Treatment of Rheumatoid Arthritis with Roxithromycin: A Randomized Trial

References

• . Feely MG, Erickson A, O'Dell JR. Therapeutic options for rheumatoid arthritis. Expert Opin Pharmacother. 2009; 10(13):2095–2106
   PubMed Web of Science ®Google Scholar
• . de Pablo P, Chapple IL, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol. 2009; 5(4):218–224
   PubMed Web of Science ®Google Scholar
• . Mercado FB, Marshall RI, Klestov AC, Bartold PM. Relationship between rheumatoid arthritis and periodontitis. J Periodontol. 2001; 72(6): 779–787
   PubMed Web of Science ®Google Scholar
• . Detert J, Pischon N, Burmester GR, Buttgereit F. The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther. 2010; 12(5):218
   PubMed Web of Science ®Google Scholar
• . Bonfil JJ, Dillier FL, Mercier P, . A “case control” study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR. SSO). J Clin Periodontol. 1999; 26(2):77–84
   PubMed Web of Science ®Google Scholar
• . Gran JT, Husby G, Thorsby E. The association between rheumatoid arthritis and HLA antigen DR4. Ann Rheum Dis. 1983; 42(3): 292–296
   PubMed Web of Science ®Google Scholar
• . Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007; 13(3):134–137
   PubMed Web of Science ®Google Scholar
• . Moen K, Brun JG, Madland TM, Tynning T, Jonsson R. Immunoglobulin G and A antibody responses to Bacteroides forsythus and Prevotella intermedia in sera and synovial fluids of arthritis patients. Clin Diagn Lab Immunol. 2003; 10(6):1043–1050
   PubMedGoogle Scholar
• . Ogrendik M, Kokino S, Ozdemir F, Bird PS, Hamlet S. Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis. MedGenMed. 2005; 7(2):2
   PubMedGoogle Scholar
• . Moen K, Brun JG, Valen M, . Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006; 24(6):656–663
   PubMed Web of Science ®Google Scholar
• . Ogrendik M. efficacy of roxithromycin in adult patients with rheumatoid arthritis who had not received disease-modifying antirheumatic drugs: A 3-month, randomized, double-blind, placebo-controlled trial. Clin Ther. 2009; 31(8):1754–1764
   PubMed Web of Science ®Google Scholar
• . Ogrendik M. Effects of clarithromycin in patients with active rheumatoid arthritis. Curr Med Res Opin. 2007; 23(3):515–522
   PubMed Web of Science ®Google Scholar
• . Hannonen P, Mottonen T, Hakola M, Oka M. Sulfasalazine in early rheumatoid arthritis. A 48-week double-blind, prospective, placebo-controlled study. Arthritis Rheum. 1993; 36(11):1501–1509
   PubMed Web of Science ®Google Scholar
• . Das KM. Sulfasalazine therapy in inflammatory bowel disease. Gastroenterol Clin North Am. 1989; 18(1):1–20
   PubMed Web of Science ®Google Scholar
• . Oyama T, Matsushita K, Sakuta T, . Roxithromycin inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-1 expression through regulating mitogen-activated protein kinase phosphorylation and Ets-1 expression. J Periodontal Res. 2007; 42(1):53–61
   PubMed Web of Science ®Google Scholar
• . Furst DE, Saag K, Fleischmann MR, . efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: A six-month, double-blind, randomized, dose-ranging study. Arthritis Rheum. 2002; 46(8):2020–2028
   PubMed Web of Science ®Google Scholar
• . Arnett FC, Edworthy SM, Bloch DA, . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31(3):315–324
   PubMed Web of Science ®Google Scholar
• . Pincus T, Summey JA, Soraci SA Jr, Wallston KA, Hummon NP. Assessment of patient satisfaction in activities of daily living using a modified Stanford Health Assessment Questionnaire. Arthritis Rheum. 1983; 26(4):1346–1353
   PubMed Web of Science ®Google Scholar
• . Fries JF, Spitz PW, Young DY. The dimensions of health outcomes: The health assessment questionnaire, disability and pain scales. J Rheumatol. 1982; 9(5):789–793
   PubMed Web of Science ®Google Scholar
• . Felson DT, Anderson JJ, Boers M, . The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials. Arthritis Rheum. 1993; 36:729–740
   PubMed Web of Science ®Google Scholar
• . Felson DT, Anderson JJ, Boers M, . American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995; 38(6):727–735
   PubMed Web of Science ®Google Scholar
• . Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts: Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995; 38(1):44–48
   PubMed Web of Science ®Google Scholar
• . Fransen J, van Riel PL. The Disease Activity Score and the EULAR response criteria. Clin Exp Rheumatol. 2005; 23(5 suppl 39):S93–S99
   PubMed Web of Science ®Google Scholar
• . Fransen J, Creemers MC, Van Riel PL. Remission in rheumatoid arthritis: Agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria. Rheumatology (Oxford). 2004; 43(10):1252–1255
   PubMed Web of Science ®Google Scholar
• . Vrijhoef HJ, Diederiks JP, Spreeuwenberg C, Van der Linden S. Applying low disease activity criteria using the DAS28 to assess stability in patients with rheumatoid arthritis. Ann Rheum Dis. 2003; 62(5):419–422
   PubMed Web of Science ®Google Scholar
• . Amin AR, Attur MG, Thakker GD, . A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases. Proc Natl Acad Sci USA. 1996; 93(24):14014–14019
   PubMed Web of Science ®Google Scholar
• . Tilley BC, Alarcón GS, Heyse SP, . Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group. Ann Intern Med. 1995; 122(2):81–89
   PubMed Web of Science ®Google Scholar
• . Kloppenburg M, Breedveld FC, Terwiel JP, Mallee C, Dijkmans BA. Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial. Arthritis Rheum. 1994; 37(5):629–636
   PubMed Web of Science ®Google Scholar
• . O'Dell JR, Haire CE, Palmer W, . Treatment of early rheumatoid arthritis with minocycline or placebo: Results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 1997; 40(5): 842–848
   PubMed Web of Science ®Google Scholar
• . O'Dell JR, Paulsen G, Haire CE, . Treatment of early seropositive rheumatoid arthritis with minocycline: Four-year followup of a double-blind, placebo-controlled trial. Arthritis Rheum. 1999; 42(8):1691–1695
   PubMed Web of Science ®Google Scholar
• . Modi DK, Chopra VS, Bhau U. Rheumatoid arthritis and periodontitis: Biological links and the emergence of dual purpose therapies. Indian J Dent Res. 2009; 20(1):86–90
   PubMedGoogle Scholar
• . van der Heijden IM, Wilbrink B, Tchetverikov I, . Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum. 2000; 43(3):593–598
   PubMed Web of Science ®Google Scholar
• . Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, . Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009; 36(12):1004–1010
   PubMed Web of Science ®Google Scholar
• . Moreland LW, Baumgartner SW, Schiff MH, . Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med. 1997; 337(3):141–147
   PubMed Web of Science ®Google Scholar
• . Seymour GJ, Gemmell E. Cytokines in periodontal disease: Where to from here? Acta Odontol Scand. 2001; 59(3):167–173
   PubMed Web of Science ®Google Scholar
• . Yoshimura A, Hara Y, Kaneko T, Kato I. Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria. J Periodontal Res. 1997; 32(3):279–286
   PubMed Web of Science ®Google Scholar
• . Kjeldsen M, Holmstrup P, Lindemann RA, Bendtzen K. Bacterial-stimulated cytokine production of peripheral mononuclear cells from patients of various periodontitis categories. J Periodontol. 1995; 66(2):139–144
   PubMed Web of Science ®Google Scholar
• . Rossano F, Rizzo A, Sanges MR, Cipollaro de L'Ero G, Tufano MA. Human monocytes and gingival fibroblasts release tumor necrosis factor-alpha, interleukin-1 alpha and interleukin-6 in response to particulate and soluble fractions of Prevotella melaninogenica and Fusobacterium nucleatum. Int J Clin Lab Res. 1993; 23(3):165–168
   PubMedGoogle Scholar
• . Ianaro A, Ialenti A, Maffia P, . Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther. 2000; 292(1): 156–163
   PubMed Web of Science ®Google Scholar
• . Urasaki Y, Nori M, Iwata S, . Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages. J Rheumatol. 2005; 32(9):1765–1774
   PubMed Web of Science ®Google Scholar
• . Kanai K, Asano K, Hisamitsu T, Suzaki H. Suppression of matrix metalloproteinase production from nasal fibroblasts by macrolide antibiotics in vitro. Eur Respir J. 2004; 23(5):671–678
   PubMed Web of Science ®Google Scholar