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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 14
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Original Articles

Knoevenagel Condensation of Aldehydes with Meldrum's Acid in Ionic Liquids

, &
Pages 2605-2613 | Received 04 Sep 2008, Published online: 16 Jun 2009
 

Abstract

The Knoevenagel condensation of Meldrum's acid with aromatic aldehydes proceeded efficiently in the recyclable ionic liquid [bmim]BF4 at room temperature in the presence of catalytic amounts of piperidine.

ACKNOWLEDGMENT

This work was supported by an Indiana University–Purdue University Fort Wayne Summer Faculty Research Grant.

Notes

a All reactions run with 4-methoxybenzaldehyde (2 mmol) and Meldrum's acid (2 mmol) in ionic liquids (1 g) at room temperature for 10 h.

b Isolated 3e yields.

a At room temperature in [bmim]BF4 in the presence of 10 µL piperidine as the catalyst.

b Isolated yields.

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