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Original Articles: Clinical

Biallelic ATM alterations detected at diagnosis identify a subset of treatment-naïve chronic lymphocytic leukemia patients with reduced overall survival similar to patients with p53 deletion

Carol Lozano-SantosHematology Department, Molecular Cytogenetics Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain; ;Institute of Research Puerta de Hierro-Majadahonda (IDIPHIM), Spain;

José A. García-VelaHematology Department, Hospital Universitario de Getafe, Madrid, Spain;

Nuria Pérez-SanzHematology Department, Molecular Cytogenetics Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain;

Sara Nova-GurumetaHematology Department, Molecular Cytogenetics Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain;

Belen Fernandez-CuevasHematology Department, Molecular Cytogenetics Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain;

Natalia Gomez-LozanoInstitute of Research Puerta de Hierro-Majadahonda (IDIPHIM), Spain;

Margarita Sánchez-BeatoInstitute of Research Puerta de Hierro-Majadahonda (IDIPHIM), Spain;

Pedro Sanchez-GodoyHematology Departament, Hospital Severo Ochoa de Leganés, Madrid, Spain;

José Luis BuenoBlood Bank Unit, Hematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain

José A. Garcia-MarcoHematology Department, Molecular Cytogenetics Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain; Correspondence[email protected]

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Supplemental material

ICMJE Forms for Disclosure of Potential Conflicts of Interest

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Supplemental Table IV: Multivariate analysis of TTFT in the CLL cohort at diagnosis with ATM mutation and 11q deletion status.

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Supplemental Table IV: Multivariate analysis of TTFT in the CLL cohort at diagnosis with ATM mutation and 11q deletion status.

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Supplemental Table II: ATM and BIRC3 mutations in CLL patients.

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Supplemental Table I: Therapeutic regimens and clinical response in 58/118 patients requiring treatment.

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Supporting Methods

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Biallelic ATM alterations detected at diagnosis identify a subset of treatment-naïve chronic lymphocytic leukemia patients with reduced overall survival similar to patients with p53 deletion

ICMJE Forms for Disclosure of Potential Conflicts of Interest

Supplemental Table IV: Multivariate analysis of TTFT in the CLL cohort at diagnosis with ATM mutation and 11q deletion status.

Supplemental Table IV: Multivariate analysis of TTFT in the CLL cohort at diagnosis with ATM mutation and 11q deletion status.

Supplemental Table II: ATM and BIRC3 mutations in CLL patients.

Supplemental Table I: Therapeutic regimens and clinical response in 58/118 patients requiring treatment.

Supporting Methods

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Biallelic ATM alterations detected at diagnosis identify a subset of treatment-naïve chronic lymphocytic leukemia patients with reduced overall survival similar to patients with p53 deletion

ICMJE Forms for Disclosure of Potential Conflicts of Interest

Supplemental Table IV: Multivariate analysis of TTFT in the CLL cohort at diagnosis with ATM mutation and 11q deletion status.

Supplemental Table IV: Multivariate analysis of TTFT in the CLL cohort at diagnosis with ATM mutation and 11q deletion status.

Supplemental Table II: ATM and BIRC3 mutations in CLL patients.

Supplemental Table I: Therapeutic regimens and clinical response in 58/118 patients requiring treatment.

Supporting Methods

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