Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

Asmaa A. Mandoura Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt

Ibrahim F. Nassarb Faculty of Specific Education, Ain Shams University (ASU), Cairo, Egypt

https://orcid.org/0000-0002-8123-2238

Mohammed T. Abdel Aalc Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Mahmoud A. E. Shahinc Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Wael A. El-Sayedd Chemistry Department, College of Science, Qassim University, Qassim, Saudi Arabia;e Photochemistry Department, National Research Centre, Cairo, Egypt

https://orcid.org/0000-0002-8232-1830

Maghawry Hegazyf Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Amr Mohamed Yehiaf Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Ahmed Ismailf Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Mohamed Hagrasg Department of Pharmaceutical Organic Chemistry, College of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Eslam B. Elkaeedh Department of Pharmaceutical Science, College of Pharmacy, Al Maarefa University, Riyadh, Saudi Arabia

Hanan M. Refaata Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt

Nasser S. M. Ismaila Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, EgyptCorrespondence[email protected]

https://orcid.org/0000-0002-5119-9318

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Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

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Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity

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