Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

Mainul HusainEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada,

Dongmei WuEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada,

Anne T. SaberThe Danish NanoSafety Centre, National Research Centre for the Working Environment, Copenhagen, Denmark,

Nathalie DecanEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada,

Nicklas R. JacobsenThe Danish NanoSafety Centre, National Research Centre for the Working Environment, Copenhagen, Denmark,

Andrew WilliamsThe Danish NanoSafety Centre, National Research Centre for the Working Environment, Copenhagen, Denmark,

Carole L. YaukEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada,

Hakan WallinThe Danish NanoSafety Centre, National Research Centre for the Working Environment, Copenhagen, Denmark, ;Institute of Public Health, University of Copenhagen, Copenhagen, Denmark, and

Ulla VogelThe Danish NanoSafety Centre, National Research Centre for the Working Environment, Copenhagen, Denmark, ;Department of Micro- and Nanotechnology, Technical University of Denmark, Kgs, Lyngby, Denmark

Sabina HalappanavarEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada, Correspondence[email protected]

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Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

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Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

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