Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR^WT and EGFR^T790M inhibitors

Tarfah Al-Warhia Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Ahmed A. Al-Karmalawyb Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, EgyptCorrespondence[email protected]

https://orcid.org/0000-0002-8173-6073

Ayman Abo Elmaatyc Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt

Maha A. Alshubramyd Department of Chemistry, College of Science, Qassim University, Buraydah, Saudi Arabia

Marwa Abdel-Motaald Department of Chemistry, College of Science, Qassim University, Buraydah, Saudi Arabia;e Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

Taghreed A. Majrashif Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia

Medhat Asemg College of Engineering and Information Technology, Onaizah Colleges, Al-Qassim, Saudi Arabia

Ahmed Nabilh Research Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan;i Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt

Wagdy M. Eldehnaj Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt;k School of Biotechnology, Badr University in Cairo, Badr City, EgyptCorrespondence[email protected]

https://orcid.org/0000-0001-6996-4017

Marwa Sharakyl Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt

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Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR^WT and EGFR^T790M inhibitors

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Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors

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Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR^WT and EGFR^T790M inhibitors