Journal of Inflammation Research, Volume 15, Issue (2022)

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Journal of Inflammation Research, Volume 15, Issue (2022)

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RETRACTION

Retraction
Synthesis, in silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment [Retraction]
Pages: 6067-6068
Published online: 03 Nov 2022
CitationforSynthesis, in silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment [Retraction] | Full Text | PDF (242.4 KB) | EPUB
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REVIEW

Review
Procalcitonin as a Tool to Antimicrobial Stewardship in COVID-19 Patients with Superimposed Bacterial Infections: A Systematic Review
Ibrahim Omer, Noorah Abuthiyab, Nura Al Zaid, Raghad Alkanani, Reema Abualnaja & Ghadeer Khan
Pages: 6055-6064
Published online: 26 Sep 2023
AbstractforProcalcitonin as a Tool to Antimicrobial Stewardship in COVID-19 Patients with Superimposed Bacterial Infections: A Systematic Review | Full Text | References | PDF (479.7 KB) | EPUB
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RETRACTION

Retraction
Benzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment [Retraction]
Pages: 6065-6066
Published online: 04 Nov 2022
CitationforBenzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment [Retraction] | Full Text | PDF (245 KB) | EPUB
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ORIGINAL RESEARCH

Article
Diagnostic and Prognostic Value of Dysregulated miR-10a-3p in Patients with Severe Pneumonia
Jianwan Xie, Yanchu Li, Man Wang, Wenping He & Xinxin Zhao
Pages: 6097-6104
Published online: 26 Sep 2023
AbstractforDiagnostic and Prognostic Value of Dysregulated miR-10a-3p in Patients with Severe Pneumonia | Full Text | References | PDF (1.7 MB) | EPUB
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CASE REPORT

Case Report
Dermatomyositis Flare After a COVID-19 Infection Successfully Treated with Rituximab: A Case Report and Literature Review
Ahmed Mohammed Albakri, Ahmed Hussein Subki, Abdurahman Albeity & Hussein Halabi
Pages: 6047-6053
Published online: 02 Nov 2022
AbstractforDermatomyositis Flare After a COVID-19 Infection Successfully Treated with Rituximab: A Case Report and Literature Review | Full Text | References | PDF (390.6 KB) | EPUB
  • 386 Views
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ORIGINAL RESEARCH

Article
Neutrophil to High-Density Lipoprotein Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
Ruirui Zhang, Fanfu Jin, Lanlan Zheng, Tingwei Liao, Guangling Guan, Jianfei Wang, Shoucai Zhao, Shizao Fei, Zhaohu Chu & Yang Xu
Pages: 6073-6085
Published online: 26 Sep 2023
AbstractforNeutrophil to High-Density Lipoprotein Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke | Full Text | References | PDF (1.6 MB) | EPUB
  • 107 Views
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Article
A Systemic Inflammation Response Score for Prognostic Prediction in Hepatocellular Carcinoma Patients After Hepatectomy
Deyao Zhang, Lanqing Huo, Yangxun Pan, Zhenyun Yang, Huilan Zeng, Xin Wang, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Minshan Chen & Dandan Hu
Pages: 6869-6881
Published online: 29 Dec 2022
AbstractforA Systemic Inflammation Response Score for Prognostic Prediction in Hepatocellular Carcinoma Patients After Hepatectomy | Full Text | References | PDF (1.6 MB) | EPUB
  • 34 Views
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Open Access
Article
Associations of Inflammation with Risk of Cardiovascular and All-Cause Mortality in Adults with Hypertension: An Inflammatory Prognostic Scoring System
Iokfai Cheang, Xu Zhu, Xinyi Lu, Xin Yue, Yuan Tang, Rongrong Gao, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Kai-Hang Yiu & Xinli Li
Pages: 6125-6136
Published online: 08 Nov 2022
AbstractforAssociations of Inflammation with Risk of Cardiovascular and All-Cause Mortality in Adults with Hypertension: An Inflammatory Prognostic Scoring System | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Peripheral Blood Lymphocyte Subsets as a Risk Predictor of Patients with Endometrioid Endometrial Cancer
Pingping Su, Jian An, Lirui Yu, Huifang Lei, Lixiang Huang, Xiaodan Mao & Pengming Sun
Pages: 6153-6163
Published online: 26 Sep 2023
AbstractforPeripheral Blood Lymphocyte Subsets as a Risk Predictor of Patients with Endometrioid Endometrial Cancer | Full Text | References | PDF (4.7 MB) | EPUB
  • 85 Views
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Article
Construction of Autophagy-Related Gene Classifier for Early Diagnosis, Prognosis and Predicting Immune Microenvironment Features in Sepsis by Machine Learning Algorithms
Zhen Chen, Liming Zeng, Genglong Liu, Yangpeng Ou, Chuangang Lu, Ben Yang & Liuer Zuo
Pages: 6165-6186
Published online: 08 Nov 2022
AbstractforConstruction of Autophagy-Related Gene Classifier for Early Diagnosis, Prognosis and Predicting Immune Microenvironment Features in Sepsis by Machine Learning Algorithms | Full Text | References | PDF (20.2 MB) | EPUB
  • 87 Views
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Article
FGF15 Protects Septic Mice by Inhibiting Inflammation and Modulating Treg Responses
Xing Li, Zexiang Zhu, Zhenkun Xia & Bo Xu
Pages: 6187-6197
Published online: 08 Nov 2022
AbstractforFGF15 Protects Septic Mice by Inhibiting Inflammation and Modulating Treg Responses | Full Text | References | PDF (5.1 MB) | EPUB
  • 71 Views
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Article
Screening Key lncRNAs of Ankylosing Spondylitis Using Bioinformatics Analysis
Jian-Xiong Wang, Xu Zhao & Sheng-Qian Xu
Pages: 6087-6096
Published online: 26 Sep 2023
AbstractforScreening Key lncRNAs of Ankylosing Spondylitis Using Bioinformatics Analysis | Full Text | References | PDF (4.4 MB) | EPUB
  • 89 Views
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Article
Mast Cell Specific Receptor Mrgprb2 Regulating Experimental Colitis is Associated with the Microbiota-Gut-Brain Axis
Ming Shao, Fangting Yuan, Jingwen Liu & Hesheng Luo
Pages: 6137-6151
Published online: 26 Sep 2023
AbstractforMast Cell Specific Receptor Mrgprb2 Regulating Experimental Colitis is Associated with the Microbiota-Gut-Brain Axis | Full Text | References | PDF (14.1 MB) | EPUB
  • 112 Views
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Article
Bergaptol Alleviates LPS-Induced Neuroinflammation, Neurological Damage and Cognitive Impairment via Regulating the JAK2/STAT3/p65 Pathway
Jianbing Wu, Jie Zhang, Qiangli Xie, Xiaohuan He, Zhangchao Guo, Bo Zheng, Sisong Wang, Qiumei Yang & Chunfu Du
Pages: 6199-6211
Published online: 09 Nov 2022
AbstractforBergaptol Alleviates LPS-Induced Neuroinflammation, Neurological Damage and Cognitive Impairment via Regulating the JAK2/STAT3/p65 Pathway | Full Text | References | PDF (10.5 MB) | EPUB
  • 94 Views
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REVIEW

Review
Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases
Yimin Han, Boya Wang, Han Gao, Chengwei He, Rongxuan Hua, Chen Liang, Sitian Zhang, Ying Wang, Shuzi Xin & Jingdong Xu
Pages: 6213-6230
Published online: 26 Sep 2023
AbstractforVagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases | Full Text | References | PDF (6 MB) | EPUB
  • 2051 Views
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ORIGINAL RESEARCH

Article
Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa
Yang-Kun Wang, Chun Li, Yong-Mei Zhou, Lei Zeng, Ying-Ying Li, Si-Lin Huang, Chao-Ya Zhu, Yue Wang, Su-Nan Wang & Xiao-Dong Chen
Pages: 6231-6243
Published online: 26 Sep 2023
AbstractforHistopathological Features of Helicobacter pylori Infection in Gastric Mucosa | Full Text | References | PDF (3.1 MB) | EPUB
  • 146 Views
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Article
Pro-Inflammatory and Anti-Inflammatory Cytokines Levels are Significantly Altered in Cerebrospinal Fluid of Unruptured Intracranial Aneurysm (UIA) Patients
Joanna Kamińska, Mateusz Maciejczyk, Agnieszka Ćwiklińska, Joanna Matowicka-Karna & Olga Martyna Koper-Lenkiewicz
Pages: 6245-6261
Published online: 26 Sep 2023
AbstractforPro-Inflammatory and Anti-Inflammatory Cytokines Levels are Significantly Altered in Cerebrospinal Fluid of Unruptured Intracranial Aneurysm (UIA) Patients | Full Text | References | PDF (1.2 MB) | EPUB
  • 109 Views
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Open Access
Article
Macrophage-Specific Cathepsin as a Marker Correlated with Prognosis and Tumor Microenvironmental Characteristics of Clear Cell Renal Cell Carcinoma
Fan Zhang, Jiayu Liang, You Lu, Yongquan Tang, Shengzhuo Liu, Kan Wu, Fuxun Zhang, Yiping Lu, Zhihong Liu & Xianding Wang
Pages: 6275-6292
Published online: 11 Nov 2022
AbstractforMacrophage-Specific Cathepsin as a Marker Correlated with Prognosis and Tumor Microenvironmental Characteristics of Clear Cell Renal Cell Carcinoma | Full Text | References | PDF (14.2 MB) | EPUB
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Article
Sympathectomy Ameliorates CFA-Induced Mechanical Allodynia via Modulating Phenotype of Macrophages in Sensory Ganglion in Mice
Lijia Mai, Shilin Jia, Qing Liu, Yanhao Chu, Jinyue Liu, Shengyan Yang, Fang Huang & Wenguo Fan
Pages: 6263-6274
Published online: 11 Nov 2022
AbstractforSympathectomy Ameliorates CFA-Induced Mechanical Allodynia via Modulating Phenotype of Macrophages in Sensory Ganglion in Mice | Full Text | References | PDF (4.6 MB) | EPUB
  • 81 Views
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Article
Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis
Ji Zhu, Hang Chen, Jianan Guo, Chen Zha & Dezhao Lu
Pages: 6293-6306
Published online: 26 Sep 2023
AbstractforSodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis | Full Text | References | PDF (10.9 MB) | EPUB
  • 76 Views
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REVIEW

Review
Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie
Shufeng Liang, Xin Tian & Chunyan Wang
Pages: 6307-6328
Published online: 15 Nov 2022
AbstractforNanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie | Full Text | References | PDF (8.2 MB) | EPUB
  • 278 Views
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ORIGINAL RESEARCH

Article
Systemic Inflammatory Response in Spontaneous Subarachnoid Hemorrhage from Aneurysmal Rupture versus Subarachnoid Hemorrhage of Unknown Origin
Susanna Bacigaluppi, Nicola L Bragazzi, Federico Ivaldi, Federica Benvenuto, Antonio Uccelli & Gianluigi Zona
Pages: 6329-6342
Published online: 26 Sep 2023
AbstractforSystemic Inflammatory Response in Spontaneous Subarachnoid Hemorrhage from Aneurysmal Rupture versus Subarachnoid Hemorrhage of Unknown Origin | Full Text | References | PDF (5.5 MB) | EPUB
  • 67 Views
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Open Access
Article
The Effect of PD-1 Inhibitor Combined with Irradiation on HMGB1-Associated Inflammatory Cytokines and Myocardial Injury
Jie Bai, Bibo Wu, Shasha Zhao, Gang Wang, Shengfa Su, Bing Lu, Yinxiang Hu, Yichao Geng, Zhengneng Guo, Jun Wan, Weiwei OuYang, Cheng Hu & Jie Liu
Pages: 6357-6371
Published online: 26 Sep 2023
AbstractforThe Effect of PD-1 Inhibitor Combined with Irradiation on HMGB1-Associated Inflammatory Cytokines and Myocardial Injury | Full Text | References | PDF (8.8 MB) | EPUB
  • 56 Views
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Article
Studies on HBcAg-rBlo t 5-21 Fusion Protein Vaccine That Alleviates Blomia tropicalis Airway Inflammation
Yechun Pei, Zhengpan Xiao, Shuangshuang Wei, Meiqi Peng, Chenghui Luo & Dayong Wang
Pages: 6343-6355
Published online: 26 Sep 2023
AbstractforStudies on HBcAg-rBlo t 5-21 Fusion Protein Vaccine That Alleviates Blomia tropicalis Airway Inflammation | Full Text | References | PDF (9.7 MB) | EPUB
  • 70 Views
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CASE SERIES

Resolved Hypereosinophilic Syndrome and Immune Thrombocytopenic Purpura in Ulcerative Colitis Patients Post Colectomy: A Case Series and Literature Review
Ahmed Hussein Subki, Manal Ismail Bokhary, Sultan Abdulrahman Alandijani, Mohannad Abdulrahman Aljehani, Ahmed Wasel Alharbi, May Alzahrani, Saud Suliman Almuhammadi, Bassim Tahseen Albeirouti, Mohamed Abdulmajid Abduljabar & Silvio Danese
Pages: 6373-6380
Published online: 26 Sep 2023
AbstractforResolved Hypereosinophilic Syndrome and Immune Thrombocytopenic Purpura in Ulcerative Colitis Patients Post Colectomy: A Case Series and Literature Review | Full Text | References | PDF (437.9 KB) | EPUB
  • 122 Views
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ORIGINAL RESEARCH

Article
Anti-Inflammatory and Analgesic Activity of Methanolic Root Extract of Verbascum sinaiticum Benth
Minda Asefa, Nathnael Teshome & Abel Degu
Pages: 6381-6392
Published online: 22 Nov 2022
AbstractforAnti-Inflammatory and Analgesic Activity of Methanolic Root Extract of Verbascum sinaiticum Benth | Full Text | References | PDF (533.3 KB) | EPUB
  • 220 Views
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Article
Development and Validation of an Age-Related Gastric Cancer-Specific Immune Index
Hao Wang, Xin Yin, Tianyi Fang, Shenghan Lou, Bangling Han, Jialiang Gao, Yufei Wang, Daoxu Zhang, Xibo Wang, Zhanfei Lu, Junpeng Wu, Jiaqi Zhang, Yimin Wang, Yao Zhang & Yingwei Xue
Pages: 6393-6407
Published online: 26 Sep 2023
AbstractforDevelopment and Validation of an Age-Related Gastric Cancer-Specific Immune Index | Full Text | References | PDF (7.9 MB) | EPUB
  • 47 Views
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Article
Effects of Semaglutide on Cardiac Protein Expression and Cardiac Function of Obese Mice
Xiaoyu Pan, Lin Yue, Jiangli Ban, Lin Ren & Shuchun Chen
Pages: 6409-6425
Published online: 26 Sep 2023
AbstractforEffects of Semaglutide on Cardiac Protein Expression and Cardiac Function of Obese Mice | Full Text | References | PDF (14.6 MB) | EPUB
  • 410 Views
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REVIEW

Review
The Immunomodulatory Functions of BTK Inhibition in the Central Nervous System
Tingyu Cao, Zengguang Wang & Xiaodong Zhu
Pages: 6427-6438
Published online: 24 Nov 2022
AbstractforThe Immunomodulatory Functions of BTK Inhibition in the Central Nervous System | Full Text | References | PDF (1.6 MB) | EPUB
  • 143 Views
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Review
Topical Anti-Inflammatory Agents for Non-Infectious Uveitis: Current Treatment and Perspectives
Balini Balasubramaniam, Yu Jeat Chong, Matthew Azzopardi, Abison Logeswaran & Alastair K Denniston
Pages: 6439-6451
Published online: 26 Sep 2023
AbstractforTopical Anti-Inflammatory Agents for Non-Infectious Uveitis: Current Treatment and Perspectives | Full Text | References | PDF (2.4 MB) | EPUB
  • 179 Views
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ORIGINAL RESEARCH

Article
Prognostic Value of Inflammation-Immunity-Nutrition Score and Inflammatory Burden Index for Hepatocellular Carcinoma Patients After Hepatectomy
Rui Song, Hanghang Ni, Juntao Huang, Chenglei Yang, Shangdong Qin, Huaning Wei, Jiefu Luo, Yuxiang Huang & Bangde Xiang
Pages: 6463-6479
Published online: 28 Nov 2022
AbstractforPrognostic Value of Inflammation-Immunity-Nutrition Score and Inflammatory Burden Index for Hepatocellular Carcinoma Patients After Hepatectomy | Full Text | References | PDF (2.2 MB) | EPUB
  • 73 Views
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REVIEW

Review
The Role of AIM2 Inflammasome in Knee Osteoarthritis
Jiyong Yang & Wengang Liu
Pages: 6453-6461
Published online: 26 Sep 2023
AbstractforThe Role of AIM2 Inflammasome in Knee Osteoarthritis | Full Text | References | PDF (1.6 MB) | EPUB
  • 73 Views
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ORIGINAL RESEARCH

Article
Predictive Values of White Blood Cell Count in Peripheral Blood at Admission on In-Hospital Complications and 90-Day Outcomes of Patients with Aneurysmal Subarachnoid Hemorrhage: Insights from the LongTEAM Registry
Runting Li, Yuanli Zhao, Xiaolin Chen & Qiang Hao
Pages: 6481-6494
Published online: 26 Sep 2023
AbstractforPredictive Values of White Blood Cell Count in Peripheral Blood at Admission on In-Hospital Complications and 90-Day Outcomes of Patients with Aneurysmal Subarachnoid Hemorrhage: Insights from the LongTEAM Registry | Full Text | References | PDF (2 MB) | EPUB
  • 63 Views
  • 2 CrossRef citations
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Article
Construction of a Nomogram for Identifying Refractory Mycoplasma pneumoniae Pneumonia Among Macrolide-Unresponsive Mycoplasma pneumoniae Pneumonia in Children
Qiaoyi Xie, Xiaote Zhang, Wei Cui & Yajiao Pang
Pages: 6495-6504
Published online: 26 Sep 2023
AbstractforConstruction of a Nomogram for Identifying Refractory Mycoplasma pneumoniae Pneumonia Among Macrolide-Unresponsive Mycoplasma pneumoniae Pneumonia in Children | Full Text | References | PDF (2.8 MB) | EPUB
  • 88 Views
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Article
Association of Blood Glucose Variability with Sepsis-Related Disseminated Intravascular Coagulation Morbidity and Mortality
Dan Liu, YiWen Fan, YuGang Zhuang, Hu Peng, ChengJin Gao & YanQing Chen
Pages: 6505-6516
Published online: 26 Sep 2023
AbstractforAssociation of Blood Glucose Variability with Sepsis-Related Disseminated Intravascular Coagulation Morbidity and Mortality | Full Text | References | PDF (1.6 MB) | EPUB
  • 82 Views
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Article
Oral Lycopene Administration Attenuates Inflammation and Oxidative Stress by Regulating Plasma Lipids in Rats with Lipopolysaccharide-Induced Epididymitis
Yu Li, Jinde Zhu, Xiaodong Zhao, Yi Sun, Feng Xu, Song Xu & Xuejun Shang
Pages: 6517-6531
Published online: 26 Sep 2023
AbstractforOral Lycopene Administration Attenuates Inflammation and Oxidative Stress by Regulating Plasma Lipids in Rats with Lipopolysaccharide-Induced Epididymitis | Full Text | References | PDF (12.1 MB) | EPUB
  • 125 Views
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REVIEW

Review
Lupus Nephritis: Current Perspectives and Moving Forward
Julia Lichtnekert, Hans-Joachim Anders & Maciej Lech
Pages: 6533-6552
Published online: 26 Sep 2023
AbstractforLupus Nephritis: Current Perspectives and Moving Forward | Full Text | References | PDF (2.5 MB) | EPUB
  • 148 Views
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ORIGINAL RESEARCH

Article
Lipidomics Changes in a Murine Model of Neuropsychiatric Lupus
Yihan Wang, Yating Ren, Tao Hong, Dingqi Lu, Fan Zhang, Yi Cao & Xinchang Wang
Pages: 6569-6580
Published online: 26 Sep 2023
AbstractforLipidomics Changes in a Murine Model of Neuropsychiatric Lupus | Full Text | References | PDF (8.3 MB) | EPUB
  • 57 Views
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Article
Effects of Gabexate Mesylate on the Gut Microbiota and Metabolomics in Rats with Sepsis
Wenju Sun, Yuqing Cui, Xiaojuan Zhang, Yuze Wang, Zihao Zhang, Xianfei Ding, Huoyan Liang, Dong Wang, Yali Sun, Shaohua Liu, Xiaoguang Duan, Yibin Lu & Tongwen Sun
Pages: 6581-6594
Published online: 26 Sep 2023
AbstractforEffects of Gabexate Mesylate on the Gut Microbiota and Metabolomics in Rats with Sepsis | Full Text | References | PDF (7.8 MB) | EPUB
  • 80 Views
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Article
The Infiltration of Neutrophil Granulocytes Due to Loss of PTEN Was Associated with Poor Response to Immunotherapy in Renal Cell Carcinoma
Fei Wu, Jie Chen, Kang Yao, Daming Fan, Minglei Wang, Yongjun Liu, Shouhu Xin, Zeqiang Sun, Shun Li, Yang Sun & Qingyong Liu
Pages: 6553-6567
Published online: 26 Sep 2023
AbstractforThe Infiltration of Neutrophil Granulocytes Due to Loss of PTEN Was Associated with Poor Response to Immunotherapy in Renal Cell Carcinoma | Full Text | References | PDF (11.9 MB) | EPUB
  • 61 Views
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Article
NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome
De-Gang Mo, Lin Wang, Qian-Feng Han, Kang Yu, Jia-Hui Liu & Heng-Chen Yao
Pages: 6595-6605
Published online: 26 Sep 2023
AbstractforNLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome | Full Text | References | PDF (1.8 MB) | EPUB
  • 49 Views
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Article
miR-31-5p Regulates Type I Interferon by Targeting SLC15A4 in Plasmacytoid Dendritic Cells of Systemic Lupus Erythematosus
Shifei Li, Qijun Wu, Zhuyan Jiang, Yaguang Wu, Yuhong Li, Bing Ni, Jun Xiao & Zhifang Zhai
Pages: 6607-6616
Published online: 06 Dec 2022
AbstractformiR-31-5p Regulates Type I Interferon by Targeting SLC15A4 in Plasmacytoid Dendritic Cells of Systemic Lupus Erythematosus | Full Text | References | PDF (5.2 MB) | EPUB
  • 81 Views
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Article
Acute Ischemic Stroke in Tubercular Meningitis Patients Without Conventional Vascular Risk Factors: A Retrospective Case Control Study
Shiting Tang, Liuyu Liu, Zhouhua Xie, Yaoqin He, Yunli Zhang, Yiju Xie, Shijian Chen, Yayuan Liu, Yunfei Wei & Zhijian Liang
Pages: 6617-6627
Published online: 07 Dec 2022
AbstractforAcute Ischemic Stroke in Tubercular Meningitis Patients Without Conventional Vascular Risk Factors: A Retrospective Case Control Study | Full Text | References | PDF (2.6 MB) | EPUB
  • 74 Views
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Article
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
Maria Belland Olsen, Camilla Huse, Mirta Mittelstedt Leal de Sousa, Sarah Louise Murphy, Antonio Sarno, Tobias Sebastian Obermann, Kuan Yang, Jan Cato Holter, Marte Jøntvedt Jørgensen, Erik Egeland Christensen, Wei Wang, Ping Ji, Lars Heggelund, Hedda Hoel, Anne Margarita Dyrhol-Riise, Ida Gregersen, Pål Aukrust, Magnar Bjørås, Bente Halvorsen & Tuva Børresdatter Dahl
Pages: 6629-6644
Published online: 26 Sep 2023
AbstractforDNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients | Full Text | References | PDF (7.1 MB) | EPUB
  • 131 Views
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Article
Independent and Joint Association of Statin Therapy with Adverse Outcomes in Heart Failure Patients with Atrial Fibrillation Treated with Cardiac Resynchronization Therapy
Yu Yu, Ligang Ding, Yu Deng, Hao Huang, Sijing Cheng, Chi Cai, Min Gu, Xuhua Chen, Xiaohui Ning, Hongxia Niu & Wei Hua
Pages: 6645-6656
Published online: 09 Dec 2022
AbstractforIndependent and Joint Association of Statin Therapy with Adverse Outcomes in Heart Failure Patients with Atrial Fibrillation Treated with Cardiac Resynchronization Therapy | Full Text | References | PDF (1.5 MB) | EPUB
  • 70 Views
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Article
TNF-α and IL-1β Promote Renal Podocyte Injury in T2DM Rats by Decreasing Glomerular VEGF/eNOS Expression Levels and Altering Hemodynamic Parameters
Jufang Wang, Yating Feng, Yan Zhang, Jing Liu, Le Gong, Xiaohong Zhang & Hui Liao
Pages: 6657-6673
Published online: 26 Sep 2023
AbstractforTNF-α and IL-1β Promote Renal Podocyte Injury in T2DM Rats by Decreasing Glomerular VEGF/eNOS Expression Levels and Altering Hemodynamic Parameters | Full Text | References | PDF (12.2 MB) | EPUB
  • 118 Views
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Article
Age Related Cognitive Function Was Positively Associated with Diastolic Pressure and Negatively Associated with Antibody Expression in Chinese Oldest-Old and Centenarian Adults
Long Feng, Di Wu, Ping Ping, Jieqiong Lin, Yali Zhao, Yao Yao, Pei Zhang & Shihui Fu
Pages: 6675-6682
Published online: 10 Dec 2022
AbstractforAge Related Cognitive Function Was Positively Associated with Diastolic Pressure and Negatively Associated with Antibody Expression in Chinese Oldest-Old and Centenarian Adults | Full Text | References | PDF (926.6 KB) | EPUB
  • 76 Views
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REVIEW

Review
Leptin Deficiency May Influence the Divergence of Cell-Mediated Immunity Between Lepromatous and Tuberculoid Leprosy Patients
Sisay Teka Degechisa & Yosef Tsegaye Dabi
Pages: 6719-6728
Published online: 26 Sep 2023
AbstractforLeptin Deficiency May Influence the Divergence of Cell-Mediated Immunity Between Lepromatous and Tuberculoid Leprosy Patients | Full Text | References | PDF (1.7 MB) | EPUB
  • 84 Views
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ORIGINAL RESEARCH

Article
Special Focus on the Cellular Anti-Inflammatory Effects of Several Micro-Immunotherapy Formulations: Considerations Regarding Intestinal-, Immune-Axis-Related- and Neuronal-Inflammation Contexts
Camille Jacques & Ilaria Floris
Pages: 6695-6717
Published online: 13 Dec 2022
AbstractforSpecial Focus on the Cellular Anti-Inflammatory Effects of Several Micro-Immunotherapy Formulations: Considerations Regarding Intestinal-, Immune-Axis-Related- and Neuronal-Inflammation Contexts | Full Text | References | PDF (9.3 MB) | EPUB
  • 108 Views
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Article
A Novel Gene Signature Associated with Inflammatory Responses and Immune Status Assists in Prognosis and Intervention for Patients with HCC
Guofang Lu, Rui Du, Bin Feng, Jianlin Wang, Fengrui Zhang, Jianming Pei, Yuanyong Wang & Yulong Shang
Pages: 6729-6743
Published online: 13 Dec 2022
AbstractforA Novel Gene Signature Associated with Inflammatory Responses and Immune Status Assists in Prognosis and Intervention for Patients with HCC | Full Text | References | PDF (9.2 MB) | EPUB
  • 87 Views
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REVIEW

Review
Progress of Research into the Interleukin-1 Family in Cardiovascular Disease
Zimin Wu, Cheng Luo & Baoshi Zheng
Pages: 6683-6694
Published online: 13 Dec 2022
AbstractforProgress of Research into the Interleukin-1 Family in Cardiovascular Disease | Full Text | References | PDF (3.3 MB) | EPUB
  • 109 Views
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HYPOTHESIS

The Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions
Zeev Elkoshi
Pages: 6761-6771
Published online: 26 Sep 2023
AbstractforThe Contrasting Seasonality Patterns of Some Cancer-Types and Herpes Zoster Can Be Explained by a Binary Classification of Immunological Reactions | Full Text | References | PDF (1.3 MB) | EPUB
  • 86 Views
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ORIGINAL RESEARCH

Article
Expression of Human Interleukin 8 in Mice Alters Their Natural Behaviors
Zuozhen Tian, Frances S Shofer, Alec Z Sandroni, Lan Zhao, Carla R Scanzello & Yejia Zhang
Pages: 2413-2424
Published online: 13 Apr 2022
AbstractforExpression of Human Interleukin 8 in Mice Alters Their Natural Behaviors | Full Text | References | PDF (4.7 MB) | EPUB
  • 126 Views
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RETRACTION

Retraction
A Potential Role of Ethosuximide and Pentoxifylline in Relieving Abdominal Pain in Irritable Bowel Syndrome Patients Treated with Mebeverine: A Randomized, Double-Blind, Placebo-Controlled Trial [Retraction]
Pages: 2381-2382
Published online: 17 Sep 2022
CitationforA Potential Role of Ethosuximide and Pentoxifylline in Relieving Abdominal Pain in Irritable Bowel Syndrome Patients Treated with Mebeverine: A Randomized, Double-Blind, Placebo-Controlled Trial [Retraction] | Full Text | PDF (138 KB) | EPUB
  • 111 Views
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ORIGINAL RESEARCH

Article
Vanin 1 Gene Role in Modulation of iNOS/MCP-1/TGF-β1 Signaling Pathway in Obese Diabetic Patients
Yasser O Mosaad, Mohammed Abdalla Hussein, Hayam Ateyya, Ahmed H Mohamed, Ali A Ali, Alaa Ramadan Youssuf, Michael Wink & Amal A El-Kholy
Pages: 6745-6759
Published online: 14 Dec 2022
AbstractforVanin 1 Gene Role in Modulation of iNOS/MCP-1/TGF-β1 Signaling Pathway in Obese Diabetic Patients | Full Text | References | PDF (4.4 MB) | EPUB
  • 140 Views
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Article
Slightly Elevated Lymphocyte to Monocyte Ratio Predicting Favorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage
Jinjin Wang, Wenjuan Wang, Anxin Wang, Xiaoli Zhang, Liheng Bian, Yang Du, Jingjing Lu & Xingquan Zhao
Pages: 6773-6783
Published online: 16 Dec 2022
AbstractforSlightly Elevated Lymphocyte to Monocyte Ratio Predicting Favorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage | Full Text | References | PDF (2.8 MB) | EPUB
  • 67 Views
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Article
Benzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment
Aman Ullah, Lina Tariq Al Kury, Yusuf S Althobaiti, Tahir Ali & Fawad ALi Shah
Pages: 3873-3890
Published online: 11 Jul 2022
AbstractforBenzimidazole Derivatives as New Potential NLRP3 Inflammasome Inhibitors That Provide Neuroprotection in a Rodent Model of Neurodegeneration and Memory Impairment | Full Text | References | PDF (14.4 MB) | EPUB
  • 450 Views
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Article
A Novel Nomogram Integrated with Systemic Inflammation Markers and Traditional Prognostic Factors for Adverse Events’ Prediction in Patients with Chronic Heart Failure in the Southwest of China
Zhaojun Liu, Ren Zhang, Yingjie Xv, Jinkui Wang, Jie Chen & Xiaoli Zhou
Pages: 6785-6800
Published online: 20 Dec 2022
AbstractforA Novel Nomogram Integrated with Systemic Inflammation Markers and Traditional Prognostic Factors for Adverse Events’ Prediction in Patients with Chronic Heart Failure in the Southwest of China | Full Text | References | PDF (5 MB) | EPUB
  • 88 Views
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REVIEW

Review
Ferroptosis: Reviewing CRC with the Third Eye
Xingyu Liu, Halahati Tuerxun, Yawen Li, Yaping Li, Yuanyuan He & Yuguang Zhao
Pages: 6801-6812
Published online: 26 Sep 2023
AbstractforFerroptosis: Reviewing CRC with the Third Eye | Full Text | References | PDF (1.7 MB) | EPUB
  • 76 Views
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ORIGINAL RESEARCH

Article
Effectiveness of Soluble CTLA-4-Fc in the Inhibition of Bone Marrow T-Cell Activation in Context of Indoleamine 2.3-Dioxygenase (IDO) and CD4+Foxp3+ Treg Induction
Magdalena Massalska, Marzena Ciechomska, Ewa Kuca-Warnawin, Tomasz Burakowski, Anna Kornatka, Anna Radzikowska, Dariusz Pawlak, Barbara Muz, Adrianna Loniewska-Lwowska, Andrzej Palucha, Pawel Maldyk & Wlodzimierz Maslinski
Pages: 6813-6829
Published online: 26 Sep 2023
AbstractforEffectiveness of Soluble CTLA-4-Fc in the Inhibition of Bone Marrow T-Cell Activation in Context of Indoleamine 2.3-Dioxygenase (IDO) and CD4+Foxp3+ Treg Induction | Full Text | References | PDF (7.6 MB) | EPUB
  • 119 Views
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Article
Association Between Promoter Methylation of Vitamin D Metabolic Pathway Genes and Tuberculosis and Diabetes Comorbidity in a Chinese Han Population: A Case–Control Study
Yong Chen, An-Zhou Peng, Kun Li, Lei Liu, Fazhen Zhang, Jin Chen, Huifen Zhang, Linyang Li, Hailin Yang, Xihai Xu & Qiu Zhang
Pages: 6831-6842
Published online: 26 Sep 2023
AbstractforAssociation Between Promoter Methylation of Vitamin D Metabolic Pathway Genes and Tuberculosis and Diabetes Comorbidity in a Chinese Han Population: A Case–Control Study | Full Text | References | PDF (3.7 MB) | EPUB
  • 74 Views
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Article
CCL20/CCR6 Mediated Macrophage Activation and Polarization Can Promote Adenoid Epithelial Inflammation in Adenoid Hypertrophy
Chenchen Ye, Xinxue Guo, Jiani Wu, Minhua Wang, Haiyan Ding & Xianzhi Ren
Pages: 6843-6855
Published online: 23 Dec 2022
AbstractforCCL20/CCR6 Mediated Macrophage Activation and Polarization Can Promote Adenoid Epithelial Inflammation in Adenoid Hypertrophy | Full Text | References | PDF (5.3 MB) | EPUB
  • 117 Views
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Article
Analysis of Staged Features of Gastritis-Cancer Transformation and Identification of Potential Biomarkers in Gastric Cancer
Ruikang Jia, Xiaohui Guo, Huiyun Liu, Feiyue Zhao, Zhibin Fan, Menglei Wang, Jianliang Sui, Binghua Yin, Zhihong Wang & Zhen Wang
Pages: 6857-6868
Published online: 28 Dec 2022
AbstractforAnalysis of Staged Features of Gastritis-Cancer Transformation and Identification of Potential Biomarkers in Gastric Cancer | Full Text | References | PDF (10.3 MB) | EPUB
  • 99 Views
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REVIEW

Review
The Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes
Lei Zhang, Huan-Huan Liu, Feng Li, Fan Yang, Ling-Ling Qian & Ru-Xing Wang
Pages: 6883-6889
Published online: 29 Dec 2022
AbstractforThe Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes | Full Text | References | PDF (1.7 MB) | EPUB
  • 75 Views
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ORIGINAL RESEARCH

Article
Systemic Inflammation is Associated with Cardiometabolic Risk Factors and Clinical Outcomes
Brandon Tejada, Roby Joehanes, Shih-Jen Hwang, Tianxiao Huan, Chen Yao, Jennifer E Ho & Daniel Levy
Pages: 6891-6903
Published online: 29 Dec 2022
AbstractforSystemic Inflammation is Associated with Cardiometabolic Risk Factors and Clinical Outcomes | Full Text | References | PDF (501.5 KB) | EPUB
  • 109 Views
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Article
Zinc Modulates the Priming of T Helper 1, T Helper 17, and T Regulatory Cells in Allogeneic and Autologous in vitro Models
Hanan E Alrashidi & Amna A Alotiby
Pages: 6931-6939
Published online: 30 Dec 2022
AbstractforZinc Modulates the Priming of T Helper 1, T Helper 17, and T Regulatory Cells in Allogeneic and Autologous in vitro Models | Full Text | References | PDF (2.6 MB) | EPUB
  • 59 Views
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Article
Clinical Value of Serum Interleukin-18 in Neonatal Sepsis Diagnosis and Mortality Prediction
Xiaojuan Li, Tiewei Li, Geng Dong, Yulei Wei, Zhe Xu & Junmei Yang
Pages: 6923-6930
Published online: 26 Sep 2023
AbstractforClinical Value of Serum Interleukin-18 in Neonatal Sepsis Diagnosis and Mortality Prediction | Full Text | References | PDF (465.2 KB) | EPUB
  • 92 Views
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Article
Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice
Sophiya Pundalik, Krishna Ram Hanumappa, Aladahalli S Giresha, Deepadarshan Urs, Sharath Rajashekarappa, Narayanappa Muniyappa, Manjunatha Jamballi G, Devaraju Kuaramkote Shivanna, Rajkumar S Meti, Sathisha Anekere Dasappa Setty, Prabhakar Bettadathunga Thippegowda & Dharmappa Kattepura Krishnappa
Pages: 6905-6921
Published online: 31 Dec 2022
AbstractforCorosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice | Full Text | References | PDF (10.4 MB) | EPUB
  • 147 Views
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Article
Evaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression
Nikola Ferencova, Zuzana Visnovcova, Igor Ondrejka, Dana Funakova, Igor Hrtanek, Simona Kelcikova & Ingrid Tonhajzerova
Pages: 5959-5976
Published online: 26 Sep 2023
AbstractforEvaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression | Full Text | References | PDF (1.7 MB) | EPUB
  • 441 Views
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Article
Metallothionein-1 is Positively Correlated with Inflammation and Ankylosing Spondylitis Activity
Yanmei Ma, Jing Du, Zhihua Yin, Hanying Dai, Yazhi Wei, Yuhao Xia, Lingyun Li, Zhizhong Ye & Zhong Huang
Pages: 5935-5944
Published online: 26 Sep 2023
AbstractforMetallothionein-1 is Positively Correlated with Inflammation and Ankylosing Spondylitis Activity | Full Text | References | PDF (4.2 MB) | EPUB
  • 170 Views
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Article
Dynamic Status of SII and SIRI Alters the Risk of Cardiovascular Diseases: Evidence from Kailuan Cohort Study
Jun Li, Di He, Jiazhou Yu, Shuohua Chen, Qiong Wu, Zongxue Cheng, Qiaohui Wei, Yuying Xu, Yimin Zhu & Shouling Wu
Pages: 5945-5957
Published online: 26 Sep 2023
AbstractforDynamic Status of SII and SIRI Alters the Risk of Cardiovascular Diseases: Evidence from Kailuan Cohort Study | Full Text | References | PDF (6.3 MB) | EPUB
  • 280 Views
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Article
Experimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino Mice
Arif Khan, Mohammed A Alsahli, Mohammad A Aljasir, Hamzah Maswadeh, Mugahid A Mobark, Faizul Azam, Khaled S Allemailem, Faris Alrumaihi, Fahad A Alhumaydhi, Ahmad A Almatroudi, Naif AlSuhaymi & Masood A Khan
Pages: 2263-2280
Published online: 08 Apr 2022
AbstractforExperimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino Mice | Full Text | References | PDF (9.6 MB) | EPUB
  • 379 Views
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Article
Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways
Baixing Li, Xiao Yang, Pu Zhang, Jiadong Guo, Kewei Rong, Xin Wang, Xiankun Cao, Tangjun Zhou & Jie Zhao
Pages: 5767-5783
Published online: 10 Oct 2022
AbstractforEngeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways | Full Text | References | PDF (12.8 MB) | EPUB
  • 212 Views
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Article
C-X-C-Chemokine-Receptor-Type-4 Inhibitor AMD3100 Attenuates Pulmonary Inflammation and Fibrosis in Silicotic Mice
Qixian Sun, Xinrong Tao, Bing Li, Hangbing Cao, Haoming Chen, Yuanjie Zou, Huihui Tao, Min Mu, Wenyang Wang & Keyi Xu
Pages: 5827-5843
Published online: 26 Sep 2023
AbstractforC-X-C-Chemokine-Receptor-Type-4 Inhibitor AMD3100 Attenuates Pulmonary Inflammation and Fibrosis in Silicotic Mice | Full Text | References | PDF (17.2 MB) | EPUB
  • 137 Views
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Article
Effect of Alcohol Intake on Inflammatory Status and Prognosis in Cancer Patients
Xiangliang Liu, Wenxin Zhang, Wei Ji, Kaiwen Zheng, Yixin Zhao, Yuwei He, Jiuwei Cui & Wei Li
Pages: 5815-5826
Published online: 26 Sep 2023
AbstractforEffect of Alcohol Intake on Inflammatory Status and Prognosis in Cancer Patients | Full Text | References | PDF (4.7 MB) | EPUB
  • 129 Views
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Article
Short- and Mid-Term Survival Prediction in Patients with Acute Type A Aortic Dissection Undergoing Surgical Repair: Based on the Systemic Immune-Inflammation Index
Zeshi Li, He Zhang, Sulaiman Baraghtha, Jiabao Mu, Yusanjan Matniyaz, Xinyi Jiang, Kuo Wang, Dongjin Wang & Yun Xing Xue
Pages: 5785-5799
Published online: 26 Sep 2023
AbstractforShort- and Mid-Term Survival Prediction in Patients with Acute Type A Aortic Dissection Undergoing Surgical Repair: Based on the Systemic Immune-Inflammation Index | Full Text | References | PDF (1.2 MB) | EPUB
  • 145 Views
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Article
Downregulation of ST6GAL1 Promotes Liver Inflammation and Predicts Adverse Prognosis in Hepatocellular Carcinoma
Ruijia Liu, Xu Cao, Yijun Liang, Xiaobin Li, Qian Jin, Ying Li, Hongbo Du, Xiaobin Zao & Yong’an Ye
Pages: 5801-5814
Published online: 10 Oct 2022
AbstractforDownregulation of ST6GAL1 Promotes Liver Inflammation and Predicts Adverse Prognosis in Hepatocellular Carcinoma | Full Text | References | PDF (10.4 MB) | EPUB
  • 137 Views
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REVIEW

Review
Subcutaneously-Administered Infliximab in the Management of Rheumatoid Arthritis: A Short Narrative Review of Current Clinical Evidence
Florenzo Iannone, Fabrizio Conti, Alberto Cauli, Alberto Farina & Roberto Caporali
Pages: 3259-3267
Published online: 01 Jun 2022
AbstractforSubcutaneously-Administered Infliximab in the Management of Rheumatoid Arthritis: A Short Narrative Review of Current Clinical Evidence | Full Text | References | PDF (2.1 MB) | EPUB
  • 199 Views
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Review
Utilizing Predictive Inflammatory Markers for Guiding the Use of Biologicals in Severe Asthma
Martin Runnstrom, Hilary Pitner, Jennifer Xu, F Eun-Hyung Lee & Merin Kuruvilla
Pages: 241-249
Published online: 17 Sep 2022
AbstractforUtilizing Predictive Inflammatory Markers for Guiding the Use of Biologicals in Severe Asthma | Full Text | References | PDF (1.9 MB) | EPUB
  • 246 Views
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Review
The Role of Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives
Erin Sternhagen, Brittany Bettendorf, Aleksander Lenert & Petar S Lenert
Pages: 1133-1145
Published online: 18 Feb 2022
AbstractforThe Role of Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives | Full Text | References | PDF (934.5 KB) | EPUB
  • 291 Views
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Review
Mechanistic Understanding of Lung Inflammation: Recent Advances and Emerging Techniques
Chrysi Keskinidou, Alice G Vassiliou, Ioanna Dimopoulou, Anastasia Kotanidou & Stylianos E Orfanos
Pages: 3501-3546
Published online: 17 Sep 2022
AbstractforMechanistic Understanding of Lung Inflammation: Recent Advances and Emerging Techniques | Full Text | References | PDF (2.1 MB) | EPUB
  • 286 Views
  • 6 CrossRef citations
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Review
Managing Gout in Women: Current Perspectives
Aakash V Patel & Angelo L Gaffo
Pages: 1591-1598
Published online: 03 Mar 2022
AbstractforManaging Gout in Women: Current Perspectives | Full Text | References | PDF (810.1 KB) | EPUB
  • 530 Views
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Review
ANCA Associated Vasculitis Subtypes: Recent Insights and Future Perspectives
Keziah Austin, Shalini Janagan, Matthew Wells, Helena Crawshaw, Stephen McAdoo & Joanna C Robson
Pages: 2567-2582
Published online: 17 Sep 2022
AbstractforANCA Associated Vasculitis Subtypes: Recent Insights and Future Perspectives | Full Text | References | PDF (1.3 MB) | EPUB
  • 678 Views
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Review
Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation
Arne Gehlhaar, Ashwin Inala, Dhana Llivichuzhca-Loja, Tatiana N Silva, Comfort Y Adegboye, Amy E O’Connell & Liza Konnikova
Pages: 1873-1887
Published online: 17 Sep 2022
AbstractforInsights into the Role of Commensal-Specific T Cells in Intestinal Inflammation | Full Text | References | PDF (3.6 MB) | EPUB
  • 170 Views
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ORIGINAL RESEARCH

Article
The Effects of Non-Surgical Periodontitis Therapy on the Clinical Features and Serological Parameters of Patients Suffering from Rheumatoid Arthritis as Well as Chronic Periodontitis
Nan Ding, Mei Luo, Ya-Hui Wen, Rong-Yin Li & Qi-Yan Bao
Pages: 177-185
Published online: 17 Sep 2022
AbstractforThe Effects of Non-Surgical Periodontitis Therapy on the Clinical Features and Serological Parameters of Patients Suffering from Rheumatoid Arthritis as Well as Chronic Periodontitis | Full Text | References | PDF (307.7 KB) | EPUB
  • 225 Views
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Article
The κ-Opioid Receptor Agonist U50488H Ameliorates Neuropathic Pain Through the Ca2+/CaMKII/CREB Pathway in Rats
Xiao-Min Zhang, Ming-Hui Lun, Wei Du, Fang Ma & Ze-Qing Huang
Pages: 3039-3051
Published online: 17 Sep 2022
AbstractforThe κ-Opioid Receptor Agonist U50488H Ameliorates Neuropathic Pain Through the Ca2+/CaMKII/CREB Pathway in Rats | Full Text | References | PDF (11.4 MB) | EPUB
  • 154 Views
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REVIEW

Review
Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress
Ricardo A Pinho, Daniela PS Haupenthal, Paulo Emílio Fauser, Anand Thirupathi & Paulo CL Silveira
Pages: 3219-3234
Published online: 31 May 2022
AbstractforGold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress | Full Text | References | PDF (3.1 MB) | EPUB
  • 470 Views
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ORIGINAL RESEARCH

Article
Transcriptional Landscape of Enhancer RNAs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus
Gangqiang Guo, Huijing Wang, Xinya Tong, Lele Ye, Xinyu Shi, Su Fang, Ya Hu, Fei Han, Chaosheng Chen, Ning Ding, Bofeng Su, Xiangyang Xue & Huidi Zhang
Pages: 775-791
Published online: 17 Sep 2022
AbstractforTranscriptional Landscape of Enhancer RNAs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus | Full Text | References | PDF (8.2 MB) | EPUB
  • 159 Views
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Article
SAHA Alleviates Diarrhea-Predominant Irritable Bowel Syndrome Through Regulation of the p-STAT3/SERT/5-HT Signaling Pathway
Jian Shen, Bimeng Zhang, Jianjie Chen, Jiazheng Cheng, Jiali Wang, Xianhui Zheng, Yu Lan & Xiaowen Zhang
Pages: 1745-1756
Published online: 10 Mar 2022
AbstractforSAHA Alleviates Diarrhea-Predominant Irritable Bowel Syndrome Through Regulation of the p-STAT3/SERT/5-HT Signaling Pathway | Full Text | References | PDF (4.1 MB) | EPUB
  • 197 Views
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Article
Stressor-Induced Reduction in Cognitive Behavior is Associated with Impaired Colonic Mucus Layer Integrity and is Dependent Upon the LPS-Binding Protein Receptor CD14
Robert M Jaggers, Damon J DiSabato, Brett R Loman, Danica Kontic, Kyle D Spencer, Jacob M Allen, Jonathan P Godbout, Ning Quan, Tamar L Gur & Michael T Bailey
Pages: 1617-1635
Published online: 17 Sep 2022
AbstractforStressor-Induced Reduction in Cognitive Behavior is Associated with Impaired Colonic Mucus Layer Integrity and is Dependent Upon the LPS-Binding Protein Receptor CD14 | Full Text | References | PDF (8.7 MB) | EPUB
  • 183 Views
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ORIGINAL Research

Article
CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor
Chan Zou, Jordan A Beard, Guoping Yang, William E Evans & Erik J Bonten
Pages: 1183-1194
Published online: 19 Feb 2022
AbstractforCASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor | Full Text | References | PDF (5.5 MB) | EPUB
  • 166 Views
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ORIGINAL RESEARCH

Article
Tumor Necrosis Factor-α Gene Polymorphism is Associated with Short- and Long-Term Kidney Allograft Outcomes
Felix Poppelaars, Mariana Gaya da Costa, Bernardo Faria, Siawosh K Eskandari, Marc A Seelen & Jeffrey Damman
Pages: 2243-2254
Published online: 17 Sep 2022
AbstractforTumor Necrosis Factor-α Gene Polymorphism is Associated with Short- and Long-Term Kidney Allograft Outcomes | Full Text | References | PDF (3.2 MB) | EPUB
  • 143 Views
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Article
Hypermethylation Effects of Yiqihuoxue Decoction in Diabetic Atherosclerosis Using Genome-Wide DNA Methylation Analyses
Qing-Bing Zhou, Yao Chen, Yan Zhang, Dan-Dan Li, Hong-Qin Wang, Zi-Jun Jia, Yu Jin, Feng-Qin Xu & Ying Zhang
Pages: 163-176
Published online: 17 Sep 2022
AbstractforHypermethylation Effects of Yiqihuoxue Decoction in Diabetic Atherosclerosis Using Genome-Wide DNA Methylation Analyses | Full Text | References | PDF (12.9 MB) | EPUB
  • 114 Views
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Article
Insight into the Molecular Characteristics of Langhans Giant Cell by Combination of Laser Capture Microdissection and RNA Sequencing
Yanqing Chen, Haiqin Jiang, Jingshu Xiong, Jingzhe Shang, Zhiming Chen, Aiping Wu & Hongsheng Wang
Pages: 621-634
Published online: 17 Sep 2022
AbstractforInsight into the Molecular Characteristics of Langhans Giant Cell by Combination of Laser Capture Microdissection and RNA Sequencing | Full Text | References | PDF (11.9 MB) | EPUB
  • 168 Views
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Article
Associations Among Disseminated Intravascular Coagulation, Thrombocytopenia Cytokines/Chemokines and Genetic Polymorphisms of Toll-Like Receptor 2/4 in Chinese Patients with Sepsis
Shaowei Jiang, Jing Ma, Shan Ye, Connor Meaney, Timothy Evan Moore, Shuming Pan & Chengjin Gao
Pages: 1-15
Published online: 17 Sep 2022
AbstractforAssociations Among Disseminated Intravascular Coagulation, Thrombocytopenia Cytokines/Chemokines and Genetic Polymorphisms of Toll-Like Receptor 2/4 in Chinese Patients with Sepsis | Full Text | References | PDF (1.4 MB) | EPUB
  • 201 Views
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Article
Increased eEF2K Promotes Glycolysis and Aggressive Behaviors of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Dongying Chen, Xiaoyan Cai, Hui Ouyang, Shiwen Yuan, Xiaodong Wang, Lian Lin, Zhiqing Chen & Mingcheng Huang
Pages: 1729-1744
Published online: 17 Sep 2022
AbstractforIncreased eEF2K Promotes Glycolysis and Aggressive Behaviors of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis | Full Text | References | PDF (11.7 MB) | EPUB
  • 156 Views
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Article
Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease: miRNA and mRNA Regulation
Lijing Wang, Hongjun Zhao, Indu Raman, Mei Yan, Qiong Chen & Quan-Zhen Li
Pages: 2167-2180
Published online: 01 Apr 2022
AbstractforPeripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease: miRNA and mRNA Regulation | Full Text | References | PDF (3.1 MB) | EPUB
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REVIEW

Review
Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
Yongli Pan, Ting Wang, Zhiqiang Zhao, Wei Wei, Xinyu Yang, Xianbin Wang & Wenqiang Xin
Pages: 557-571
Published online: 17 Sep 2022
AbstractforNovel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation | Full Text | References | PDF (1.3 MB) | EPUB
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ORIGINAL RESEARCH

Article
Alterations and Prediction of Functional Profiles of Gut Microbiota After Fecal Microbiota Transplantation for Iranian Recurrent Clostridioides difficile Infection with Underlying Inflammatory Bowel Disease: A Pilot Study
Masoumeh Azimirad, YoungJae Jo, Min-Sueng Kim, Minsoo Jeong, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Seungjun Lee, Abbas Yadegar & Jae-Ho Shin
Pages: 105-116
Published online: 17 Sep 2022
AbstractforAlterations and Prediction of Functional Profiles of Gut Microbiota After Fecal Microbiota Transplantation for Iranian Recurrent Clostridioides difficile Infection with Underlying Inflammatory Bowel Disease: A Pilot Study | Full Text | References | PDF (956.9 KB) | EPUB
  • 376 Views
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Article
A Novel Inflammatory-Nutritional Prognostic Scoring System for Patients with Early-Stage Breast Cancer
Xin Hua, Fangfang Duan, Wenyu Zhai, Chenge Song, Chang Jiang, Li Wang, Jiajia Huang, Huanxin Lin & Zhongyu Yuan
Pages: 381-394
Published online: 16 Jan 2022
AbstractforA Novel Inflammatory-Nutritional Prognostic Scoring System for Patients with Early-Stage Breast Cancer | Full Text | References | PDF (4.9 MB) | EPUB
  • 259 Views
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Article
IL-17 is a Potential Therapeutic Target in a Rodent Model of Otitis Media with Effusion
Nanfeng Zhang, Tingting Qian, Shan Sun, Wei Cao, Zhixian Wang, Danling Liu, Peifan Li, Jingfang Wu, Huawei Li & Jianming Yang
Pages: 635-648
Published online: 17 Sep 2022
AbstractforIL-17 is a Potential Therapeutic Target in a Rodent Model of Otitis Media with Effusion | Full Text | References | PDF (10.1 MB) | EPUB
  • 152 Views
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Article
SK-Channel Activation Alters Peripheral Metabolic Pathways in Mice, but Not Lipopolysaccharide-Induced Fever or Inflammation
Janne Bredehöft, Amalia M Dolga, Birgit Honrath, Sybille Wache, Sybille Mazurek, Carsten Culmsee, Regien G Schoemaker, Rüdiger Gerstberger, Joachim Roth & Christoph Rummel
Pages: 509-531
Published online: 17 Sep 2022
AbstractforSK-Channel Activation Alters Peripheral Metabolic Pathways in Mice, but Not Lipopolysaccharide-Induced Fever or Inflammation | Full Text | References | PDF (11.3 MB) | EPUB
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REVIEW

Review
Emerging Roles of Post-Translational Modifications in Skin Diseases: Current Knowledge, Challenges and Future Perspectives
Luting Yang & Yaping Yan
Pages: 965-975
Published online: 11 Feb 2022
AbstractforEmerging Roles of Post-Translational Modifications in Skin Diseases: Current Knowledge, Challenges and Future Perspectives | Full Text | References | PDF (2.4 MB) | EPUB
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ORIGINAL RESEARCH

Article
MiR-143 Targets IGF-1R to Suppress Autoimmunity in Thyroid-Associated Ophthalmopathy
Wei Tang, Qian Lv, Xiao Huang, Yuzhen Li, JunJie Zou, Jiaoyang Zheng, Liangliang Sun, Yi Bao, Haiyan Chen, Tuo Li, Bei Zhang, Song Xue, Yan Song, Xingxing Zhang, Xiangfang Chen, Jiping Cai & Yongquan Shi
Pages: 1543-1554
Published online: 01 Mar 2022
AbstractforMiR-143 Targets IGF-1R to Suppress Autoimmunity in Thyroid-Associated Ophthalmopathy | Full Text | References | PDF (8.4 MB) | EPUB
  • 174 Views
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Article
Seminal Levels of Omentin-1/ITLN1 in Inflammatory Conditions Related to Male Infertility and Localization in Spermatozoa and Tissues of Male Reproductive System
Elena Moretti, Cinzia Signorini, Daria Noto, Sergio Antonio Tripodi, Andrea Menchiari, Ester Sorrentino & Giulia Collodel
Pages: 2019-2031
Published online: 17 Sep 2022
AbstractforSeminal Levels of Omentin-1/ITLN1 in Inflammatory Conditions Related to Male Infertility and Localization in Spermatozoa and Tissues of Male Reproductive System | Full Text | References | PDF (2.3 MB) | EPUB
  • 158 Views
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Article
The Mutation of BTG2 Gene Predicts a Poor Outcome in Primary Testicular Diffuse Large B-Cell Lymphoma
Dan Guo, Lemin Hong, Hao Ji, Yuwen Jiang, Ling Lu, Xinfeng Wang & Hongming Huang
Pages: 1757-1769
Published online: 17 Sep 2022
AbstractforThe Mutation of BTG2 Gene Predicts a Poor Outcome in Primary Testicular Diffuse Large B-Cell Lymphoma | Full Text | References | PDF (5.8 MB) | EPUB
  • 173 Views
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Article
CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway
Zhen-Ni Liu, Xue Wu, Qian Fang, Zi-Xuan Li, Guo-Qing Xia, Jun-Nan Cai & Xiong-Wen Lv
Pages: 53-70
Published online: 17 Sep 2022
AbstractforCD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway | Full Text | References | PDF (16.4 MB) | EPUB
  • 197 Views
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Article
A Pyroptosis-Related Gene Prognostic Index Correlated with Survival and Immune Microenvironment in Glioma
Jianglin Zheng, Zijie Zhou, Yue Qiu, Minjie Wang, Hao Yu, Zhipeng Wu, Xuan Wang & Xiaobing Jiang
Pages: 17-32
Published online: 24 Sep 2022
AbstractforA Pyroptosis-Related Gene Prognostic Index Correlated with Survival and Immune Microenvironment in Glioma | Full Text | References | PDF (16.8 MB) | EPUB
  • 220 Views
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Article
The Alterations of Serum IgG Fucosylation as a Potential Additional New Diagnostic Marker in Advanced Endometriosis
Katarzyna Sołkiewicz, Hubert Krotkiewski, Marcin Jędryka, Andrzej Czekański & Ewa Maria Kratz
Pages: 251-266
Published online: 13 Jan 2022
AbstractforThe Alterations of Serum IgG Fucosylation as a Potential Additional New Diagnostic Marker in Advanced Endometriosis | Full Text | References | PDF (738.9 KB) | EPUB
  • 172 Views
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Article
Increased Level of Serum Wingless-Type Mouse Mammary Tumor Virus Integration Site Family Member 5a in Patients with Cutaneous Lichen Planus
Jianwen Ren, Xiaoying Ning, Dingwei Zhang & Yanfei Zhang
Pages: 235-239
Published online: 11 Jan 2022
AbstractforIncreased Level of Serum Wingless-Type Mouse Mammary Tumor Virus Integration Site Family Member 5a in Patients with Cutaneous Lichen Planus | Full Text | References | PDF (1,022.7 KB) | EPUB
  • 134 Views
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Article
Dimethyl Fumarate as the Peripheral Blood Inflammatory Mediators Inhibitor in Prevention of Streptozotocin-Induced Neuroinflammation in Aged Rats
Danuta Wrona, Irena Majkutewicz, Grzegorz Świątek, Joanna Dunacka, Beata Grembecka & Wojciech Glac
Pages: 33-52
Published online: 06 Jan 2022
AbstractforDimethyl Fumarate as the Peripheral Blood Inflammatory Mediators Inhibitor in Prevention of Streptozotocin-Induced Neuroinflammation in Aged Rats | Full Text | References | PDF (6.2 MB) | EPUB
  • 215 Views
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Article
Dietary Fish Oil Increases the Number of CD11b+CD27− NK Cells at the Inflammatory Site and Enhances Key Hallmarks of Resolution of Murine Antigen-Induced Peritonitis
Kirstine Nolling Jensen, Marieke Heijink, Martin Giera, Jona Freysdottir & Ingibjorg Hardardottir
Pages: 311-324
Published online: 17 Sep 2022
AbstractforDietary Fish Oil Increases the Number of CD11b+CD27− NK Cells at the Inflammatory Site and Enhances Key Hallmarks of Resolution of Murine Antigen-Induced Peritonitis | Full Text | References | PDF (6.7 MB) | EPUB
  • 170 Views
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Article
Shared and Specific Lung Microbiota with Metabolic Profiles in Bronchoalveolar Lavage Fluid Between Infectious and Inflammatory Respiratory Diseases
Yukun He, Wenyi Yu, Pu Ning, Qiongzhen Luo, Lili Zhao, Yu Xie, Yan Yu, Xinqian Ma, Li Chen, Yali Zheng & Zhancheng Gao
Pages: 187-198
Published online: 17 Sep 2022
AbstractforShared and Specific Lung Microbiota with Metabolic Profiles in Bronchoalveolar Lavage Fluid Between Infectious and Inflammatory Respiratory Diseases | Full Text | References | PDF (1.8 MB) | EPUB
  • 277 Views
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Article
GIMAP7 as a Potential Predictive Marker for Pan-Cancer Prognosis and Immunotherapy Efficacy
Yan Qin, He Liu, Xiaoliang Huang, Lihaoyun Huang, Lixian Liao, Jiasheng Li, Lihua Zhang, Wei Li & Jianrong Yang
Pages: 1047-1061
Published online: 17 Sep 2022
AbstractforGIMAP7 as a Potential Predictive Marker for Pan-Cancer Prognosis and Immunotherapy Efficacy | Full Text | References | PDF (10.9 MB) | EPUB
  • 277 Views
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Article
The Relationship Between Mild Cognitive Impairment and Anti-Inflammatory/Pro-Inflammatory Nutrients in the Elderly in Northern China: A Bayesian Kernel Machine Regression Approach
Ruiqiang Li, Wenqiang Zhan, Xin Huang, Limin Zhang, Zechen Zhang, Meiqi Zhou, Zhihong Wang & Yuxia Ma
Pages: 325-339
Published online: 14 Jan 2022
AbstractforThe Relationship Between Mild Cognitive Impairment and Anti-Inflammatory/Pro-Inflammatory Nutrients in the Elderly in Northern China: A Bayesian Kernel Machine Regression Approach | Full Text | References | PDF (5 MB) | EPUB
  • 207 Views
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Article
Comparison of Clinical Features, Immune-Inflammatory Markers, and Outcomes Between Patients with Acute In-Hospital and Out-of-Hospital Ischemic Stroke
Pei-Ya Chen, Guei-Chiuan Chen, Cheng-Lun Hsiao, Po-Jen Hsu, Fu-Yi Yang, Chih-Yang Liu, Adam Tsou, Wan-Ling Chang, Hsiu-Hsun Liu & Shinn-Kuang Lin
Pages: 881-895
Published online: 17 Sep 2022
AbstractforComparison of Clinical Features, Immune-Inflammatory Markers, and Outcomes Between Patients with Acute In-Hospital and Out-of-Hospital Ischemic Stroke | Full Text | References | PDF (3.9 MB) | EPUB
  • 205 Views
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Article
Single Nuclear RNA Sequencing Highlights Intra-Tumoral Heterogeneity and Tumor Microenvironment Complexity in Testicular Embryonic Rhabdomyosarcoma
Xuezheng Xu, Zhizhong Liu, Yi Li, Liqing Fan, Shuang Wang, Jie Guo, Yanwei Luo & Hao Bo
Pages: 493-507
Published online: 22 Jan 2022
AbstractforSingle Nuclear RNA Sequencing Highlights Intra-Tumoral Heterogeneity and Tumor Microenvironment Complexity in Testicular Embryonic Rhabdomyosarcoma | Full Text | References | PDF (13.7 MB) | EPUB
  • 290 Views
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Article
Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model
Moumita Saha, Krishnendu Manna & Krishna Das Saha
Pages: 3235-3258
Published online: 31 May 2022
AbstractforMelatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model | Full Text | References | PDF (15.8 MB) | EPUB
  • 397 Views
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REVIEW

Review
Improving Diagnosis and Clinical Management of Acquired Systemic Autoinflammatory Diseases
Adam Al-Hakim, Anoop Mistry & Sinisa Savic
Pages: 5739-5755
Published online: 26 Sep 2023
AbstractforImproving Diagnosis and Clinical Management of Acquired Systemic Autoinflammatory Diseases | Full Text | References | PDF (666.5 KB) | EPUB
  • 171 Views
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ORIGINAL RESEARCH

Article
Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds
Mohamed A Abdelgawad, Mohammad M Al-Sanea, Arafa Musa, Mohammed Elmowafy, Ashraf K El-Damasy, Amany A Azouz, Mohammed M Ghoneim & Rania B Bakr
Pages: 451-463
Published online: 20 Jan 2022
AbstractforDocking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds | Full Text | References | PDF (2 MB) | EPUB
  • 342 Views
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SHORT REPORT

Brief Report
Inflammatory Phenotypes of Cough Variant Asthma as Response Predictors to Anti-Asthmatic Therapy
Aleksandra Rybka-Fraczek, Marta Dabrowska, Elzbieta M Grabczak, Katarzyna Bialek-Gosk, Karolina Klimowicz, Olga Truba, Patrycja Nejman-Gryz, Magdalena Paplinska-Goryca & Rafal Krenke
Pages: 595-602
Published online: 26 Jan 2022
AbstractforInflammatory Phenotypes of Cough Variant Asthma as Response Predictors to Anti-Asthmatic Therapy | Full Text | References | PDF (311.7 KB) | EPUB
  • 186 Views
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ORIGINAL RESEARCH

Article
Tumor-Infiltrating CD4+ Central Memory T Cells Correlated with Favorable Prognosis in Oral Squamous Cell Carcinoma
Jin Wu, Tianyi Zhang, Haofeng Xiong, Liujun Zeng, Zijia Wang, Ying Peng, Weijun Chen, Xin Hu & Tong Su
Pages: 141-152
Published online: 17 Sep 2022
AbstractforTumor-Infiltrating CD4+ Central Memory T Cells Correlated with Favorable Prognosis in Oral Squamous Cell Carcinoma | Full Text | References | PDF (8.6 MB) | EPUB
  • 368 Views
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Article
UCHL1 Promoted Polarization of M1 Macrophages by Regulating the PI3K/AKT Signaling Pathway
Yulan Huang, Shitong He, Yitian Chen, Junli Sheng, Yuling Fu, Xialin Du, Yalong Yang, Honglin Liu, Zhenyu Han, Yingqi Huang, Qian Wen, Chaoying Zhou, Xinying Zhou, Shengfeng Hu & Li Ma
Pages: 735-746
Published online: 04 Feb 2022
AbstractforUCHL1 Promoted Polarization of M1 Macrophages by Regulating the PI3K/AKT Signaling Pathway | Full Text | References | PDF (6.9 MB) | EPUB
  • 169 Views
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Article
Exploring Long Non-Coding RNAs Associated with IP3/DAG Signaling Pathway as Potential Biomarkers Involved in Mast Cell Degranulation in Chronic Spontaneous Urticaria with 2-Year Follow-Up
Yudan Liang, Qinghuo Kong, Huiwen Luo, Jinhua Tan & Huizheng Zhu
Pages: 267-283
Published online: 14 Jan 2022
AbstractforExploring Long Non-Coding RNAs Associated with IP3/DAG Signaling Pathway as Potential Biomarkers Involved in Mast Cell Degranulation in Chronic Spontaneous Urticaria with 2-Year Follow-Up | Full Text | References | PDF (16.9 MB) | EPUB
  • 180 Views
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Article
Low Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD
Tingting Wei, Xiaocen Wang, Ke Lang, Cuicui Chen, Yansha Song, Jinlong Luo, Zhaolin Gu, Xianglin Hu & Dong Yang
Pages: 1259-1271
Published online: 17 Sep 2022
AbstractforLow Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD | Full Text | References | PDF (6.9 MB) | EPUB
  • 145 Views
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Article
Decreased Tissue Kallikrein Levels and the Risk of Ischemic Stroke: A Community-Based Cross-Sectional Study in China
Xiao Ran, Dao Wen Wang, Zhen Yu, Rongxue Wu & Qin Zhang
Pages: 117-126
Published online: 06 Jan 2022
AbstractforDecreased Tissue Kallikrein Levels and the Risk of Ischemic Stroke: A Community-Based Cross-Sectional Study in China | Full Text | References | PDF (2.4 MB) | EPUB
  • 128 Views
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Article
The Potential Role of Serum IGF-1 and Leptin as Biomarkers: Towards Screening for and Diagnosing Postmenopausal Osteoporosis
Yili Zhang, Xinyi Huang, Kai Sun, Mengyuan Li, Xu Wang, Tao Han, Hao Shen, Baoyu Qi, Yanming Xie & Xu Wei
Pages: 533-543
Published online: 22 Jan 2022
AbstractforThe Potential Role of Serum IGF-1 and Leptin as Biomarkers: Towards Screening for and Diagnosing Postmenopausal Osteoporosis | Full Text | References | PDF (2.8 MB) | EPUB
  • 145 Views
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CASE SERIES

Case Report
Therapeutic Plasma Exchanges in Combination with High-Dose Steroid-Induced Immunosuppression as an Ultima Ratio Therapy in Severe Coronavirus Disease 2019 (COVID-19): A Case-Series Report
Agata Janikowska, Jens Soukup, Rainer U Pliquett & Rabah Abdel-Rahim
Pages: 715-722
Published online: 03 Feb 2022
AbstractforTherapeutic Plasma Exchanges in Combination with High-Dose Steroid-Induced Immunosuppression as an Ultima Ratio Therapy in Severe Coronavirus Disease 2019 (COVID-19): A Case-Series Report | Full Text | References | PDF (365.2 KB) | EPUB
  • 121 Views
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REVIEW

Review
NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation
Zhilei Wang, Guang Xu, Zhiyong Li, Xiaohe Xiao, Jianyuan Tang & Zhaofang Bai
Pages: 409-422
Published online: 19 Jan 2022
AbstractforNLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation | Full Text | References | PDF (3 MB) | EPUB
  • 259 Views
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ORIGINAL RESEARCH

Article
Complement Terminal Pathway Activation is Associated with Organ Failure in Sepsis Patients
Fatima M Ahmad, Maysaa’ A Al-Binni, Amjad Bani Hani, Mahmoud Abu Abeeleh & Anas HA Abu-Humaidan
Pages: 153-162
Published online: 08 Jan 2022
AbstractforComplement Terminal Pathway Activation is Associated with Organ Failure in Sepsis Patients | Full Text | References | PDF (7 MB) | EPUB
  • 319 Views
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REVIEW

Review
Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression
Sisi Mo, Haiming Ru, Maosen Huang, Linyao Cheng, Xianwei Mo & Linhai Yan
Pages: 747-759
Published online: 04 Feb 2022
AbstractforOral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression | Full Text | References | PDF (2.3 MB) | EPUB
  • 221 Views
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ORIGINAL RESEARCH

Article
Low-Dose Interleukin-2 Altered Gut Microbiota and Ameliorated Collagen-Induced Arthritis
Na Li, Xuefei Li, Rui Su, Ruihe Wu, Hong-Qing Niu, Jing Luo, Chong Gao, Xiaofeng Li & Caihong Wang
Pages: 1365-1379
Published online: 17 Sep 2022
AbstractforLow-Dose Interleukin-2 Altered Gut Microbiota and Ameliorated Collagen-Induced Arthritis | Full Text | References | PDF (7.8 MB) | EPUB
  • 204 Views
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Article
Development and Validation of a Novel Prognostic Score Based on Thrombotic and Inflammatory Biomarkers for Predicting 28-Day Adverse Outcomes in Patients with Acute Pancreatitis
Tianyong Han, Tao Cheng, Ye Liao, Yarong He, Bofu Liu, Qiang Lai, Pan Pan, Junzhao Liu, Chenxi Lei & Yu Cao
Pages: 395-408
Published online: 17 Sep 2022
AbstractforDevelopment and Validation of a Novel Prognostic Score Based on Thrombotic and Inflammatory Biomarkers for Predicting 28-Day Adverse Outcomes in Patients with Acute Pancreatitis | Full Text | References | PDF (2.7 MB) | EPUB
  • 132 Views
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Article
Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGF-β/SMAD Signaling Against Candida albicans Infection
Fanping Wang, Yonghui Yang, Zhixin Li, Yan Wang, Zhenchao Zhang, Wei Zhang, Yonghui Mu, Jingwen Yang, Lili Yu & Mingyong Wang
Pages: 1797-1810
Published online: 11 Mar 2022
AbstractforMannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGF-β/SMAD Signaling Against Candida albicans Infection | Full Text | References | PDF (7.2 MB) | EPUB
  • 164 Views
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Article
Clenbuterol, a Selective β2-Adrenergic Receptor Agonist, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO Mice
Younian Xu, Yangyang Ge, Miaomiao Zhou & Zongze Zhang
Pages: 295-309
Published online: 14 Jan 2022
AbstractforClenbuterol, a Selective β2-Adrenergic Receptor Agonist, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO Mice | Full Text | References | PDF (8.1 MB) | EPUB
  • 218 Views
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Article
Secretory Autophagosomes from Alveolar Macrophages Exacerbate Acute Respiratory Distress Syndrome by Releasing IL-1β
Xinyi Xu, Xu Liu, Xuecheng Dong, Haibo Qiu, Yi Yang & Ling Liu
Pages: 127-140
Published online: 07 Jan 2022
AbstractforSecretory Autophagosomes from Alveolar Macrophages Exacerbate Acute Respiratory Distress Syndrome by Releasing IL-1β | Full Text | References | PDF (9.1 MB) | EPUB
  • 166 Views
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Article
Identification of Significant Modules and Targets of Xian-Lian-Jie-Du Decoction Based on the Analysis of Transcriptomics, Proteomics and Single-Cell Transcriptomics in Colorectal Tumor
Cheng-Tao Yu, Tongqing Chen, Sicheng Lu, Wenlong Hu, Qinchang Zhang, Jiani Tan, Dongdong Sun, Liu Li, Xin Sun, Changliang Xu, Yueyang Lai, Minmin Fan, Zhengjie Shen, Weixing Shen & Haibo Cheng
Pages: 1483-1499
Published online: 17 Sep 2022
AbstractforIdentification of Significant Modules and Targets of Xian-Lian-Jie-Du Decoction Based on the Analysis of Transcriptomics, Proteomics and Single-Cell Transcriptomics in Colorectal Tumor | Full Text | References | PDF (13.5 MB) | EPUB
  • 225 Views
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Article
Environmental Enrichment Protects Against Sepsis-Associated Encephalopathy-Induced Learning and Memory Deficits by Enhancing the Synthesis and Release of Vasopressin in the Supraoptic Nucleus
Shan Jiang, Yong-Qiang Wang, Yifei Tang, Xi Lu & Dan Guo
Pages: 363-379
Published online: 16 Jan 2022
AbstractforEnvironmental Enrichment Protects Against Sepsis-Associated Encephalopathy-Induced Learning and Memory Deficits by Enhancing the Synthesis and Release of Vasopressin in the Supraoptic Nucleus | Full Text | References | PDF (7.5 MB) | EPUB
  • 135 Views
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Article
Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway
Shushu Qian, Xuan Han, Xiaocao Sha, Fang Tian, Hong Huang, Pengjun Jiang, Guoshun Huang, Bangyun Ma, Hong Zhang, Yiye Zhu & Xuemei Sun
Pages: 1027-1046
Published online: 15 Feb 2022
AbstractforAqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway | Full Text | References | PDF (18.6 MB) | EPUB
  • 193 Views
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Article
Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201
Christian Kretzer, Paul M Jordan, Rossella Bilancia, Antonietta Rossi, Tuğçe Gür Maz, Erden Banoglu, Ulrich S Schubert & Oliver Werz
Pages: 911-925
Published online: 17 Sep 2022
AbstractforShifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201 | Full Text | References | PDF (8.2 MB) | EPUB
  • 287 Views
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Article
The Therapeutic Effect of iMSC-Derived Small Extracellular Vesicles on Tendinopathy Related Pain Through Alleviating Inflammation: An in vivo and in vitro Study
Zhaochen Zhu, Renzhi Gao, Teng Ye, Kai Feng, Juntao Zhang, Yu Chen, Zongping Xie & Yang Wang
Pages: 1421-1436
Published online: 24 Sep 2022
AbstractforThe Therapeutic Effect of iMSC-Derived Small Extracellular Vesicles on Tendinopathy Related Pain Through Alleviating Inflammation: An in vivo and in vitro Study | Full Text | References | PDF (9.6 MB) | EPUB
  • 342 Views
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Article
EGF Protects Epithelial Cells from Barrier Damage in Chronic Rhinosinusitis with Nasal Polyps
Le Chen, Quan Liu, Zhuofu Liu, Han Li, Xiang Liu & Hongmeng Yu
Pages: 439-450
Published online: 19 Jan 2022
AbstractforEGF Protects Epithelial Cells from Barrier Damage in Chronic Rhinosinusitis with Nasal Polyps | Full Text | References | PDF (9.2 MB) | EPUB
  • 183 Views
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Article
Polyploidy Spectrum Correlates with Immunophenotype and Shapes Hepatocellular Carcinoma Recurrence Following Liver Transplantation
Liang Zhang, Zhentao Yang, Shiyu Zhang, Ke Zhou, Wu Zhang, Sunbin Ling, Ruiqi Sun, Hong Tang, Xue Wen, Xiaowen Feng, Penghong Song, Xiao Xu, Haiyang Xie & Shusen Zheng
Pages: 217-233
Published online: 17 Sep 2022
AbstractforPolyploidy Spectrum Correlates with Immunophenotype and Shapes Hepatocellular Carcinoma Recurrence Following Liver Transplantation | Full Text | References | PDF (6.7 MB) | EPUB
  • 152 Views
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Article
Nrf2 Inhibits the Progression of Parkinson’s Disease by Upregulating AABR07032261.5 to Repress Pyroptosis
Yunxiao Zhong, Xiaodong Cai, Li Ding, Jinchi Liao, Xu Liu, Yiying Huang, Xiaohong Chen & Ling Long
Pages: 669-685
Published online: 17 Sep 2022
AbstractforNrf2 Inhibits the Progression of Parkinson’s Disease by Upregulating AABR07032261.5 to Repress Pyroptosis | Full Text | References | PDF (10.2 MB) | EPUB
  • 189 Views
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Article
Time to Occurrence of Phlebitis After Continuous Infusion of Total Nutrient Admixture Through Peripheral Veins: An Experimental Animal Study
Jin-Li Guo, Xian-Yan Yan, Qing-Li Zhao, Chao-Na Gao, Chen-Hui Wei, Zhuan Wei, Yi-Ting Yue & Xiu-Juan Guo
Pages: 205-215
Published online: 23 Dec 2022
AbstractforTime to Occurrence of Phlebitis After Continuous Infusion of Total Nutrient Admixture Through Peripheral Veins: An Experimental Animal Study | Full Text | References | PDF (4.3 MB) | EPUB
  • 293 Views
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Article
Clinical Characteristics of HIV-Infected Patients with Venous Thromboembolism and Different CD4+ T Lymphocyte Levels
Yan-Fen Tang, Yu Wang, Tian-Jiao Xue, Gang Liu, Qi Chen, Wen Zhao, Yan-Yan Liu, Rong-Qian Chen, Li Chen & Jing Liu
Pages: 613-620
Published online: 17 Sep 2022
AbstractforClinical Characteristics of HIV-Infected Patients with Venous Thromboembolism and Different CD4+ T Lymphocyte Levels | Full Text | References | PDF (256.2 KB) | EPUB
  • 143 Views
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Article
Transcriptomic Analysis Reveals a Link Between Hippo Signaling Pathway and Macrophages in Lungs of Mice with OVA-Induced Allergic Asthma
Huan Xiao, Qian-nan Zhang, Qi-xiang Sun, Lao-dong Li, Si-yue Xu & Chao-qian Li
Pages: 423-437
Published online: 17 Sep 2022
AbstractforTranscriptomic Analysis Reveals a Link Between Hippo Signaling Pathway and Macrophages in Lungs of Mice with OVA-Induced Allergic Asthma | Full Text | References | PDF (9.6 MB) | EPUB
  • 165 Views
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Article
A Potential Role of Ethosuximide and Pentoxifylline in Relieving Abdominal Pain in Irritable Bowel Syndrome Patients Treated with Mebeverine: A Randomized, Double-Blind, Placebo-Controlled Trial
Sahar M El-Haggar, Sahar K Hegazy, Sherief M Abd-Elsalam, Eslam B Elkaeed, Ahmed A Al-Karmalawy & Mostafa M Bahaa
Pages: 1159-1172
Published online: 19 Feb 2022
AbstractforA Potential Role of Ethosuximide and Pentoxifylline in Relieving Abdominal Pain in Irritable Bowel Syndrome Patients Treated with Mebeverine: A Randomized, Double-Blind, Placebo-Controlled Trial | Full Text | References | PDF (3.8 MB) | EPUB
  • 158 Views
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Article
Prophylactic Effects of NFκB Essential Modulator–Binding Domain Peptides on Bone Infection: An Experimental Study in a Rabbit Model
Wen-Jiao Wu, Chang-Liang Xia, Shuan-Ji Ou, Yang Yang, Xiao-Zhong Zhou, Yun-Fei Ma, Yi-Long Hou, Fa-Zheng Wang, Qing-Po Yang, Yong Qi & Chang-Peng Xu
Pages: 2745-2759
Published online: 28 Apr 2022
AbstractforProphylactic Effects of NFκB Essential Modulator–Binding Domain Peptides on Bone Infection: An Experimental Study in a Rabbit Model | Full Text | References | PDF (13.4 MB) | EPUB
  • 189 Views
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Article
The Involvement of Endothelin Pathway in Chronic Psychological Stress-Induced Bladder Hyperalgesia Through Capsaicin-Sensitive C-Fiber Afferents
Chuying Qin, Yinhuai Wang, Sai Li, Yuanyuan Tang & Yunliang Gao
Pages: 1209-1226
Published online: 22 Feb 2022
AbstractforThe Involvement of Endothelin Pathway in Chronic Psychological Stress-Induced Bladder Hyperalgesia Through Capsaicin-Sensitive C-Fiber Afferents | Full Text | References | PDF (12.6 MB) | EPUB
  • 142 Views
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Article
Elevated Albumin to Globulin Ratio on Day 7 is Associated with Improved Function Outcomes in Acute Ischemic Stroke Patients with Intravenous Thrombolysis
Dehao Yang, Jiamin Shen, Honghao Huang, Jianing Wang, Fangyue Sun, Tian Zeng, Haojie Qiu, Haobo Xie, Yilin Chen, Shengqi Li, Yiqun Chen, Guangyong Chen & Yiyun Weng
Pages: 2695-2705
Published online: 26 Apr 2022
AbstractforElevated Albumin to Globulin Ratio on Day 7 is Associated with Improved Function Outcomes in Acute Ischemic Stroke Patients with Intravenous Thrombolysis | Full Text | References | PDF (2.5 MB) | EPUB
  • 137 Views
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REVIEW

Review
Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration
Jiangbo Ren, Anli Ren, Xizhi Deng, Zhengrong Huang, Ziyu Jiang, Zhi Li & Yan Gong
Pages: 865-880
Published online: 09 Feb 2022
AbstractforLong-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration | Full Text | References | PDF (4.5 MB) | EPUB
  • 278 Views
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ORIGINAL RESEARCH

Article
MicroRNA miR-24-3p Mediates the Negative Regulation of Lipopolysaccharide-Induced Endometrial Inflammatory Response by Targeting TNF Receptor-Associated Factor 6 (TRAF6)
Ayodele Olaolu Oladejo, Yajuan Li, Bereket Habte Imam, Xiaoyu Ma, Wenxiang Shen, Xiaohu Wu, Wei Jiang, Jie Yang, Yanan Lv, Xuezhi Ding, Shengyi Wang & Zuoting Yan
Pages: 807-825
Published online: 17 Sep 2022
AbstractforMicroRNA miR-24-3p Mediates the Negative Regulation of Lipopolysaccharide-Induced Endometrial Inflammatory Response by Targeting TNF Receptor-Associated Factor 6 (TRAF6) | Full Text | References | PDF (6.4 MB) | EPUB
  • 180 Views
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Article
Characterization of the TCR β Chain Repertoire in Peripheral Blood from Hepatitis B Vaccine Responders and Non-Responders
Jiezuan Yang, Yongtao Li, Jing Ye, Ju Wang, Haifeng Lu & Xinsheng Yao
Pages: 939-951
Published online: 14 Feb 2022
AbstractforCharacterization of the TCR β Chain Repertoire in Peripheral Blood from Hepatitis B Vaccine Responders and Non-Responders | Full Text | References | PDF (4.9 MB) | EPUB
  • 164 Views
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Article
No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study
Jialyu Huang, Leizhen Xia, Jiaying Lin, Bangdong Liu, Yan Zhao, Cailin Xin, Xiaoyan Ai, Wenting Cao, Xiaocui Zhang, Lifeng Tian & Qiongfang Wu
Pages: 839-849
Published online: 09 Feb 2022
AbstractforNo Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study | Full Text | References | PDF (2 MB) | EPUB
  • 331 Views
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Article
Pan-Cancer Transcriptomic Analysis Identifies PLK1 Crucial for the Tumorigenesis of Clear Cell Renal Cell Carcinoma
Yiguan Qian, Yang Li, Ke Chen, Ning Liu, Xi Hong, Di Wu, Zheng Xu, Liuhua Zhou, Luwei Xu, Ruipeng Jia & Yu-Zheng Ge
Pages: 1099-1116
Published online: 17 Sep 2022
AbstractforPan-Cancer Transcriptomic Analysis Identifies PLK1 Crucial for the Tumorigenesis of Clear Cell Renal Cell Carcinoma | Full Text | References | PDF (15.9 MB) | EPUB
  • 178 Views
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Article
The Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing
Shifu Li, Wengui Tao, Zheng Huang, Langchao Yan, Bo Chen, Chudai Zeng & Fenghua Chen
Pages: 1381-1397
Published online: 26 Feb 2022
AbstractforThe Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing | Full Text | References | PDF (13 MB) | EPUB
  • 209 Views
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Article
Tumor-Infiltrating PD-L1+ Neutrophils Induced by GM-CSF Suppress T Cell Function in Laryngeal Squamous Cell Carcinoma and Predict Unfavorable Prognosis
Di Tang, Duo Zhang, Yu Heng, Xiao-Ke Zhu, Han-Qing Lin, Jian Zhou, Lei Tao & Li-Ming Lu
Pages: 1079-1097
Published online: 17 Sep 2022
AbstractforTumor-Infiltrating PD-L1+ Neutrophils Induced by GM-CSF Suppress T Cell Function in Laryngeal Squamous Cell Carcinoma and Predict Unfavorable Prognosis | Full Text | References | PDF (15.4 MB) | EPUB
  • 234 Views
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Article
Factors Influencing the Withdrawal of Antiepileptic Drugs in Adult Patients with Symptomatic Seizures Secondary to Neuronal Surface Antibodies-Associated Autoimmune Encephalitis
Fang Huang, Yu Wu, Weidong Nong, Fengping Mao, Xiaoli Cao, Wen Huang & Jinou Zheng
Pages: 927-937
Published online: 09 Feb 2022
AbstractforFactors Influencing the Withdrawal of Antiepileptic Drugs in Adult Patients with Symptomatic Seizures Secondary to Neuronal Surface Antibodies-Associated Autoimmune Encephalitis | Full Text | References | PDF (2 MB) | EPUB
  • 130 Views
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Article
Probiotic Combination CBLEB Alleviates Streptococcus pneumoniae Infection Through Immune Regulation in Immunocompromised Rats
Longxian Lv, Ling Peng, Ding Shi, Li Shao, Huiyong Jiang & Ren Yan
Pages: 987-1004
Published online: 15 Feb 2022
AbstractforProbiotic Combination CBLEB Alleviates Streptococcus pneumoniae Infection Through Immune Regulation in Immunocompromised Rats | Full Text | References | PDF (11.4 MB) | EPUB
  • 251 Views
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REVIEW

Review
Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives
Wenjie Shi, Ning Xu, Xuelin Wang, Isabelle Vallée, Mingyuan Liu & Xiaolei Liu
Pages: 475-491
Published online: 21 Jan 2022
AbstractforHelminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives | Full Text | References | PDF (3.7 MB) | EPUB
  • 933 Views
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ORIGINAL RESEARCH

Article
A Survival Prediction for Acute Heart Failure Patients via Web-Based Dynamic Nomogram with Internal Validation: A Prospective Cohort Study
Ting Yin, Shi Shi, Xu Zhu, Iokfai Cheang, Xinyi Lu, Rongrong Gao, Haifeng Zhang, Wenming Yao, Yanli Zhou & Xinli Li
Pages: 1953-1967
Published online: 23 Dec 2022
AbstractforA Survival Prediction for Acute Heart Failure Patients via Web-Based Dynamic Nomogram with Internal Validation: A Prospective Cohort Study | Full Text | References | PDF (4.3 MB) | EPUB
  • 147 Views
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Article
Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway
Hui Zhang, Jinyi Lin, Yihui Shen, Jianan Pan, Chunhui Wang & Leilei Cheng
Pages: 1653-1666
Published online: 05 Mar 2022
AbstractforProtective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway | Full Text | References | PDF (11.9 MB) | EPUB
  • 252 Views
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Article
Establishment and Effectiveness Evaluation of a Scoring System-RAAS (RDW, AGE, APACHE II, SOFA) for Sepsis by a Retrospective Analysis
Yingying Huang, Shaowei Jiang, Wenjie Li, Yiwen Fan, Yuxin Leng & Chengjin Gao
Pages: 465-474
Published online: 17 Sep 2022
AbstractforEstablishment and Effectiveness Evaluation of a Scoring System-RAAS (RDW, AGE, APACHE II, SOFA) for Sepsis by a Retrospective Analysis | Full Text | References | PDF (4.1 MB) | EPUB
  • 265 Views
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REVIEW

Review
p38MAPK Signaling Pathway in Osteoarthritis: Pathological and Therapeutic Aspects
Zongchao Li, Aonan Dai, Ming Yang, Siyu Chen, Zhenhan Deng & Liangjun Li
Pages: 723-734
Published online: 17 Sep 2022
Abstractforp38MAPK Signaling Pathway in Osteoarthritis: Pathological and Therapeutic Aspects | Full Text | References | PDF (1.9 MB) | EPUB
  • 381 Views
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ORIGINAL RESEARCH

Article
Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women
Yingbo Ma, Xueqing Ding, Mingxi Shao, Yichao Qiu, Shengjie Li, Wenjun Cao & Gezhi Xu
Pages: 285-294
Published online: 17 Sep 2022
AbstractforAssociation of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women | Full Text | References | PDF (2.1 MB) | EPUB
  • 188 Views
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Article
LncRNA GAS5 rs145204276 Polymorphism Reduces Renal Cell Carcinoma Susceptibility in Southern Chinese Population
Xiaoyao Xiang, Linfa Chen, Jiawen He, Guoda Ma & You Li
Pages: 1147-1158
Published online: 18 Feb 2022
AbstractforLncRNA GAS5 rs145204276 Polymorphism Reduces Renal Cell Carcinoma Susceptibility in Southern Chinese Population | Full Text | References | PDF (1.2 MB) | EPUB
  • 127 Views
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Article
TLR3 Expression is a Potential Prognosis Biomarker and Shapes the Immune-Active Tumor Microenvironment in Esophageal Squamous Cell Carcinoma
Ruibing Su, Lijun Cai, Pan Xiong, Zhiwei Liu, Shaobin Chen, Xi Liu, Runhua Lin, Zhijin Lei, Dongping Tian & Min Su
Pages: 1437-1456
Published online: 28 Feb 2022
AbstractforTLR3 Expression is a Potential Prognosis Biomarker and Shapes the Immune-Active Tumor Microenvironment in Esophageal Squamous Cell Carcinoma | Full Text | References | PDF (13.6 MB) | EPUB
  • 155 Views
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Article
Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS
Yafei Yuan, Wei Wang, Yue Zhang, Qiaohui Hong, Wenhui Huang, Lijuan Li, Zhanzhan Xie, Yixin Chen, Xu Li & Ying Meng
Pages: 2121-2139
Published online: 17 Sep 2022
AbstractforApelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS | Full Text | References | PDF (13.2 MB) | EPUB
  • 206 Views
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Article
Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway
Chenyang Zhang, Meixin Han, Xuelian Zhang, Hongna Tong, Xiaobo Sun & Guibo Sun
Pages: 71-83
Published online: 17 Sep 2022
AbstractforGinsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway | Full Text | References | PDF (7.6 MB) | EPUB
  • 225 Views
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Article
Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota
Gong Cheng, Ji Zhang, Shuo Jia, Panpan Feng, Fengjun Chang, Li Yan, Pranay Gupta & Haoyu Wu
Pages: 1637-1651
Published online: 05 Mar 2022
AbstractforCardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota | Full Text | References | PDF (8.3 MB) | EPUB
  • 231 Views
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SHORT REPORT

Brief Report
Transient HIV Reservoirs and Interleukin-6 Increase After Anti-Programmed Death-1 Antibody Infusion in HIV Patients with Lung Cancer
Xiaorong Peng, Ran Tao, Ying Chen, Junwei Su, Ying Huang & Biao Zhu
Pages: 199-204
Published online: 10 Jan 2022
AbstractforTransient HIV Reservoirs and Interleukin-6 Increase After Anti-Programmed Death-1 Antibody Infusion in HIV Patients with Lung Cancer | Full Text | References | PDF (1.5 MB) | EPUB
  • 156 Views
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ORIGINAL RESEARCH

Article
Pyroptosis-Mediated Molecular Subtypes are Characterized by Distinct Tumor Microenvironment Infiltration Characteristics in Breast Cancer
Lijun Xu, Yaomin Hu & Wenwen Liu
Pages: 345-362
Published online: 17 Sep 2022
AbstractforPyroptosis-Mediated Molecular Subtypes are Characterized by Distinct Tumor Microenvironment Infiltration Characteristics in Breast Cancer | Full Text | References | PDF (19.9 MB) | EPUB
  • 160 Views
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Article
Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-κB in Normal Human Keratinocytes and Fibroblasts
Natalia Kordulewska, Justyna Topa, Anna Cieślińska & Beata Jarmołowska
Pages: 1501-1519
Published online: 01 Mar 2022
AbstractforOsthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-κB in Normal Human Keratinocytes and Fibroblasts | Full Text | References | PDF (14.2 MB) | EPUB
  • 226 Views
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Article
Adherence to the Mediterranean Diet Improved Clinical Scores and Inflammatory Markers in Children with Active Inflammatory Bowel Disease: A Randomized Trial
Doaa El Amrousy, Heba Elashry, Abeer Salamah, Sara Maher, Sherief M Abd-Elsalam & Samir Hasan
Pages: 2075-2086
Published online: 17 Sep 2022
AbstractforAdherence to the Mediterranean Diet Improved Clinical Scores and Inflammatory Markers in Children with Active Inflammatory Bowel Disease: A Randomized Trial | Full Text | References | PDF (270.6 KB) | EPUB
  • 405 Views
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REVIEW

Review
Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
Qi-Ming Pang, Si-Yu Chen, Sheng-Ping Fu, Hui Zhou, Qian Zhang, Jun Ao, Xiao-Ping Luo & Tao Zhang
Pages: 573-593
Published online: 17 Sep 2022
AbstractforRegulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury | Full Text | References | PDF (2.2 MB) | EPUB
  • 316 Views
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ORIGINAL RESEARCH

Article
Endothelial Microparticles Derived from Primary Pulmonary Microvascular Endothelial Cells Mediate Lung Inflammation in Chronic Obstructive Pulmonary Disease by Transferring microRNA-126
Yiming Ma, Xue He, Xiangming Liu, Yingjiao Long & Yan Chen
Pages: 1399-1411
Published online: 17 Sep 2022
AbstractforEndothelial Microparticles Derived from Primary Pulmonary Microvascular Endothelial Cells Mediate Lung Inflammation in Chronic Obstructive Pulmonary Disease by Transferring microRNA-126 | Full Text | References | PDF (6 MB) | EPUB
  • 148 Views
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Article
Anti-Inflammatory Effects of Camellia fascicularis Polyphenols via Attenuation of NF-κB and MAPK Pathways in LPS-Induced THP-1 Macrophages
Miaozi Gao, Xiaowei Peng, Junrong Tang, Jia Deng, Fang Wang, Yingjun Zhang, Ping Zhao, Huan Kan & Yun Liu
Pages: 851-864
Published online: 17 Sep 2022
AbstractforAnti-Inflammatory Effects of Camellia fascicularis Polyphenols via Attenuation of NF-κB and MAPK Pathways in LPS-Induced THP-1 Macrophages | Full Text | References | PDF (8.9 MB) | EPUB
  • 283 Views
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Article
The Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure
Zesong Hu, Jie Wang, Yangjing Xue, Qianqian Zhang, Qianqian Xu, Kangting Ji & Ripeng Yin
Pages: 701-713
Published online: 17 Sep 2022
AbstractforThe Neutrophil-to-Albumin Ratio as a New Predictor of All-Cause Mortality in Patients with Heart Failure | Full Text | References | PDF (4.4 MB) | EPUB
  • 228 Views
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Article
Multiple-Cytokine Profiling: A Novel Method for Early Prediction of the Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients
Yanni Zhang, Kang Zhu, Cui Xia, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Huihui Zhang & Xiaoyong Ren
Pages: 603-612
Published online: 27 Jan 2022
AbstractforMultiple-Cytokine Profiling: A Novel Method for Early Prediction of the Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients | Full Text | References | PDF (6 MB) | EPUB
  • 139 Views
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RESEARCH LETTER

Letter
Inverted J-Shaped Association of High-Sensitivity C-Reactive Protein with the Levels of Serum Uric Acid: Cross-Sectional and Longitudinal Analyses
Xing Zhen Liu, Ya Jun Tian, Jie Fan & Lian Yong Liu
Pages: 341-344
Published online: 16 Jan 2022
First Page PreviewforInverted J-Shaped Association of High-Sensitivity C-Reactive Protein with the Levels of Serum Uric Acid: Cross-Sectional and Longitudinal Analyses | Full Text | References | PDF (221.1 KB) | EPUB
  • 118 Views
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REVIEW

Review
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases
Menglong Wang, Wei Pan, Yao Xu, Jishou Zhang, Jun Wan & Hong Jiang
Pages: 3083-3094
Published online: 25 May 2022
AbstractforMicroglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases | Full Text | References | PDF (255.4 KB) | EPUB
  • 858 Views
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ORIGINAL RESEARCH

Article
Effect of PD-1 Inhibitor Combined with X-Ray Irradiation on the Inflammatory Microenvironment and Lung Tissue Injury in Mice
Yichao Geng, Shengfa Su, Li Cao, Ting Yang, Weiwei Ouyang, Lingfeng Liu, Bibo Wu, Qiuning Zhang, Bing Lu & Xiaohu Wang
Pages: 545-556
Published online: 17 Sep 2022
AbstractforEffect of PD-1 Inhibitor Combined with X-Ray Irradiation on the Inflammatory Microenvironment and Lung Tissue Injury in Mice | Full Text | References | PDF (5.2 MB) | EPUB
  • 130 Views
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Article
Dynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS
Daniel P Nemeth, Xiaoyu Liu, Daniel B McKim, Damon J DiSabato, Braedan Oliver, Anu Herd, Asish Katta, Christina E Negray, James Floyd, Samantha McGovern, Paige S Pruden, Feiyang Zhutang, Maria Smirnova, Jonathan P Godbout, John Sheridan & Ning Quan
Pages: 1575-1590
Published online: 04 Mar 2022
AbstractforDynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS | Full Text | References | PDF (11.4 MB) | EPUB
  • 194 Views
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Article
Association of Growth and Differentiation Factor 15 in Rheumatoid Arthritis
Yan-Wei He & Cheng-Song He
Pages: 1173-1181
Published online: 19 Feb 2022
AbstractforAssociation of Growth and Differentiation Factor 15 in Rheumatoid Arthritis | Full Text | References | PDF (2.1 MB) | EPUB
  • 198 Views
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Article
Recovery of Dysregulated Genes in Cancer-Related Lower Limb Lymphedema After Supermicrosurgical Lymphaticovenous Anastomosis – A Prospective Longitudinal Cohort Study
Johnson Chia-Shen Yang, Lien-Hung Huang, Shao-Chun Wu, Yi-Chan Wu, Chia-Jung Wu, Chia-Wei Lin, Pei-Yu Tsai, Peng-Chen Chien & Ching-Hua Hsieh
Pages: 761-773
Published online: 17 Sep 2022
AbstractforRecovery of Dysregulated Genes in Cancer-Related Lower Limb Lymphedema After Supermicrosurgical Lymphaticovenous Anastomosis – A Prospective Longitudinal Cohort Study | Full Text | References | PDF (3.9 MB) | EPUB
  • 144 Views
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REVIEW

Review
Chloride Channel and Inflammation-Mediated Pathogenesis of Osteoarthritis
Zicong Lin, Zhiqin Deng, Jianquan Liu, Zhongshi Lin, Siyu Chen, Zhenhan Deng & Wencui Li
Pages: 953-964
Published online: 11 Feb 2022
AbstractforChloride Channel and Inflammation-Mediated Pathogenesis of Osteoarthritis | Full Text | References | PDF (2.1 MB) | EPUB
  • 156 Views
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ORIGINAL RESEARCH

Article
Gut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid
Huidan Zhang, Jing Xu, Qingrui Wu, Heng Fang, Xin Shao, Xin Ouyang, Zhimei He, Yiyu Deng & Chunbo Chen
Pages: 2103-2119
Published online: 17 Sep 2022
AbstractforGut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid | Full Text | References | PDF (11.2 MB) | EPUB
  • 335 Views
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Article
CD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm
Xiaonan Zhou, Kai Zhu, Yiqiu Zhang, Yang Ming, Dai Shi, Hui Tan, Bitao Xiang, Shichao Zhu, Dengfeng Cheng, Hao Lai, Chunsheng Wang & Guobing Liu
Pages: 1921-1933
Published online: 24 Sep 2022
AbstractforCD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm | Full Text | References | PDF (7.6 MB) | EPUB
  • 155 Views
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Article
Elevated ALCAM Expression Associated with Endotypes and Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps
Hua Zhang, Shaobing Xie, Ruohao Fan, Fengjun Wang, Zhihai Xie & Weihong Jiang
Pages: 1063-1077
Published online: 17 Sep 2022
AbstractforElevated ALCAM Expression Associated with Endotypes and Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps | Full Text | References | PDF (12.1 MB) | EPUB
  • 120 Views
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Article
HDL-Associated Lipoproteins: Potential Prognostic Biomarkers for Gram-Negative Sepsis
Guoying Zou, Qing Zhu, Biqiong Ren, Qi Guo, Yuanyuan Wu, Junyu He, Ying Wu & Zhihong Luo
Pages: 1117-1131
Published online: 17 Feb 2022
AbstractforHDL-Associated Lipoproteins: Potential Prognostic Biomarkers for Gram-Negative Sepsis | Full Text | References | PDF (6 MB) | EPUB
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Article
Nonlinear Relationship Between Chinese Visceral Adiposity Index and New-Onset Myocardial Infarction in Patients with Hypertension and Obstructive Sleep Apnoea: Insights from a Cohort Study
Xintian Cai, Nanfang Li, Junli Hu, Wen Wen, Xiaoguang Yao, Qing Zhu, Mulalibieke Heizhati, Jing Hong, Le Sun, Guzailinuer Tuerxun, Delian Zhang & Qin Luo
Pages: 687-700
Published online: 17 Sep 2022
AbstractforNonlinear Relationship Between Chinese Visceral Adiposity Index and New-Onset Myocardial Infarction in Patients with Hypertension and Obstructive Sleep Apnoea: Insights from a Cohort Study | Full Text | References | PDF (5 MB) | EPUB
  • 163 Views
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Article
Downregulation of TIGIT Expression in FOXP3+Regulatory T Cells in Acute Coronary Syndrome
Xinlin Xiong, Zhenhua Luo, Haiyan Zhou, Zonggang Duan, Li Niu, Kai Zhang, Guangwei Huang & Wei Li
Pages: 1195-1207
Published online: 17 Sep 2022
AbstractforDownregulation of TIGIT Expression in FOXP3+Regulatory T Cells in Acute Coronary Syndrome | Full Text | References | PDF (5.5 MB) | EPUB
  • 144 Views
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Article
Development and Validation of a Nomogram to Assist Monitoring Nosocomial SARS-CoV-2 Infection of Hospitalized Patients
Chen Wang, Chunyan Peng, Leping Ning, Xueping Qiu, Kaisong Wu, Na Yang, Bingyu Jin, Yue Zhao & Fang Zheng
Pages: 1471-1481
Published online: 17 Sep 2022
AbstractforDevelopment and Validation of a Nomogram to Assist Monitoring Nosocomial SARS-CoV-2 Infection of Hospitalized Patients | Full Text | References | PDF (6.7 MB) | EPUB
  • 102 Views
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Article
ATP-Activated P2X7R Promote the Attack of Acute Gouty Arthritis in Rats Through Activating NLRP3 Inflammasome and Inflammatory Cytokine Production
Xiaojuan Dai, Xuan Fang, Yuan Xia, Manyun Li, Xiaomei Li, Yiping Wang, Jinhui Tao & Xiangpei Li
Pages: 1237-1248
Published online: 23 Feb 2022
AbstractforATP-Activated P2X7R Promote the Attack of Acute Gouty Arthritis in Rats Through Activating NLRP3 Inflammasome and Inflammatory Cytokine Production | Full Text | References | PDF (7.8 MB) | EPUB
  • 237 Views
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Article
LncRNA-miRNA-mRNA Network Analysis Reveals the Potential Biomarkers in Crohn's Disease Rats Treated with Herb-Partitioned Moxibustion
Xue-Jun Wang, Xiao-Ying Li, Xiao-Cong Guo, Li Liu, You-You Jin, Yun-Qiong Lu, Yao-Jia-Ni Cao, Jun-Yi Long, Huan-Gan Wu, Dan Zhang, Guang Yang, Jue Hong, Yan-Ting Yang & Xiao-Peng Ma
Pages: 1699-1716
Published online: 17 Sep 2022
AbstractforLncRNA-miRNA-mRNA Network Analysis Reveals the Potential Biomarkers in Crohn's Disease Rats Treated with Herb-Partitioned Moxibustion | Full Text | References | PDF (11.5 MB) | EPUB
  • 226 Views
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REVIEW

Review
Ferroptosis and Its Potential Role in the Nervous System Diseases
Yiyang Zhou, Wei Lin, Tian Rao, Jinyu Zheng, Tianlei Zhang, Min Zhang & Zhenlang Lin
Pages: 1555-1574
Published online: 03 Mar 2022
AbstractforFerroptosis and Its Potential Role in the Nervous System Diseases | Full Text | References | PDF (2.3 MB) | EPUB
  • 456 Views
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Review
The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis
Rupesh K Srivastava & Leena Sapra
Pages: 1667-1698
Published online: 17 Sep 2022
AbstractforThe Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis | Full Text | References | PDF (12.4 MB) | EPUB
  • 1046 Views
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ORIGINAL RESEARCH

Article
Integrated Analysis of Ferroptosis and Immunity-Related Genes Associated with Intestinal Ischemia/Reperfusion Injury
Lin Zhu, Wanyi Lian, Zhiwen Yao, Xiao Yang, Ziyi Wang, Yupei Lai, Shiting Xu, Bingcheng Zhao & Kexuan Liu
Pages: 2397-2411
Published online: 17 Sep 2022
AbstractforIntegrated Analysis of Ferroptosis and Immunity-Related Genes Associated with Intestinal Ischemia/Reperfusion Injury | Full Text | References | PDF (13.8 MB) | EPUB
  • 207 Views
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Article
KL-6 as a Biomarker of Interstitial Lung Disease Development in Patients with Sjögren Syndrome: A Retrospective Case–Control Study
Yu-Hsiang Chiu, Chen-Chih Chu, Chun-Chi Lu, Feng-Cheng Liu, Shin-En Tang, Shi-Jye Chu, San-Yuan Kuo & Hsiang-Cheng Chen
Pages: 2255-2262
Published online: 24 Sep 2022
AbstractforKL-6 as a Biomarker of Interstitial Lung Disease Development in Patients with Sjögren Syndrome: A Retrospective Case–Control Study | Full Text | References | PDF (254.3 KB) | EPUB
  • 183 Views
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Article
Combination of Nutritional Risk Index and Handgrip Strength on the Survival of Patients with Cancer Cachexia: A Multi- Center Cohort Study
Hailun Xie, Guotian Ruan, Qi Zhang, Yizhong Ge, Mengmeng Song, Xi Zhang, Xiaoyue Liu, Shiqi Lin, Xiaowei Zhang, Xiangrui Li, Kangping Zhang, Ming Yang, Meng Tang, Minghua Cong & Hanping Shi
Pages: 1005-1015
Published online: 17 Sep 2022
AbstractforCombination of Nutritional Risk Index and Handgrip Strength on the Survival of Patients with Cancer Cachexia: A Multi- Center Cohort Study | Full Text | References | PDF (3.9 MB) | EPUB
  • 226 Views
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Article
Targeting CXCL12/CXCR4 Signaling with AMD3100 Might Selectively Suppress CXCR4+ T-Cell Chemotaxis Leading to the Alleviation of Chronic Prostatitis
Meng Zhang, Yi Liu, Jing Chen, Lei Chen, Li Zhang, Xianguo Chen, Zongyao Hao & Chaozhao Liang
Pages: 2551-2566
Published online: 17 Sep 2022
AbstractforTargeting CXCL12/CXCR4 Signaling with AMD3100 Might Selectively Suppress CXCR4+ T-Cell Chemotaxis Leading to the Alleviation of Chronic Prostatitis | Full Text | References | PDF (14.7 MB) | EPUB
  • 173 Views
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Article
Long-Term Exposure to Sulfur Dioxide Before Sensitization Decreased the Production of Specific IgE in HDM-Sensitized Allergic Rhinitis Mice
Maoyu Ye, Honghui Liu, Honglei Li, Qian Liu, Zheng Zhou, Tiansheng Wang & Guolin Tan
Pages: 2477-2490
Published online: 18 Apr 2022
AbstractforLong-Term Exposure to Sulfur Dioxide Before Sensitization Decreased the Production of Specific IgE in HDM-Sensitized Allergic Rhinitis Mice | Full Text | References | PDF (9.6 MB) | EPUB
  • 148 Views
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Article
Pressure Ulcer Incidence and Blood Lactate Levels in Intensive Care Unit Patients
Anna Woźniak, Irena Smółka, Aleksandra Dusińska, Weronika Misiąg & Mariusz Chabowski
Pages: 1249-1257
Published online: 17 Sep 2022
AbstractforPressure Ulcer Incidence and Blood Lactate Levels in Intensive Care Unit Patients | Full Text | References | PDF (728.2 KB) | EPUB
  • 308 Views
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Article
TNF-α is a Novel Biomarker for Predicting Plaque Rupture in Patients with ST-Segment Elevation Myocardial Infarction
Xing Luo, Chen Zhao, Shengfang Wang, Haibo Jia & Bo Yu
Pages: 1889-1898
Published online: 14 Mar 2022
AbstractforTNF-α is a Novel Biomarker for Predicting Plaque Rupture in Patients with ST-Segment Elevation Myocardial Infarction | Full Text | References | PDF (3.6 MB) | EPUB
  • 151 Views
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REVIEW

Review
Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
Jingjing Liu, Guoqing Fan, Ningning Tao & Tieying Sun
Pages: 2033-2050
Published online: 17 Sep 2022
AbstractforRole of Pyroptosis in Respiratory Diseases and its Therapeutic Potential | Full Text | References | PDF (1.5 MB) | EPUB
  • 214 Views
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ORIGINAL RESEARCH

Article
Gegen Qinlian Decoction Alleviates Experimental Colitis and Concurrent Lung Inflammation by Inhibiting the Recruitment of Inflammatory Myeloid Cells and Restoring Microbial Balance
Yalan Li, Na Li, Jiajing Liu, Tieshan Wang, Ruijuan Dong, Dongyu Ge & Guiying Peng
Pages: 1273-1291
Published online: 24 Feb 2022
AbstractforGegen Qinlian Decoction Alleviates Experimental Colitis and Concurrent Lung Inflammation by Inhibiting the Recruitment of Inflammatory Myeloid Cells and Restoring Microbial Balance | Full Text | References | PDF (7.5 MB) | EPUB
  • 174 Views
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Article
HSP70 Ameliorates Septic Acute Kidney Injury via Binding with TRAF6 to Inhibit of Inflammation-Mediated Apoptosis
Yiqiu Zhang, Chenlu Song, Wei Ni, Qing Pei, Caixia Wang, Youguo Ying & Min Yao
Pages: 2213-2228
Published online: 05 Apr 2022
AbstractforHSP70 Ameliorates Septic Acute Kidney Injury via Binding with TRAF6 to Inhibit of Inflammation-Mediated Apoptosis | Full Text | References | PDF (12.2 MB) | EPUB
  • 138 Views
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Article
The Effect of Atopy on the Incidence of Osteitis in Patients with Chronic Rhinosinusitis
Nur Saadah Mohamad, Sakinah Mohamad, Mohd Ezane Aziz & Baharudin Abdullah
Pages: 1017-1026
Published online: 15 Feb 2022
AbstractforThe Effect of Atopy on the Incidence of Osteitis in Patients with Chronic Rhinosinusitis | Full Text | References | PDF (2.4 MB) | EPUB
  • 115 Views
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Article
Ban-Lan-Gen Granule Alleviates Dextran Sulfate Sodium-Induced Chronic Relapsing Colitis in Mice via Regulating Gut Microbiota and Restoring Gut SCFA Derived-GLP-1 Production
Jiao Peng, Xi Li, Lin Zheng, Lifang Duan, Zhengxian Gao, Die Hu, Jie Li, Xiaofeng Li, Xiangchun Shen & Haitao Xiao
Pages: 1457-1470
Published online: 17 Sep 2022
AbstractforBan-Lan-Gen Granule Alleviates Dextran Sulfate Sodium-Induced Chronic Relapsing Colitis in Mice via Regulating Gut Microbiota and Restoring Gut SCFA Derived-GLP-1 Production | Full Text | References | PDF (6.8 MB) | EPUB
  • 234 Views
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REVIEW

Review
Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics
Quan Lu, Mei-feng Yang, Yu-jie Liang, Jing Xu, Hao-ming Xu, Yu-qiang Nie, Li-sheng Wang, Jun Yao & De-feng Li
Pages: 1825-1844
Published online: 12 Mar 2022
AbstractforImmunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics | Full Text | References | PDF (6.7 MB) | EPUB
  • 929 Views
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ORIGINAL RESEARCH

Article
Autophagy-Related Genes Predict the Progression of Periodontitis Through the ceRNA Network
Mengyao Bian, Wenhao Wang, Chengjie Song, Lai Pan, Yanmin Wu & Lili Chen
Pages: 1811-1824
Published online: 17 Sep 2022
AbstractforAutophagy-Related Genes Predict the Progression of Periodontitis Through the ceRNA Network | Full Text | References | PDF (3.2 MB) | EPUB
  • 211 Views
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Article
A Retrospective Analysis of Clinical Features and Treatment of the Inflammatory Bowel Disease in China
Su’e Shao, Meifang Huang, Heng Zhang, Gangqiang Peng, Min Song, Jing Liu & Dan Xu
Pages: 3587-3597
Published online: 20 Jun 2022
AbstractforA Retrospective Analysis of Clinical Features and Treatment of the Inflammatory Bowel Disease in China | Full Text | References | PDF (1.6 MB) | EPUB
  • 148 Views
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Article
Gender-Specific Impact of Metabolic Obesity Phenotypes on the Risk of Hashimoto's Thyroiditis: A Retrospective Data Analysis Using a Health Check-Up Database
Hao Yang, Qing Xia, Yan Shen, Ting-Li Chen, Jing Wang & Ya-Yun Lu
Pages: 827-837
Published online: 17 Sep 2022
AbstractforGender-Specific Impact of Metabolic Obesity Phenotypes on the Risk of Hashimoto's Thyroiditis: A Retrospective Data Analysis Using a Health Check-Up Database | Full Text | References | PDF (1.8 MB) | EPUB
  • 149 Views
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REVIEW

Review
COVID-19-Related Brain Injury: The Potential Role of Ferroptosis
Ruoyu Zhang, Chen Sun, Xuemei Chen, Yunze Han, Weidong Zang, Chao Jiang, Junmin Wang & Jian Wang
Pages: 2181-2198
Published online: 05 Apr 2022
AbstractforCOVID-19-Related Brain Injury: The Potential Role of Ferroptosis | Full Text | References | PDF (2.2 MB) | EPUB
  • 436 Views
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Review
Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review
Teklie Mengie Ayele, Zelalem Tilahun Muche, Awgichew Behaile Teklemariam, Achenef Bogale Kassie & Endeshaw Chekol Abebe
Pages: 1349-1364
Published online: 25 Feb 2022
AbstractforRole of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review | Full Text | References | PDF (1.4 MB) | EPUB
  • 780 Views
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Review
New Insights in the Treatment of SAPHO Syndrome and Medication Recommendations
Wei Cheng, Fen Li, Jing Tian, Xi Xie, Jin-Wei Chen, Xiao-Fei Peng, Qi Tang & Yan Ge
Pages: 2365-2380
Published online: 13 Apr 2022
AbstractforNew Insights in the Treatment of SAPHO Syndrome and Medication Recommendations | Full Text | References | PDF (2 MB) | EPUB
  • 378 Views
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ORIGINAL RESEARCH

Article
Lung Microbiota Signature and Corticosteroid Responses in Pneumonia-Associated Acute Respiratory Distress Syndrome in Hematological Patients
Jiawei Shen, Yan Hu, Jie Lv, Huiying Zhao, Bin Wang, Shuguang Yang, Anqi Du, Shuang Liu & Youzhong An
Pages: 1317-1329
Published online: 24 Feb 2022
AbstractforLung Microbiota Signature and Corticosteroid Responses in Pneumonia-Associated Acute Respiratory Distress Syndrome in Hematological Patients | Full Text | References | PDF (2.2 MB) | EPUB
  • 120 Views
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Article
Neutrophil Ratio of White Blood Cells as a Prognostic Predictor of Clostridioides difficile Infection
Ching-Chi Lee, Jen-Chieh Lee, Chun-Wei Chiu, Pei-Jane Tsai, Wen-Chien Ko & Yuan-Pin Hung
Pages: 1943-1951
Published online: 22 Sep 2022
AbstractforNeutrophil Ratio of White Blood Cells as a Prognostic Predictor of Clostridioides difficile Infection | Full Text | References | PDF (725.7 KB) | EPUB
  • 158 Views
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Article
High Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study
Xiaojun Wang, Xuanqi Liu, Yiding Qi, Shuyi Zhang, Kailei Shi, Huagang Lin, Paul Grossfeld, Wenhao Wang, Tao Wu, Xinkai Qu, Jing Xiao & Maoqing Ye
Pages: 1859-1872
Published online: 12 Mar 2022
AbstractforHigh Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study | Full Text | References | PDF (8.5 MB) | EPUB
  • 178 Views
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Article
Serum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity
Gema Frühbeck, Victoria Catalán, Beatriz Ramírez, Víctor Valentí, Sara Becerril, Amaia Rodríguez, Rafael Moncada, Jorge Baixauli, Camilo Silva, Javier Escalada & Javier Gómez-Ambrosi
Pages: 1331-1345
Published online: 17 Sep 2022
AbstractforSerum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity | Full Text | References | PDF (7.1 MB) | EPUB
  • 247 Views
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Article
MULT1-Encoding DNA Alleviates Schistosomiasis-Associated Hepatic Fibrosis via Modulating Cellular Immune Response
Lu Yang, Li Sun, Yalan Cao, Qi Wang, Anni Song, Ru Zhu, Wenqi Liu & Shengjun Lu
Pages: 4027-4045
Published online: 17 Sep 2022
AbstractforMULT1-Encoding DNA Alleviates Schistosomiasis-Associated Hepatic Fibrosis via Modulating Cellular Immune Response | Full Text | References | PDF (18.3 MB) | EPUB
  • 127 Views
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Article
Mendelian Randomization Study Implies Causal Linkage Between Telomere Length and Juvenile Idiopathic Arthritis in a European Population
Jun Zhang
Pages: 977-986
Published online: 15 Feb 2022
AbstractforMendelian Randomization Study Implies Causal Linkage Between Telomere Length and Juvenile Idiopathic Arthritis in a European Population | Full Text | References | PDF (2.1 MB) | EPUB
  • 185 Views
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Article
Reduction of Hepatic Steatosis, Oxidative Stress, Inflammation, Ballooning and Insulin Resistance After Therapy with Safranal in NAFLD Animal Model: A New Approach
Usman Sabir, Hafiz Muhammad Irfan, Alamgeer, Aman Ullah, Yusuf S Althobaiti & Mulazim Hussain Asim
Pages: 1293-1316
Published online: 24 Feb 2022
AbstractforReduction of Hepatic Steatosis, Oxidative Stress, Inflammation, Ballooning and Insulin Resistance After Therapy with Safranal in NAFLD Animal Model: A New Approach | Full Text | References | PDF (8.8 MB) | EPUB
  • 771 Views
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REVIEW

Review
Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals
Hui Li, Wen-Ying Zhou, Yi-Yuan Xia & Jun-Xia Zhang
Pages: 1771-1783
Published online: 11 Mar 2022
AbstractforEndothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals | Full Text | References | PDF (1.7 MB) | EPUB
  • 259 Views
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ORIGINAL RESEARCH

Article
Identification and Validation of Autophagy-Related Genes in Sepsis-Induced Acute Respiratory Distress Syndrome and Immune Infiltration
Mengfei Sun, Qianqian Yang, Chunling Hu, Hengchao Zhang & Lihua Xing
Pages: 2199-2212
Published online: 05 Apr 2022
AbstractforIdentification and Validation of Autophagy-Related Genes in Sepsis-Induced Acute Respiratory Distress Syndrome and Immune Infiltration | Full Text | References | PDF (607.5 KB) | EPUB
  • 132 Views
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Article
HBV Infection Status Does Not Influence the Initial Metastatic Pattern and the Prognosis of Breast Cancer Patients with de novo and Relapsed Metastatic Disease
Ningning Zhang, Dan Tao, Haike Lei, Qing Shao, Yumin Liu, Hua Long & Xiaohua Zeng
Pages: 2509-2521
Published online: 17 Sep 2022
AbstractforHBV Infection Status Does Not Influence the Initial Metastatic Pattern and the Prognosis of Breast Cancer Patients with de novo and Relapsed Metastatic Disease | Full Text | References | PDF (4.9 MB) | EPUB
  • 160 Views
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Article
Association Between Depression or Anxiety and the Risk of Hepatitis B Flares: A Nationwide Population-Based Cohort Study
Meng-Ko Tsai, Huey-Kang Sytwu, Tsai-Yuan Hsieh, Wu-Chien Chien, Chao-Hung Lai & Hsiang-Cheng Chen
Pages: 2983-2993
Published online: 17 Sep 2022
AbstractforAssociation Between Depression or Anxiety and the Risk of Hepatitis B Flares: A Nationwide Population-Based Cohort Study | Full Text | References | PDF (3.3 MB) | EPUB
  • 181 Views
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Article
Helicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China
He Liu, Yan Qin, Jie Yang, Guoxiu Huang, Xiaoying Wei, Lulu Wang & Wei Li
Pages: 2009-2017
Published online: 17 Sep 2022
AbstractforHelicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China | Full Text | References | PDF (1.4 MB) | EPUB
  • 183 Views
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Article
MSC Transplantation Attenuates Inflammation, Prevents Endothelial Damage and Enhances the Angiogenic Potency of Endogenous MSCs in a Model of Pulmonary Arterial Hypertension
Fengjin Shao, Rui Liu, Xun Tan, Qiaoyan Zhang, Lujie Ye, Bingxuan Yan, Ying Zhuang & Jiaxue Xu
Pages: 2087-2101
Published online: 17 Sep 2022
AbstractforMSC Transplantation Attenuates Inflammation, Prevents Endothelial Damage and Enhances the Angiogenic Potency of Endogenous MSCs in a Model of Pulmonary Arterial Hypertension | Full Text | References | PDF (4.4 MB) | EPUB
  • 210 Views
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REVIEW

Review
The Anti-Inflammatory Effects of Cannabidiol (CBD) on Acne
Nadia Peyravian, Sapna Deo, Sylvia Daunert & Joaquin J Jimenez
Pages: 2795-2801
Published online: 03 May 2022
AbstractforThe Anti-Inflammatory Effects of Cannabidiol (CBD) on Acne | Full Text | References | PDF (1.4 MB) | EPUB
  • 1847 Views
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Review
Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review
Ameena Mohammed, Arunasree M Kalle & Pallu Reddanna
Pages: 4349-4358
Published online: 26 Sep 2023
AbstractforManaging SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review | Full Text | References | PDF (3.2 MB) | EPUB
  • 119 Views
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ORIGINAL RESEARCH

Article
Inflammatory Cytokine-Neutralizing Antibody Treatment Prevented Increases in Follicular Helper T Cells and Follicular Regulatory T Cells in a Mouse Model of Arthritis
Xingyue Zeng, Songsong Lu, Meng Li, Mohan Zheng, Tianci Liu, Rui Kang, Lijuan Xu, Qinzhu Xu, Ying Song & Chen Liu
Pages: 3997-4011
Published online: 17 Sep 2022
AbstractforInflammatory Cytokine-Neutralizing Antibody Treatment Prevented Increases in Follicular Helper T Cells and Follicular Regulatory T Cells in a Mouse Model of Arthritis | Full Text | References | PDF (10.3 MB) | EPUB
  • 168 Views
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Article
CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis
Da-Wei Zhang, Jing-Jing Ye, Ying Sun, Shuang Ji, Jia-Ying Kang, Yuan-Yuan Wei & Guang-He Fei
Pages: 2491-2507
Published online: 17 Sep 2022
AbstractforCD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis | Full Text | References | PDF (9.5 MB) | EPUB
  • 135 Views
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Article
Differential Diagnosis of Nonabsorbable Inflammatory and Malignant Subsolid Nodules with a Solid Component ≤5 mm
Xiao-Qun He, Xian Li, Yan Wu, Shun Wu, Tian-You Luo, Fa-Jin Lv & Qi Li
Pages: 1785-1796
Published online: 11 Mar 2022
AbstractforDifferential Diagnosis of Nonabsorbable Inflammatory and Malignant Subsolid Nodules with a Solid Component ≤5 mm | Full Text | References | PDF (1.2 MB) | EPUB
  • 103 Views
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Article
Oxidation, Glycation, and Carbamylation of Salivary Biomolecules in Healthy Children, Adults, and the Elderly: Can Saliva Be Used in the Assessment of Aging?
Mateusz Maciejczyk, Miłosz Nesterowicz, Julita Szulimowska & Anna Zalewska
Pages: 2051-2073
Published online: 17 Sep 2022
AbstractforOxidation, Glycation, and Carbamylation of Salivary Biomolecules in Healthy Children, Adults, and the Elderly: Can Saliva Be Used in the Assessment of Aging? | Full Text | References | PDF (7 MB) | EPUB
  • 362 Views
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Article
P2X7 Receptor and Heart Function in a Mouse Model of Systemic Inflammation Due to High Fat Diet
Francesco Raggi, Chiara Rossi, Francesco Faita, Mariarosaria Distaso, Claudia Kusmic & Anna Solini
Pages: 2425-2439
Published online: 17 Sep 2022
AbstractforP2X7 Receptor and Heart Function in a Mouse Model of Systemic Inflammation Due to High Fat Diet | Full Text | References | PDF (10 MB) | EPUB
  • 147 Views
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REVIEW

Review
Application of Baricitinib in Dermatology
Jingya Zhang, Fei Qi, Jie Dong, Yaqi Tan, Ling Gao & Fang Liu
Pages: 1935-1941
Published online: 18 Mar 2022
AbstractforApplication of Baricitinib in Dermatology | Full Text | References | PDF (1.7 MB) | EPUB
  • 563 Views
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ORIGINAL RESEARCH

Article
The Role of Bone Morphogenetic Protein 4 in Microglial Polarization in the Process of Neuropathic Pain
Changqing Liu, Qi Sun, Junmei Xu, Weiyun Shen, Hui Li & Lin Yang
Pages: 2803-2817
Published online: 03 May 2022
AbstractforThe Role of Bone Morphogenetic Protein 4 in Microglial Polarization in the Process of Neuropathic Pain | Full Text | References | PDF (8.8 MB) | EPUB
  • 170 Views
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Article
Multi-Transcriptomic Analysis and Experimental Validation Implicate a Central Role of STAT3 in Skin Barrier Dysfunction Induced Aggravation of Rosacea
Yaling Wang, Ben Wang, Yingxue Huang, Yangfan Li, Sha Yan, Hongfu Xie, Yiya Zhang & Ji Li
Pages: 2141-2156
Published online: 17 Sep 2022
AbstractforMulti-Transcriptomic Analysis and Experimental Validation Implicate a Central Role of STAT3 in Skin Barrier Dysfunction Induced Aggravation of Rosacea | Full Text | References | PDF (14.4 MB) | EPUB
  • 206 Views
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Article
Elevated TNF-α Induces Thrombophagocytosis by Mononuclear Cells in ex vivo Whole-Blood Co-Culture with Dengue Virus
Rahmat Dani Satria, Ming-Kai Jhan, Chia-Ling Chen, Po-Chun Tseng, Yung-Ting Wang & Chiou-Feng Lin
Pages: 1717-1728
Published online: 17 Sep 2022
AbstractforElevated TNF-α Induces Thrombophagocytosis by Mononuclear Cells in ex vivo Whole-Blood Co-Culture with Dengue Virus | Full Text | References | PDF (8.2 MB) | EPUB
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Article
m6A Regulator-Mediated Methylation Modification Patterns and Characterisation of Tumour Microenvironment Infiltration in Non-Small Cell Lung Cancer
Yongfei Fan, Yong Zhou, Ming Lou, Xinwei Li, Xudong Zhu & Kai Yuan
Pages: 1969-1989
Published online: 23 Mar 2022
Abstractform6A Regulator-Mediated Methylation Modification Patterns and Characterisation of Tumour Microenvironment Infiltration in Non-Small Cell Lung Cancer | Full Text | References | PDF (16.1 MB) | EPUB
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Article
Analysis of the Value of the Blood Urea Nitrogen to Albumin Ratio as a Predictor of Mortality in Patients with Sepsis
Tianyong Han, Tao Cheng, Ye Liao, Shiyuan Tang, Bofu Liu, Yarong He, Zhihan Gu, Chenxi Lei, Yuling Cao & Yu Cao
Pages: 1227-1235
Published online: 23 Feb 2022
AbstractforAnalysis of the Value of the Blood Urea Nitrogen to Albumin Ratio as a Predictor of Mortality in Patients with Sepsis | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Nociceptor Neurons are Involved in the Host Response to Escherichia coli Urinary Tract Infections
Zhengdong Gao, Yaxiao Liu, Lekai Zhang, Zizhuo Yang, Linchen Lv, Shuai Wang, Lipeng Chen, Nan Zhou, Yaofeng Zhu, Xuewen Jiang, Benkang Shi & Yan Li
Pages: 3337-3353
Published online: 17 Sep 2022
AbstractforNociceptor Neurons are Involved in the Host Response to Escherichia coli Urinary Tract Infections | Full Text | References | PDF (9 MB) | EPUB
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Article
Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization
Kehong Zhang, Paul Mike Jordan, Simona Pace, Robert K Hofstetter, Markus Werner, Xinchun Chen & Oliver Werz
Pages: 3285-3304
Published online: 17 Sep 2022
AbstractforModulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization | Full Text | References | PDF (7.4 MB) | EPUB
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Article
Dexmedetomidine Activates Akt, STAT6 and IRF4 Modulating Cytoprotection and Macrophage Anti-Inflammatory Phenotype Against Acute Lung Injury in vivo and in vitro
Qian Chen, Zhigang Qin, Yibing Sun, Xiangfeng Liu, Aurelie Pac Soo, Enqiang Chang, Qizhe Sun, Bin Yi, Dong-Xin Wang, Hailin Zhao, Daqing Ma & Jianteng Gu
Pages: 2707-2720
Published online: 26 Apr 2022
AbstractforDexmedetomidine Activates Akt, STAT6 and IRF4 Modulating Cytoprotection and Macrophage Anti-Inflammatory Phenotype Against Acute Lung Injury in vivo and in vitro | Full Text | References | PDF (11.2 MB) | EPUB
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Article
Synthesis, In Silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment
Shagufta Naz, Lina Tariq Al Kury, Humaira Nadeem, Fawad Ali Shah, Aman Ullah, Rehan Zafar Paracha, Muhammad Imran & Shupeng Li
Pages: 3643-3660
Published online: 25 Jun 2022
AbstractforSynthesis, In Silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment | Full Text | References | PDF (8.4 MB) | EPUB
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Article
Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer
Nan Wang, Yuanting Gu, Lin Li, Jiangrui Chi, Xinwei Liu, Youyi Xiong & Chaochao Zhong
Pages: 3477-3499
Published online: 17 Sep 2022
AbstractforDevelopment and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer | Full Text | References | PDF (13.3 MB) | EPUB
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Article
Combination of Uric Acid and Pro-Inflammatory Cytokines in Discriminating Patients with Gout from Healthy Controls
Xuwen Zha, Bo Yang, Guangyun Xia & Shan Wang
Pages: 1413-1420
Published online: 28 Feb 2022
AbstractforCombination of Uric Acid and Pro-Inflammatory Cytokines in Discriminating Patients with Gout from Healthy Controls | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Antioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects
Miaomiao Li, Yue Yuan, Xue Han, Xinjuan Liu, Weizhen Zhang & Jianyu Hao
Pages: 4409-4420
Published online: 26 Sep 2023
AbstractforAntioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects | Full Text | References | PDF (2 MB) | EPUB
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Article
MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis
Yunzhi Liu, Na Zhao, Qishan Xu, Fan Deng, Ping Wang, Lijun Dong, Xiao Lu, Lihua Xia, Mingyong Wang, Zhengliang Chen, Jia Zhou & Daming Zuo
Pages: 4315-4329
Published online: 26 Sep 2023
AbstractforMBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis | Full Text | References | PDF (6.9 MB) | EPUB
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Rapid Communication
The Neutrophil/Lymphocyte Ratio is an Independent Predictor of All-Cause Mortality in Patients with Idiopathic Hypereosinophilic Syndrome
Junshuai Xue, Jianjun Jiang & Yang Liu
Pages: 1899-1906
Published online: 15 Mar 2022
AbstractforThe Neutrophil/Lymphocyte Ratio is an Independent Predictor of All-Cause Mortality in Patients with Idiopathic Hypereosinophilic Syndrome | Full Text | References | PDF (2.5 MB) | EPUB
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ORIGINAL RESEARCH

Article
Systematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma
Wenqing Gao, Yuanyuan Li, Teng Zhang, Jianglong Lu, Jiasong Pan, Qi Qi, Siqi Dong, Xiangjun Chen, Zhipeng Su & Jixi Li
Pages: 2731-2743
Published online: 28 Apr 2022
AbstractforSystematic Analysis of Chemokines Reveals CCL18 is a Prognostic Biomarker in Glioblastoma | Full Text | References | PDF (6.8 MB) | EPUB
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Article
Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs
Mohammad Abul Kashem, Lin Li, Xin-Yong Yuan, Francis A Plummer & Ma Luo
Pages: 2925-2937
Published online: 12 May 2022
AbstractforToll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates
Tiewei Li, Xiaojuan Li, Xinrui Liu, Zhiwei Zhu, Min Zhang, Zhe Xu, Yulei Wei, Yichuang Feng, Xiaoliang Qiao, Junmei Yang & Geng Dong
Pages: 2313-2321
Published online: 12 Apr 2022
AbstractforAssociation of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates | Full Text | References | PDF (682 KB) | EPUB
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Article
Therapeutic Effects of Retinoic Acid in Lipopolysaccharide-Induced Cardiac Dysfunction: Network Pharmacology and Experimental Validation
Xi Wang, Chang Kong, Pan Liu, Baofeng Zhou, Wujun Geng & Hongli Tang
Pages: 4963-4979
Published online: 26 Sep 2023
AbstractforTherapeutic Effects of Retinoic Acid in Lipopolysaccharide-Induced Cardiac Dysfunction: Network Pharmacology and Experimental Validation | Full Text | References | PDF (11.9 MB) | EPUB
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Article
Identification of a circRNA/miRNA/mRNA ceRNA Network as a Cell Cycle-Related Regulator for Chronic Sinusitis with Nasal Polyps
Qi Sun, Zhen Liu, Xiangya Xu, Yujuan Yang, Xiao Han, Cai Wang, Fei Song, Yakui Mou, Yumei Li & Xicheng Song
Pages: 2601-2615
Published online: 23 Apr 2022
AbstractforIdentification of a circRNA/miRNA/mRNA ceRNA Network as a Cell Cycle-Related Regulator for Chronic Sinusitis with Nasal Polyps | Full Text | References | PDF (9.1 MB) | EPUB
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REVIEW

Review
Role of Ferroptosis in Fibrotic Diseases
Jian Zhou, Yuan Tan, Rurong Wang & Xuehan Li
Pages: 3689-3708
Published online: 27 Jun 2022
AbstractforRole of Ferroptosis in Fibrotic Diseases | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Doxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation
Chao Tian, Yanyan Yang, Bing Li, Meixin Liu, Xiangqin He, Liang Zhao, Xiaoxia Song, Tao Yu & Xian-Ming Chu
Pages: 4467-4486
Published online: 06 Aug 2022
AbstractforDoxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation | Full Text | References | PDF (14.1 MB) | EPUB
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Review
Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis
Kaixuan Ren & Yumin Xia
Pages: 2157-2166
Published online: 17 Sep 2022
AbstractforLipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis | Full Text | References | PDF (888.4 KB) | EPUB
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Article
Sustained Inflammation Induced by LPS Leads to Tolerable Anorexia and Fat Loss via Tlr4 in Mice
Yale Yang, Wuling Zhong, Yali Zhang, Yalan Cheng, Hejin Lai, Huimin Yu, Ning Feng, Yumo Han, Rui Huang & Qiwei Zhai
Pages: 5635-5648
Published online: 26 Sep 2023
AbstractforSustained Inflammation Induced by LPS Leads to Tolerable Anorexia and Fat Loss via Tlr4 in Mice | Full Text | References | PDF (10.8 MB) | EPUB
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Article
α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation
Mateusz Maciejczyk, Ewa Żebrowska, Miłosz Nesterowicz, Elżbieta Supruniuk, Barbara Choromańska, Adrian Chabowski, Małgorzata Żendzian-Piotrowska & Anna Zalewska
Pages: 2295-2312
Published online: 08 Apr 2022
Abstractforα-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation | Full Text | References | PDF (7.2 MB) | EPUB
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Article
Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model
Wenchao Gu, Liangkun Zhang, Tao Han, Hailiang Huang & Jian Chen
Pages: 2631-2647
Published online: 24 Apr 2022
AbstractforDynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats
Indah Suasani Wahyuni, Irna Sufiawati, Wipawee Nittayananta & Jutti Levita
Pages: 2281-2294
Published online: 08 Apr 2022
AbstractforAnti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats | Full Text | References | PDF (4.4 MB) | EPUB
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Article
The Deletion of IL-17A Enhances Helicobacter hepaticus Colonization and Triggers Colitis
Liqi Zhu, Zhihao Wu, Chen Zhu, Jun Yin, Yuzheng Huang, Jie Feng & Quan Zhang
Pages: 2761-2773
Published online: 29 Apr 2022
AbstractforThe Deletion of IL-17A Enhances Helicobacter hepaticus Colonization and Triggers Colitis | Full Text | References | PDF (10.9 MB) | EPUB
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Article
Combining Pre- and Postoperative Lymphocyte–C-Reactive Protein Ratios Can Better Predict Hepatocellular Carcinoma Prognosis After Partial Hepatectomy
Hanghang Ni, Zhan Lu, Xi Huang, Shangwu Ning, Xiaoling Liang, Shuyi Zhang & Bangde Xiang
Pages: 2229-2241
Published online: 17 Sep 2022
AbstractforCombining Pre- and Postoperative Lymphocyte–C-Reactive Protein Ratios Can Better Predict Hepatocellular Carcinoma Prognosis After Partial Hepatectomy | Full Text | References | PDF (7.1 MB) | EPUB
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Review
The Application of Extracellular Vesicles Mediated miRNAs in Osteoarthritis: Current Knowledge and Perspective
Xiaobin Shang, Yan Fang, Wenqiang Xin & Hongbo You
Pages: 2583-2599
Published online: 17 Sep 2022
AbstractforThe Application of Extracellular Vesicles Mediated miRNAs in Osteoarthritis: Current Knowledge and Perspective | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Identification of Immune-Related Key Genes as Potential Diagnostic Biomarkers of Sepsis in Children
Huabin Wang, Junbin Huang, Wenfang Yi, Jiahong Li, Nannan He, Liangliang Kang, Zhijie He & Chun Chen
Pages: 2441-2459
Published online: 17 Sep 2022
AbstractforIdentification of Immune-Related Key Genes as Potential Diagnostic Biomarkers of Sepsis in Children | Full Text | References | PDF (13.8 MB) | EPUB
  • 202 Views
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Article
Circular RNA Fbxl5 Regulates Cardiomyocyte Apoptosis During Ischemia Reperfusion Injury via Sponging microRNA-146a
Dongjiu Li, Jiayin You, Chengyu Mao, En Zhou, Zhihua Han, Junfeng Zhang, Tiantian Zhang & Changqian Wang
Pages: 2539-2550
Published online: 17 Sep 2022
AbstractforCircular RNA Fbxl5 Regulates Cardiomyocyte Apoptosis During Ischemia Reperfusion Injury via Sponging microRNA-146a | Full Text | References | PDF (5.4 MB) | EPUB
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Fatal COVID-19 is Associated with Reduced HLA-DR, CD123 or CD11c Expression on Circulating Dendritic Cells
Amal Hasan, Ebaa Al-Ozairi, Nosiba YM Hassan, Shamsha Ali, Rasheed Ahmad, Nada Al-Shatti, Salem Alshemmari & Fahd Al-Mulla
Pages: 5665-5675
Published online: 10 Oct 2022
AbstractforFatal COVID-19 is Associated with Reduced HLA-DR, CD123 or CD11c Expression on Circulating Dendritic Cells | Full Text | References | PDF (2.1 MB) | EPUB
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LETTER

Sepsis Heterogeneity and Progression: Appraisal of Scoring System [Letter]
Honglian Huang, Renjie Wei & Haihang Qin
Pages: 1347-1348
Published online: 25 Feb 2022
CitationforSepsis Heterogeneity and Progression: Appraisal of Scoring System [Letter] | Full Text | References | PDF (179.4 KB) | EPUB
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Review
Current Perspectives in ABO-Incompatible Kidney Transplant
Federica Maritati, Claudia Bini, Vania Cuna, Francesco Tondolo, Sarah Lerario, Valeria Grandinetti, Marco Busutti, Valeria Corradetti, Gaetano La Manna & Giorgia Comai
Pages: 3095-3103
Published online: 28 Dec 2022
AbstractforCurrent Perspectives in ABO-Incompatible Kidney Transplant | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Characterization of Immune-Related Genes and Immune Infiltration Features in Epilepsy by Multi-Transcriptome Data
Yunqi Hou, Zhen Chen, Liping Wang, Yingxin Deng, Genglong Liu, Yongfen Zhou, Haiqin Shi, Xiangqun Shi & Qianhua Jiang
Pages: 2855-2876
Published online: 05 May 2022
AbstractforCharacterization of Immune-Related Genes and Immune Infiltration Features in Epilepsy by Multi-Transcriptome Data | Full Text | References | PDF (16.7 MB) | EPUB
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Article
Risk Factors and Predictive Models for Intravenous Immunoglobulin Resistance in Children with Recurrent Kawasaki Disease
Xi Chen, Lu Gao, Zhen Zhen, Ying Wang, Jia Na, Wen Yu, Xinyuan Chu, Yue Yuan & Suyun Qian
Pages: 2877-2889
Published online: 17 Sep 2022
AbstractforRisk Factors and Predictive Models for Intravenous Immunoglobulin Resistance in Children with Recurrent Kawasaki Disease | Full Text | References | PDF (5.6 MB) | EPUB
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Article
Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke
Zhijun Pu, Xinyu Bao, Shengnan Xia, Pengfei Shao & Yun Xu
Pages: 2649-2663
Published online: 24 Apr 2022
AbstractforSerpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke | Full Text | References | PDF (11.2 MB) | EPUB
  • 211 Views
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Article
Proteomic and Morphological Profiling of Mice Ocular Tissue During High-altitude Acclimatization Process: An Animal Study at Lhasa
Jun Hou, Dezhi Zheng, Xudong Wen, Wenjing Xiao, Fei Han, Hongmei Lang, Shiqiang Xiong, Wei Jiang, Yonghe Hu, Mengshan He & Pan Long
Pages: 2835-2853
Published online: 04 May 2022
AbstractforProteomic and Morphological Profiling of Mice Ocular Tissue During High-altitude Acclimatization Process: An Animal Study at Lhasa | Full Text | References | PDF (13.8 MB) | EPUB
  • 196 Views
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Review
A Comparative Review of Pyroptosis in Mammals and Fish
Zixi Song, Jiahong Zou, Mengya Wang, Zhenwei Chen & Qingchao Wang
Pages: 2323-2331
Published online: 11 Apr 2022
AbstractforA Comparative Review of Pyroptosis in Mammals and Fish | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Prognostic Roles of Inflammation- and Nutrition-Based Indicators for Female Patients with Cancer
Ming Yang, Qi Zhang, Yizhong Ge, Meng Tang, Chunlei Hu, Ziwen Wang, Xi Zhang, Mengmeng Song, Guotian Ruan, Xiaowei Zhang, Tong Liu, Hailun Xie, Heyang Zhang, Kangping Zhang, Qinqin Li, Xiangrui Li, Xiaoyue Liu, Shiqi Lin & Hanping Shi
Pages: 3573-3586
Published online: 17 Jun 2022
AbstractforPrognostic Roles of Inflammation- and Nutrition-Based Indicators for Female Patients with Cancer | Full Text | References | PDF (1.2 MB) | EPUB
  • 214 Views
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Article
An Analysis Regarding the Association Between Connexins and Colorectal Cancer (CRC) Tumor Microenvironment
Yuan-jie Liu, Mei Han, Jie-pin Li, Shu-hong Zeng, Qian-wen Ye, Zhong-hua Yin, Shen-lin Liu & Xi Zou
Pages: 2461-2476
Published online: 17 Sep 2022
AbstractforAn Analysis Regarding the Association Between Connexins and Colorectal Cancer (CRC) Tumor Microenvironment | Full Text | References | PDF (15.6 MB) | EPUB
  • 211 Views
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Article
Electroacupuncture at ST36 (Zusanli) Prevents T-Cell Lymphopenia and Improves Survival in Septic Mice
Zhi-Ying Lv, Yang-Lin Shi, Gabriel Shimizu Bassi, Yan-Jiao Chen, Lei-Miao Yin, Yu Wang, Luis Ulloa, Yong-Qing Yang & Yu-Dong Xu
Pages: 2819-2833
Published online: 17 Sep 2022
AbstractforElectroacupuncture at ST36 (Zusanli) Prevents T-Cell Lymphopenia and Improves Survival in Septic Mice | Full Text | References | PDF (2.8 MB) | EPUB
  • 237 Views
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Article
Long Noncoding RNA MIAT Regulates Hyperosmotic Stress-Induced Corneal Epithelial Cell Injury via Inhibiting the Caspase-1-Dependent Pyroptosis and Apoptosis in Dry Eye Disease
Jinjian Li, Kun Yang, Xinghui Pan, Hui Peng, Chenting Hou, Jie Xiao & Qing Wang
Pages: 3269-3283
Published online: 02 Jun 2022
AbstractforLong Noncoding RNA MIAT Regulates Hyperosmotic Stress-Induced Corneal Epithelial Cell Injury via Inhibiting the Caspase-1-Dependent Pyroptosis and Apoptosis in Dry Eye Disease | Full Text | References | PDF (10.8 MB) | EPUB
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Article
Association Between Increased Lipid Profiles and Risk of Diabetic Retinopathy in a Population-Based Case-Control Study
Zhenzhen Liu, Mingxi Shao, Jun Ren, Yichao Qiu, Shengjie Li & Wenjun Cao
Pages: 3433-3446
Published online: 10 Jun 2022
AbstractforAssociation Between Increased Lipid Profiles and Risk of Diabetic Retinopathy in a Population-Based Case-Control Study | Full Text | References | PDF (3.2 MB) | EPUB
  • 204 Views
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Article
Transcriptomic Profiling Reveals Underlying Immunoregulation Mechanisms of Resistant Hypertension in Injection Drug Users
Jie Jia, Ji-Qun Yang, Ying-Rong Du, Yu Xu, Deshenyue Kong, Xiu-Ling Zhang, Jun-Hong Mao, Gui-Fang Hu, Kun-Hua Wang & Yi-Qun Kuang
Pages: 3409-3420
Published online: 17 Sep 2022
AbstractforTranscriptomic Profiling Reveals Underlying Immunoregulation Mechanisms of Resistant Hypertension in Injection Drug Users | Full Text | References | PDF (7.9 MB) | EPUB
  • 142 Views
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Article
A Potential Role of B7-H4 Expression in Predicting the Recurrence of Chronic Rhinosinusitis with Nasal Polyps
Fengjun Wang, Wei Chu, Zhenghao Deng, Qiancheng Jing & Bin Xie
Pages: 3421-3431
Published online: 09 Jun 2022
AbstractforA Potential Role of B7-H4 Expression in Predicting the Recurrence of Chronic Rhinosinusitis with Nasal Polyps | Full Text | References | PDF (4.7 MB) | EPUB
  • 110 Views
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Article
Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice
Hyeji Jung, Hyojeong Lee, Dongwook Kim, Eunji Cheong, Young-Min Hyun, Je-Wook Yu & Ji Won Um
Pages: 3053-3063
Published online: 17 Sep 2022
AbstractforDifferential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice | Full Text | References | PDF (5 MB) | EPUB
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Article
Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells 
Justyna Śmiałek, Monika Bzowska, Alicja Hinz, Renata Mężyk-Kopeć, Kamilla Sołtys & Paweł Mak
Pages: 4601-4621
Published online: 26 Sep 2023
AbstractforBacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells  | Full Text | References | PDF (7.1 MB) | EPUB
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A Nomogram Model for Predicting Recurrence of Stage I–III Endometrial Cancer Based on Inflammation-Immunity-Nutrition Score (IINS) and Traditional Classical Predictors
Peng Jiang, Jinyu Wang, Chunxia Gong, Qianlin Yi, Mengqiu Zhu & Zhuoying Hu
Pages: 3021-3037
Published online: 22 May 2022
AbstractforA Nomogram Model for Predicting Recurrence of Stage I–III Endometrial Cancer Based on Inflammation-Immunity-Nutrition Score (IINS) and Traditional Classical Predictors | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Inhibition of miRNA-1-Mediated Inflammation and Autophagy by Astragaloside IV Improves Lipopolysaccharide-Induced Cardiac Dysfunction in Rats
Qiuning Wang, Weiying Chen, Xuefeng Yang, Ying Song, Xiaowei Sun, Guizhou Tao, Hong Wang, Nan Zhao, Yue Huang, Erqing Chai & Futian Tang
Pages: 2617-2629
Published online: 17 Sep 2022
AbstractforInhibition of miRNA-1-Mediated Inflammation and Autophagy by Astragaloside IV Improves Lipopolysaccharide-Induced Cardiac Dysfunction in Rats | Full Text | References | PDF (6.2 MB) | EPUB
  • 170 Views
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Article
Astragaloside A Protects Against Photoreceptor Degeneration in Part Through Suppressing Oxidative Stress and DNA Damage-Induced Necroptosis and Inflammation in the Retina
Mei Li, Jing Xu, Yujue Wang, Xiaoye Du, Teng Zhang & Yu Chen
Pages: 2995-3020
Published online: 20 May 2022
AbstractforAstragaloside A Protects Against Photoreceptor Degeneration in Part Through Suppressing Oxidative Stress and DNA Damage-Induced Necroptosis and Inflammation in the Retina | Full Text | References | PDF (26.6 MB) | EPUB
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Article
Coactosin-Like Protein in Breast Carcinoma: Friend or Foe?
Bei Wang, Limiao Zhao & Dandan Chen
Pages: 4013-4025
Published online: 17 Sep 2022
AbstractforCoactosin-Like Protein in Breast Carcinoma: Friend or Foe? | Full Text | References | PDF (7.4 MB) | EPUB
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Article
USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma
Qian Zhang, Yuan-Jie Liu, Jie-Pin Li, Shu-Hong Zeng, Hui Shen, Mei Han, Shun Guo, Shen-Lin Liu & Xi Zou
Pages: 3065-3082
Published online: 24 May 2022
AbstractforUSP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma | Full Text | References | PDF (16.4 MB) | EPUB
  • 126 Views
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Article
Clinical Values and Underlying Mechanism Analysis of Serum miR-455-5p in Carotid Artery Stenosis
Bin Zhu, Wei Liu, Qiang Xu & Hong-liang Liu
Pages: 3207-3217
Published online: 17 Sep 2022
AbstractforClinical Values and Underlying Mechanism Analysis of Serum miR-455-5p in Carotid Artery Stenosis | Full Text | References | PDF (3 MB) | EPUB
  • 114 Views
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REVIEW

Review
The Emerging Role of the Interaction of Extracellular Vesicle and Autophagy—Novel Insights into Neurological Disorders
Wei Wei, Yongli Pan, Xinyu Yang, Zhonglun Chen, Yue Heng, Bufan Yang, Mingjun Pu, Jiacai Zuo, Zhuhong Lai, Yufeng Tang & Wenqiang Xin
Pages: 3395-3407
Published online: 17 Sep 2022
AbstractforThe Emerging Role of the Interaction of Extracellular Vesicle and Autophagy—Novel Insights into Neurological Disorders | Full Text | References | PDF (2 MB) | EPUB
  • 297 Views
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ORIGINAL RESEARCH

Article
Comparison of the Concentration of Encephalitozoon cuniculi Genotypes I and III in Inflammatory Foci Under Experimental Conditions
Bohumil Sak, Nikola Holubová, Dana Květoňová, Lenka Hlásková, Jana Tinavská, Marta Kicia, Żaneta Zajączkowska & Martin Kváč
Pages: 2721-2730
Published online: 26 Apr 2022
AbstractforComparison of the Concentration of Encephalitozoon cuniculi Genotypes I and III in Inflammatory Foci Under Experimental Conditions | Full Text | References | PDF (4 MB) | EPUB
  • 121 Views
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Article
Comparative Transcriptome Analysis of Gingival Immune-Mediated Inflammation in Peri-Implantitis and Periodontitis Within the Same Host Environment
Shasha Yuan, Cui Wang, Wenting Jiang, Yiping Wei, Qingqing Li, Zhanming Song, Siqi Li, Fei Sun, Zhongtian Liu, Ying Wang & Wenjie Hu
Pages: 3119-3133
Published online: 25 May 2022
AbstractforComparative Transcriptome Analysis of Gingival Immune-Mediated Inflammation in Peri-Implantitis and Periodontitis Within the Same Host Environment | Full Text | References | PDF (7.4 MB) | EPUB
  • 300 Views
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REVIEW

Review
The Role of Vitamin D in Immune System and Inflammatory Bowel Disease
Zengrong Wu, Deliang Liu & Feihong Deng
Pages: 3167-3185
Published online: 28 May 2022
AbstractforThe Role of Vitamin D in Immune System and Inflammatory Bowel Disease | Full Text | References | PDF (2.4 MB) | EPUB
  • 732 Views
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ORIGINAL RESEARCH

Article
Induction of Trained Immunity Protects Neonatal Mice Against Microbial Sepsis by Boosting Both the Inflammatory Response and Antimicrobial Activity
Huiting Zhou, Xiaying Lu, Jie Huang, Patrick Jordan, Shurong Ma, Lingqi Xu, Fangjie Hu, Huan Gui, He Zhao, Zhenjiang Bai, H Paul Redmond, Jiang Huai Wang & Jian Wang
Pages: 3829-3845
Published online: 07 Jul 2022
AbstractforInduction of Trained Immunity Protects Neonatal Mice Against Microbial Sepsis by Boosting Both the Inflammatory Response and Antimicrobial Activity | Full Text | References | PDF (10.6 MB) | EPUB
  • 223 Views
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Article
Novel Signatures Based on the Lymphocyte-to-C-Reactive Protein Ratio Predict the Prognosis of Patients with Early Breast Cancer: A Retrospective Study
Li Wang, Yu-Ling Zhang, Chang Jiang, Fang-Fang Duan, Zhong-Yu Yuan, Jia-Jia Huang & Xi-Wen Bi
Pages: 3957-3974
Published online: 17 Sep 2022
AbstractforNovel Signatures Based on the Lymphocyte-to-C-Reactive Protein Ratio Predict the Prognosis of Patients with Early Breast Cancer: A Retrospective Study | Full Text | References | PDF (9.6 MB) | EPUB
  • 130 Views
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Article
PD-1-mAb Plus Regimen in the First and Second Lines of Advanced and Unresectable Biliary Tract Carcinoma: A Real-World, Multicenter Retrospective Analysis
Fang Wang, Feng-Hua Wang, Kaiyu Sun, Chang Jiang, Sui Peng, Li-Xia Xu, Ming Kuang, Gui-Fang Guo & Shu-Ling Chen
Pages: 6031-6046
Published online: 31 Oct 2022
AbstractforPD-1-mAb Plus Regimen in the First and Second Lines of Advanced and Unresectable Biliary Tract Carcinoma: A Real-World, Multicenter Retrospective Analysis | Full Text | References | PDF (4.9 MB) | EPUB
  • 81 Views
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Article
The Diagnostic Value of Various Inflammatory Biomarkers for Diagnosing Periprosthetic Joint Infection is Gender-Specific
Weipeng Shi, Yaping Jiang, Yingzhen Wang, Cailong Zhang, Tengbo Yu & Tao Li
Pages: 3975-3982
Published online: 14 Jul 2022
AbstractforThe Diagnostic Value of Various Inflammatory Biomarkers for Diagnosing Periprosthetic Joint Infection is Gender-Specific | Full Text | References | PDF (1.1 MB) | EPUB
  • 184 Views
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Article
The Construction of ITP Diagnostic Modeling Based on the Expressions of Hub Genes Associated with M1 Polarization of Macrophages
Ming-Jing Wang, Ying Song, Xiao-Qing Guo, Diu Wei, Xin-Tian Cao, Yan Sun, Yong-Gang Xu & Xiao-Mei Hu
Pages: 5905-5915
Published online: 20 Oct 2022
AbstractforThe Construction of ITP Diagnostic Modeling Based on the Expressions of Hub Genes Associated with M1 Polarization of Macrophages | Full Text | References | PDF (7.3 MB) | EPUB
  • 81 Views
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Article
TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang & Lei Cheng
Pages: 3613-3630
Published online: 17 Sep 2022
AbstractforTLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis | Full Text | References | PDF (1.7 MB) | EPUB
  • 230 Views
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Article
Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study
Wenguang Lai, Xiaoli Zhao, Zhidong Huang, Yun Xie, Sijia Yu, Jiabin Tu, Dachuan Guo, Jiaming Xiu, Ziling Mai, Qiang Li, Haozhang Huang, Huanqiang Li, Jun-Yan Xu, Hongyu Lu, Guanzhong Chen, Shiqun Chen, Jin Liu & Yong Liu
Pages: 2959-2969
Published online: 13 May 2022
AbstractforElevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study | Full Text | References | PDF (2.4 MB) | EPUB
  • 133 Views
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Article
Dual Effect of the Extract from the Fungus Coriolus versicolor on Lipopolysaccharide-Induced Cytokine Production in RAW 264.7 Macrophages Depending on the Lipopolysaccharide Concentration
Tomasz Jędrzejewski, Justyna Sobocińska, Małgorzata Pawlikowska, Artur Dzialuk & Sylwia Wrotek
Pages: 3599-3611
Published online: 20 Jun 2022
AbstractforDual Effect of the Extract from the Fungus Coriolus versicolor on Lipopolysaccharide-Induced Cytokine Production in RAW 264.7 Macrophages Depending on the Lipopolysaccharide Concentration | Full Text | References | PDF (6.2 MB) | EPUB
  • 338 Views
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Article
Gastroprotective Effect of Azilsartan Through Ameliorating Oxidative Stress, Inflammation, and Restoring Hydroxyproline, and Gastrin Levels in Ethanol-Induced Gastric Ulcer
Renas Raouf Hama Amin & Tavga Ahmed Aziz
Pages: 2911-2923
Published online: 11 May 2022
AbstractforGastroprotective Effect of Azilsartan Through Ameliorating Oxidative Stress, Inflammation, and Restoring Hydroxyproline, and Gastrin Levels in Ethanol-Induced Gastric Ulcer | Full Text | References | PDF (5.2 MB) | EPUB
  • 411 Views
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Article
The Anti-Sepsis Effect of Isocorydine Screened from Guizhou Ethnic Medicine is Closely Related to Upregulation of Vitamin D Receptor Expression and Inhibition of NFκB p65 Translocation into the Nucleus
Jing Luo, Nuoyan Wang, Ling Hua, Fei Deng, Dan Liu, Jun Zhou, Yue Yuan, Fumin Ouyang, Xuemin Chen, Shujuan Long, Yasi Huang, Zhanxing Hu & Hong Zhou
Pages: 5649-5664
Published online: 26 Sep 2023
AbstractforThe Anti-Sepsis Effect of Isocorydine Screened from Guizhou Ethnic Medicine is Closely Related to Upregulation of Vitamin D Receptor Expression and Inhibition of NFκB p65 Translocation into the Nucleus | Full Text | References | PDF (7.6 MB) | EPUB
  • 96 Views
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Article
Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway
Zhen-Xiao Teng, Xuan-Chen Zhou, Run-Tong Xu, Fang-Yuan Zhu, Xin Bing, Na Guo, Lei Shi, Wen-Wen Qi, Cheng-Cheng Liu & Ming Xia
Pages: 3187-3205
Published online: 17 Sep 2022
AbstractforTfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway | Full Text | References | PDF (15.4 MB) | EPUB
  • 246 Views
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Article
Elevated Rheumatoid Factor Associates with Dry Eye in Patients with Common Autoimmune Diseases
Shan Zhao, Yifan Xiao, Song Zhang, Lei Liu & Kang Chen
Pages: 2789-2794
Published online: 03 May 2022
AbstractforElevated Rheumatoid Factor Associates with Dry Eye in Patients with Common Autoimmune Diseases | Full Text | References | PDF (888.7 KB) | EPUB
  • 153 Views
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CASE SERIES

Case Report
Veno-Arterial Extracorporeal Membrane Oxygenation in the Treatment of Hemodynamically Unstable Lupus Myocarditis: A Retrospective Case Series Study
Yu-Jun Shi, Li-Feng Wang, Jun Ma, Yi Chen, Wei-Jun Wang & Cui-Ying Xie
Pages: 3761-3768
Published online: 20 Sep 2022
AbstractforVeno-Arterial Extracorporeal Membrane Oxygenation in the Treatment of Hemodynamically Unstable Lupus Myocarditis: A Retrospective Case Series Study | Full Text | References | PDF (209.2 KB) | EPUB
  • 175 Views
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ORIGINAL RESEARCH

Article
The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy
Zhengquan Dong, Zhou Ma, Meiju Yang, Linlin Cong, Ruipeng Zhao, Liyun Cheng, Jian Sun, Yunfei Wang, Ruijia Yang, Xiaochun Wei & Pengcui Li
Pages: 3547-3560
Published online: 17 Sep 2022
AbstractforThe Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy | Full Text | References | PDF (12.2 MB) | EPUB
  • 158 Views
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Article
An inflammatory Signature of Glucose Impairment in Cystic Fibrosis
Anna Lisa Montemari, Melania Manco, Alessandro Giovanni Fiocchi, Manuela Bartoli, Francesco Facchiano, Claudio Tabolacci, Maria Scatigna, Fabiana Ciciriello, Federico Alghisi, Enza Montemitro, Rita Carsetti, Vincenzina Lucidi & Ersilia Vita Fiscarelli
Pages: 5677-5685
Published online: 10 Oct 2022
AbstractforAn inflammatory Signature of Glucose Impairment in Cystic Fibrosis | Full Text | References | PDF (471.4 KB) | EPUB
  • 70 Views
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Article
Comparison of Absolute Expression and Turnover Number of COX-1 and COX-2 in Human and Rodent Cells and Tissues
Li Li, Rongjin Sun, Joseph Zenga, Heather Himburg, Lu Wang, Shengnan Duan, Jingwen Liu, Dinh Bui, Zuoxu Xie, Ting Du, Lijun Xie, Taijun Yin, Stu Wong, Song Gao & Ming Hu
Pages: 4435-4447
Published online: 26 Sep 2023
AbstractforComparison of Absolute Expression and Turnover Number of COX-1 and COX-2 in Human and Rodent Cells and Tissues | Full Text | References | PDF (2.8 MB) | EPUB
  • 138 Views
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Article
Inhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats
Renhui Huang, Qi Shi, Shutian Zhang, Hong Lin, Chengzhi Han, Xinyi Qian, Yijun Huang, Xiaorong Ren, Jiayuan Sun, Nana Feng, Chunmei Xia & Meng Shi
Pages: 5103-5119
Published online: 05 Sep 2022
AbstractforInhibition of the cGAS-STING Pathway Attenuates Lung Ischemia/Reperfusion Injury via Regulating Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells of Rats | Full Text | References | PDF (11.3 MB) | EPUB
  • 219 Views
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Article
Skeletal Myosteatosis is Associated with Systemic Inflammation and a Loss of Muscle Bioenergetics in Stable COPD
Hans Lennart Persson, Apostolos Sioutas, Magnus Kentson, Petra Jacobson, Peter Lundberg, Olof Dahlqvist Leinhard & Mikael Fredrik Forsgren
Pages: 4367-4384
Published online: 26 Sep 2023
AbstractforSkeletal Myosteatosis is Associated with Systemic Inflammation and a Loss of Muscle Bioenergetics in Stable COPD | Full Text | References | PDF (666.7 KB) | EPUB
  • 143 Views
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Article
Thrombo-Inflammatory Prognostic Scores Improve BISAP-Based Risk Stratification in Acute Pancreatitis Patients: A Retrospective Cohort Study
Tianyong Han, Tao Cheng, Ye Liao, Qiang Lai, Shiyuan Tang, Bofu Liu, Yarong He, Chenxi Lei, Yuling Cao & Yu Cao
Pages: 3323-3335
Published online: 17 Sep 2022
AbstractforThrombo-Inflammatory Prognostic Scores Improve BISAP-Based Risk Stratification in Acute Pancreatitis Patients: A Retrospective Cohort Study | Full Text | References | PDF (2.5 MB) | EPUB
  • 110 Views
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Article
Fibromodulin Ablation Exacerbates the Severity of Acute Colitis
Marianna Halasi, Mor Grinstein, Avner Adini & Irit Adini
Pages: 4515-4526
Published online: 08 Aug 2022
AbstractforFibromodulin Ablation Exacerbates the Severity of Acute Colitis | Full Text | References | PDF (8 MB) | EPUB
  • 67 Views
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Article
Nomogram Based on Inflammatory Biomarkers and Nutritional Indicators for Predicting Overall Survival in Locoregionally Advanced Nasopharyngeal Carcinoma
Rong Zhao, Zhongguo Liang, Kaihua Chen & Xiaodong Zhu
Pages: 2971-2981
Published online: 17 Sep 2022
AbstractforNomogram Based on Inflammatory Biomarkers and Nutritional Indicators for Predicting Overall Survival in Locoregionally Advanced Nasopharyngeal Carcinoma | Full Text | References | PDF (5.4 MB) | EPUB
  • 130 Views
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Article
Prenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants
Hao-Wei Chung, Hui-Min Hsieh, Chung-Hsiang Lee, Yi-Ching Lin, Yu-Hsiang Tsao, Huang-Wei Wu, Fu-Chen Kuo & Chih-Hsing Hung
Pages: 3771-3781
Published online: 17 Sep 2022
AbstractforPrenatal and Postnatal Exposure to Ambient Air Pollution and Preschool Asthma in Neonatal Jaundice Infants | Full Text | References | PDF (926.9 KB) | EPUB
  • 204 Views
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CORRIGENDUM

Correction
Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells [Corrigendum]
Pages: 1991-1992
Published online: 24 Mar 2022
CitationforGamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells [Corrigendum] | Full Text | PDF (1.1 MB) | EPUB
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REVIEW

Review
The Role of Podoplanin in the Immune System and Inflammation
Zhiyuan Zhang, Nan Zhang, Jing Yu, Wenting Xu, Jiameng Gao, Xin Lv & Zongmei Wen
Pages: 3561-3572
Published online: 17 Sep 2022
AbstractforThe Role of Podoplanin in the Immune System and Inflammation | Full Text | References | PDF (1.1 MB) | EPUB
  • 274 Views
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CORRIGENDUM

Correction
Low Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD [Corrigendum]
Pages: 1993-1994
Published online: 24 Mar 2022
CitationforLow Eosinophil Phenotype Predicts Noninvasive Mechanical Ventilation Use in Patients with Hospitalized Exacerbations of COPD [Corrigendum] | Full Text | PDF (130.5 KB) | EPUB
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ORIGINAL RESEARCH

Article
Expression and Clinical Significance of Th1/Th2/Th17 Cytokines and Lymphocyte Subsets in PCNSL
Haiyan Bian, Lisheng Wang, Chengwen Gao, Zhihe Liu, Yang Sun, Minghui Hu, Yujing Xiao, Fengyun Hao, Yushuo Ma & Xia Zhao
Pages: 3815-3828
Published online: 07 Jul 2022
AbstractforExpression and Clinical Significance of Th1/Th2/Th17 Cytokines and Lymphocyte Subsets in PCNSL | Full Text | References | PDF (430.3 KB) | EPUB
  • 146 Views
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Article
Carbon 60 Dissolved in Grapeseed Oil Inhibits Dextran Sodium Sulfate-Induced Experimental Colitis
Rayko Lazcano-Silveira, Xiaoxiao Jia, Kaixuan Liu, Honggang Liu, Xinrong Li & Mizhou Hui
Pages: 4185-4198
Published online: 25 Jul 2022
AbstractforCarbon 60 Dissolved in Grapeseed Oil Inhibits Dextran Sodium Sulfate-Induced Experimental Colitis | Full Text | References | PDF (6.9 MB) | EPUB
  • 90 Views
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Article
RuleFit-Based Nomogram Using Inflammatory Indicators for Predicting Survival in Nasopharyngeal Carcinoma, a Bi-Center Study
Chao Luo, Shuqi Li, Qin Zhao, Qiaowen Ou, Wenjie Huang, Guangying Ruan, Shaobo Liang, Lizhi Liu, Yu Zhang & Haojiang Li
Pages: 4803-4815
Published online: 26 Sep 2023
AbstractforRuleFit-Based Nomogram Using Inflammatory Indicators for Predicting Survival in Nasopharyngeal Carcinoma, a Bi-Center Study | Full Text | References | PDF (1.4 MB) | EPUB
  • 118 Views
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Article
Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia
Yu Cui, Nan-Nan Zhang, Dan Wang, Wei-Hong Meng & Hui-Sheng Chen
Pages: 3369-3385
Published online: 09 Jun 2022
AbstractforModified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia | Full Text | References | PDF (14.8 MB) | EPUB
  • 259 Views
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Article
Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats
Yaseen Awad-Igbaria, Shilo Dadon, Alon Shamir, Alejandro Livoff, Mark Shlapobersky, Jacob Bornstein & Eilam Palzur
Pages: 3901-3923
Published online: 11 Jul 2022
AbstractforCharacterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats | Full Text | References | PDF (7.5 MB) | EPUB
  • 282 Views
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Article
From Suspicion to Diagnosis: Analysis on the Clinical Characteristics of 37 Cases of IgG4-Related Disease (IgG4-RD) in Northeast China
Shanshan Zhang, Jun Zhang, Yifang Li & Jian Jiao
Pages: 4487-4497
Published online: 06 Aug 2022
AbstractforFrom Suspicion to Diagnosis: Analysis on the Clinical Characteristics of 37 Cases of IgG4-Related Disease (IgG4-RD) in Northeast China | Full Text | References | PDF (4 MB) | EPUB
  • 81 Views
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Article
Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin
Felix Nagel, Anne Susemihl, Norman Geist, Kevin Möhlis, Gottfried J Palm, Michael Lammers & Mihaela Delcea
Pages: 3633-3642
Published online: 24 Jun 2022
AbstractforStructural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin | Full Text | References | PDF (3 MB) | EPUB
  • 153 Views
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Article
Pathologic Complete Response Prediction to Neoadjuvant Immunotherapy Combined with Chemotherapy in Resectable Locally Advanced Esophageal Squamous Cell Carcinoma: Real-World Evidence from Integrative Inflammatory and Nutritional Scores
Jifeng Feng, Liang Wang, Xun Yang, Qixun Chen & Xiangdong Cheng
Pages: 3783-3796
Published online: 17 Sep 2022
AbstractforPathologic Complete Response Prediction to Neoadjuvant Immunotherapy Combined with Chemotherapy in Resectable Locally Advanced Esophageal Squamous Cell Carcinoma: Real-World Evidence from Integrative Inflammatory and Nutritional Scores | Full Text | References | PDF (8.5 MB) | EPUB
  • 191 Views
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REVIEW

Review
From Anti-HER-2 to Anti-HER-2-CAR-T Cells: An Evolutionary Immunotherapy Approach for Gastric Cancer
Jiangang Sun, Xiaojing Li, Peng Chen & Yongshun Gao
Pages: 4061-4085
Published online: 26 Sep 2023
AbstractforFrom Anti-HER-2 to Anti-HER-2-CAR-T Cells: An Evolutionary Immunotherapy Approach for Gastric Cancer | Full Text | References | PDF (4.5 MB) | EPUB
  • 152 Views
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ORIGINAL RESEARCH

Article
Co-Application of C16 and Ang-1 Improves the Effects of Levodopa in Parkinson Disease Treatment
Xiao-Xiao Fu, Jin Wang, Hua-Ying Cai, Hong Jiang, Jin-Zhan Jiang, Hao-Hao Chen & Shu Han
Pages: 3797-3814
Published online: 07 Jul 2022
AbstractforCo-Application of C16 and Ang-1 Improves the Effects of Levodopa in Parkinson Disease Treatment | Full Text | References | PDF (19.9 MB) | EPUB
  • 142 Views
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Article
IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation
Nadeem Akhter, Shihab Kochumon, Amal Hasan, Ajit Wilson, Rasheeba Nizam, Ashraf Al Madhoun, Fatema Al-Rashed, Hossein Arefanian, Fawaz Alzaid, Sardar Sindhu, Fahd Al-Mulla & Rasheed Ahmad
Pages: 4291-4302
Published online: 26 Sep 2023
AbstractforIFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Construction of circRNA-Mediated Immune-Related ceRNA Network and Identification of Circulating circRNAs as Diagnostic Biomarkers in Acute Ischemic Stroke
Xing-Zhi Wang, Shuo Li, Yun Liu, Gui-Yun Cui & Fu-Ling Yan
Pages: 4087-4104
Published online: 26 Sep 2023
AbstractforConstruction of circRNA-Mediated Immune-Related ceRNA Network and Identification of Circulating circRNAs as Diagnostic Biomarkers in Acute Ischemic Stroke | Full Text | References | PDF (8.1 MB) | EPUB
  • 102 Views
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REVIEW

Review
Pyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis
Xingyu Chang, Yuchen Kang, Yuxuan Yang, Yajie Chen, Yanyu Shen, Chenjun Jiang & Yi Shen
Pages: 3859-3871
Published online: 11 Jul 2022
AbstractforPyroptosis: A Novel Intervention Target in the Progression of Osteoarthritis | Full Text | References | PDF (2.6 MB) | EPUB
  • 297 Views
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ORIGINAL RESEARCH

Article
The Analysis of the Ubiquitylomic Responses to Streptococcus agalactiae Infection in Bovine Mammary Gland Epithelial Cells
Jinjin Tong, Xintong Ji, Hua Zhang, Benhai Xiong, Defeng Cui & Linshu Jiang
Pages: 4331-4343
Published online: 26 Sep 2023
AbstractforThe Analysis of the Ubiquitylomic Responses to Streptococcus agalactiae Infection in Bovine Mammary Gland Epithelial Cells | Full Text | References | PDF (5.9 MB) | EPUB
  • 81 Views
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Article
High Expression of DEPDC1B Predicts Poor Prognosis in Lung Adenocarcinoma
Pulin Li, Xiaojuan Chen, Sijing Zhou, Xingyuan Xia, Enze Wang, Rui Han, Daxiong Zeng, Guanghe Fei & Ran Wang
Pages: 4171-4184
Published online: 23 Jul 2022
AbstractforHigh Expression of DEPDC1B Predicts Poor Prognosis in Lung Adenocarcinoma | Full Text | References | PDF (9.3 MB) | EPUB
  • 70 Views
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REVIEW

Review
The Functional Mechanism of MicroRNA in Oral Lichen Planus
Yunshan Li, Yaodong He, Junwei Xiang, Linfei Feng, Yuanyin Wang & Ran Chen
Pages: 4261-4274
Published online: 26 Sep 2023
AbstractforThe Functional Mechanism of MicroRNA in Oral Lichen Planus | Full Text | References | PDF (1.2 MB) | EPUB
  • 168 Views
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ORIGINAL RESEARCH

Article
Development and Validation of a Nomogram for Predicting 28-Day Mortality on Admission in Elderly Patients with Severe Community-Acquired Pneumonia
Yansha Song, Xiaocen Wang, Ke Lang, Tingting Wei, Jinlong Luo, Yuanlin Song & Dong Yang
Pages: 4149-4158
Published online: 21 Jul 2022
AbstractforDevelopment and Validation of a Nomogram for Predicting 28-Day Mortality on Admission in Elderly Patients with Severe Community-Acquired Pneumonia | Full Text | References | PDF (4.7 MB) | EPUB
  • 75 Views
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Article
Single-Cell Analyses of Heterotopic Ossification: Characteristics of Injury-Related Senescent Fibroblasts
Qiang Zhang, Dong Zhou & Yu Liang
Pages: 5579-5593
Published online: 26 Sep 2023
AbstractforSingle-Cell Analyses of Heterotopic Ossification: Characteristics of Injury-Related Senescent Fibroblasts | Full Text | References | PDF (8.8 MB) | EPUB
  • 135 Views
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Article
Moderate Dose Irradiation Induces DNA Damage and Impairments of Barrier and Host Defense in Nasal Epithelial Cells in vitro
Yue-Ying Yang, Jing Liu, Yi-Tong Liu, Hsiao-Hui Ong, Qian-Min Chen, Ce-Belle Chen, Mark Thong, Xinni Xu, Sui-Zi Zhou, Qian-Hui Qiu & De-Yun Wang
Pages: 3661-3675
Published online: 25 Jun 2022
AbstractforModerate Dose Irradiation Induces DNA Damage and Impairments of Barrier and Host Defense in Nasal Epithelial Cells in vitro | Full Text | References | PDF (8.9 MB) | EPUB
  • 139 Views
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Article
Predictive Value of Ionized Calcium for Prognosis of Sepsis in Very Low Birth Weight Infants
Xuejie Zheng, Yuanzhi Li, Qiyuan Cheng & Lili Wang
Pages: 3749-3760
Published online: 24 Sep 2022
AbstractforPredictive Value of Ionized Calcium for Prognosis of Sepsis in Very Low Birth Weight Infants | Full Text | References | PDF (3.7 MB) | EPUB
  • 192 Views
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Article
SPP1/AnxA1/TIMP1 as Essential Genes Regulate the Inflammatory Response in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats
Qian-Qian Nie, Zong-Qing Zheng, Juan Liao, Yu-Chao Li, Yan-Ting Chen, Tian-Ye Wang, Gui-Qiang Yuan, Zhong Wang & Qun Xue
Pages: 4873-4890
Published online: 26 Sep 2023
AbstractforSPP1/AnxA1/TIMP1 as Essential Genes Regulate the Inflammatory Response in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats | Full Text | References | PDF (13.9 MB) | EPUB
  • 156 Views
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Article
Biomarker Changes and Molecular Signatures Associated with Takayasu Arteritis Following Treatment with Glucocorticoids and Tofacitinib
Xiaojuan Dai, Jinghua Wang, Xiao Zhang, Li Wang, Sifan Wu, Huiyong Chen, Ying Sun, Lili Ma, Lingying Ma, Xiufang Kong & Lindi Jiang
Pages: 4395-4407
Published online: 26 Sep 2023
AbstractforBiomarker Changes and Molecular Signatures Associated with Takayasu Arteritis Following Treatment with Glucocorticoids and Tofacitinib | Full Text | References | PDF (7.8 MB) | EPUB
  • 70 Views
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CASE REPORT

Case Report
A Rare Case of Acute Infectious Purpura Fulminans Caused by Klebsiella Pneumoniae and Human Herpesvirus Type 5
Xiao-Lan Li, Chun-Yan Luan, Ying-Jun Fan, Xiao-Ying Lin, Dong Jiang, Mei-Xian Su, Gang Wang & Xu Yang
Pages: 4251-4260
Published online: 26 Sep 2023
AbstractforA Rare Case of Acute Infectious Purpura Fulminans Caused by Klebsiella Pneumoniae and Human Herpesvirus Type 5 | Full Text | References | PDF (3.5 MB) | EPUB
  • 95 Views
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ORIGINAL RESEARCH

Article
Modified Glasgow Prognostic Score is Better for Predicting Oncological Outcome in Patients with Soft Tissue Sarcoma, Compared to High-Sensitivity Modified Glasgow Prognostic Score
Tomoki Nakamura, Kunihiro Asanuma, Tomohito Hagi & Akihiro Sudo
Pages: 3891-3899
Published online: 11 Jul 2022
AbstractforModified Glasgow Prognostic Score is Better for Predicting Oncological Outcome in Patients with Soft Tissue Sarcoma, Compared to High-Sensitivity Modified Glasgow Prognostic Score | Full Text | References | PDF (5.7 MB) | EPUB
  • 123 Views
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Article
Preprocedural SII Combined with High-Sensitivity C-Reactive Protein Predicts the Risk of Contrast-Induced Acute Kidney Injury in STEMI Patients Undergoing Percutaneous Coronary Intervention
Kai Ma, Hang Qiu, Yinghua Zhu, Yuan Lu & Wenhua Li
Pages: 3677-3687
Published online: 25 Jun 2022
AbstractforPreprocedural SII Combined with High-Sensitivity C-Reactive Protein Predicts the Risk of Contrast-Induced Acute Kidney Injury in STEMI Patients Undergoing Percutaneous Coronary Intervention | Full Text | References | PDF (1.2 MB) | EPUB
  • 169 Views
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REVIEW

Review
The Role of Inflammasomes in Mediating Urological Disease: A Short Literature Review
Sarah Shidid, Martin H Bluth & Tamar A Smith-Norowitz
Pages: 4359-4365
Published online: 26 Sep 2023
AbstractforThe Role of Inflammasomes in Mediating Urological Disease: A Short Literature Review | Full Text | References | PDF (556.6 KB) | EPUB
  • 75 Views
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Review
The NLRP3 Inflammasome as a Novel Therapeutic Target for Cardiac Fibrosis
Jiwen Fan, Meng Ren, Binay Kumar Adhikari, Haodong Wang & Yuquan He
Pages: 3847-3858
Published online: 22 Sep 2022
AbstractforThe NLRP3 Inflammasome as a Novel Therapeutic Target for Cardiac Fibrosis | Full Text | References | PDF (2.3 MB) | EPUB
  • 290 Views
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ORIGINAL RESEARCH

Article
Necroptosis-Mediated eCIRP Release in Sepsis
Bridgette Reilly, Chuyi Tan, Atsushi Murao, Colleen Nofi, Alok Jha, Monowar Aziz & Ping Wang
Pages: 4047-4059
Published online: 17 Jul 2022
AbstractforNecroptosis-Mediated eCIRP Release in Sepsis | Full Text | References | PDF (6.1 MB) | EPUB
  • 97 Views
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Article
Resistin Concentration in Early Sepsis and All-Cause Mortality at a Safety-Net Hospital in Riverside County
Jeffrey Bonenfant, Jiang Li, Luqman Nasouf, Joseph Miller, Tammy Lowe, Lukasz Jaroszewski, Xinru Qiu, Suman Thapamagar, Aarti Mittal, Adam Godzik, Walter Klein & Meera G Nair
Pages: 3925-3940
Published online: 13 Jul 2022
AbstractforResistin Concentration in Early Sepsis and All-Cause Mortality at a Safety-Net Hospital in Riverside County | Full Text | References | PDF (5.1 MB) | EPUB
  • 252 Views
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Article
Relationship Between Prognostic Nutrition Index and New York Heart Association Classification in Patients with Coronary Heart Disease: A RCSCD-TCM Study
Mei Ma, Yijia Liu, Fanfan Liu, Zhu Li, Qi Cheng, Zhao Liu, Rongrong Yang & Chunquan Yu
Pages: 4303-4314
Published online: 26 Sep 2023
AbstractforRelationship Between Prognostic Nutrition Index and New York Heart Association Classification in Patients with Coronary Heart Disease: A RCSCD-TCM Study | Full Text | References | PDF (3.1 MB) | EPUB
  • 153 Views
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Article
Assessment of Long-Term Effects on Pulmonary Functions Between Severe and Non-Severe Convalescent COVID-19 Patients: A Single-Center Study in China
Yan-Fen Tang, Jun-Yan Han, Ai-Min Ren, Li Chen, Tian-Jiao Xue, Yong-Hong Yan, Xi Wang, Yu Wang & Rong-Hua Jin
Pages: 4751-4761
Published online: 19 Aug 2022
AbstractforAssessment of Long-Term Effects on Pulmonary Functions Between Severe and Non-Severe Convalescent COVID-19 Patients: A Single-Center Study in China | Full Text | References | PDF (268.2 KB) | EPUB
  • 68 Views
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Article
Characterization of Cathepsin B in Mediating Silica Nanoparticle-Induced Macrophage Pyroptosis via an NLRP3-Dependent Manner
Lan Ma, Zhengpu Han, Haoyu Yin, Jiaqi Tian, Jing Zhang, Ning Li, Chunjie Ding & Lin Zhang
Pages: 4537-4545
Published online: 08 Aug 2022
AbstractforCharacterization of Cathepsin B in Mediating Silica Nanoparticle-Induced Macrophage Pyroptosis via an NLRP3-Dependent Manner | Full Text | References | PDF (4.6 MB) | EPUB
  • 143 Views
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Article
Naples Prognostic Score is an Independent Prognostic Factor in Patients with Small Cell Lung Cancer and Nomogram Predictive Model Established
Shuangqing Chen, Shicheng Liu, Siwei Xu, Shumin Cao, Zhaohui Han, Lingxin Kong, Dahu Ren & Guochen Duan
Pages: 3719-3731
Published online: 24 Sep 2022
AbstractforNaples Prognostic Score is an Independent Prognostic Factor in Patients with Small Cell Lung Cancer and Nomogram Predictive Model Established | Full Text | References | PDF (4.4 MB) | EPUB
  • 125 Views
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Article
Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2
Huixia Feng, Guilin Chen, Yongli Zhang & Mingquan Guo
Pages: 4677-4692
Published online: 15 Aug 2022
AbstractforPotential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2 | Full Text | References | PDF (6.6 MB) | EPUB
  • 122 Views
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Article
Vitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia
Jinhui Hu, Zhixin Wu, Huawei Wang, Haifeng Geng, Jie Huo, Xueping Zhu & Xiaoli Zhu
Pages: 4891-4906
Published online: 26 Sep 2023
AbstractforVitamin D Ameliorates Apoptosis and Inflammation by Targeting the Mitochondrial and MEK1/2-ERK1/2 Pathways in Hyperoxia-Induced Bronchopulmonary Dysplasia | Full Text | References | PDF (9.7 MB) | EPUB
  • 106 Views
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REVIEW

Review
The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing
Jianying Song, Lixin Hu, Bo Liu, Nan Jiang, Houqiang Huang, JieSi Luo, Long Wang, Jing Zeng, Feihong Huang, Min Huang, Luyao Cai, Lingyu Tang, Shunli Chen, Yinyi Chen, Anguo Wu, Silin Zheng & Qi Chen
Pages: 4119-4138
Published online: 26 Sep 2023
AbstractforThe Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing | Full Text | References | PDF (2 MB) | EPUB
  • 358 Views
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Review
Therapeutic Benefits of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome: Potential Mechanisms and Challenges
Chao Cao, Lin Zhang, Fuli Liu & Jie Shen
Pages: 5235-5246
Published online: 10 Sep 2022
AbstractforTherapeutic Benefits of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome: Potential Mechanisms and Challenges | Full Text | References | PDF (3.7 MB) | EPUB
  • 102 Views
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ORIGINAL RESEARCH

Article
A Predictive Model Based on Inflammatory and Coagulation Indicators for Sepsis-Induced Acute Kidney Injury
Qi Xin, Tonghui Xie, Rui Chen, Xing Zhang, Yingmu Tong, Hai Wang, Shufeng Wang, Chang Liu & Jingyao Zhang
Pages: 4561-4571
Published online: 26 Sep 2023
AbstractforA Predictive Model Based on Inflammatory and Coagulation Indicators for Sepsis-Induced Acute Kidney Injury | Full Text | References | PDF (2.8 MB) | EPUB
  • 104 Views
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Article
Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites
Ling Li, Yaoyao Du, Yang Wang, Ning He, Bing Wang & Tong Zhang
Pages: 4709-4723
Published online: 26 Sep 2023
AbstractforAtractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites | Full Text | References | PDF (11.1 MB) | EPUB
  • 153 Views
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Article
Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice
Anish Maskey, Kamal Srivastava, Gary Soffer, David Dunkin, Qian Yuan & Xiu-Min Li
Pages: 5527-5540
Published online: 26 Sep 2023
AbstractforInduction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice | Full Text | References | PDF (8 MB) | EPUB
  • 114 Views
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Article
Augmentation of NAD+ by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice
Seung Hoon Lee, Hyung-Jin Kim, Gi-Su Oh, Su-Bin Lee, Dipendra Khadka, Wal Cao, Seong-Kyu Choe, Hyeok Shim, Chang-Deok Kim, Tae Hwan Kwak & Hong-Seob So
Pages: 4623-4636
Published online: 13 Aug 2022
AbstractforAugmentation of NAD+ by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice | Full Text | References | PDF (11.6 MB) | EPUB
  • 121 Views
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REVIEW

Review
Diagnostic and Prognostic Value of Monocyte Distribution Width in Sepsis
Juehui Wu, Laisheng Li & Jinmei Luo
Pages: 4107-4117
Published online: 26 Sep 2023
AbstractforDiagnostic and Prognostic Value of Monocyte Distribution Width in Sepsis | Full Text | References | PDF (1.2 MB) | EPUB
  • 290 Views
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ORIGINAL RESEARCH

Article
Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation
Jung Lo, Ching-Chih Liu, Yueh-Shan Li, Po-Yen Lee, Po-Len Liu, Pei-Chang Wu, Tzu-Chieh Lin, Chi-Shuo Chen, Chien-Chih Chiu, Yu-Hung Lai, Yo-Chen Chang, Hsin-En Wu, Yuan-Ru Chen, Yu-Kai Huang, Shu-Pin Huang, Shu-Chi Wang & Chia-Yang Li
Pages: 5347-5359
Published online: 26 Sep 2023
AbstractforPunicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation | Full Text | References | PDF (6.8 MB) | EPUB
  • 334 Views
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Article
Potential Pathogenetic Role of Antimicrobial Peptides Carried by Extracellular Vesicles in an in vitro Psoriatic Model
Lorena Capriotti, Marco Iuliano, Roberto Lande, Loredana Frasca, Mario Falchi, Paolo Rosa, Giorgio Mangino & Giovanna Romeo
Pages: 5387-5399
Published online: 16 Sep 2022
AbstractforPotential Pathogenetic Role of Antimicrobial Peptides Carried by Extracellular Vesicles in an in vitro Psoriatic Model | Full Text | References | PDF (8 MB) | EPUB
  • 110 Views
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Article
Long-Term Efficacy and Low Adverse Events of Methylprednisolone Pulses Combined to Low-Dose Glucocorticoids for Systemic Sclerosis: A Retrospective Clinical Study of 10 Years’ Follow-Up
Hao Cheng, Zhen Yu, Cheng-lan Yan, Hui-dan Yang, Chong Gao & Hong-yan Wen
Pages: 4421-4433
Published online: 26 Sep 2023
AbstractforLong-Term Efficacy and Low Adverse Events of Methylprednisolone Pulses Combined to Low-Dose Glucocorticoids for Systemic Sclerosis: A Retrospective Clinical Study of 10 Years’ Follow-Up | Full Text | References | PDF (6.6 MB) | EPUB
  • 111 Views
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Article
TXNIP Participated in NLRP3-Mediated Inflammation in a Rat Model of Cervical Spondylotic Myelopathy
Peisheng Liu, Xiaofeng Li, Jing Liu, Hengjia Zhang, Zhitao You & Jianfeng Zhang
Pages: 4547-4559
Published online: 09 Aug 2022
AbstractforTXNIP Participated in NLRP3-Mediated Inflammation in a Rat Model of Cervical Spondylotic Myelopathy | Full Text | References | PDF (12.5 MB) | EPUB
  • 83 Views
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Article
Correlation Between the RNA Methylation Genes and Immune Infiltration and Prognosis of Patients with Hepatocellular Carcinoma: A Pan-Cancer Analysis
Xin-Yu Li & Xi-Tao Yang
Pages: 3941-3956
Published online: 13 Jul 2022
AbstractforCorrelation Between the RNA Methylation Genes and Immune Infiltration and Prognosis of Patients with Hepatocellular Carcinoma: A Pan-Cancer Analysis | Full Text | References | PDF (14.3 MB) | EPUB
  • 148 Views
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REVIEW

Review
Recent Advances in Reactive Oxygen Species (ROS)-Responsive Polyfunctional Nanosystems 3.0 for the Treatment of Osteoarthritis
Dao-Fang Ding, Yan Xue, Xi-Chen Wu, Zhi-Heng Zhu, Jia-Ying Ding, Yong-Jia Song, Xiao-Ling Xu & Jian-Guang Xu
Pages: 5009-5026
Published online: 26 Sep 2023
AbstractforRecent Advances in Reactive Oxygen Species (ROS)-Responsive Polyfunctional Nanosystems 3.0 for the Treatment of Osteoarthritis | Full Text | References | PDF (3.6 MB) | EPUB
  • 225 Views
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ORIGINAL RESEARCH

Article
The Key Molecular Mechanisms of Sini Decoction Plus Ginseng Soup to Rescue Acute Liver Failure: Regulating PPARα to Reduce Hepatocyte Necroptosis?
Ying He, Yang Zhang, Junli Zhang & Xiaoyu Hu
Pages: 4763-4784
Published online: 26 Sep 2023
AbstractforThe Key Molecular Mechanisms of Sini Decoction Plus Ginseng Soup to Rescue Acute Liver Failure: Regulating PPARα to Reduce Hepatocyte Necroptosis? | Full Text | References | PDF (16.1 MB) | EPUB
  • 72 Views
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Article
Preoperative White Blood Cell-Related Indicators Can Predict the Prognosis of Patients with Transurethral Resection of Bladder Cancer
Mingde Gao, Qiuxing Yang, Haifei Xu, Zhigang Chen, Xiaolin Wang & Haifeng Guo
Pages: 4139-4147
Published online: 21 Jul 2022
AbstractforPreoperative White Blood Cell-Related Indicators Can Predict the Prognosis of Patients with Transurethral Resection of Bladder Cancer | Full Text | References | PDF (3.6 MB) | EPUB
  • 66 Views
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Article
P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia
Yanqin Li, Xiaoqian Sun, Xiangning Liu, Junjun Li, Xuan Li, Gang Wang, Yizhou Liu, Xiangyu Lu, Lingwen Cui, Mingyan Shao, Yong Wang, Wei Wang & Chun Li
Pages: 5309-5326
Published online: 26 Sep 2023
AbstractforP2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia | Full Text | References | PDF (12.9 MB) | EPUB
  • 84 Views
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REVIEW

Review
Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives
Alin Laurentiu Tatu, Thomas Nadasdy, Anca Arbune, Valentin Chioncel, Carmen Bobeica, Elena Niculet, Alina Viorica Iancu, Caterina Dumitru, Valentin Tudor Popa, Nicolas Kluger, Victor Gabriel Clatici, Claudiu Ionut Vasile, Cristian Onisor & Alexandru Nechifor
Pages: 5163-5184
Published online: 26 Sep 2023
AbstractforInterrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives | Full Text | References | PDF (2.3 MB) | EPUB
  • 310 Views
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Review
Research Progress on the Mechanism of Sepsis Induced Myocardial Injury
Cheng-Fei Bi, Jia Liu, Li-Shan Yang & Jun-Fei Zhang
Pages: 4275-4290
Published online: 26 Sep 2023
AbstractforResearch Progress on the Mechanism of Sepsis Induced Myocardial Injury | Full Text | References | PDF (2 MB) | EPUB
  • 198 Views
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ORIGINAL RESEARCH

Article
Differences in B-Cell Immunophenotypes and Neutralizing Antibodies Against SARS-CoV-2 After Administration of BNT162b2 (Pfizer-BioNTech) Vaccine in Individuals with and without Prior COVID-19 - A Prospective Cohort Study
José Javier Morales-Núñez, Mariel García-Chagollán, José Francisco Muñoz-Valle, Saúl Alberto Díaz-Pérez, Paola Carolina Torres-Hernández, Saraí Citlalic Rodríguez-Reyes, Guillermo Santoscoy-Ascencio, José Julio Sierra García de Quevedo & Jorge Hernández-Bello
Pages: 4449-4466
Published online: 26 Sep 2023
AbstractforDifferences in B-Cell Immunophenotypes and Neutralizing Antibodies Against SARS-CoV-2 After Administration of BNT162b2 (Pfizer-BioNTech) Vaccine in Individuals with and without Prior COVID-19 - A Prospective Cohort Study | Full Text | References | PDF (8.2 MB) | EPUB
  • 102 Views
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Article
LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis
Mu-zi Li, Xiao-yang Wen, Xiao-qiang Liu, Yu-qing Wang & Lei Yan
Pages: 5707-5720
Published online: 26 Sep 2023
AbstractforLPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis | Full Text | References | PDF (8.7 MB) | EPUB
  • 198 Views
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Article
Outcome of Lenalidomide Treatment for Cognitive Impairment Caused by Immune Reconstitution Inflammatory Syndrome in Patients with HIV-Related Cryptococcal Meningitis
Ran Tao, Xiaorong Peng, Xiang Liu, Lijun Xu, Junwei Su, Guanjing Lang, Ying Huang & Biao Zhu
Pages: 5327-5336
Published online: 26 Sep 2023
AbstractforOutcome of Lenalidomide Treatment for Cognitive Impairment Caused by Immune Reconstitution Inflammatory Syndrome in Patients with HIV-Related Cryptococcal Meningitis | Full Text | References | PDF (2 MB) | EPUB
  • 143 Views
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Article
May the Nitrosative and Carbonyl Stress Promote Inflammation in Patients with Colorectal Cancer?
Justyna Dorf, Konrad Zaręba, Joanna Matowicka-Karna, Anna Pryczynicz, Katarzyna Guzińska-Ustymowicz, Anna Zalewska & Mateusz Maciejczyk
Pages: 4585-4600
Published online: 26 Sep 2023
AbstractforMay the Nitrosative and Carbonyl Stress Promote Inflammation in Patients with Colorectal Cancer? | Full Text | References | PDF (1.2 MB) | EPUB
  • 78 Views
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Article
Cannabidiol Inhibits Inflammation Induced by Cutibacterium acnes-Derived Extracellular Vesicles via Activation of CB2 Receptor in Keratinocytes
Ziqi Jiang, Shanglin Jin, Xiaoyao Fan, Ke Cao, Ye Liu, Xuan Wang, Ying Ma & Leihong Xiang
Pages: 4573-4583
Published online: 11 Aug 2022
AbstractforCannabidiol Inhibits Inflammation Induced by Cutibacterium acnes-Derived Extracellular Vesicles via Activation of CB2 Receptor in Keratinocytes | Full Text | References | PDF (6.9 MB) | EPUB
  • 316 Views
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Article
Investigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis
Hong-Miao Li, Fei Tang, Qian Huang, Hai-Feng Pan & Tian-Ping Zhang
Pages: 4527-4536
Published online: 08 Aug 2022
AbstractforInvestigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis | Full Text | References | PDF (341.9 KB) | EPUB
  • 68 Views
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Article
Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes
Yingze Li, Guojian Fang, Wei Cao, Jiali Yuan, Shuai Song, Hong Peng, Yuepeng Wang & Qunshan Wang
Pages: 4693-4708
Published online: 16 Aug 2022
AbstractforEzh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes | Full Text | References | PDF (11 MB) | EPUB
  • 140 Views
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Article
Assessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic Study
Wei-Hung Chan, Yu-Juei Hsu, Chiao-Pei Cheng, Kuan-Nien Chou, Chin-Li Chen, Shih-Ming Huang, Wei-Chih Kan & Yi-Lin Chiu
Pages: 4833-4851
Published online: 26 Sep 2023
AbstractforAssessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic Study | Full Text | References | PDF (17.2 MB) | EPUB
  • 100 Views
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Article
Aspirin Ameliorates Pancreatic Inflammation and Fibrosis by Inhibiting COX-2 Expression in Experimental Chronic Pancreatitis
Xiao-Fan Xu, Jian-Wei Fan, Jia-Qi Xin, Nan Wu, He Gao, Li-Fang Duan, Wen-Bin Zou, Hong Zhang & Zhao-Shen Li
Pages: 4737-4749
Published online: 19 Aug 2022
AbstractforAspirin Ameliorates Pancreatic Inflammation and Fibrosis by Inhibiting COX-2 Expression in Experimental Chronic Pancreatitis | Full Text | References | PDF (12.8 MB) | EPUB
  • 111 Views
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Article
Chlorite-Oxidized Oxyamylose (COAM) Has Antibacterial Activity and Positively Affects Skin Wound Healing
Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Jennifer Vandooren, Karin Nylander, Erik Martens, Lieve Van Mellaert, Jo Van Damme, Jan Jeroen Vranckx, Patrick Matthys, Tiina Alamäe, Mia Phillipson, Triinu Visnapuu & Ghislain Opdenakker
Pages: 4995-5008
Published online: 26 Sep 2023
AbstractforChlorite-Oxidized Oxyamylose (COAM) Has Antibacterial Activity and Positively Affects Skin Wound Healing | Full Text | References | PDF (7.2 MB) | EPUB
  • 71 Views
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REVIEW

Review
An Overview of Neurological and Psychiatric Complications During Post-COVID Period: A Narrative Review
Dan Li, Qiang Wang, Chengyou Jia, Zhongwei Lv & Jianshe Yang
Pages: 4199-4215
Published online: 26 Sep 2023
AbstractforAn Overview of Neurological and Psychiatric Complications During Post-COVID Period: A Narrative Review | Full Text | References | PDF (882.5 KB) | EPUB
  • 247 Views
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ORIGINAL RESEARCH

Article
Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study
Mei Ma, Yijia Liu, Lichun Wang, Rongrong Yang, Zhu Li, Sheng Gao, Lin Li & Chunquan Yu
Pages: 5141-5156
Published online: 07 Sep 2022
AbstractforRelationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study | Full Text | References | PDF (3.6 MB) | EPUB
  • 131 Views
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Article
The Network of miRNA–mRNA Interactions in Circulating T Cells of Patients Following Major Trauma – A Pilot Study
Cheng-Shyuan Rau, Pao-Jen Kuo, Hui-Ping Lin, Chia-Jung Wu, Yi-Chan Wu, Peng-Chen Chien, Ting-Min Hsieh, Hang-Tsung Liu, Chun-Ying Huang & Ching-Hua Hsieh
Pages: 5491-5503
Published online: 26 Sep 2023
AbstractforThe Network of miRNA–mRNA Interactions in Circulating T Cells of Patients Following Major Trauma – A Pilot Study | Full Text | References | PDF (4.1 MB) | EPUB
  • 103 Views
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Article
The Neuroprotective Propensity of Organic Extracts of Acacia stenophylla Bark and Their Effectiveness Against Scopolamine-/Diazepam-Induced Amnesia in Mice
Dawood Shah, Arshad Iqbal, Fahad S Alshehri, Aman Ullah, Gowhar Ali, Tahir Muhammad, Rahim Ullah, Robert D E Sewell & Yusuf S Althobaiti
Pages: 4785-4802
Published online: 26 Sep 2023
AbstractforThe Neuroprotective Propensity of Organic Extracts of Acacia stenophylla Bark and Their Effectiveness Against Scopolamine-/Diazepam-Induced Amnesia in Mice | Full Text | References | PDF (8.7 MB) | EPUB
  • 166 Views
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Article
The Efficacy of the Systemic Immune-Inflammation Index and Prognosis Nutritional Index for the Diagnosis of Venous Thromboembolism in Gastrointestinal Cancers
Lu Zhang, Yue Fang, Jianghao Xing, Hao Cheng, Xiaonan Sun, Zhichao Yuan, Yidan Xu & Jiqing Hao
Pages: 4649-4661
Published online: 15 Aug 2022
AbstractforThe Efficacy of the Systemic Immune-Inflammation Index and Prognosis Nutritional Index for the Diagnosis of Venous Thromboembolism in Gastrointestinal Cancers | Full Text | References | PDF (4.9 MB) | EPUB
  • 125 Views
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Article
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora
Mingqian Hao, Chuanbo Ding, Shuwen Sun, Xiaojuan Peng & Wencong Liu
Pages: 4921-4938
Published online: 26 Sep 2023
AbstractforChitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora | Full Text | References | PDF (16 MB) | EPUB
  • 259 Views
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CASE REPORT

Case Report
Reactive Hemophagocytic Lymphohistiocytosis Secondary to Ovarian Adenocarcinoma: A Rare Case Report
Xiao-Yan Li, Shu-Min Zhu, Xin-Yuan Li, Rui-Sheng Dong, Ai-Ai Zhang, Shu-Jing Li & Yu-Lan Geng
Pages: 5121-5128
Published online: 26 Sep 2023
AbstractforReactive Hemophagocytic Lymphohistiocytosis Secondary to Ovarian Adenocarcinoma: A Rare Case Report | Full Text | References | PDF (512.3 KB) | EPUB
  • 106 Views
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ORIGINAL RESEARCH

Article
Expression of PD-1 on Memory T Lymphocytes Predicts 28-Day Mortality of Patients with Sepsis: A Prospective Observational Study
Qingxiang Liu, Ming Xue, Qianwen Song, Jianfeng Xie, Yi Yang & Songqiao Liu
Pages: 5043-5052
Published online: 26 Sep 2023
AbstractforExpression of PD-1 on Memory T Lymphocytes Predicts 28-Day Mortality of Patients with Sepsis: A Prospective Observational Study | Full Text | References | PDF (6.2 MB) | EPUB
  • 73 Views
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Article
Impaired Circulating Antibody-Secreting Cells Generation Predicts the Dismal Outcome in the Elderly Septic Shock Patients
Huihui Xu, Teng Li, Xiaoming Zhang, Hongqiang Li, Diyu Lv, Yiyuan Wang, Fangjie Huo, Jianwen Bai & Chunmei Wang
Pages: 5293-5308
Published online: 13 Sep 2022
AbstractforImpaired Circulating Antibody-Secreting Cells Generation Predicts the Dismal Outcome in the Elderly Septic Shock Patients | Full Text | References | PDF (8 MB) | EPUB
  • 62 Views
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Article
YAP Activates STAT3 Signalling to Promote Colonic Epithelial Cell Proliferation in DSS-Induced Colitis and Colitis Associated Cancer
Feihong Deng, Zengrong Wu, Mengmeng Xu & Pianpian Xia
Pages: 5471-5482
Published online: 26 Sep 2023
AbstractforYAP Activates STAT3 Signalling to Promote Colonic Epithelial Cell Proliferation in DSS-Induced Colitis and Colitis Associated Cancer | Full Text | References | PDF (6.4 MB) | EPUB
  • 125 Views
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Article
An Integrated Analysis of Inflammatory Endotypes and Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps
Dingqian Hao, Yisha Wu, Ping Li, Chunhao Li, Tianjiao Jiang, Qian Zhang, Shengyang Liu & Li Shi
Pages: 5557-5565
Published online: 26 Sep 2023
AbstractforAn Integrated Analysis of Inflammatory Endotypes and Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps | Full Text | References | PDF (5.1 MB) | EPUB
  • 94 Views
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Article
Whole Exome Sequencing Revealed Variants That Predict Pulmonary Artery Involvement in Patients with Takayasu Arteritis
Lingyu Liu, Jing Chen, Jing Li, Yunjiao Yang, Xiaofeng Zeng & Xinping Tian
Pages: 4817-4831
Published online: 26 Sep 2023
AbstractforWhole Exome Sequencing Revealed Variants That Predict Pulmonary Artery Involvement in Patients with Takayasu Arteritis | Full Text | References | PDF (4 MB) | EPUB
  • 84 Views
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Article
Response Guided Slow Infusion of Albumin, Vasoconstrictors and Furosemide Improves Ascites Mobilization and Survival in Acute on Chronic Liver Failure: A Proof-of-Concept Study
Gaurav Pande, Manjunath Hatti, Mohit Kumar Rai, Praveer Rai, Kamlesh Kumar, Krishna VP, Abhimanyu Nehra, Sudeep Kumar, Smarak Ranjan Rout, Sourav Kumar Mishra, Dinesh Kumar, Umesh Kumar, Prabhaker Mishra, Abdul Majeed, Vivek Anand Saraswat, Kritika Singh, Harshit Singh, Durga Prasanna Misra & Vikas Agarwal
Pages: 5027-5039
Published online: 01 Sep 2022
AbstractforResponse Guided Slow Infusion of Albumin, Vasoconstrictors and Furosemide Improves Ascites Mobilization and Survival in Acute on Chronic Liver Failure: A Proof-of-Concept Study | Full Text | References | PDF (4.2 MB) | EPUB
  • 139 Views
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Article
C/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling
Yalan Luo, Peng Ge, Haiyun Wen, Yibo Zhang, Jin Liu, Xuanchi Dong, Bowen Lan, Guixin Zhang, Qi Yang & Hailong Chen
Pages: 5247-5263
Published online: 26 Sep 2023
AbstractforC/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling | Full Text | References | PDF (9.2 MB) | EPUB
  • 99 Views
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Article
The DPY30-H3K4me3 Axis-Mediated PD-L1 Expression in Melanoma
Zhichun Zhang, Yixuan Han, Qiuyue Sun, Yipeng Wang & Lichao Sun
Pages: 5595-5609
Published online: 26 Sep 2022
AbstractforThe DPY30-H3K4me3 Axis-Mediated PD-L1 Expression in Melanoma | Full Text | References | PDF (14.1 MB) | EPUB
  • 74 Views
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Article
Elevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction
Yeshen Zhang, Zhengrong Xu, Wenfei He, Zehuo Lin, Yaoxin Liu, Yining Dai, Wei Chen, Weikun Chen, Wenlong He, Chongyang Duan, Pengcheng He, Yuanhui Liu & Ning Tan
Pages: 5361-5371
Published online: 15 Sep 2022
AbstractforElevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction | Full Text | References | PDF (1.8 MB) | EPUB
  • 118 Views
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Article
Risk Factors and the Role of the Albumin-to-Globulin Ratio in Predicting Recurrence Among Patients with Idiopathic Granulomatous Mastitis
Ahmet Burak Ciftci, Ömer Faruk Bük, Kürşat Yemez, Süleyman Polat & İrem Melike Yazıcıoğlu
Pages: 5401-5412
Published online: 26 Sep 2023
AbstractforRisk Factors and the Role of the Albumin-to-Globulin Ratio in Predicting Recurrence Among Patients with Idiopathic Granulomatous Mastitis | Full Text | References | PDF (3.6 MB) | EPUB
  • 150 Views
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Article
The Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population
Zhaojin Lu, Zepeng Zheng, Yufen Xu, Chenlu Wang, Yueling Lin, Kun Lin, LanYan Fu, Huazhong Zhou, Lei Pi, Di Che & Xiaoqiong Gu
Pages: 5053-5062
Published online: 26 Sep 2023
AbstractforThe Associated of the Risk of IVIG Resistance in Kawasaki Disease with ZNF112 Gene and ZNF180 Gene in a Southern Chinese Population | Full Text | References | PDF (2 MB) | EPUB
  • 82 Views
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Article
AMPK/SIRT1 Deficiency Drives Adjuvant-Induced Arthritis in Rats by Promoting Glycolysis-Mediated Monocytes Inflammatory Polarization
Dan-Dan Wang, Chi-Yi He, Yi-Jin Wu, Liang Xu, Chao Shi, Opeyemi Joshua Olatunji, Jian Zuo & Cong-Lan Ji
Pages: 4663-4675
Published online: 15 Aug 2022
AbstractforAMPK/SIRT1 Deficiency Drives Adjuvant-Induced Arthritis in Rats by Promoting Glycolysis-Mediated Monocytes Inflammatory Polarization | Full Text | References | PDF (8.1 MB) | EPUB
  • 96 Views
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Article
Nomogram Based on Inflammatory Biomarkers to Predict the Recurrence of Hepatocellular Carcinoma—A Multicentre Experience
Zehao Zheng, Renguo Guan, Yiping Zou, Zhixiang Jian, Ye Lin, Rongping Guo & Haosheng Jin
Pages: 5089-5102
Published online: 26 Sep 2023
AbstractforNomogram Based on Inflammatory Biomarkers to Predict the Recurrence of Hepatocellular Carcinoma—A Multicentre Experience | Full Text | References | PDF (7.2 MB) | EPUB
  • 48 Views
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Article
Lipid Metabolic-Related Signature CYP19A1 is a Potential Biomarker for Prognosis and Immune Cell Infiltration in Gastric Cancer
Nan Wang, Xuanyu Huang & Qian Long
Pages: 5075-5088
Published online: 26 Sep 2023
AbstractforLipid Metabolic-Related Signature CYP19A1 is a Potential Biomarker for Prognosis and Immune Cell Infiltration in Gastric Cancer | Full Text | References | PDF (10.7 MB) | EPUB
  • 86 Views
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Article
Peri-Ulcerative Mucosal Inflammation Appearance is an Independent Risk Factor for 30-Day Rebleeding in Patients with Gastric Ulcer Bleeding: A Multicenter Retrospective Study
Yixuan Bai, Chenggang Lei, Na Zhang, Yuhui Liu, Zhengyu Hu, Yan Li & Ran Qi
Pages: 4951-4961
Published online: 26 Sep 2023
AbstractforPeri-Ulcerative Mucosal Inflammation Appearance is an Independent Risk Factor for 30-Day Rebleeding in Patients with Gastric Ulcer Bleeding: A Multicenter Retrospective Study | Full Text | References | PDF (2.1 MB) | EPUB
  • 79 Views
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Article
Predicting Mucosal Healing in Crohn’s Disease: A Nomogram Model Developed from a Retrospective Cohort
Nana Tang, Han Chen, Ruidong Chen, Wen Tang & Hongjie Zhang
Pages: 5515-5525
Published online: 26 Sep 2023
AbstractforPredicting Mucosal Healing in Crohn’s Disease: A Nomogram Model Developed from a Retrospective Cohort | Full Text | References | PDF (3.9 MB) | EPUB
  • 68 Views
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Article
Role of NINJ1 in Gout Flare and Potential as a Drug Target
Hongliang Zhang, Jie Gao, Wenxiang Fang, Yujie Tang, Xuan Fang, Tengchuan Jin & Jinhui Tao
Pages: 5611-5620
Published online: 26 Sep 2023
AbstractforRole of NINJ1 in Gout Flare and Potential as a Drug Target | Full Text | References | PDF (4.5 MB) | EPUB
  • 144 Views
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Article
Remdesivir Reduces Mortality in Hemato-Oncology Patients with COVID-19
Bogusz Jan Aksak-Wąs, Daniel Chober, Karol Serwin, Kaja Scheibe, Jolanta Niścigorska-Olsen, Anna Niedźwiedź, Monika Dobrowolska, Katarzyna Żybul, Marta Kubacka, Agnieszka Zimoń, Ewa Hołda, Joanna Mieżyńska-Kurtycz, Marta Gryczman, Grzegorz Jamro, Paweł Szakoła & Miłosz Parczewski
Pages: 4907-4920
Published online: 26 Sep 2023
AbstractforRemdesivir Reduces Mortality in Hemato-Oncology Patients with COVID-19 | Full Text | References | PDF (526.9 KB) | EPUB
  • 108 Views
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Article
Pharmacological Inhibition of Chitotriosidase (CHIT1) as a Novel Therapeutic Approach for Sarcoidosis
Barbara Dymek, Piotr Sklepkiewicz, Michal Mlacki, Nazan Cemre Güner, Patrycja Nejman-Gryz, Katarzyna Drzewicka, Natalia Przysucha, Aleksandra Rymaszewska, Magdalena Paplinska-Goryca, Agnieszka Zagozdzon, Małgorzata Proboszcz, Łukasz Krzemiński, Jan H von der Thüsen, Katarzyna Górska, Karolina Dzwonek, Zbigniew Zasłona, Pawel Dobrzanski & Rafał Krenke
Pages: 5621-5634
Published online: 29 Sep 2022
AbstractforPharmacological Inhibition of Chitotriosidase (CHIT1) as a Novel Therapeutic Approach for Sarcoidosis | Full Text | References | PDF (7.5 MB) | EPUB
  • 100 Views
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Article
Plasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status
Hao Hong, Suya Zhou, Haimin Shi & Ming Li
Pages: 5129-5139
Published online: 07 Sep 2022
AbstractforPlasma and Urine Indoleamine 2,3-Dioxygenase Activity: Promising Biomarkers for Chronic Kidney Disease and Inflammation Status | Full Text | References | PDF (4.5 MB) | EPUB
  • 79 Views
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Article
Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult
Jee Yeon Baek, Ji-Man Kang, Ji Young Lee, Sung Min Lim & Jong Gyun Ahn
Pages: 5505-5514
Published online: 26 Sep 2023
AbstractforComparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult | Full Text | References | PDF (488.1 KB) | EPUB
  • 90 Views
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Article
Fibrinogen-Like Protein 1 as a Novel Biomarker of Psoriasis Severity
Xiaoying Sun, Liu Liu, Siting Chen, Jiao Wang, Xiaoce Cai, Jiankun Song, Mi Zhou, Dongjie Guo, Le Kuai, Xiaojie Ding, Bin Li & Xin Li
Pages: 4637-4647
Published online: 15 Aug 2022
AbstractforFibrinogen-Like Protein 1 as a Novel Biomarker of Psoriasis Severity | Full Text | References | PDF (4.2 MB) | EPUB
  • 145 Views
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Article
B Cell Receptor Signaling Pathway Mutation as Prognosis Predictor of Immune Checkpoint Inhibitors in Lung Adenocarcinoma by Bioinformatic Analysis
Anqi Lin, Jianbo Fang, Quan Cheng, Zaoqu Liu, Peng Luo & Jian Zhang
Pages: 5541-5555
Published online: 26 Sep 2023
AbstractforB Cell Receptor Signaling Pathway Mutation as Prognosis Predictor of Immune Checkpoint Inhibitors in Lung Adenocarcinoma by Bioinformatic Analysis | Full Text | References | PDF (5.5 MB) | EPUB
  • 64 Views
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Review

Review
Normalization of Neuroinflammation: A New Strategy for Treatment of Persistent Pain and Memory/Emotional Deficits in Chronic Pain
Xian-Guo Liu
Pages: 5201-5233
Published online: 26 Sep 2023
AbstractforNormalization of Neuroinflammation: A New Strategy for Treatment of Persistent Pain and Memory/Emotional Deficits in Chronic Pain | Full Text | References | PDF (4.3 MB) | EPUB
  • 209 Views
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ORIGINAL RESEARCH

Article
Single-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like Model
Shasha Jin, Yixin Wang, Chenxin Qie, Lu Yang, Yinhao Wu, Tingting Zhang, Jianwen Di & Jun Liu
Pages: 5999-6012
Published online: 28 Oct 2022
AbstractforSingle-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like Model | Full Text | References | PDF (9.5 MB) | EPUB
  • 353 Views
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Article
A Prediction Model Based on Blood Biomarker for Mortality Risk in Patients with Acute Venous Thromboembolism
Jianjun Jiang, Junshuai Xue & Yang Liu
Pages: 4725-4735
Published online: 18 Aug 2022
AbstractforA Prediction Model Based on Blood Biomarker for Mortality Risk in Patients with Acute Venous Thromboembolism | Full Text | References | PDF (5.3 MB) | EPUB
  • 72 Views
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RETRACTION

Retraction
1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages [Retraction]
Pages: 3631-3632
Published online: 23 Jun 2022
Citationfor1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages [Retraction] | Full Text | PDF (134.4 KB) | EPUB
  • 87 Views
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ORIGINAL RESEARCH

Article
Exosomes Derived hsa-miR-4669 as a Novel Biomarker for Early Predicting the Response of Subcutaneous Immunotherapy in Pediatric Allergic Rhinitis
Sijie Jiang, Shaobing Xie, Ruohao Fan, Qingping Tang, Hua Zhang, Fengjun Wang, Shumin Xie, Kelei Gao, Junyi Zhang, Zhihai Xie & Weihong Jiang
Pages: 5063-5074
Published online: 03 Sep 2022
AbstractforExosomes Derived hsa-miR-4669 as a Novel Biomarker for Early Predicting the Response of Subcutaneous Immunotherapy in Pediatric Allergic Rhinitis | Full Text | References | PDF (6.6 MB) | EPUB
  • 121 Views
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Article
Therapeutic Effects of Silibinin Against Polycystic Ovary Syndrome Induced by Letrozole in Rats via Its Potential Anti-Inflammatory and Anti-Oxidant Activities
Bushra Hassan Marouf, Dana Omer Ismaeel, Ali Hussein Hassan & Othman Jalal Ali
Pages: 5185-5199
Published online: 26 Sep 2023
AbstractforTherapeutic Effects of Silibinin Against Polycystic Ovary Syndrome Induced by Letrozole in Rats via Its Potential Anti-Inflammatory and Anti-Oxidant Activities | Full Text | References | PDF (10.6 MB) | EPUB
  • 262 Views
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REVIEW

Review
Progress in the Clinical Assessment and Treatment of Myocardial Depression in Critically Ill Patient with Sepsis
Xu-Dong Shen, Hua-Sheng Zhang, Rui Zhang, Jun Li, Zhi-Gang Zhou, Zhi-Xian Jin & Yin-Jia Wang
Pages: 5483-5490
Published online: 26 Sep 2023
AbstractforProgress in the Clinical Assessment and Treatment of Myocardial Depression in Critically Ill Patient with Sepsis | Full Text | References | PDF (502.7 KB) | EPUB
  • 92 Views
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Review
DPP4 as a Potential Candidate in Cardiovascular Disease
Si-Yu Chen, Xiang-Quan Kong, Ke-Fan Zhang, Shuai Luo, Feng Wang & Jun-Jie Zhang
Pages: 5457-5469
Published online: 16 Sep 2022
AbstractforDPP4 as a Potential Candidate in Cardiovascular Disease | Full Text | References | PDF (498.8 KB) | EPUB
  • 155 Views
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ORIGINAL RESEARCH

Article
Adiponectin and Leptin as Biomarkers of Disease Activity and Metabolic Disorders in Rheumatoid Arthritis Patients
Bożena Targońska-Stępniak & Krzysztof Grzechnik
Pages: 5845-5855
Published online: 13 Oct 2022
AbstractforAdiponectin and Leptin as Biomarkers of Disease Activity and Metabolic Disorders in Rheumatoid Arthritis Patients | Full Text | References | PDF (2.2 MB) | EPUB
  • 124 Views
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REVIEW

Review
TYK2 in Immune Responses and Treatment of Psoriasis
Lin Shang, Jiali Cao, Siqi Zhao, Jingya Zhang & Yanling He
Pages: 5373-5385
Published online: 26 Sep 2023
AbstractforTYK2 in Immune Responses and Treatment of Psoriasis | Full Text | References | PDF (1.7 MB) | EPUB
  • 194 Views
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CORRIGENDUM

Correction
Clinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai–Dorfman Disease [Corrigendum]
Pages: 3769-3770
Published online: 17 Sep 2022
CitationforClinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai–Dorfman Disease [Corrigendum] | Full Text | PDF (126.1 KB) | EPUB
  • 90 Views
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CASE REPORT

Case Report
Interstitial Lung Disease as an Extraintestinal Manifestation of Crohn’s Disease in the Time of COVID-19: A Rare Case Report and Review of the Literature
Lin Li, Pengwei Liu, Xiaoping Niu & Chiyi He
Pages: 5733-5737
Published online: 26 Sep 2023
AbstractforInterstitial Lung Disease as an Extraintestinal Manifestation of Crohn’s Disease in the Time of COVID-19: A Rare Case Report and Review of the Literature | Full Text | References | PDF (2.3 MB) | EPUB
  • 78 Views
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REVIEW

Review
Platelets, Macrophages, and Thromboinflammation in Chagas Disease
Subhadip Choudhuri & Nisha J Garg
Pages: 5689-5706
Published online: 26 Sep 2023
AbstractforPlatelets, Macrophages, and Thromboinflammation in Chagas Disease | Full Text | References | PDF (5.8 MB) | EPUB
  • 108 Views
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ORIGINAL RESEARCH

Article
A Rapid Prognostic Score Based on Bedside Arterial Blood Gas Analysis (ABG) Established for Predicting 60-Day Adverse Outcomes in Patients with Acute Pancreatitis in the Emergency Department
Qiang Lai, Wei Wei, Yarong He, Tao Cheng, Tianyong Han & Yu Cao
Pages: 5337-5346
Published online: 15 Sep 2022
AbstractforA Rapid Prognostic Score Based on Bedside Arterial Blood Gas Analysis (ABG) Established for Predicting 60-Day Adverse Outcomes in Patients with Acute Pancreatitis in the Emergency Department | Full Text | References | PDF (513.3 KB) | EPUB
  • 99 Views
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Article
The Pre-Ablation Circulating Tumor-Associated Inflammatory Index Predicts the Prognosis of Patients with Liver Metastasis from Pancreatic Cancer
Yujie Li, Linjia Peng, Ke Zhang, Yong Wu, Huifeng Gao & Hao Chen
Pages: 5977-5987
Published online: 26 Sep 2023
AbstractforThe Pre-Ablation Circulating Tumor-Associated Inflammatory Index Predicts the Prognosis of Patients with Liver Metastasis from Pancreatic Cancer | Full Text | References | PDF (5.5 MB) | EPUB
  • 91 Views
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REVIEW

Review
Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications
Yuying Ge, Yuying Chen, Chijiao Guo, Huan Luo, Fangda Fu, Weifeng Ji, Chengliang Wu & Hongfeng Ruan
Pages: 5857-5871
Published online: 17 Oct 2022
AbstractforPyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications | Full Text | References | PDF (2.7 MB) | EPUB
  • 213 Views
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CORRIGENDUM

Correction
Identification of a circRNA/miRNA/mRNA ceRNA Network as a Cell Cycle-Related Regulator for Chronic Sinusitis with Nasal Polyps [Corrigendum]
Pages: 4345-4346
Published online: 26 Sep 2023
CitationforIdentification of a circRNA/miRNA/mRNA ceRNA Network as a Cell Cycle-Related Regulator for Chronic Sinusitis with Nasal Polyps [Corrigendum] | Full Text | PDF (125.3 KB) | EPUB
  • 54 Views
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ORIGINAL RESEARCH

Article
α-Chaconine Facilitates Chondrocyte Pyroptosis and Nerve Ingrowth to Aggravate Osteoarthritis Progression by Activating NF-κB Signaling
Zhiguo Zhang, Fangda Fu, Yishan Bian, Huihao Zhang, Sai Yao, Chengcong Zhou, Yuying Ge, Huan Luo, Yuying Chen, Weifeng Ji, Kun Tian, Ming Yue, Weibin Du, Hongting Jin, Peijian Tong, Chengliang Wu & Hongfeng Ruan
Pages: 5873-5888
Published online: 26 Sep 2023
Abstractforα-Chaconine Facilitates Chondrocyte Pyroptosis and Nerve Ingrowth to Aggravate Osteoarthritis Progression by Activating NF-κB Signaling | Full Text | References | PDF (13.5 MB) | EPUB
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RETRACTION

Retraction
SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury [Retraction]
Pages: 4105-4106
Published online: 20 Jul 2022
CitationforSIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury [Retraction] | Full Text | PDF (131.5 KB) | EPUB
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ORIGINAL RESEARCH

Article
Tumor Necrosis Factor Alpha Level in the Uterine Fluid of Patients with Polycystic Ovary Syndrome and Its Correlation with Clinical Parameters
Ling-Xia Ha, Wei-Xia Li, Yu-Dong Du, Ying-Ying Yuan & Xiao-Xiao Qu
Pages: 6015-6020
Published online: 29 Oct 2022
AbstractforTumor Necrosis Factor Alpha Level in the Uterine Fluid of Patients with Polycystic Ovary Syndrome and Its Correlation with Clinical Parameters | Full Text | References | PDF (380.4 KB) | EPUB
  • 138 Views
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Article
Association Between Neutrophil-to-Lymphocyte Ratio/Lymphocyte-to-Monocyte Ratio and In-Hospital Clinical Outcomes in Ischemic Stroke Treated with Intravenous Thrombolysis
Guangshuo Li, Yahui Hao, Chuanying Wang, Shang Wang, Yunyun Xiong & Xingquan Zhao
Pages: 5567-5578
Published online: 24 Sep 2022
AbstractforAssociation Between Neutrophil-to-Lymphocyte Ratio/Lymphocyte-to-Monocyte Ratio and In-Hospital Clinical Outcomes in Ischemic Stroke Treated with Intravenous Thrombolysis | Full Text | References | PDF (1 MB) | EPUB
  • 78 Views
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Article
Resveratrol Prevents Skeletal Muscle Atrophy and Senescence via Regulation of Histone Deacetylase 2 in Cigarette Smoke-Induced Mice with Emphysema
Chao Li, ZhaoHui Deng, GuiXian Zheng, Ting Xie, XinYan Wei, ZengYu Huo & Jing Bai
Pages: 5425-5437
Published online: 16 Sep 2022
AbstractforResveratrol Prevents Skeletal Muscle Atrophy and Senescence via Regulation of Histone Deacetylase 2 in Cigarette Smoke-Induced Mice with Emphysema | Full Text | References | PDF (10.9 MB) | EPUB
  • 129 Views
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Article
The Relationship Between Plasma Selenium, Antioxidant Status, Inflammatory Responses and Ischemic Cardiomyopathy: A Case-Control Study Based on Matched Propensity Scores
Yinhua Luo, Xiaohong He, Linbo Hu, Jinbo Zhao, Ke Su, Yuhua Lei & Yuanhong Li
Pages: 5757-5765
Published online: 26 Sep 2023
AbstractforThe Relationship Between Plasma Selenium, Antioxidant Status, Inflammatory Responses and Ischemic Cardiomyopathy: A Case-Control Study Based on Matched Propensity Scores | Full Text | References | PDF (443.8 KB) | EPUB
  • 99 Views
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CORRIGENDUM

Correction
Necroptosis-Mediated eCIRP Release in Sepsis [Corrigendum]
Pages: 4347-4348
Published online: 26 Sep 2023
CitationforNecroptosis-Mediated eCIRP Release in Sepsis [Corrigendum] | Full Text | PDF (126.8 KB) | EPUB
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ORIGINAL RESEARCH

Article
Potential Roles of miRNAs in Acute Rejection for Vascularized Composite Allotransplantation
Haibo Li, Yuan Fang, Xu Li, Jingting Chen, Yao Xiong, Yongzhou Shi, Shengli Li, Lincai Ye, Shoubao Wang & Jianda Zhou
Pages: 6021-6030
Published online: 28 Oct 2022
AbstractforPotential Roles of miRNAs in Acute Rejection for Vascularized Composite Allotransplantation | Full Text | References | PDF (4.1 MB) | EPUB
  • 82 Views
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Article
Predicting the Recurrence of Operable Cervical Cancer Patients Based on Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Classical Clinicopathological Parameters
Peng Jiang, Wei Kong, Chunxia Gong, Yanlin Chen, Fenglian Li, Lingya Xu, Yang Yang, Shikai Gou & Zhuoying Hu
Pages: 5265-5281
Published online: 12 Sep 2022
AbstractforPredicting the Recurrence of Operable Cervical Cancer Patients Based on Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Classical Clinicopathological Parameters | Full Text | References | PDF (5.9 MB) | EPUB
  • 139 Views
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Article
Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results
Zhiquan Ding, Zhenzhong Zhong, Jun Wang, Run Zhang, Jinlian Shao, Yulong Li, Guiwei Wu, Huiru Tu, Wen Yuan, Haitao Sun & Qinghua Wang
Pages: 5917-5933
Published online: 26 Sep 2023
AbstractforInhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results | Full Text | References | PDF (10.7 MB) | EPUB
  • 127 Views
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Article
Water Extract of Senecio scandens Buch.-Ham Ameliorates Pruritus by Inhibiting MrgprB2 Receptor
Fan Ye, Yucui Jiang, Jian Zhang, Yingxin Zong, Mei Yu, Cuihua Chen, Chan Zhu, Yan Yang, Keke Jia, Gongxi Chen & Zongxiang Tang
Pages: 5989-5998
Published online: 26 Sep 2023
AbstractforWater Extract of Senecio scandens Buch.-Ham Ameliorates Pruritus by Inhibiting MrgprB2 Receptor | Full Text | References | PDF (4.7 MB) | EPUB
  • 57 Views
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Article
Low Level FLT3LG is a Novel Poor Prognostic Biomarker for Cervical Cancer with Immune Infiltration
Lihua chen, Yuxuan Huang, Binhua Dong, Yu Gu, Ye Li, Wei Cang, Pengming Sun & Yang Xiang
Pages: 5889-5904
Published online: 19 Oct 2022
AbstractforLow Level FLT3LG is a Novel Poor Prognostic Biomarker for Cervical Cancer with Immune Infiltration | Full Text | References | PDF (13 MB) | EPUB
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LETTER

ANCA Associated Vasculitis Subtypes: Response [Letter]
Peter A Merkel, David RW Jayne & Pirow Bekker
Pages: 5161-5162
Published online: 09 Sep 2022
CitationforANCA Associated Vasculitis Subtypes: Response [Letter] | Full Text | References | PDF (178.6 KB) | EPUB
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ORIGINAL RESEARCH

Article
Low Pre-ChemoradiotherapyPan-Immune-Inflammation Value (PIV) Measures Predict Better Survival Outcomes in Locally Advanced Pancreatic Adenocarcinomas
Erkan Topkan, Ugur Selek, Ahmet Kucuk & Berrin Pehlivan
Pages: 5413-5423
Published online: 26 Sep 2023
AbstractforLow Pre-ChemoradiotherapyPan-Immune-Inflammation Value (PIV) Measures Predict Better Survival Outcomes in Locally Advanced Pancreatic Adenocarcinomas | Full Text | References | PDF (1.7 MB) | EPUB
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RAPID COMMUNICATION

Rapid Communication
Single-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee
Wang Tang, Zhen-Wei Li, Gui-Qiang Miao, Zhi-Peng Li, Tao Gui, Chong-Jie Wu, Zhen-Yan Li, Jie Yang, Xiao-Dong Zhao, Ning Liu, Zhen-Gang Zha, Lu-Tian Yao & Huan-Tian Zhang
Pages: 6105-6112
Published online: 05 Nov 2022
AbstractforSingle-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee | Full Text | References | PDF (5.1 MB) | EPUB
  • 174 Views
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ORIGINAL RESEARCH

Article
Inflammation-Based Scores Predict Responses to PD-1 Inhibitor Treatment in Intrahepatic Cholangiocarcinoma
Zhenyun Yang, Deyao Zhang, Huilan Zeng, Yizhen Fu, Zili Hu, Yangxun Pan, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Li Xu, Dandan Hu & Minshan Chen
Pages: 5721-5731
Published online: 06 Oct 2022
AbstractforInflammation-Based Scores Predict Responses to PD-1 Inhibitor Treatment in Intrahepatic Cholangiocarcinoma | Full Text | References | PDF (2.3 MB) | EPUB
  • 68 Views
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Article
Systemic Immune-Inflammation Index Predicts Long-Term Outcomes in Patients with Three-Vessel Coronary Disease After Revascularization: Results from a Large Cohort of 3561 Patients
Ji Zhao, Haichen Lv, Da Yin, Xuchen Zhou, Hao Zhu, Lei Guo & Junjie Wang
Pages: 5283-5292
Published online: 26 Sep 2023
AbstractforSystemic Immune-Inflammation Index Predicts Long-Term Outcomes in Patients with Three-Vessel Coronary Disease After Revascularization: Results from a Large Cohort of 3561 Patients | Full Text | References | PDF (1.5 MB) | EPUB
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LETTER

Long-Term Efficacy and Low Adverse Events of Methylprednisolone Pulses Combined to Low-Dose Glucocorticoids for Systemic Sclerosis: A Retrospective Clinical Study of 10 Years’ Follow-Up [Letter]
Mingrui Xie
Pages: 5041-5042
Published online: 02 Sep 2022
CitationforLong-Term Efficacy and Low Adverse Events of Methylprednisolone Pulses Combined to Low-Dose Glucocorticoids for Systemic Sclerosis: A Retrospective Clinical Study of 10 Years’ Follow-Up [Letter] | Full Text | References | PDF (182.9 KB) | EPUB
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CORRIGENDUM

Correction
Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer [Corrigendum]
Pages: 5157-5159
Published online: 09 Sep 2022
First Page PreviewforDevelopment and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer [Corrigendum] | Full Text | PDF (2.8 MB) | EPUB
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ORIGINAL RESEARCH

Article
Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats
Harzhin Hiwa Ali, Zheen Aorahman Ahmed & Tavag Ahmed Aziz
Pages: 6113-6124
Published online: 26 Sep 2023
AbstractforEffect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats | Full Text | References | PDF (3.4 MB) | EPUB
  • 229 Views
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RETRACTION

Retraction
1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway [Retraction]
Pages: 6013-6014
Published online: 31 Oct 2022
Citationfor1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway [Retraction] | Full Text | PDF (265.6 KB) | EPUB
  • 53 Views
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Retraction
Repurposing FDA Approved Drugs as JNK3 Inhibitor for Prevention of Neuroinflammation Induced by MCAO in Rats [Retraction]
Pages: 6069-6070
Published online: 07 Nov 2022
CitationforRepurposing FDA Approved Drugs as JNK3 Inhibitor for Prevention of Neuroinflammation Induced by MCAO in Rats [Retraction] | Full Text | PDF (243.4 KB) | EPUB
  • 48 Views
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Retraction
Natural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors via the Nrf2/HO-1 Pathway [Retraction]
Pages: 6071-6072
Published online: 07 Nov 2022
CitationforNatural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors via the Nrf2/HO-1 Pathway [Retraction] | Full Text | PDF (240.8 KB) | EPUB
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REVIEW

Review
Monitoring and Management of the Patient with Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis: Current Perspectives
Karmela K Chan & Anne R Bass
Pages: 3105-3118
Published online: 11 Oct 2022
AbstractforMonitoring and Management of the Patient with Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis: Current Perspectives | Full Text | References | PDF (459.7 KB) | EPUB
  • 345 Views
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ORIGINAL RESEARCH

Article
The Multi-Omics Analysis of Key Genes Regulating EGFR-TKI Resistance, Immune Infiltration, SCLC Transformation in EGFR-Mutant NSCLC
Zhi Wang, Lingling Zhang, Wenwen Xu, Jie Li, Yi Liu, Xiaozhu Zeng, Maoxi Zhong & Yuxi Zhu
Pages: 649-667
Published online: 11 Oct 2022
AbstractforThe Multi-Omics Analysis of Key Genes Regulating EGFR-TKI Resistance, Immune Infiltration, SCLC Transformation in EGFR-Mutant NSCLC | Full Text | References | PDF (15.8 MB) | EPUB
  • 343 Views
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Article
The Specific Changes of Urine Raman Spectra Can Serve as Novel Diagnostic Tools for Disease Characteristics in Patients with Crohn’s Disease
Yaling Wu, Zijie Wang, Mengmeng Xing, Bingyan Li, Zhiyuan Liu, Peng Du, Huinan Yang & Xiaolei Wang
Pages: 897-910
Published online: 11 Oct 2022
AbstractforThe Specific Changes of Urine Raman Spectra Can Serve as Novel Diagnostic Tools for Disease Characteristics in Patients with Crohn’s Disease | Full Text | References | PDF (5.1 MB) | EPUB
  • 164 Views
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Article
Serum Albumin to Globulin Ratio is Associated with the Presence and Severity of Inflammatory Bowel Disease
Yanyan Wang, Chengyong Li, Weiyi Wang, Jiajia Wang, Jinhui Li, Shuangjie Qian, Chao Cai & Yuntao Liu
Pages: 1907-1920
Published online: 14 Mar 2022
AbstractforSerum Albumin to Globulin Ratio is Associated with the Presence and Severity of Inflammatory Bowel Disease | Full Text | References | PDF (5.7 MB) | EPUB
  • 424 Views
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Article
Quantile-Specific Heritability of Inflammatory and Oxidative Stress Biomarkers Linked to Cardiovascular Disease
Paul T Williams
Pages: 85-103
Published online: 11 Oct 2022
AbstractforQuantile-Specific Heritability of Inflammatory and Oxidative Stress Biomarkers Linked to Cardiovascular Disease | Full Text | References | PDF (7.2 MB) | EPUB
  • 154 Views
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REVIEW

Review
Health and Environmental Risks of Incense Smoke: Mechanistic Insights and Cumulative Evidence
Virendra Kumar Yadav, Parth Malik, Vineet Tirth, Samreen Heena Khan, Krishna Kumar Yadav, Saiful Islam, Nisha Choudhary, Gajendra Kumar Inwati, Amir Arabi, Do-Hyeon Kim & Byong-Hun Jeon
Pages: 2665-2693
Published online: 11 Oct 2022
AbstractforHealth and Environmental Risks of Incense Smoke: Mechanistic Insights and Cumulative Evidence | Full Text | References | PDF (8.6 MB) | EPUB
  • 1155 Views
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ORIGINAL RESEARCH

Article
SCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops
Anna Pacwa, Joanna Machowicz, Alicja Wojtyniak, Marita Pietrucha-Dutczak, Elisa Toropainen, Ali Koskela, Ewa Mrukwa-Kominek, Joanna Lewin-Kowalik & Adrian Smedowski
Pages: 793-806
Published online: 11 Oct 2022
AbstractforSCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops | Full Text | References | PDF (10.9 MB) | EPUB
  • 170 Views
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PERSPECTIVES

Article
Clevidipine and COVID 19: From Hypertension to Inflammatory Response
Jose Luis Guerrero Orriach & Guillermo Quesada Muñoz
Pages: 2383-2386
Published online: 13 Apr 2022
AbstractforClevidipine and COVID 19: From Hypertension to Inflammatory Response | Full Text | References | PDF (306.3 KB) | EPUB
  • 118 Views
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ORIGINAL RESEARCH

Article
Predictive Value of the Baseline and Early Changes in Blood Eosinophils for Short-Term Mortality in Patients with Acute Respiratory Distress Syndrome
Junnan Peng, Rui Tang, Di Qi, Qian Yu, Hao Hu, Wen Tang, Jing He & Daoxin Wang
Pages: 1845-1858
Published online: 14 Mar 2022
AbstractforPredictive Value of the Baseline and Early Changes in Blood Eosinophils for Short-Term Mortality in Patients with Acute Respiratory Distress Syndrome | Full Text | References | PDF (6.2 MB) | EPUB
  • 133 Views
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Article
The Complement and Coagulation Cascades Pathway is Associated with Acute Necrotizing Pancreatitis by Genomics and Proteomics Analysis
Xinyu Zhang, Zenghui Li, Wei Liu, Juanjuan Du, Yun Liu, Ningjun Yu, Chao Liu, Mei Zeng & Xiaoming Zhang
Pages: 2349-2363
Published online: 13 Apr 2022
AbstractforThe Complement and Coagulation Cascades Pathway is Associated with Acute Necrotizing Pancreatitis by Genomics and Proteomics Analysis | Full Text | References | PDF (4.8 MB) | EPUB
  • 184 Views
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CASE SERIES

Article
Lenalidomide Improves Cognitive Function and Reduces Immune Reconstitution Inflammatory Syndrome in HIV-1-Related Cryptococcal Meningitis
Ran Tao, Xiaorong Peng, Xiang Liu, Junwei Su, Guanjing Lang, Ying Huang, Yafei Zhang & Biao Zhu
Pages: 2891-2899
Published online: 11 Oct 2022
AbstractforLenalidomide Improves Cognitive Function and Reduces Immune Reconstitution Inflammatory Syndrome in HIV-1-Related Cryptococcal Meningitis | Full Text | References | PDF (2.6 MB) | EPUB
  • 169 Views
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ORIGINAL RESEARCH

Article
Establishment of a Stable Acute Drug-Induced Liver Injury Mouse Model by Sodium Cyclamate
Quan Zhou, Zhongtian Peng & Xialing Huang
Pages: 1599-1615
Published online: 03 Mar 2022
AbstractforEstablishment of a Stable Acute Drug-Induced Liver Injury Mouse Model by Sodium Cyclamate | Full Text | References | PDF (10.1 MB) | EPUB
  • 183 Views
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Article
Identification of Key Genes and Potential Mechanisms Based on the Autophagy Regulatory Network in Osteoclasts Using a Murine Osteoarthritis Model
Haifeng Zhang, Houyi Sun, Wei Zhang, Yaozeng Xu & Dechun Geng
Pages: 2333-2347
Published online: 12 Apr 2022
AbstractforIdentification of Key Genes and Potential Mechanisms Based on the Autophagy Regulatory Network in Osteoclasts Using a Murine Osteoarthritis Model | Full Text | References | PDF (9.9 MB) | EPUB
  • 165 Views
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Article
Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease
Kritika Singh, Upendra Rathore, Mohit Kumar Rai, Manas R Behera, Neeraj Jain, Manish Ora, Dharmendra Bhadauria, Supriya Sharma, Gaurav Pande, Sanjay Gambhir, Alok Nath, Sudeep Kumar, Aman Sharma, Vikas Agarwal & Durga Prasanna Misra
Pages: 1521-1541
Published online: 01 Mar 2022
AbstractforNovel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease | Full Text | References | PDF (3.4 MB) | EPUB
  • 243 Views
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Article
Soluble Programmed Cell Death Protein 1 and Its Ligand: Potential Biomarkers to Predict Acute Kidney Injury After Surgery in Critically Ill Patients
Jingyi Wang, Xi Zheng, Yijia Jiang, Huimiao Jia, Xiaocui Shi, Yue Han, Qingping Li & Wenxiong Li
Pages: 1995-2008
Published online: 11 Oct 2022
AbstractforSoluble Programmed Cell Death Protein 1 and Its Ligand: Potential Biomarkers to Predict Acute Kidney Injury After Surgery in Critically Ill Patients | Full Text | References | PDF (7.7 MB) | EPUB
  • 142 Views
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Article
Adiponectin Ameliorates Hyperglycemia-Induced Retinal Endothelial Dysfunction, Highlighting Pathways, Regulators, and Networks
Sumbul Bushra, Duaa W Al-Sadeq, Redwana Bari, Afifah Sahara, Amina Fadel & Nasser Rizk
Pages: 3135-3166
Published online: 27 May 2022
AbstractforAdiponectin Ameliorates Hyperglycemia-Induced Retinal Endothelial Dysfunction, Highlighting Pathways, Regulators, and Networks | Full Text | References | PDF (11.3 MB) | EPUB
  • 194 Views
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Article
Prognostic Value of Serum Procalcitonin Based Model in Moderate to Severe Traumatic Brain Injury Patients
Ruoran Wang, Yusi Hua, Min He & Jianguo Xu
Pages: 4981-4993
Published online: 26 Sep 2023
AbstractforPrognostic Value of Serum Procalcitonin Based Model in Moderate to Severe Traumatic Brain Injury Patients | Full Text | References | PDF (2.6 MB) | EPUB
  • 100 Views
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Article
Identification of Immune-Related Genes in Patients with Acute Myocardial Infarction Using Machine Learning Methods
Xu Zhu, Ting Yin, Ting Zhang, Qingqing Zhu, Xinyi Lu, Luyang Wang, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang & Xinli Li
Pages: 3305-3321
Published online: 11 Oct 2022
AbstractforIdentification of Immune-Related Genes in Patients with Acute Myocardial Infarction Using Machine Learning Methods | Full Text | References | PDF (22.7 MB) | EPUB
  • 207 Views
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Article
Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population
Linfa Chen, Xinglan Chen, Yajun Wang, Shengnan Li, Shaoting Huang, Zhaochun Wu, Jiawen He, Shaofeng Chen, Fu Deng, Peiyi Zhu, Wangtao Zhong, Bin Zhao, Guoda Ma & You Li
Pages: 3355-3368
Published online: 11 Oct 2022
AbstractforPolymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population | Full Text | References | PDF (2 MB) | EPUB
  • 151 Views
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Article
Multi-Omics Analysis of Western-style Diet Increased Susceptibility to Experimental Colitis in Mice
Lihui Lin, Ying Li, Gaoshi Zhou, Ying Wang, Li Li, Jing Han, Minhu Chen, Yao He & Shenghong Zhang
Pages: 2523-2537
Published online: 21 Apr 2022
AbstractforMulti-Omics Analysis of Western-style Diet Increased Susceptibility to Experimental Colitis in Mice | Full Text | References | PDF (9.8 MB) | EPUB
  • 166 Views
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SHORT REPORT

Brief Report
Pulsed-Ultrasound Irradiation Induces the Production of Itaconate and Attenuates Inflammatory Responses in Macrophages
Atomu Yamaguchi, Noriaki Maeshige, Xiaoqi Ma, Mikiko Uemura, Hikari Noguchi, Mami Matsuda, Yuya Nishimura, Tomohisa Hasunuma, Hiroyo Kondo & Hidemi Fujino
Pages: 2387-2395
Published online: 11 Oct 2022
AbstractforPulsed-Ultrasound Irradiation Induces the Production of Itaconate and Attenuates Inflammatory Responses in Macrophages | Full Text | References | PDF (4.1 MB) | EPUB
  • 217 Views
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ORIGINAL RESEARCH

Article
Early Humoral Responses of Hemodialysis Patients After Inactivated SARS-CoV-2 Vaccination
Wen-Man Zhao, Rui Shi, Peng Wang, Jun He, Yue Chen, Ya-Ting Feng, Hai-Feng Pan & De-Guang Wang
Pages: 3467-3475
Published online: 14 Jun 2022
AbstractforEarly Humoral Responses of Hemodialysis Patients After Inactivated SARS-CoV-2 Vaccination | Full Text | References | PDF (507.8 KB) | EPUB
  • 119 Views
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Article
CREST Syndrome in Systemic Sclerosis Patients – Is Dystrophic Calcinosis a Key Element to a Positive Diagnosis?
Carmen Bobeica, Elena Niculet, Mihaela Craescu, Elena-Laura Parapiru, Carmina Liana Musat, Ciprian Dinu, Iulia Chiscop, Luiza Nechita, Mihaela Debita, Victorita Stefanescu, Ioana Anca Stefanopol, Alexandru Nechifor, Ana Maria Pelin, Gabriela Balan, Silvia Chirobocea, Claudiu Ionut Vasile & Alin Laurentiu Tatu
Pages: 3387-3394
Published online: 09 Jun 2022
AbstractforCREST Syndrome in Systemic Sclerosis Patients – Is Dystrophic Calcinosis a Key Element to a Positive Diagnosis? | Full Text | References | PDF (1.2 MB) | EPUB
  • 330 Views
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Article
An AAV-Based NF-κB-Targeting Gene Therapy (rAAV-DMP-miR533) to Inflammatory Diseases
Tao Luo, Yile Wang, Hailin Tang, Fei Zhou, Ying Chen, Bing Pei & Jinke Wang
Pages: 3447-3466
Published online: 14 Jun 2022
AbstractforAn AAV-Based NF-κB-Targeting Gene Therapy (rAAV-DMP-miR533) to Inflammatory Diseases | Full Text | References | PDF (9.3 MB) | EPUB
  • 182 Views
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Article
The Efficacy of Percutaneous Transhepatic Gallbladder Drainage Combined with Gallbladder-Preserving Cholecystolithotomy in High-Risk Patients with Acute Calculous Cholecystitis
Chunbo Kang, Jie Zhang, Shiyang Hou, Jinlei Wang, Xubin Li, Xiaowei Li, Xiaoqian Chi, Haifeng Shan, Qijun Zhang & Tiejun Liu
Pages: 2901-2910
Published online: 10 May 2022
AbstractforThe Efficacy of Percutaneous Transhepatic Gallbladder Drainage Combined with Gallbladder-Preserving Cholecystolithotomy in High-Risk Patients with Acute Calculous Cholecystitis | Full Text | References | PDF (2 MB) | EPUB
  • 268 Views
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Article
Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype
Jesús Beltrán-García, Rebeca Osca-Verdegal, Daniel Pérez-Cremades, Susana Novella, Carlos Hermenegildo, Federico V Pallardó & José Luis García-Giménez
Pages: 4217-4238
Published online: 25 Jul 2022
AbstractforExtracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype | Full Text | References | PDF (9.4 MB) | EPUB
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REVIEW

Review
The Influence of Arginine Methylation in Immunity and Inflammation
Nivine Srour, Sarah Khan & Stephane Richard
Pages: 2939-2958
Published online: 11 Oct 2022
AbstractforThe Influence of Arginine Methylation in Immunity and Inflammation | Full Text | References | PDF (2.1 MB) | EPUB
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ORIGINAL RESEARCH

Article
Clinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai–Dorfman Disease
Ming Tang, Xue-Zhong Gu, Peng-Chun Wu & Xuan-Tao Yang
Pages: 2775-2787
Published online: 29 Apr 2022
AbstractforClinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai–Dorfman Disease | Full Text | References | PDF (2.7 MB) | EPUB
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CLINICAL TRIAL REPORT

The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial
Ling Jin, Kai Fan, Shiwang Tan, Shangxi Liu, Qin Ge, Yang Wang, Zisheng Ai & Shaoqing Yu
Pages: 3983-3995
Published online: 15 Jul 2022
AbstractforThe Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial | Full Text | References | PDF (6.4 MB) | EPUB
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ORIGINAL RESEARCH

Article
Anticipation of Relapse and Acute Graft-Versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation: The Fundamental Role of Antigen-Presenting (Dendritic) Cells
Khalid Ali Nasif, Awad S Al Samghan, Nahla El-Sharkawy, Amr M Abass, Ebtesam Elgezawy, Safaa AA Khaled, Mahmoud I Elbadry & Marwa M Thabet
Pages: 3733-3747
Published online: 30 Jun 2022
AbstractforAnticipation of Relapse and Acute Graft-Versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation: The Fundamental Role of Antigen-Presenting (Dendritic) Cells | Full Text | References | PDF (6.4 MB) | EPUB
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CLINICAL TRIAL REPORT

Case Report
Imbalanced T-Cell Subsets May Facilitate the Occurrence of Osteonecrosis of the Femoral Head
Changjun Chen, Xin Zhao, Yue Luo, Bohua Li, Qianhao Li, Chengcheng Zhao, Yan Huang & Pengde Kang
Pages: 4159-4169
Published online: 22 Jul 2022
AbstractforImbalanced T-Cell Subsets May Facilitate the Occurrence of Osteonecrosis of the Femoral Head | Full Text | References | PDF (3.1 MB) | EPUB
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ORIGINAL RESEARCH

Article
Pulmonary Tuberculosis-Related Ischemic Stroke: A Retrospective Case Control Study
Yunfei Wei, Shiting Tang, Zhouhua Xie, Yaoqin He, Yunli Zhang, Yiju Xie, Shijian Chen, Liuyu Liu, Yayuan Liu & Zhijian Liang
Pages: 4239-4249
Published online: 26 Sep 2023
AbstractforPulmonary Tuberculosis-Related Ischemic Stroke: A Retrospective Case Control Study | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Blood Coral Polysaccharide Helps Prevent D-Gal/LPS-Induced Acute Liver Failure in Mice
Chong Li, Shu Lai, Ruokun Yi, Xianrong Zhou, Xin Zhao & Qiang Li
Pages: 4499-4513
Published online: 08 Aug 2022
AbstractforBlood Coral Polysaccharide Helps Prevent D-Gal/LPS-Induced Acute Liver Failure in Mice | Full Text | References | PDF (6.3 MB) | EPUB
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CASE SERIES

Case Report
Acquired Hemophilia Associated with Rheumatic Diseases: A Case-Based Systematic Review
Qi Tang, Jiafen Liao & Xi Xie
Pages: 4385-4393
Published online: 26 Sep 2023
AbstractforAcquired Hemophilia Associated with Rheumatic Diseases: A Case-Based Systematic Review | Full Text | References | PDF (3.3 MB) | EPUB
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CLINICAL TRIAL REPORT

Case Report
Anti-Inflammatory Effect of Ulinastatin on the Association Between Inflammatory Phenotypes in Acute Type A Aortic Dissection
Hong Liu, Si-chong Qian, Yong-feng Shao, Hai-yang Li & On behalf of the Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A) Investigators Group
Pages: 3709-3718
Published online: 27 Jun 2022
AbstractforAnti-Inflammatory Effect of Ulinastatin on the Association Between Inflammatory Phenotypes in Acute Type A Aortic Dissection | Full Text | References | PDF (2.7 MB) | EPUB
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STUDY PROTOCOL

Article
Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages
Kejun Peng, Nianhua Deng, Yao Meng, Qianchuan He, Hao Meng, Ting Luo, Yanru Wei, Yue Kang, Xiaodong Zhou & Fubing Shen
Pages: 4853-4872
Published online: 26 Sep 2023
AbstractforAlpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages | Full Text | References | PDF (14.5 MB) | EPUB
  • 98 Views
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CLINICAL TRIAL REPORT

Case Report
Variant Angina is Associated with Myocarditis
Xin Xu, James Jiqi Wang, Hu Zhao, Kun Miao, Guanglin Cui, Yuxuan Zhang, Xiaoyun Yang, Luyun Wang, Junfang Wu & Dao Wen Wang
Pages: 4939-4949
Published online: 26 Sep 2023
AbstractforVariant Angina is Associated with Myocarditis | Full Text | References | PDF (4 MB) | EPUB
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ORIGINAL RESEARCH

Article
PLXDC1 Can Be a Biomarker for Poor Prognosis and Immune Evasion in Gastric Cancer
Xinwei Li, Yongfei Fan, Mingyue Tang, Huiyuan Li, Yue Zhang, Jiaqi Mi, Yanyan Wang, Menglin Zhao, Zishu Wang & Fang Su
Pages: 5439-5455
Published online: 26 Sep 2023
AbstractforPLXDC1 Can Be a Biomarker for Poor Prognosis and Immune Evasion in Gastric Cancer | Full Text | References | PDF (13.1 MB) | EPUB
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RESPONSE TO LETTER

ANCA Associated Vasculitis Subtypes: Response [Response to Letter]
Keziah Austin, Shalini Janagan, Matthew Wells, Helena Crawshaw, Stephen McAdoo & Joanna C Robson
Pages: 5687-5688
Published online: 26 Sep 2023
CitationforANCA Associated Vasculitis Subtypes: Response [Response to Letter] | Full Text | References | PDF (291.3 KB) | EPUB
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