Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

Ahmed A. Al-Karmalawya Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, EgyptCorrespondence[email protected]

https://orcid.org/0000-0002-8173-6073 View further author information

Dalia S. El-Gamila Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, EgyptView further author information

Rabeh El-Sheshenyb Water Pollution Research Department, The Center of Scientific Excellence for Influenza Viruses, Environmental Research Institute, National Research Centre, Giza, EgyptView further author information

Marwa Sharakyc Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, EgyptView further author information

Radwan Alnajjard Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya;e Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya;f Department of Chemistry, University of Cape Town, Rondebosch, South AfricaView further author information

Omnia Kutkatb Water Pollution Research Department, The Center of Scientific Excellence for Influenza Viruses, Environmental Research Institute, National Research Centre, Giza, EgyptView further author information

Yassmin Moatasimb Water Pollution Research Department, The Center of Scientific Excellence for Influenza Viruses, Environmental Research Institute, National Research Centre, Giza, EgyptView further author information

Mohamed Elagawanyg Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptView further author information

Sara T. Al-Rashoodh Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information

Faizah A. Binjubairh Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information

Wagdy M. Eldehnai Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt;j School of Biotechnology, Badr University in Cairo, Badr City, Egypt

https://orcid.org/0000-0001-6996-4017 View further author information

Ayman M. Noreddink Department of Internal Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA;l Department of Clinical Pharmacy, Faculty of Pharmacy, Ahram Canadian University, Giza, EgyptView further author information

Mohamed Y. Zakariam Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said, EgyptView further author information

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Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

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Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

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