Clinical Pharmacology: Advances and Applications, Volume 12, Issue (2020)

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Clinical Pharmacology: Advances and Applications, Volume 12, Issue (2020)

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Clinical Trial Report

Case Report
A Single- and Multiple-Dose Study to Evaluate the Pharmacokinetics of Fixed-Dose Grazoprevir/Elbasvir in Healthy Chinese Participants
Haiyan Li, Zhenhua Yang, Shuang Zhang, Lin Xu, Yudong Wei, Jun Jiang, Luzelena Caro, Hwa-Ping Feng, Jacqueline B McCrea, Meng Li, Shuang Xie, Jiangdian Wang, Xu Min Zhao & Shengmei Mu
Pages: 1-11
Published online: 15 Dec 2022
AbstractforA Single- and Multiple-Dose Study to Evaluate the Pharmacokinetics of Fixed-Dose Grazoprevir/Elbasvir in Healthy Chinese Participants | Full Text | References | PDF (6.3 MB) | EPUB
  • 115 Views
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Open Access

Original Research

Article
Determination of the Permeation and Penetration of Flurbiprofen into Cadaveric Human Pharynx Tissue
Rob Turner, Sean Robert Wevrett, Suzanne Edmunds, Marc B Brown, Robert Atkinson, Oluwajoba Adegoke, Anuradha Kulasekaran & Tim Shea
Pages: 13-20
Published online: 15 Dec 2022
AbstractforDetermination of the Permeation and Penetration of Flurbiprofen into Cadaveric Human Pharynx Tissue | Full Text | References | PDF (1.2 MB) | EPUB
  • 128 Views
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Open Access
Article
Pharmacokinetics, Safety, and Preliminary Efficacy of Oral Trifluridine/Tipiracil in Chinese Patients with Solid Tumors: A Phase 1b, Open-Label Study
Xicheng Wang, Jianfeng Zhou, Yan Li, Yuping Ge, Yanping Zhou, Chunmei Bai & Lin Shen
Pages: 21-33
Published online: 15 Dec 2022
AbstractforPharmacokinetics, Safety, and Preliminary Efficacy of Oral Trifluridine/Tipiracil in Chinese Patients with Solid Tumors: A Phase 1b, Open-Label Study | Full Text | References | PDF (612.3 KB) | EPUB
  • 142 Views
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Open Access
Article
Impact of Routine Platelet Reactivity Testing with VerifyNow Assay on Antiplatelet Choice After Percutaneous Coronary Intervention
Fakilahyel S Mshelbwala, Daniel W Hugenberg & Rolf P Kreutz
Pages: 35-41
Published online: 16 Apr 2020
AbstractforImpact of Routine Platelet Reactivity Testing with VerifyNow Assay on Antiplatelet Choice After Percutaneous Coronary Intervention | Full Text | References | PDF (1.2 MB) | EPUB
  • 94 Views
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Open Access

Expression of Concern

Expression of Concern
The Parkinson’s Disease Death Rate: Carbidopa and Vitamin B6 [Expression of Concern]
Page: 43
Published online: 15 Dec 2022
CitationforThe Parkinson’s Disease Death Rate: Carbidopa and Vitamin B6 [Expression of Concern] | Full Text | PDF (147.6 KB) | EPUB
  • 71 Views
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Expression of Concern
Parkinson’s Disease: Carbidopa, Nausea, and Dyskinesia [Expression of Concern]
Page: 45
Published online: 15 Dec 2022
CitationforParkinson’s Disease: Carbidopa, Nausea, and Dyskinesia [Expression of Concern] | Full Text | PDF (147.5 KB) | EPUB
  • 72 Views
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Open Access
Expression of Concern
Administration of Supplemental L-Tyrosine with Phenelzine: A Clinical Literature Review [Expression of Concern]
Page: 47
Published online: 23 Apr 2020
CitationforAdministration of Supplemental L-Tyrosine with Phenelzine: A Clinical Literature Review [Expression of Concern] | Full Text | PDF (146.4 KB) | EPUB
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Open Access

Short Report

Brief Report
The Effect of Moderate- and High-Fat Meals on the Bioavailability of Dolutegravir/Rilpivirine Fixed-Dose Combination Tablet
Rashmi Mehta, Joseph Piscitelli, Allen Wolstenholme, Caifeng Fu, Herta Crauwels, Brian Wynne & Kimberly Adkison
Pages: 49-52
Published online: 13 Nov 2022
AbstractforThe Effect of Moderate- and High-Fat Meals on the Bioavailability of Dolutegravir/Rilpivirine Fixed-Dose Combination Tablet | Full Text | References | PDF (749.9 KB) | EPUB
  • 214 Views
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Open Access

Original Research

Article
Biomarkers of IL-33 and sST2 and Lack of Association with Carvedilol Therapy in Heart Failure
Negar Firouzabadi, Maryam Dashti, Ali Dehshahri & Ehsan Bahramali
Pages: 53-58
Published online: 13 Nov 2022
AbstractforBiomarkers of IL-33 and sST2 and Lack of Association with Carvedilol Therapy in Heart Failure | Full Text | References | PDF (348.7 KB) | EPUB
  • 104 Views
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Open Access
Article
Overexpression of Adiponectin Receptors in Opium Users with and without Cancer
Negar Firouzabadi, Maral Haghnegahdar, Bahman Khalvati, Ali Dehshahri & Ehsan Bahramali
Pages: 59-65
Published online: 15 Jun 2020
AbstractforOverexpression of Adiponectin Receptors in Opium Users with and without Cancer | Full Text | References | PDF (378.2 KB) | EPUB
  • 93 Views
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Open Access
Article
Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats
Yazachew Engida Yismaw, Mohammedbrhan Abdelwuhab, Digambar B Ambikar, Ayenew Engida Yismaw, Dagninet Derebe & Wondim Melkam
Pages: 67-73
Published online: 26 Jun 2020
AbstractforPhytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats | Full Text | References | PDF (1 MB) | EPUB
  • 463 Views
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Open Access
Article
Clinical Efficacy of Transurethral Resection of the Prostate Combined with Oral Anticholinergics or Botulinum Toxin – A Injection to Treat Benign Prostatic Hyperplasia with Overactive Bladder: A Case–Control Study
Farzad Allameh, Abbas Basiri, Mohammadreza Razzaghi, Amir reza Abedi, Morteza Fallah-karkan, Saleh Ghiasy, Seyyed Mohammad Hosseininia & Saeed Montazeri
Pages: 75-81
Published online: 26 Jun 2020
AbstractforClinical Efficacy of Transurethral Resection of the Prostate Combined with Oral Anticholinergics or Botulinum Toxin – A Injection to Treat Benign Prostatic Hyperplasia with Overactive Bladder: A Case–Control Study | Full Text | References | PDF (342.4 KB) | EPUB
  • 196 Views
  • 2 CrossRef citations
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Open Access
Article
Pharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies
Yan Li, Maria Palmisano, Duxin Sun & Simon Zhou
Pages: 83-96
Published online: 13 Nov 2022
AbstractforPharmacokinetic Disposition Difference Between Cyclosporine and Voclosporin Drives Their Distinct Efficacy and Safety Profiles in Clinical Studies | Full Text | References | PDF (5.1 MB) | EPUB
  • 334 Views
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Open Access

Review

Review Article
Inhibitors of the Autotaxin-Lysophosphatidic Acid Axis and Their Potential in the Treatment of Interstitial Lung Disease: Current Perspectives
Sabrina Zulfikar, Sarah Mulholland, Huzaifa Adamali & Shaney L Barratt
Pages: 97-108
Published online: 13 Jul 2020
AbstractforInhibitors of the Autotaxin-Lysophosphatidic Acid Axis and Their Potential in the Treatment of Interstitial Lung Disease: Current Perspectives | Full Text | References | PDF (768 KB) | EPUB
  • 153 Views
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Open Access

Original Research

Article
Dose Regimen Rationale for Panitumumab in Cancer Patients: To Be Based on Body Weight or Not
Michael Z Liao, Marloes Berkhout, Hans Prenen, Sandeep Dutta & Vijay V Upreti
Pages: 109-114
Published online: 13 Nov 2022
AbstractforDose Regimen Rationale for Panitumumab in Cancer Patients: To Be Based on Body Weight or Not | Full Text | References | PDF (399.5 KB) | EPUB
  • 86 Views
  • 2 CrossRef citations
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Open Access

Commentary

Article Commentary
Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety
Sitaram Khadka, Dhan Bahadur Shrestha, Pravash Budhathoki & Era Rawal
Pages: 115-121
Published online: 13 Nov 2022
AbstractforHydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety | Full Text | References | PDF (267.5 KB) | EPUB
  • 103 Views
  • 3 CrossRef citations
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Open Access

Clinical Trial Report

Case Report
The Efficacy and Safety of Low Dose versus Usual Dose of Hyoscine During Endoscopic Retrograde Cholangiopancreatography: A Randomized Clinical Trial
Hassan Salmanroghani, Massoud Mirvakili, Mahtabalsadat Mirjalili, Mahmud Baghbanian & Roham Salmanroghani
Pages: 123-130
Published online: 13 Nov 2022
AbstractforThe Efficacy and Safety of Low Dose versus Usual Dose of Hyoscine During Endoscopic Retrograde Cholangiopancreatography: A Randomized Clinical Trial | Full Text | References | PDF (480.4 KB) | EPUB
  • 137 Views
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Open Access

Short Report

Brief Report
Reduced Prescription of Baloxavir After Suspected Prevalence of a Baloxavir-Resistant Influenza Virus Strain and the Emergence of SARS-CoV-2 in a Tertiary Hospital in Japan
Yasuhiro Kamioka, Shota Kashiwagura & Masafumi Seki
Pages: 131-134
Published online: 21 Aug 2020
AbstractforReduced Prescription of Baloxavir After Suspected Prevalence of a Baloxavir-Resistant Influenza Virus Strain and the Emergence of SARS-CoV-2 in a Tertiary Hospital in Japan | Full Text | References | PDF (826.3 KB) | EPUB
  • 77 Views
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Open Access

Original Research

Article
Predicted Efficacy of Once-Daily Extended-Release Oxcarbazepine (Oxtellar XR®) Monotherapy in Adults and Children with Partial-Onset Seizures: Exposure-Response Modeling and Simulation
Shamia Faison, Roberto Gomeni, Shannon Mendes, Welton O’Neal, Stefan Schwabe & Azmi Nasser
Pages: 135-147
Published online: 13 Nov 2022
AbstractforPredicted Efficacy of Once-Daily Extended-Release Oxcarbazepine (Oxtellar XR®) Monotherapy in Adults and Children with Partial-Onset Seizures: Exposure-Response Modeling and Simulation | Full Text | References | PDF (1.8 MB) | EPUB
  • 147 Views
  • 1 CrossRef citations
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Open Access
Article
Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats
Dagninet Derebe, Muluken Wubetu & Amare Alamirew
Pages: 149-157
Published online: 13 Nov 2022
AbstractforHypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats | Full Text | References | PDF (316.2 KB) | EPUB
  • 193 Views
  • 3 CrossRef citations
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Open Access
Article
Magnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study
Ali Reza Sobhani, Hossein Farshidi, Fariba Azarkish, Mahdiya Eslami, Ebrahim Eftekhar, Mansoor Keshavarz & Nepton Soltani
Pages: 159-169
Published online: 13 Nov 2022
AbstractforMagnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study | Full Text | References | PDF (2.8 MB) | EPUB
  • 133 Views
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Open Access
Article
Vitamin D Pretreatment Attenuates Ciprofloxacin-Induced Antibacterial Activity
Majed M Masadeh, Karem H Alzoubi, Bashar M Al-Taani, Majd M Masadeh, Zainah O Aburashed & Nasr Alrabadi
Pages: 171-176
Published online: 13 Nov 2022
AbstractforVitamin D Pretreatment Attenuates Ciprofloxacin-Induced Antibacterial Activity | Full Text | References | PDF (981.5 KB) | EPUB
  • 184 Views
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Open Access

Letter

Letter
Is Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Letter]
Jeroen J M A Hendrikx, Jos H Beijnen & Alwin D R Huitema
Pages: 177-178
Published online: 13 Nov 2022
CitationforIs Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Letter] | Full Text | References | PDF (214.7 KB) | EPUB
  • 83 Views
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Open Access

Original Research

Article
Psychotropic Medications-Induced Tardive Dyskinesia and Associated Factors Among Patients with Mental Illness in Ethiopia
Assefa Kumsa, Shimelis Girma, Bezaye Alemu & Liyew Agenagnew
Pages: 179-187
Published online: 13 Nov 2022
AbstractforPsychotropic Medications-Induced Tardive Dyskinesia and Associated Factors Among Patients with Mental Illness in Ethiopia | Full Text | References | PDF (696.4 KB) | EPUB
  • 217 Views
  • 2 CrossRef citations
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Open Access

Response to Letter

Is Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Response to Letter]
Michael Z Liao, Johannes Kast, Marloes Berkhout, Hans Prenen, Sandeep Dutta & Vijay V Upreti
Pages: 189-190
Published online: 13 Nov 2022
CitationforIs Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Response to Letter] | Full Text | References | PDF (212.1 KB) | EPUB
  • 93 Views
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Open Access

Review

Review Article
Safety and Tolerability of PCSK9 Inhibitors: Current Insights
Constantine E Kosmas, Andreas Skavdis, Andreas Sourlas, Evangelia J Papakonstantinou, Edilberto Peña Genao, Rogers Echavarria Uceta & Eliscer Guzman
Pages: 191-202
Published online: 11 Dec 2020
AbstractforSafety and Tolerability of PCSK9 Inhibitors: Current Insights | Full Text | References | PDF (340.2 KB) | EPUB
  • 398 Views
  • 9 CrossRef citations
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Open Access
Review Article
An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease
Tafere Mulaw Belete
Pages: 203-212
Published online: 14 Dec 2020
AbstractforAn Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease | Full Text | References | PDF (993.8 KB) | EPUB
  • 132 Views
  • 6 CrossRef citations
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Open Access

Original Research

Article
Wound Healing Effect of Acokanthera schimperi Schweinf (Apocynaceae) Methanol Leaf Extract Ointment in Mice and Its in-vitro Antioxidant Activity
Belete Kassa Alemu, Desye Misganaw & Getnet Mengistu
Pages: 213-222
Published online: 13 Nov 2022
AbstractforWound Healing Effect of Acokanthera schimperi Schweinf (Apocynaceae) Methanol Leaf Extract Ointment in Mice and Its in-vitro Antioxidant Activity | Full Text | References | PDF (378.8 KB) | EPUB
  • 440 Views
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