106
Views
48
CrossRef citations to date
0
Altmetric
Clinical Focus: Hypertension and Related Disorders

Proposed Role of Calcium and Dairy Food Components in Weight Management and Metabolic Health

, PhD
Pages 29-39 | Published online: 13 Mar 2015

References

  • . Zemel MB, Kim JH, Woychik RP, . Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice. Proc Nat Acad Sci U S A. 1995; 92(11):4733–4737
  • . Jones BH, Kim JH, Zemel MB, . Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am J Physiol. 1996;270:E192–E196
  • . Xue B, Moustaid-Moussa N, Wilkison WO, Zemel MB. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+ dependent mechanism. FASEB J. 1998;12(13):1391–1396
  • . Xue B, Greenberg AG, Kraemer FB, Zemel MB. Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. FASEB J. 2001;15(13):2527–2529
  • . Kim JH, Mynatt RL, Moore JW, . The effects of calcium channel blockade on agouti-induced obesity. FASEB J. 1996;10(14):1646–1652
  • . Claycombe KH, Wang Y, Jones BH, . Transcriptional regulation of the adipocyte fatty acid synthase gene by the agouti gene product: interaction with insulin. Physiol Genomics. 2000;3(3):157–162
  • . Shi H, Moustaid-Moussa N, Wilkison WO, Zemel MB. Role of the sulfonylurea receptor in regulating human adipocyte metabolism. FASEB J. 1999;13(13):1833–1838
  • . Xue B, Zemel MB. Relationship between human adipose tissue agouti and fatty acid synthase (FAS). J Nutr. 2000;130(10):2478–2481
  • . Zemel MB, Xue B. Agouti/melanocortin interactions with leptin pathways in obesity. Nutr Rev. 1998;56(9):271–274
  • . Xue BZ, Wilkison WO, Mynatt RL, Moustaid N, Goldman M, Zemel MB. The agouti gene product stimulates pancreatic [beta]-cell Ca2+signaling and insulin release. Physiol Genomics. 1999;1(1):11–19
  • . Mynatt RL, Miltenberger RJ, Klebig ML, . Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity. Proc Natl Acad Sci U S A. 1997;94(3):919–922
  • . Kim JH, Mynatt RL, Moore JW, . The effects of calcium channel blockade on agouti-induced obesity. FASEB J. 1996;10(14):1646–1652
  • . Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. Regulation of adiposity by dietary calcium. FASEB J. 2000;14(9):1132–1138
  • . Shi H, Norman AW, Okamura WH, Sen A, Zemel MB. 1 alpha, 25-dihyroxyvitamin D3 modulates human adipocyte metabolism via non-genomic action. FASEB J. 2001;15(14):2751–2753
  • . Zemel MB. Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr. 2004;79(5):907S–912S
  • . Shi H, Dirienzo D, Zemel MB. Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J. 2001;15(2):291–293
  • . Rohe B, Safford SE, Nemere I, Farach-Carson MC. Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS)-binding protein in rat IEC-6 cells. Steroids. 2005;70(5–7):458–463
  • . Petrov V, Lijnen P. Modification of intracellular calcium and plasma renin by dietary calcium in men. Am J Hypertens. 1999;12(12 pt 1–2):1217–1224
  • . Rao RM, Yan Y, Wu Y. Dietary calcium reduces blood pressure, parathyroid hormone, and platelet cytosolic calcium responses in spontaneously hypertensive rats. Am J Hypertens. 1994;7(12):1052–1057
  • . Ye WZ, Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G. Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur J Endocrinol. 2001;145(2):181–186
  • . Barger-Lux MJ, Heaney RP, Hayes HF, DeLuca HF, Johnson ML, Gong G. Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density. Calcif Tissue Int. 1995;57(2):161–162
  • . Andersen T, McNair P, Hyldstrup L, . Secondary hyperparathyroidism of morbid obesity regresses during weight reduction. Metabolism. 1988;37(5):425–428
  • . Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest. 1985;76(1):370–373
  • . Shi H, Norman AW, Okamura WH, Sen A, Zemel MB. 1 alpha, 25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J. 2002;16(13):1808–1810
  • . Sun X, Zemel MB. Role of uncoupling protein 2 (UCP2) expression and 1 alpha, 25-dihydroxyvitamin D3 in modulating adipocyte apoptosis. FASEB J. 2004;18(12):1430–1432
  • . Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E. Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond). 2005;29(4):391–397
  • . Zemel MB, Richards J, Milstead A, Campbell P. Effects of calcium and dairy on body composition and weight loss in African American adults. Obes Res. 2005;13(7):1218–1225
  • . Melanson EL, Donahoo WT, Dong F, Ida T, Zemel MB. Effect of low- and high-calcium diets on macronutrient oxidation in humans. Obesity Res. 2005;13(12):2102–2112
  • . Gunther CW, Lyle RM, Legowski PA, . Fat oxidation and its relation to serum parathyroid hormone in young women enrolled in a 1-y dairy calcium intervention. Am J Clin Nutr. 2005;82(6):1228–1234
  • . Major GC, Chaput PP, Ledoux M, . Recent developments in calcium-related obesity research. Obes Rev. 2008;9(5):428–445
  • . Papakonstantinou E, Flatt WP, Huth PJ, Harris RB. High dietary calcium reduces body fat content, digestibility of fat, and serum vitamin D in rats. Obes Res. 2003;11(3):387–394
  • . Jacobsen R, Lorenzen JK, Toubro S, Krog-Mikkelsen K, Astrup A. Effect of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretion. Int J Obes (Lond). 2005;29(3):292–301
  • . Zemel MB, Morgan K. Interaction between calcium, dairy and dietary macronutrients in modulating body composition in obese mice [abstract]. FASEB J. 2002;301:6
  • . Morris KL, Zemel MB. 1, 25-dihydroxyvitamin D3 modulation of adipocyte glucocorticoid function. Obes Res. 2005;13(4):670–677
  • . Sun X, Morris KL, Zemel MB. Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1:30–48
  • . Sun X, Zemel MB. Dietary calcium regulates ROS production in aP2-agouti transgenic mice on high-fat/high-sucrose diets. Int J Obes (Lond). 2006;30(9):1341–1346
  • . Sun X, Zemel MB. 1 alpha, 25-dihyroxyvitamin D and corticosteroid regulate adipocyte nuclear vitamin D receptor. Int J Obes (Lond). 2008;32(8):1305–1311
  • . Shah NP. Effects of milk-derived bioactives: an overview. Br J Nutr. 2000;84( suppl 1):S3–S10
  • . FitzGerald RJ, Murray BA, Walsh DJ. Hypotensive peptides from milk proteins. J Nutr. 2004;134(4):980S–988S
  • . Morris K, Wang Y, Kim S, Moustaid-Moussa N. Dietary and hormal regulation of the mammalian FA synthase gene. In: Moustaid-Moussa N, Bernardier CD, eds. Nutrient-Gene Interactions in Health and Disease. Boca Raton, FL: CRC Press; 2001
  • . Causey KR, Zemel MB. Dairy augmentation of the anti-obesity effect of Ca in aP2-agouti transgenic mice [abstract]. FASEB J. 2003; A746
  • . Layman DK. The role of leucine in weight loss diets and glucose homeostasis. J Nutr. 2003;133(1):261S–267S
  • . Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by protein. J Nutr. 2000;131(3):856S–860S
  • . Garlick PJ, Grant I. Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids. Biochem J. 1988;254(2):579–584
  • . Ha E, Zemel MB. Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people. J Nutr Biochem. 2003;14(5):251–258
  • . Fouillet H, Mariotti F, Gaudichon C, Bos C, Tomé D. Peripheral and splanchnic metabolism of dietary nitrogen are differently affected by the protein source in humans as assessed by compartmental modeling. J Nutr. 2002;132(1):125–133
  • . Bruckbauer A, Guoffon J, Rekapalli B, Zemel MB. The effects of dairy components on energy partitioning and metabolic risk in mice: a microarray study. J Nutrigenet Nutrigenomics. 2009;2:64–77
  • . Sun X, Zemel MB. Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids. 2007;42(4):297–305
  • . Zemel MB, Sun X. Leucine and calcitriol modulation of mitochondrial biogenesis in muscle cells and adipocytes [abstract]. FASEB J. 2008;22:305
  • . Stipanuk MH. Leucine and protein synthesis: mTOR and beyond. Nutr Rev. 2008;65(3):122–129
  • . Cota D, Proulx K, Blake Smith KA, . Hypothalamic mTOR signaling regulates food intake. Science. 2006;312(5775):927–930
  • . Zemel MB, Thompson W, Milstead A, Morris K, Campbell P. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res. 2004;12(4):582–590
  • . Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E. Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond). 2005;29(4):391–397
  • . Zemel MB, Teegarden D, Van Loan M, . Role of dairy products in modulating weight and fat loss: a multi-center trial [abstract]. FASEB J. 2004;18:566
  • . Zemel MB, Richards J, Milstead A, Campbell P. Effects of calcium and dairy on body composition and weight loss in African-American adults. Obes Res. 2005;13(7):1218–1225
  • . Caan B, Neuhouser M, Aragaki A, . Calcium plus vitamin D supplementation and the risk of postmenopausal weight gain. Arch Intern Med. 2007;167(9):893–902
  • . Thompson WG, Rostad Holdman N, Janzow DJ, Slezak JM, Morris KL, Zemel MB. Effect of energy-reduced diets high in dairy products and fiber on weight loss in obese adults. Obes Res. 2005;13(8):1344–1353
  • . Harvey-Berino J, Gold BC, Lauber R, Starinski A. The impact of calcium and dairy product consumption on weight loss. Obes Res. 2006;13(10):1720–1726
  • . Zemel MB, Wilson B, Van Loan MD, Teegarden D, Lyle R, Matkovic V. Role of dairy products in modulation of body weight and body fat: a meta-analysis. Obesity. 2007;15:A91
  • . Lockwood CM, Moon JR, Tobkin SE, . Minimal nutrition intervention with high-protein/low-carbohydrate and low-fat, nutrient-dense food supplement improves body composition and exercise benefits in overweight adults: a randomized controlled trial. Nutr Metab (Lond). 2008;5:11
  • . Frestedt JL, Zenk JL, Kuskowski MA, Ward LS, Bastian ED. A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study. Nurt Metab (Lond). 2008;5:8
  • . Kelishadi R, Zemel MB, Hashemipour M, Hosseini M, Mohammadifard N. Can a dairy-rich diet be effective in long-term weight control of young children? In press. J Am Coll Nutr.
  • . Major GC, Alarie FP, Doré J, Tremblay A. Calcium plus vitamin D supplementation and fat mass loss in female very low calcium consumers: potential link with a calcium-specific appetite control. Br J Nutr. 2009;101(5):659–663
  • . Ochner CN, Lowe MR. Self-reported changes in dietary calcium and energy intake predict weight regain following a weight loss diet in obese women. J Nutr. 2007;137(10):2324–2328
  • . Zemel MB, Donelly JE, Smith BK, . Effects of dairy intake on weight maintenance. Nutr Metab (Lond). 2008;5:28
  • . Davies KM, Heaney RP, Recker RR, . Calcium intake and body weight. J Clin Endocrinol Metab. 2000;85(12):4635–4638
  • . Carruth BR, Skinner JD. The role of dietary calcium and other nutrients in moderating body fat in preschool children. Int J Obes Relat Metab Disord. 2001;25(4):559–566
  • . Skinner JD, Bounds W, Carruth BR, Ziegler P. Longitudinal calcium intake is negatively related to children's body fat indexes. J Am Diet Assoc. 2003;103(12):1626–1631
  • . Barba G, Troiano E, Russo P, Venezia A, Siani A. Inverse association between body mass and frequency of milk consumption in children. Brit J Nutr. 2005;93(1):15–19
  • . Tanasescu M, Ferris AM, Himmelgreen DA, Rodriguez N, Pérez-Escamilla R. Biobehavioral factors are associated with obesity in Puerto Rican children. J Nutr. 2000;130(7):1734–1742
  • . Novotny R, Daida YG, Acharya S, Grove JS, Vogt TM. Dairy intake is associated with lower body fat and soda intake with greater weight in adolescent girls. J Nutr. 2004;134(8):1905–1909
  • . Lin YC, Lyle RM, McCabe LB, McCabe GB, Weaver CM, Teegarden D. Dairy calcium is related to changes in body composition during a two-year exercise intervention in young women. J Am Coll Nutr. 2000;19(6):754–760
  • . Buchowski MS, Semenya J, Johnson AO. Dietary calcium intake in lactose maldigesting intolerant and tolerant African-American women. J Am Coll Nutr. 2002;21(1):47–54
  • . Summerbell CD, Watts C, Higgins JPT, Garrow JS. Randomised controlled trial of novel, simple, and well supervised weight reducing diets in outpatients. BMJ. 1998;317:1487–1489
  • . Azadbakht L, Esmaillzadeh A. Dietary and non-dietary determinants of central adiposity among Tehrani women. Public Health Nutr. 2008;11(5):528–534
  • . Eilat-Adar S, Xu J, Loria C, . Dietary calcium is associated with body mass index and body fat in American Indians. J Nutr. 2007;137(8):1955–1960
  • . McCarron DA. Calcium and magnesium nutrition in human hypertension. Ann Intern Med. 1983;98(5 pt 2):800–805
  • . Loos RJ, Rankinen T, Leon AS, . Calcium intake is associated with adiposity in black and white men and white women of the HERITAGE family study. J Nutr. 2004;134(7):1772–1778
  • . Jacqmain M, Doucet E, Després JP, Bouchard C, Tremblay A. Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am J Clin Nutr. 2003;77(6):1448–1452
  • . Pereira MA, Jacobs DR Jr, Van Horn L, Slattery LM, Kartashov AI, Ludwig DS. Dairy consumption, obesity and the insulin resistance syndrome in young adults: the CARDIA study. JAMA. 2002;287(16):2081–2089
  • . Mirmiran P, Esmaillzadeh A, Azizi F. Dairy consumption and body mass index. An inverse relationship. Int J Obes (Lond). 2005;29(1):115–121
  • . Shapses SA, Heshka S, Heymsfiel SB. Effect of calcium supplementation on weight and fat loss in women. J Clin Endocrinol Metab. 2004;89(2):632–637
  • . Elwood PC, Pickering JE, Fehily AM. Milk and dairy consumption, diabetes and the metabolic syndrome: the Caerphilly prospective study. J Epidemiol Community Health. 2007;61(8):695–698
  • . Festa A, D'Agostino R Jr, Williams K, . The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord. 2001;25(10):1407–1415
  • . Hansel B, Giral P, Nobecourt E, . Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity. J Clin Endocrinol Metab. 2004;89(10):4963–4971
  • . Festa A, D' Agostino R Jr, Howard G, Mykkänen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000;102(1):42–47
  • . Lakka HM, Laaksonen DE, Lakka TA, . The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709–2716
  • . Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005;115(5):911–919
  • . Furukawa S, Fujita T, Shimabukuro M, . Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114:1752–1761
  • . Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol. 2004;15(11):2792–2800
  • . Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005;96(9):939–949
  • . Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care. 2003;26(8):2442–2450
  • . Hulthe J, Hulten LM, Fagerberg B. Low adipocyte-derived plasma protein adiponectin concentrations are associated with the metabolic syndrome and small dense low-density lipoprotein particles: atherosclerosis and insulin resistance study. Metabolism. 2003;52(12):1612–1614
  • . Bouloumié A, Curat CA, Sengenés C, Lolméde K, Miranville A, Busse R. Role of macrophage tissue infiltration in metabolic diseases. Curr Opin Clin Nutr Metab Care. 2005;8(4):347–354
  • . Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796–1808
  • . Xu H, Barnes GT, Yang Q, . Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112(12):1821–1830
  • . Curat CA, Miranville A, Sengenes C, Diehl M, Tonus C, Busse R, Bouloumie A. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes. 2004;53(5):1285–1292
  • . Sun X, Zemel MB. 1 alpha, 25-dihydroxyvitamin D3 modulation of reactive oxygen species production and cell proliferation in human and murine adipocytes. Obesity (Silver Spring). 2007;15(8):1944–1953
  • . Sun X, Zemel MB. Dietary calcium regulates ROS production in aP2-agouti transgenic mice on high-fat/high-sucrose diets. Int J Obes (Lond). 2006;30(9):1341–1346
  • . Sun X, Zemel MB. Calcium and 1, 25-dihydroxyvitamin D3 regulation of adipokine expression. Obesity (Silver Spring). 2007;15(2):340–348
  • . Zemel MB, Sun X. Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr. 2008;138(6):1047–1052
  • . Zemel MB, Sun X, Wilson B. Dairy modulation of oxidative and inflammatory stress in overweight and obese subjects [abstract 4]. FASEB J. 2008;22:881

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.