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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 23, 2022 - Issue 7-8
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Clinical

Using the ALSFRS-R in multicentre clinical trials for amyotrophic lateral sclerosis: potential limitations in current standard operating procedures

Jaap N.E. Bakers1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the Netherlands;2 Centre of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Centre, University Medical Centre Utrecht, and De Hoogstraat Rehabilitation, Utrecht, the Netherlands;3 Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Centre, University Medical Centre Utrecht, the NetherlandsView further author information
,
Adriaan D. de Jongh1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the NetherlandsView further author information
,
Tommy M. Bunte1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the NetherlandsView further author information
,
Lindsay Kendall4 Biostatistics, GlaxoSmithKline R&D, Stevenage, UKView further author information
,
Steve S. Han5 Neurosciences, Takeda Pharmaceuticals, Cambridge, USAView further author information
,
Noam Epstein6 Discovery Medicine, GlaxoSmithKline R&D, Upper Providence, USAView further author information
,
Arseniy Lavrov7 Clinical Development, Novartis Gene Therapies, Cambridge, UK, andView further author information
,
Anita Beelen2 Centre of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Centre, University Medical Centre Utrecht, and De Hoogstraat Rehabilitation, Utrecht, the Netherlands;3 Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Centre, University Medical Centre Utrecht, the NetherlandsView further author information
,
Johanna M.A. Visser-Meily2 Centre of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Centre, University Medical Centre Utrecht, and De Hoogstraat Rehabilitation, Utrecht, the Netherlands;3 Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Centre, University Medical Centre Utrecht, the NetherlandsView further author information
,
Leonard H. van den Berg1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the NetherlandsView further author information
&
Ruben P. A. van Eijk1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, the Netherlands;8 Biostatistics & Research Support, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the NetherlandsCorrespondence[email protected]
View further author information
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Pages 500-507 | Received 31 Oct 2021, Accepted 05 Dec 2021, Published online: 24 Dec 2021

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Using the ALSFRS-R in multicentre clinical trials for amyotrophic lateral sclerosis: potential limitations in current standard operating procedures
Source: Taylor & Francis

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