Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant

Ashraf K. El-Damasya Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;b Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptCorrespondence[email protected] [email protected]
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Hyun Ji Kima Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Jung Woo Parkc Supercomputing Application Center, Div. of National Supercomputing, Korea Institute of Science and Technology Information, Daejeon, Republic of KoreaView further author information

Yunju Namd Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Wooyoung Hurd Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Eun-Kyoung Banga Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of KoreaView further author information

Gyochang Keuma Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea;e Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of KoreaCorrespondence[email protected]
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Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant

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Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant

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