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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Research Paper

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

Jakub Benýšeka Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic;b First Faculty of Medicine, Charles University, Prague, Czech RepublicView further author information
,
Michal Bušaa Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic;c Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech RepublicView further author information
,
Petra Rubešováa Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech RepublicView further author information
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Jindřich Fanfrlíka Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech RepublicView further author information
,
Martin Lepšíka Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech RepublicView further author information
,
Jiří Bryndaa Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech RepublicView further author information
,
Zuzana Matouškováa Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech RepublicView further author information
,
Ulrike Bartzd Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, Rheinbach, GermanyView further author information
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Martin Horna Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech RepublicView further author information
,
Michael Gütschowe Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, GermanyView further author information
&
Michael Mareša Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech RepublicCorrespondence[email protected]
View further author information
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Pages 515-526 | Received 30 Nov 2021, Accepted 27 Dec 2021, Published online: 11 Feb 2022

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