The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

Alessandro Bonardia Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy;b Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Firenze, Florence, ItalyView further author information

Silvia Buaa Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, ItalyView further author information

Jacob Combsc Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USAView further author information

Carrie Lomelinoc Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USAView further author information

Jacob Andringc Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USAView further author information

Sameh Mohamed Osmand Chemistry Department, College of Science, King Saud University, Riyadh, Saudi ArabiaView further author information

Alessandra Totia Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy

https://orcid.org/0000-0002-8435-6017 View further author information

Lorenzo Di Cesare Mannellia Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy

https://orcid.org/0000-0001-8374-4432 View further author information

Paola Gratterib Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Firenze, Florence, ItalyView further author information

Carla Ghelardinia Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, ItalyView further author information

Robert McKennac Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USAView further author information

Alessio Nocentinia Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, ItalyCorrespondence[email protected]

https://orcid.org/0000-0003-3342-702X View further author information

Claudiu T. Supurana Department NEUROFARBA – Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, ItalyCorrespondence[email protected]

https://orcid.org/0000-0003-4262-0323 View further author information

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The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

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The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

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