Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

Melissa D’AscenzioSchool of Life Sciences, University of Dundee, Dundee, Scotland, UK;

Paolo GuglielmiDipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy; Correspondence[email protected]

Simone CarradoriDepartment of Pharmacy, “G. D’Annunzio” University of Chieti-Pescara, Chieti, Italy;

Daniela SecciDipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy;

Rosalba FlorioDepartment of Pharmacy, “G. D’Annunzio” University of Chieti-Pescara, Chieti, Italy;

Adriano MollicaDepartment of Pharmacy, “G. D’Annunzio” University of Chieti-Pescara, Chieti, Italy;

Mariangela CerusoLaboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy;

Atilla AkdemirDepartment of Pharmacology, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, Istanbul, Turkey;

Anatoly P. SobolevMagnetic Resonance Laboratory “Annalaura Segre”, National Research Council, Institute of Chemical Methodologies, Monterotondo, Rome, Italy;

Claudiu T. SupuranLaboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy; ;Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino, Florence, ItalyCorrespondence[email protected]

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Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

IENZ_1235040_Supplementary_material.pdf

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Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

IENZ_1235040_Supplementary_material.pdf

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