PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1–AKT–mTOR/Bcl2 pathway

Hua Zhanga Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, ChinaView further author information

Shi-Jia Zhoua Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, ChinaView further author information

Chen-Feng Shena Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, ChinaView further author information

Yong-Nan Zhoua Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, ChinaView further author information

Cai-Yun Wua Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, ChinaView further author information

Meng-Yu Zhua Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, ChinaView further author information

Qi-Meng Yua Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, ChinaView further author information

Annoor Awadasseida Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, China;c Moganshan Institute, Zhejiang University of Technology, Deqing, ChinaView further author information

Yan-Ling Wud Lab of Molecular Immunology, Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaCorrespondence[email protected]
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Wen Zhanga Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China;b Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, China;e Zhejiang Jieyuan Pharmaceutical Technology Co., LTD, Hangzhou, ChinaCorrespondence[email protected]
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PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1–AKT–mTOR/Bcl2 pathway

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PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1–AKT–mTOR/Bcl2 pathway

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