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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

Waleed A. Badawia Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, EgyptView further author information
,
Mahmoud Rashedb Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, EgyptView further author information
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Alessio Nocentinic Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy;d Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, ItalyView further author information
,
Alessandro Bonardic Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy;d Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, ItalyView further author information
,
Mohammad M. Abd-Alhaseebe Department of Pharmacology and Toxicology, Damanhour University, Damanhour, Buhaira, EgyptView further author information
,
Sara T. Al-Rashoodf Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
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Giri Babu Veerakanelloreg Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USAView further author information
,
Taghreed A. Majrashih Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi ArabiaView further author information
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Eslam B. Elkaeedi Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi ArabiaView further author information
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Bahaa Elgendyg Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA;j Chemistry Department, Faculty of Science, Benha University, Benha, EgyptView further author information
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Paola Gratteric Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, ItalyORCID Iconhttps://orcid.org/0000-0002-9137-2509View further author information
ORCID Icon,
Claudiu T. Supurand Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
ORCID Icon,
Wagdy M. Eldehnak Department of Pharmaceutical Chemistry, Kafrelsheikh University, Kafrelsheikh, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6996-4017View further author information
ORCID Icon &
Mohamed Elagawanya Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, EgyptCorrespondence[email protected]
View further author information
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Article: 2201407 | Received 18 Mar 2023, Accepted 04 Apr 2023, Published online: 20 Apr 2023

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