New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

Hamada H. H. Mohammeda Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt;b Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, EgyptView further author information

Amer Ali Abd El-Hafeezc Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA;d Cancer Biology Department, Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Cairo, EgyptView further author information

Kareem Ebeide Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt;f Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA;g Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Manufacturing, Deraya University, New Minia City, Minia, EgyptView further author information

Aml I. Mekkawyf Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA;h Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, EgyptView further author information

Mohammed A. S. Abourehabi Department of Pharmaceutics, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi ArabiaView further author information

Emad I. Wafaf Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USAView further author information

Suhaila O. Alhaj-Sulimanf Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USAView further author information

Aliasger K. Salemf Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA;j Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USACorrespondence[email protected]
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Pradipta Ghoshc Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA;k Department of Medicine, University of California San Diego, La Jolla, CA, USA;l Rebecca and John Moore Comprehensive Cancer Center, University of California San Diego, La Jolla, CA, USA;m Veterans Affairs Medical Center, La Jolla, CA, USAView further author information

Gamal El-Din A. Abuo-Rahmaa Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt;n Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, EgyptCorrespondence[email protected]
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Alaa M. Hayallaho Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt;p Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sphinx University, New Assiut, EgyptView further author information

Samar H. Abbasa Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, EgyptCorrespondence[email protected]

https://orcid.org/0000-0002-9586-2644 View further author information

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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

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