Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers

Naglaa M. Ahmeda Pharmaceutical Organic Chemistry Department, Helwan University, Ein-Helwan, EgyptCorrespondence[email protected] [email protected]
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Mosaad S. Mohameda Pharmaceutical Organic Chemistry Department, Helwan University, Ein-Helwan, EgyptView further author information

Samir M. Awada Pharmaceutical Organic Chemistry Department, Helwan University, Ein-Helwan, EgyptView further author information

Neama A. Abd El-tawaba Pharmaceutical Organic Chemistry Department, Helwan University, Ein-Helwan, EgyptView further author information

Mohamed S. Gaballahb Biochemistry and Molecular Biology Department, Helwan University, Ein-Helwan, EgyptView further author information

Ahmed M. Saida Pharmaceutical Organic Chemistry Department, Helwan University, Ein-Helwan, Egypt;c Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, USA;d Athenex Inc, Buffalo, NY, USAView further author information

Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers

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Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers

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