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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Article

Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages

Lina M. A. Abdel Ghanya Pharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, EgyptView further author information
,
Botros Y. Beshayb Pharmaceutical Sciences (Pharmaceutical Chemistry) Department, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, EgyptCorrespondence[email protected]
View further author information
,
Amal M. Youssef Moustafac Chemistry Department, College of Science, Port Said University, Port Said, EgyptView further author information
,
Ali Hassan Ahmed Maghrabid Department of Biology, Umm Al-Qura University, Makkah, Saudi ArabiaView further author information
,
Eman Hussain Khalifa Alie Department of Laboratory Medicine, Al-Baha University, Al-Baha, Saudi ArabiaView further author information
,
Rasha Mohammed Saleemf Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi ArabiaView further author information
,
Islam Zakig Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, EgyptView further author information
&
Noha Ryadh Pharmaceutical Organic Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, EgyptView further author information
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Article: 2243551 | Received 26 May 2023, Accepted 28 Jul 2023, Published online: 09 Aug 2023

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