Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

Yin Suna Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China;b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaView further author information

Haotian Tangb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;c University of Chinese Academy of Sciences, Beijing, P. R. ChinaView further author information

Xiaoyan Wanga Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China;b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaView further author information

Fang Fengb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaView further author information

Tiantian Fanb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;c University of Chinese Academy of Sciences, Beijing, P. R. ChinaView further author information

Dongmei Zhaoa Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. ChinaCorrespondence[email protected]
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Bing Xiongb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;c University of Chinese Academy of Sciences, Beijing, P. R. ChinaCorrespondence[email protected]
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Hua Xieb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China;c University of Chinese Academy of Sciences, Beijing, P. R. China;d Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaCorrespondence[email protected]
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Tongchao Liub Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. ChinaCorrespondence[email protected]
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Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

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Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

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