialities 2000 editions. London: Haymarket Publications Ltd.
  • Department of Health. Drug Tariff May 2000 edition. London: The Stationery Office.
  • Lipton RA. The economics of Factor VIII inhibitor treatment. Seminars in Haematology 1994; 31 (Suppl. 4): 37–38.
  • Goudemand J. Pharmaco-economic aspects of inhibitor treatment. European Journal of Haematology 1998; 61 (Suppl. 63): 24–27.
  • Aledort LM. Economic aspects of haemophilia care. Haemophilia 1999; 5: 216–219.
  • Ludlam C. Funding arrangements within the UK. Haemophilia 1998; 2 (Suppl. 1): 13–14.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.