Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases

Ahmed H. E. Hassana Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;b Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea

https://orcid.org/0000-0002-1048-6281 View further author information

Hyeon Jeong Kimc Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Min Sung Geed Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of KoreaView further author information

Jong-Hyun Parkc Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Hye Rim Jeone Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of KoreaView further author information

Cheol Jung Leee Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of KoreaView further author information

Yeonwoo Choie Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of KoreaView further author information

Suyeon Moone Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of KoreaView further author information

Danbi Leed Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of KoreaView further author information

Jong Kil Leed Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of KoreaView further author information

Ki Duk Parkc Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;f KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of KoreaView further author information

Yong Sup Leeb Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea;e Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea;f KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of KoreaCorrespondence[email protected]

https://orcid.org/0000-0001-6523-6979 View further author information

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Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases

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Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases

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