Journal of Experimental Pharmacology, Volume 14, Issue (2022)

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Journal of Experimental Pharmacology, Volume 14, Issue (2022)

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Commentary

Article Commentary
Clinical Interpretation of Efficacy Outcomes in Pharmacological Studies on Triple Fixed-Dose Combination Therapy for Uncontrolled Asthma: Assessment of IRIDIUM and ARGON Studies
Paola Rogliani & Luigino Calzetta
Pages: 1-5
Published online: 14 Nov 2022
AbstractforClinical Interpretation of Efficacy Outcomes in Pharmacological Studies on Triple Fixed-Dose Combination Therapy for Uncontrolled Asthma: Assessment of IRIDIUM and ARGON Studies | Full Text | References | PDF (255.8 KB) | EPUB
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Original Research

Article
Antimalarial Activity of Solvent Fractions of the Stem Bark of Periploca linearifolia Quart.-Dill. & A.Rich. (Asclepiadaceae) Against Plasmodium berghei in Mice
Wubetu Yihunie Belay, Abyot Endale Gurmu & Zewdu Birhanu Wubneh
Pages: 7-15
Published online: 11 Jan 2022
AbstractforAntimalarial Activity of Solvent Fractions of the Stem Bark of Periploca linearifolia Quart.-Dill. & A.Rich. (Asclepiadaceae) Against Plasmodium berghei in Mice | Full Text | References | PDF (389.7 KB) | EPUB
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Article
Antibacterial, Antifungal, and Cytotoxic Activity of Excoecaria agallocha Leaf Extract
Kuzhunellil Raghavanpillai Sabu, Sujith Sugathan, Akbar Idhayadhulla, Melat Woldemariam, Addis Aklilu, Gelila Biresaw, Behailu Tsegaye & Aseer Manilal
Pages: 17-26
Published online: 14 Jan 2022
AbstractforAntibacterial, Antifungal, and Cytotoxic Activity of Excoecaria agallocha Leaf Extract | Full Text | References | PDF (1.3 MB) | EPUB
  • 542 Views
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Article
Evaluation of Anti-Diabetic and Anti-Hyperlipidemic Activities of Hydro-Alcoholic Crude Extract of the Shoot Tips of Crinum abyssinicum Hochst. ex A. Rich (Amaryllidaceae) in Mice
Bantayehu Addis Tegegne, Abebe Basazn Mekuria & Eshetie Melese Birru
Pages: 27-41
Published online: 01 Feb 2022
AbstractforEvaluation of Anti-Diabetic and Anti-Hyperlipidemic Activities of Hydro-Alcoholic Crude Extract of the Shoot Tips of Crinum abyssinicum Hochst. ex A. Rich (Amaryllidaceae) in Mice | Full Text | References | PDF (407.5 KB) | EPUB
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Article
Non-Clinical Safety Pharmacology Evaluations of Trazpiroben (TAK-906), a Novel Dopamine D2/D3 Selective Receptor Antagonist for the Management of Gastroparesis
Laura Kreckler, Mark Osinski, Scott Williams & Roger Whiting
Pages: 43-57
Published online: 09 Feb 2022
AbstractforNon-Clinical Safety Pharmacology Evaluations of Trazpiroben (TAK-906), a Novel Dopamine D2/D3 Selective Receptor Antagonist for the Management of Gastroparesis | Full Text | References | PDF (426.8 KB) | EPUB
  • 167 Views
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Article
Antidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity
Woretaw Sisay, Yared Andargie & Mulugeta Molla
Pages: 59-72
Published online: 09 Feb 2022
AbstractforAntidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity | Full Text | References | PDF (579.5 KB) | EPUB
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Article
The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats
Heta Dinesh Bhatt, Steve A McClain, Hsi-Ming Lee, Thomas Zimmerman, Jie Deng, Francis Johnson, Ying Gu & Lorne M Golub
Pages: 73-85
Published online: 09 Feb 2022
AbstractforThe Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats | Full Text | References | PDF (5 MB) | EPUB
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Article
Oral Intragastric DMBA Administration Induces Acute Lymphocytic Leukemia and Other Tumors in Male Wistar Rats
Omar S El-Masry, Hussain Abdullah Alhawaj, Muaz O Fagere, Amani Y Owaidah, Aisha Alamri & Khaldoon Alsamman
Pages: 87-96
Published online: 25 Feb 2022
AbstractforOral Intragastric DMBA Administration Induces Acute Lymphocytic Leukemia and Other Tumors in Male Wistar Rats | Full Text | References | PDF (2.7 MB) | EPUB
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Review

Review Article
Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery
Leena Abdulaziz, Esraa Elhadi, Ejlal A Abdallah, Fadlalbaseer A Alnoor & Bashir A Yousef
Pages: 97-115
Published online: 08 Mar 2022
AbstractforAntiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery | Full Text | References | PDF (1.7 MB) | EPUB
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Original Research

Article
SAGE: Novel Therapy to Reduce Inflammation in a Naturally Occurring-Dog Model of Periodontal Disease
Veena Raja, Ying Gu, Hsi-Ming Lee, Jie Deng, Glenn Prestwich & Maria Ryan
Pages: 117-129
Published online: 30 Mar 2022
AbstractforSAGE: Novel Therapy to Reduce Inflammation in a Naturally Occurring-Dog Model of Periodontal Disease | Full Text | References | PDF (2.5 MB) | EPUB
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Case Report

Case Report
Success of Intralesional Purified Protein Derivative Immunotherapy in the Treatment of Anogenital Warts: A Case Report
Pati Aji Achdiat, Narizka Civiadenta Antariksa, Rasmia Rowawi, Oki Suwarsa, Yudi Mulyana Hidayat, Reiva Farah Dwiyana, Hendra Gunawan & Reti Hindritiani
Pages: 131-135
Published online: 14 Nov 2022
AbstractforSuccess of Intralesional Purified Protein Derivative Immunotherapy in the Treatment of Anogenital Warts: A Case Report | Full Text | References | PDF (539.1 KB) | EPUB
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Retraction

Retraction
Investigation of Antibacterial and Anti-Diarrhoeal Activities of 80% Methanol Leaf and Fruit Extract of Leonotis Ocymifolia (Burm. F) Iwarsson (Lamiaceae) [Retraction]
Pages: 137-138
Published online: 19 Apr 2022
CitationforInvestigation of Antibacterial and Anti-Diarrhoeal Activities of 80% Methanol Leaf and Fruit Extract of Leonotis Ocymifolia (Burm. F) Iwarsson (Lamiaceae) [Retraction] | Full Text | PDF (241.6 KB) | EPUB
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Original Research

Article
Effects of the Oral Administration of Aqueous and Methanolic Leaf Extracts of Chenopodium ambrosioides L. (Amaranthaceae) on Blood Glucose Levels in Wistar Rats
Félicien Mushagalusa Kasali, Justin Ntokamunda Kadima, Jonans Tusiimire, Clement Olusoji Ajayi & Amon Ganafa Agaba
Pages: 139-148
Published online: 26 Apr 2022
AbstractforEffects of the Oral Administration of Aqueous and Methanolic Leaf Extracts of Chenopodium ambrosioides L. (Amaranthaceae) on Blood Glucose Levels in Wistar Rats | Full Text | References | PDF (2.2 MB) | EPUB
  • 222 Views
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Article
Investigation of HPLF-111624 in Modified Experimental Models of Ulcerative Proctitis and Anal Fissure in Rats
Mallappa Onkaramurthy, Mohammed Mukhram Azeemuddin, Mirza Rizwan Baig, Pavan Heggadadevanakote Kendaganna, Mohamed Rafiq & Uddagiri Venkanna Babu
Pages: 149-165
Published online: 27 Apr 2022
AbstractforInvestigation of HPLF-111624 in Modified Experimental Models of Ulcerative Proctitis and Anal Fissure in Rats | Full Text | References | PDF (8.8 MB) | EPUB
  • 190 Views
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Open Access
Article
Wound Healing Activity of 80% Methanolic Crude Extract and Solvent Fractions of the Leaves of Justicia schimperiana (Hochst. ex Nees) T. Anderson (Acanthaceae) in Mice
Shemelis Gebrewoled G/giorgis, Digambar Ambikar, Asegedech Tsegaw & Yaschilal Muche Belayneh
Pages: 167-183
Published online: 13 May 2022
AbstractforWound Healing Activity of 80% Methanolic Crude Extract and Solvent Fractions of the Leaves of Justicia schimperiana (Hochst. ex Nees) T. Anderson (Acanthaceae) in Mice | Full Text | References | PDF (2.1 MB) | EPUB
  • 484 Views
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Article
Hypoglycemic, Antihyperglycemic, and Toxic Effects of Physalis peruviana L. Aqueous and Methanolic Leaf Extracts in Wistar Rats
Félicien Mushagalusa Kasali, Justin Ntokamunda Kadima, Jonans Tusiimire & Amon Ganafa Agaba
Pages: 185-193
Published online: 07 Jun 2022
AbstractforHypoglycemic, Antihyperglycemic, and Toxic Effects of Physalis peruviana L. Aqueous and Methanolic Leaf Extracts in Wistar Rats | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Chemical Composition, Antioxidant, and Mosquito Larvicidal Activity of Essential Oils from Hyptis capitata Jacq
Roy John, Kuzhunellil Raghavanpillai Sabu & Aseer Manilal
Pages: 195-204
Published online: 13 Jun 2022
AbstractforChemical Composition, Antioxidant, and Mosquito Larvicidal Activity of Essential Oils from Hyptis capitata Jacq | Full Text | References | PDF (643.5 KB) | EPUB
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Article
Meriandra dianthera Aqueous Extract and Its Fraction Prevents Blood Coagulation by Specifically Inhibiting the Intrinsic Coagulation Pathway: An in vitro Study
Filmon Kiflezghi Kiflemariam, Abiel Ghebrehiwet Tewelde, Ali Mahmud Hamid, Bilal Mussa Beshir, Samrawit Negasi Solomon, Tesfu Gonets Eman, Daniel Mebrahtu Abraha, Russom Kahsu, John Issac & Jeevan Jyoti Kaushik
Pages: 205-212
Published online: 29 Jun 2022
AbstractforMeriandra dianthera Aqueous Extract and Its Fraction Prevents Blood Coagulation by Specifically Inhibiting the Intrinsic Coagulation Pathway: An in vitro Study | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Testicular Toxicity of Chloroxylenol in Rats: Biochemical, Pathological and Flow Cytometric Study
Doaa Abdallah El-Naggar, Laila Mohammed Ahmad El-Zalabany, Doaa Abdelhalim Shahin, Afaf Mahmoud Attia & Shaaban Abdelfattah El-Mosallamy
Pages: 213-220
Published online: 13 Jul 2022
AbstractforTesticular Toxicity of Chloroxylenol in Rats: Biochemical, Pathological and Flow Cytometric Study | Full Text | References | PDF (4.2 MB) | EPUB
  • 237 Views
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ORIGINAL RESEARCH

Article
Local Anesthetic Like Inhibition of the Cardiac Na+ Channel Nav1.5 by Chloroquine and Hydroxychloroquine
Axel Hage, Mathis de Vries, Andreas Leffler & Carsten Stoetzer
Pages: 353-365
Published online: 08 Nov 2022
AbstractforLocal Anesthetic Like Inhibition of the Cardiac Na+ Channel Nav1.5 by Chloroquine and Hydroxychloroquine | Full Text | References | PDF (6.5 MB) | EPUB
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Article
Neurobehavioral and Immunohistochemical Studies of the Cerebral Cortex Following Treatment with Ethyl Acetate Leaf Fraction of Tamarindus indica During Prenatal Aluminum Chloride Exposure in Wistar Rats
Ibe Michael Usman, Samuel Sunday Adebisi, Sunday Abraham Musa, Ibrahim Abdullahi Iliya, Juma John Ochieng, Andrew Ekpeyong Ivang, Akwu Bala Peter & Akeem Ayodeji Okesina
Pages: 275-289
Published online: 20 Oct 2022
AbstractforNeurobehavioral and Immunohistochemical Studies of the Cerebral Cortex Following Treatment with Ethyl Acetate Leaf Fraction of Tamarindus indica During Prenatal Aluminum Chloride Exposure in Wistar Rats | Full Text | References | PDF (7.5 MB) | EPUB
  • 256 Views
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Article
Evaluation of in vivo Antidiabetic, Antidyslipidemic and in vitro Anti-Oxidant Activity of Extract and Solvent Fractions of Discopodium penninervum Hoschst Leaf in Mice: Normoglycemic and Streptozocin-Induced Model
Wakuma Wakene Jifar, Gebiso Roba Debele, Shuma Gosha Kanfe & Chaltu Takele Mule
Pages: 317-330
Published online: 28 Oct 2022
AbstractforEvaluation of in vivo Antidiabetic, Antidyslipidemic and in vitro Anti-Oxidant Activity of Extract and Solvent Fractions of Discopodium penninervum Hoschst Leaf in Mice: Normoglycemic and Streptozocin-Induced Model | Full Text | References | PDF (544.2 KB) | EPUB
  • 388 Views
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REVIEW

Review
Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia
Boris Decourt, Keith Noorda, Kevin Noorda, Jiong Shi & Marwan N Sabbagh
Pages: 331-352
Published online: 30 Oct 2022
AbstractforReview of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia | Full Text | References | PDF (694.6 KB) | EPUB
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ORIGINAL RESEARCH

Article
In-vivo Wound Healing and Anti-Inflammatory Activity of the Solvent Fraction of Zehneria scabra L.F. Sond (Cucurbitaceae) Leaves
Nebeyi Fisseha, Workineh Woldeselassie Hammeso, Dejen Nureye, Tarekegn Tesfaye & Tesfaye Yimer
Pages: 367-377
Published online: 02 Dec 2022
AbstractforIn-vivo Wound Healing and Anti-Inflammatory Activity of the Solvent Fraction of Zehneria scabra L.F. Sond (Cucurbitaceae) Leaves | Full Text | References | PDF (2.2 MB) | EPUB
  • 313 Views
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Article
Antidepressant-Like Activity of Solvent Fractions of the Root Bark of Carissa spinarum Linn. (Apocynaceae) in Rodents Involves Multiple Signaling Pathways
Hana Saif Ali & Ephrem Engidawork
Pages: 379-394
Published online: 08 Dec 2022
AbstractforAntidepressant-Like Activity of Solvent Fractions of the Root Bark of Carissa spinarum Linn. (Apocynaceae) in Rodents Involves Multiple Signaling Pathways | Full Text | References | PDF (3.3 MB) | EPUB
  • 373 Views
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Article
Estimation of Platelet Count and Bleeding Time of Mice Treated with Musa paradisiaca var. sapientum (L.) Kuntze Extract
Hendrik Setia Budi, Doaa Elsayed Ramadan, Silvia Anitasari & Elza Widya Pangestika
Pages: 301-308
Published online: 26 Oct 2022
AbstractforEstimation of Platelet Count and Bleeding Time of Mice Treated with Musa paradisiaca var. sapientum (L.) Kuntze Extract | Full Text | References | PDF (1.3 MB) | EPUB
  • 258 Views
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Article
Antidiabetic Activity of Hot Tea Infusion of Leaves of Moringa stenopetala in Streptozotocin-Induced Diabetic Rats
Alemayehu Toma
Pages: 309-316
Published online: 22 Dec 2022
AbstractforAntidiabetic Activity of Hot Tea Infusion of Leaves of Moringa stenopetala in Streptozotocin-Induced Diabetic Rats | Full Text | References | PDF (400.1 KB) | EPUB
  • 286 Views
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Article
Anticonvulsant Activity of Hydro Alcoholic Extract and Solvent Fractions of Biophytum umbraculum Welw. Syn (Oxalidaceae) Root in Mice
Nebeyi Fisseha, Workineh Woldeselassie Hammeso & Dejen Nureye
Pages: 291-299
Published online: 20 Oct 2022
AbstractforAnticonvulsant Activity of Hydro Alcoholic Extract and Solvent Fractions of Biophytum umbraculum Welw. Syn (Oxalidaceae) Root in Mice | Full Text | References | PDF (2.2 MB) | EPUB
  • 347 Views
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Article
Evaluation of Wound Healing Activity of 80% Methanol Root Crude Extract and Solvent Fractions of Stephania abyssinica (Dill. & A. Rich.) Walp. (Menispermaceae) in Mice
Tesfagegn Gobezie Yiblet, Asegedech Tsegaw, Nejat Ahmed, Samuel Berihun Dagnew, Tesfaye Yimer Tadesse & Zemene Demelash Kifle
Pages: 255-273
Published online: 08 Aug 2022
AbstractforEvaluation of Wound Healing Activity of 80% Methanol Root Crude Extract and Solvent Fractions of Stephania abyssinica (Dill. & A. Rich.) Walp. (Menispermaceae) in Mice | Full Text | References | PDF (4.3 MB) | EPUB
  • 396 Views
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Article
Evaluation of Wound Healing Activity of 80% Hydromethanolic Crude Extract and Solvent Fractions of the Leaves of Urtica simensis in Mice
Bezawit Alem Abeje, Tiruzer Bekele, Kefyalew Ayalew Getahun & Assefa Belay Asrie
Pages: 221-241
Published online: 17 Jul 2022
AbstractforEvaluation of Wound Healing Activity of 80% Hydromethanolic Crude Extract and Solvent Fractions of the Leaves of Urtica simensis in Mice | Full Text | References | PDF (4.3 MB) | EPUB
  • 623 Views
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Article
Caffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line
Eri Amalia, Ajeng Diantini, Erwahyuni Endang Prabandari, Danang Waluyo & Anas Subarnas
Pages: 243-253
Published online: 23 Jul 2022
AbstractforCaffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line | Full Text | References | PDF (4.1 MB) | EPUB
  • 246 Views
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Article
The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model
Emni Purwoningsih, Wawaimuli Arozal, Hee Jae Lee, Agian Jeffilano Barinda, Yulvian Sani & Abdul Munim
Pages: 395-407
Published online: 24 Dec 2022
AbstractforThe Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model | Full Text | References | PDF (4.7 MB) | EPUB
  • 343 Views
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