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Brief Report
Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one
Yanmei Luoa School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
, Jin Lib Division of Medicinal Chemistry, PharmaBlock Sciences (Nanjing), Inc., Nanjing, ChinaView further author information
, Yuliang Zonga School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
, Mengxin Suna School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
, Wan Zhenga School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaView further author information
, Jiapeng Zhua School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China;c Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Chinahttps://orcid.org/0000-0002-9165-0126View further author information
, Liu Liub Division of Medicinal Chemistry, PharmaBlock Sciences (Nanjing), Inc., Nanjing, ChinaCorrespondence[email protected]
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& View further author information
Bing Liua School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China;c Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaCorrespondence[email protected]
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Pages 398-404
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Received 01 Nov 2022, Accepted 19 Nov 2022, Published online: 08 Dec 2022
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