Ability to downregulate the level of cyclin-dependent kinase inhibitor p27^Kip1 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway

Leona Raskova KafkovaDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Correspondence[email protected]

Veronika NavrkalovaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;

Marie JarosovaDepartment of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Czech Republic;

Tomas LojaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;

Jana ChovancovaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;

Jana KucerovaDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;

Eva KriegovaDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;

Vit ProchazkaDepartment of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Czech Republic;

Zdenek NovakDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA

Dana SimkovaDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;

Sarka PospisilovaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;

Vladimir DivokyDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Correspondence[email protected]

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Ability to downregulate the level of cyclin-dependent kinase inhibitor p27^Kip1 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway

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Ability to downregulate the level of cyclin-dependent kinase inhibitor p27Kip1 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway

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Ability to downregulate the level of cyclin-dependent kinase inhibitor p27^Kip1 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway