OncoTargets and Therapy, Volume 14, Issue (2021)

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OncoTargets and Therapy, Volume 14, Issue (2021)

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Original Research

Article
RETRACTED ARTICLE: Long Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression
Juliang He, Jian Guan, Shian Liao, Zhenjie Wu, Bin Liu, Hao Mo & Zhenchao Yuan
Pages: 1-13
Published online: 06 Jan 2021
AbstractforRETRACTED ARTICLE: Long Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression | PDF (9.1 MB)
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Open Access
Article
MiRNA-1225 Inhibits Osteosarcoma Tumor Growth and Progression by Targeting YWHAZ
Yubao Gong, Zhengren Wei & Jianguo Liu
Pages: 15-27
Published online: 06 Jan 2021
AbstractforMiRNA-1225 Inhibits Osteosarcoma Tumor Growth and Progression by Targeting YWHAZ | Full Text | References | PDF (9.1 MB)
  • 74 Views
  • 7 CrossRef citations
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Open Access
Article
Prognostic Value of Pretreatment Serum Cystatin C Level in Nasopharyngeal Carcinoma Patients in the Intensity-modulated Radiotherapy Era
Xi-Rong Tan, Sheng-Yan Huang, Sha Gong, Yang Chen, Xiao-Jing Yang, Qing-Mei He, Shi-Wei He, Na Liu & Ying-Qing Li
Pages: 29-37
Published online: 06 Jan 2021
AbstractforPrognostic Value of Pretreatment Serum Cystatin C Level in Nasopharyngeal Carcinoma Patients in the Intensity-modulated Radiotherapy Era | Full Text | References | PDF (1.7 MB)
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Open Access
Article
Clinicopathological and Prognostic Significance of Immunoscore and PD-L1 in Intrahepatic Cholangiocarcinoma
Hong Wu, Yulong Wei, Mei Jian, Hong Lu, Qingzhu Song, Liheng Hao & Yong Yue
Pages: 39-51
Published online: 06 Jan 2021
AbstractforClinicopathological and Prognostic Significance of Immunoscore and PD-L1 in Intrahepatic Cholangiocarcinoma | Full Text | References | PDF (7.5 MB)
  • 66 Views
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Open Access

Review

Review Article
Aberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer
Lianghua Fang, Qing Xu, Jun Qian & Jin-Yong Zhou
Pages: 53-65
Published online: 06 Jan 2021
AbstractforAberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer | Full Text | References | PDF (1.5 MB)
  • 111 Views
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Open Access

Original Research

Article
Silencing of MicroRNA-503 in Rat Mesenchymal Stem Cells Exerts Potent Antitumorigenic Effects in Lung Cancer Cells
Bo Huang, Zhichun Feng, Lina Zhu, Sheng Zhang, Jun Duan, Chaochao Zhao & Xiaoying Zhang
Pages: 67-81
Published online: 06 Jan 2021
AbstractforSilencing of MicroRNA-503 in Rat Mesenchymal Stem Cells Exerts Potent Antitumorigenic Effects in Lung Cancer Cells | Full Text | References | PDF (8.6 MB)
  • 48 Views
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Open Access
Article
Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling
Peihuan Li, Zhijie Wang, Shuai Li & Liuxing Wang
Pages: 83-95
Published online: 06 Jan 2021
AbstractforCirc_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling | Full Text | References | PDF (8.3 MB)
  • 63 Views
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Open Access
Article
Circ_0007444 Inhibits the Progression of Ovarian Cancer via Mediating the miR-570-3p/PTEN Axis
Xinyu Wu, Daoyan Liu, Shuzhen Wang & Jie Liu
Pages: 97-110
Published online: 07 Jan 2021
AbstractforCirc_0007444 Inhibits the Progression of Ovarian Cancer via Mediating the miR-570-3p/PTEN Axis | Full Text | References | PDF (6.8 MB)
  • 65 Views
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Open Access
Article
Inhibitory Effect of Crocin Against Gastric Carcinoma via Regulating TPM4 Gene
Yushuang Luo, Pengjie Yu, Junhui Zhao, Qijing Guo, Baohua Fan, Yinzhuo Diao, Yulong Jin, Jing Wu & Chengwu Zhang
Pages: 111-122
Published online: 07 Jan 2021
AbstractforInhibitory Effect of Crocin Against Gastric Carcinoma via Regulating TPM4 Gene | Full Text | References | PDF (8.2 MB)
  • 75 Views
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Open Access

Retraction

Retraction
Exosomal miR-638 Inhibits Hepatocellular Carcinoma Progression by Targeting SP1 [Retraction]
Page: 123
Published online: 08 Jan 2021
CitationforExosomal miR-638 Inhibits Hepatocellular Carcinoma Progression by Targeting SP1 [Retraction] | Full Text | PDF (164.2 KB)
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Open Access

Original Research

Article
PDIA4 Correlates with Poor Prognosis and is a Potential Biomarker in Glioma
Haoyu Li, Qing Liu, Kai Xiao, Zhengxi He, Chao Wu, Jianjun Sun, Xin Chen, Suhua Chen, Jun Yang, Qianquan Ma & Jun Su
Pages: 125-138
Published online: 08 Jan 2021
AbstractforPDIA4 Correlates with Poor Prognosis and is a Potential Biomarker in Glioma | Full Text | References | PDF (5.5 MB)
  • 63 Views
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Open Access

Case Report

Case Report
Rare Primary Pulmonary Primitive Neuroectodermal Tumor: A Case Report and Literature Review
Ning Wang, Shuang-Shuang Dong, Chun-Lin Wu, Ying Wang, Lian Meng, Yan Ren, Xiao-Bin Cui, Man Li & Yan Qi
Pages: 139-144
Published online: 08 Jan 2021
AbstractforRare Primary Pulmonary Primitive Neuroectodermal Tumor: A Case Report and Literature Review | Full Text | References | PDF (2.1 MB)
  • 74 Views
  • 1 CrossRef citations
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Open Access

Original Research

Article
ALYREF Drives Cancer Cell Proliferation Through an ALYREF-MYC Positive Feedback Loop in Glioblastoma
Jianjun Wang, Yuchen Li, Binbin Xu, Jiao Dong, Haiyan Zhao, Dongxia Zhao & Yong Wu
Pages: 145-155
Published online: 08 Jan 2021
AbstractforALYREF Drives Cancer Cell Proliferation Through an ALYREF-MYC Positive Feedback Loop in Glioblastoma | Full Text | References | PDF (2.4 MB)
  • 140 Views
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Open Access
Article
LncRNA DDX11-AS1 Exerts Oncogenic Roles in Glioma Through Regulating miR-499b-5p/RWDD4 Axis
Yanyan Zheng, Jing Xie, Xiaomin Xu, Xiaoguo Yang, Yi Zhou, Qiong Yao & Ye Xiong
Pages: 157-164
Published online: 08 Jan 2021
AbstractforLncRNA DDX11-AS1 Exerts Oncogenic Roles in Glioma Through Regulating miR-499b-5p/RWDD4 Axis | Full Text | References | PDF (4.2 MB)
  • 46 Views
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Open Access
Article
Upregulation of miR-137 Expression Suppresses Tumor Growth and Progression via Interacting with DNMT3a Through Inhibiting the PTEN/Akt Signaling in HCC
Jiachen Wang, Zhao Wang, Jiaxiang Yuan, Qun Wang & Xinsheng Shen
Pages: 165-176
Published online: 08 Jan 2021
AbstractforUpregulation of miR-137 Expression Suppresses Tumor Growth and Progression via Interacting with DNMT3a Through Inhibiting the PTEN/Akt Signaling in HCC | Full Text | References | PDF (8.8 MB)
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Open Access

Case Report

Case Report
Multi Cytogenetic Changes in a Patient as Co-Existing MDS and CLL Progresses
Xiangxin Li, Jiale Ma, Luqun Wang, Shuxin Yan, Fanglin Li, Lingling Wang, Lin Wang, Guosheng Li, Daoxin Ma & Hao Li
Pages: 177-186
Published online: 08 Jan 2021
AbstractforMulti Cytogenetic Changes in a Patient as Co-Existing MDS and CLL Progresses | Full Text | References | PDF (2.1 MB)
  • 57 Views
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Open Access

Original Research

Article
A Negative Feedback Loop Between NAMPT and TGF-β Signaling Pathway in Colorectal Cancer Cells
Xiaoqun Lv, Jinguo Zhang, Jun Zhang, Wencai Guan, Weifang Ren, Yujuan Liu & Guoxiong Xu
Pages: 187-198
Published online: 08 Jan 2021
AbstractforA Negative Feedback Loop Between NAMPT and TGF-β Signaling Pathway in Colorectal Cancer Cells | Full Text | References | PDF (7.4 MB)
  • 52 Views
  • 7 CrossRef citations
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Open Access
Article
ACTL6A Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells and Correlates with Poor Clinical Outcomes
Rui-zhe Li, Yun-yun Li, Hui Qin & Shan-shan Li
Pages: 199-211
Published online: 13 Jan 2021
AbstractforACTL6A Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells and Correlates with Poor Clinical Outcomes | Full Text | References | PDF (9 MB)
  • 64 Views
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Open Access
Article
The Plasma Concentration of D-Dimer is Associated with Neoadjuvant-Chemotherapy Efficacy and the Prognosis in Osteosarcoma
Yujing Huang, Zan Shen, Yang Yao, Aina He & Daliu Min
Pages: 213-220
Published online: 11 Jan 2021
AbstractforThe Plasma Concentration of D-Dimer is Associated with Neoadjuvant-Chemotherapy Efficacy and the Prognosis in Osteosarcoma | Full Text | References | PDF (426.7 KB)
  • 58 Views
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Open Access
Article
Ultrasound-Targeted Microbubble Destruction-Mediated Downregulation of EZH2 Inhibits Stemness and Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells
Jie Wu, Lulu Sun, Tingting Liu & Gang Dong
Pages: 221-237
Published online: 11 Jan 2021
AbstractforUltrasound-Targeted Microbubble Destruction-Mediated Downregulation of EZH2 Inhibits Stemness and Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells | Full Text | References | PDF (11.1 MB)
  • 120 Views
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Open Access
Article
Peroxiredoxin1 Knockdown Inhibits Oral Carcinogenesis via Inducing Cell Senescence Dependent on Mitophagy
Yunping Lu, Lingyu Li, Hui Chen, Xinying Jing, Min Wang, Lihua Ge, Jing Yang, Min Zhang & Xiaofei Tang
Pages: 239-251
Published online: 12 Jan 2021
AbstractforPeroxiredoxin1 Knockdown Inhibits Oral Carcinogenesis via Inducing Cell Senescence Dependent on Mitophagy | Full Text | References | PDF (12.5 MB)
  • 79 Views
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Open Access

Corrigendum

Correction
LHX6 Affects Erlotinib Resistance and Migration of EGFR-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling [Corrigendum]
Page: 253
Published online: 12 Jan 2021
CitationforLHX6 Affects Erlotinib Resistance and Migration of EGFR-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling [Corrigendum] | Full Text | PDF (230.9 KB)
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Open Access

Original Research

Article
GADD45B Facilitates Metastasis of Ovarian Cancer Through Epithelial–Mesenchymal Transition
Lanqing Gong, Liqiong Cai, Guodong Li, Jing Cai & Xiaoqing Yi
Pages: 255-269
Published online: 12 Jan 2021
AbstractforGADD45B Facilitates Metastasis of Ovarian Cancer Through Epithelial–Mesenchymal Transition | Full Text | References | PDF (12.5 MB)
  • 97 Views
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Open Access

Review

Review Article
The Biological Roles of Exosomal Long Non-Coding RNAs in Cancers
Miao Da, Hao Jiang, Yangyang Xie, Weili Jin & Shuwen Han
Pages: 271-287
Published online: 12 Jan 2021
AbstractforThe Biological Roles of Exosomal Long Non-Coding RNAs in Cancers | Full Text | References | PDF (3.8 MB)
  • 114 Views
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Open Access

Original Research

Article
Lobaplatin Enhances Radioactive 125I Seed-Induced Apoptosis and Anti-Proliferative Effect in Non-Small Cell Lung Cancer by Suppressing the AKT/mTOR Pathway
Jia-hui Rong, Dong Li & Yu-liang Li
Pages: 289-300
Published online: 12 Jan 2021
AbstractforLobaplatin Enhances Radioactive 125I Seed-Induced Apoptosis and Anti-Proliferative Effect in Non-Small Cell Lung Cancer by Suppressing the AKT/mTOR Pathway | Full Text | References | PDF (8.4 MB)
  • 52 Views
  • 6 CrossRef citations
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Open Access
Article
Physalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling
Yufei Fu, Fanfan Zhu, Zhongjun Ma, Bin Lv, Xi Wang, Chunyan Dai, Xiaoqiong Ma, Pei Liu, Hang Lv, Xin Chen, Zhe Chen & Li Shen
Pages: 301-314
Published online: 12 Jan 2021
AbstractforPhysalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling | Full Text | References | PDF (6.8 MB)
  • 106 Views
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Open Access

Review

Review Article
Further Understanding of Urokinase Plasminogen Activator Overexpression in Urothelial Bladder Cancer Progression, Clinical Outcomes and Potential Therapeutic Targets
Nico C Grossmann, Victor M Schuettfort, Benjamin Pradere, Marco Moschini, Fahad Quhal, Hadi Mostafaei, Francesco Soria, Satoshi Katayama, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Cédric Poyet, Mohammad Abufaraj, Pierre I Karakiewicz, Shahrokh F Shariat & David D’Andrea
Pages: 315-324
Published online: 13 Jan 2021
AbstractforFurther Understanding of Urokinase Plasminogen Activator Overexpression in Urothelial Bladder Cancer Progression, Clinical Outcomes and Potential Therapeutic Targets | Full Text | References | PDF (318.6 KB)
  • 72 Views
  • 4 CrossRef citations
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Open Access

Original Research

Article
miR-21 Induces Chemoresistance in Ovarian Cancer Cells via Mediating the Expression and Interaction of CD44v6 and P-gp
Yanqing Wang, Gantao Chen, Fangfang Dai, Li Zhang, Mengqin Yuan, Dongyong Yang, Shiyi Liu & Yanxiang Cheng
Pages: 325-336
Published online: 12 Jan 2021
AbstractformiR-21 Induces Chemoresistance in Ovarian Cancer Cells via Mediating the Expression and Interaction of CD44v6 and P-gp | Full Text | References | PDF (7 MB)
  • 110 Views
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Open Access
Article
Prognostic Significance of Preoperative Lymphocyte-to-C-Reactive Protein Ratio in Patients with Non-Metastatic Colorectal Cancer
Wenting Ou, Caijin Zhou, Xiaoqing Zhu, Lin Lin & Qingwen Xu
Pages: 337-346
Published online: 12 Jan 2021
AbstractforPrognostic Significance of Preoperative Lymphocyte-to-C-Reactive Protein Ratio in Patients with Non-Metastatic Colorectal Cancer | Full Text | References | PDF (601 KB)
  • 58 Views
  • 8 CrossRef citations
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Open Access

Case Report

Case Report
Case Report: Myeloid Sarcoma Development During Treatment for B Cell Lymphoblastic Lymphoma in a Boy with KRAS/NRAS Gene Mutations
Xiuli Yuan, Uet Yu, Senmin Chen, Huanli Xu, Meng Yi, Xianping Jiang, Jianming Song, Xiaowen Chen, Shiyang Chen, Zhenhu Lin, Changgang Li, Feiqiu Wen & Sixi Liu
Pages: 347-353
Published online: 13 Jan 2021
AbstractforCase Report: Myeloid Sarcoma Development During Treatment for B Cell Lymphoblastic Lymphoma in a Boy with KRAS/NRAS Gene Mutations | Full Text | References | PDF (4.9 MB)
  • 78 Views
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Open Access

Original Research

Article
CRNDE Contributes Cervical Cancer Progression by Regulating miR-4262/ZEB1 Axis
Lu Ren, Shaoqin Yang, Qinxue Cao & Jun Tian
Pages: 355-366
Published online: 13 Jan 2021
AbstractforCRNDE Contributes Cervical Cancer Progression by Regulating miR-4262/ZEB1 Axis | Full Text | References | PDF (7 MB)
  • 57 Views
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Open Access
Article
RETRACTED: LncRNA EWSAT1 Promotes Colorectal Cancer Progression Through Sponging miR-326 to Modulate FBXL20 Expression
Jing Liu, Shimei Huang, Xin Liao, Zhongsheng Chen, Lianghe Li, Lei Yu, Wei Zhan & Rui Li
Pages: 367-378
Published online: 13 Jan 2021
AbstractforRETRACTED: LncRNA EWSAT1 Promotes Colorectal Cancer Progression Through Sponging miR-326 to Modulate FBXL20 Expression | PDF (9.5 MB)
  • 39 Views
  • 13 CrossRef citations
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Open Access
Article
Aberrant SLC6A14 Expression Promotes Proliferation and Metastasis of Colorectal Cancer via Enhancing the JAK2/STAT3 Pathway
Hongli Mao, Jinxiu Sheng, Jinlin Jia, Chang Wang, Shanfeng Zhang, Hongle Li & Fucheng He
Pages: 379-392
Published online: 13 Jan 2021
AbstractforAberrant SLC6A14 Expression Promotes Proliferation and Metastasis of Colorectal Cancer via Enhancing the JAK2/STAT3 Pathway | Full Text | References | PDF (10.1 MB)
  • 109 Views
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Open Access
Article
Long Non-Coding RNA PCED1B-AS1 Promotes the Progression of Clear Cell Renal Cell Carcinoma Through miR-484/ZEB1 Axis
Jianhua Qin, Tingting Zhu, Weihua Wu, Huan Chen & Yi He
Pages: 393-402
Published online: 13 Jan 2021
AbstractforLong Non-Coding RNA PCED1B-AS1 Promotes the Progression of Clear Cell Renal Cell Carcinoma Through miR-484/ZEB1 Axis | Full Text | References | PDF (5.3 MB)
  • 67 Views
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Open Access
Article
The Value and Clinical Significance of ZNF582 Gene Methylation in the Diagnosis of Cervical Cancer
Chunhe Zhang, Shaowei Fu, Luyue Wang, Fang Wang, Dan Wu, Xiangyi Zhe, Huizhen Xin, Hongtao Li, Dongmei Li, Fuyuan Jin, Renfu Shao & Zemin Pan
Pages: 403-411
Published online: 14 Jan 2021
AbstractforThe Value and Clinical Significance of ZNF582 Gene Methylation in the Diagnosis of Cervical Cancer | Full Text | References | PDF (3.1 MB)
  • 81 Views
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Open Access
Article
Establishment of a Risk Signature Based on m6A RNA Methylation Regulators That Predicts Poor Prognosis in Renal Cell Carcinoma
Jingsun Wei, Yucheng Qian, Yang Tang, Xiaoxu Ge, Kai Jiang, Yimin Fang, Dongliang Fu, Xiangxing Kong, Qian Xiao & Kefeng Ding
Pages: 413-426
Published online: 14 Jan 2021
AbstractforEstablishment of a Risk Signature Based on m6A RNA Methylation Regulators That Predicts Poor Prognosis in Renal Cell Carcinoma | Full Text | References | PDF (11.2 MB)
  • 68 Views
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Open Access
Article
Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients
Xiao-Cui Nie, Fang He, Chong Lan, Ju-Min Niu & Pu Xia
Pages: 427-434
Published online: 14 Jan 2021
AbstractforCombined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients | Full Text | References | PDF (3.7 MB)
  • 75 Views
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Open Access
Article
HSDL2 Acts as a Promoter in Pancreatic Cancer by Regulating Cell Proliferation and Lipid Metabolism
Anna Han, Ran Xu, Ying Liu, Xianglin Yin, Zhenhua Lin & Wanshan Yang
Pages: 435-444
Published online: 14 Jan 2021
AbstractforHSDL2 Acts as a Promoter in Pancreatic Cancer by Regulating Cell Proliferation and Lipid Metabolism | Full Text | References | PDF (7.2 MB)
  • 91 Views
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Open Access
Article
O-GlcNAcylation Enhances NUSAP1 Stability and Promotes Bladder Cancer Aggressiveness
Yifan Chen, Ji Liu, Wentao Zhang, Aimaitiaji Kadier, Ruiliang Wang, Haimin Zhang & Xudong Yao
Pages: 445-454
Published online: 15 Jan 2021
AbstractforO-GlcNAcylation Enhances NUSAP1 Stability and Promotes Bladder Cancer Aggressiveness | Full Text | References | PDF (4.3 MB)
  • 69 Views
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Open Access
Article
MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase
Dorival Mendes Rodrigues-Junior, Maria Fernanda de Andrade Pelarin, Helena Bonciani Nader, André Luiz Vettore & Maria Aparecida Silva Pinhal
Pages: 455-467
Published online: 15 Jan 2021
AbstractforMicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase | Full Text | References | PDF (4.3 MB)
  • 93 Views
  • 16 CrossRef citations
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Open Access
Article
Neutral Desorption Extractive Electrospray Ionization Mass Spectrometry Analysis Sputum for Non-Invasive Lung Adenocarcinoma Detection
Qiaoling Zheng, Jianyong Zhang, Xinchen Wang, Wenxiong Zhang, Yipo Xiao, Sheng Hu & Jianjun Xu
Pages: 469-479
Published online: 15 Jan 2021
AbstractforNeutral Desorption Extractive Electrospray Ionization Mass Spectrometry Analysis Sputum for Non-Invasive Lung Adenocarcinoma Detection | Full Text | References | PDF (3.4 MB)
  • 78 Views
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Open Access
Article
PD-1 Expression in Pre-Treatment Follicular Lymphoma Predicts the Risk of Subsequent High-Grade Transformation
Marie Beck Enemark, Ida Monrad, Charlotte Madsen, Kristina Lystlund Lauridsen, Bent Honoré, Trine Lindhardt Plesner, Stephen Jacques Hamilton-Dutoit, Francesco d’Amore & Maja Ludvigsen
Pages: 481-489
Published online: 18 Jan 2021
AbstractforPD-1 Expression in Pre-Treatment Follicular Lymphoma Predicts the Risk of Subsequent High-Grade Transformation | Full Text | References | PDF (2.3 MB)
  • 47 Views
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Open Access
Article
Circ_0067835 Knockdown Enhances the Radiosensitivity of Colorectal Cancer by miR-296-5p/IGF1R Axis
Peng Wang, Yongmin Sun, Yang Yang, Yanzhao Chen & Hui Liu
Pages: 491-502
Published online: 18 Jan 2021
AbstractforCirc_0067835 Knockdown Enhances the Radiosensitivity of Colorectal Cancer by miR-296-5p/IGF1R Axis | Full Text | References | PDF (10.5 MB)
  • 55 Views
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Open Access

Review

Review Article
Role of Long Non-Coding RNAs in the Chemoresistance of Gastric Cancer: A Systematic Review
Zonglin Li, Muhan Lü, Yejiang Zhou, Linxia Xu, Yifan Jiang, Yi Liu, Xin Li & Min Song
Pages: 503-518
Published online: 18 Jan 2021
AbstractforRole of Long Non-Coding RNAs in the Chemoresistance of Gastric Cancer: A Systematic Review | Full Text | References | PDF (1.7 MB)
  • 126 Views
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Open Access

Original Research

Article
MiR-153-3p Suppresses Cell Proliferation, Invasion and Glycolysis of Thyroid Cancer Through Inhibiting E3F3 Expression
Xianzhao Deng, Bomin Guo & Youben Fan
Pages: 519-529
Published online: 18 Jan 2021
AbstractforMiR-153-3p Suppresses Cell Proliferation, Invasion and Glycolysis of Thyroid Cancer Through Inhibiting E3F3 Expression | Full Text | References | PDF (6.4 MB)
  • 45 Views
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Open Access
Article
lncRNA RAET1K Promotes the Progression of Acute Myeloid Leukemia by Targeting miR-503-5p/INPP4B Axis
Li Li, Dingming Wan, Lin Li, Yang Qin & Wang Ma
Pages: 531-544
Published online: 18 Jan 2021
AbstractforlncRNA RAET1K Promotes the Progression of Acute Myeloid Leukemia by Targeting miR-503-5p/INPP4B Axis | Full Text | References | PDF (9.1 MB)
  • 56 Views
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Open Access

Case Report

Case Report
Gastric Cancer Harboring an ERBB3 Mutation Treated with a Pyrotinib–Irinotecan Combo: A Case Study
Kailin Ding, Xian Chen, Yong Li, Wenzhu Li, Yongsong Ye, Tingting He, Wenjing Wang & Haibo Zhang
Pages: 545-550
Published online: 18 Jan 2021
AbstractforGastric Cancer Harboring an ERBB3 Mutation Treated with a Pyrotinib–Irinotecan Combo: A Case Study | Full Text | References | PDF (2.2 MB)
  • 93 Views
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Open Access

Original Research

Article
Propofol Inhibits the Progression of Cervical Cancer by Regulating HOTAIR/miR-129-5p/RPL14 Axis
Nai Sun, Wei Zhang, Jiaying Liu, Xiaochen Yang & Qinjun Chu
Pages: 551-564
Published online: 19 Jan 2021
AbstractforPropofol Inhibits the Progression of Cervical Cancer by Regulating HOTAIR/miR-129-5p/RPL14 Axis | Full Text | References | PDF (13.3 MB)
  • 72 Views
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Open Access
Article
RETRACTED ARTICLE: LncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis
Ke Wang, Yu-Bo Hu, Ye Zhao & Cong Ye
Pages: 565-576
Published online: 19 Jan 2021
AbstractforRETRACTED ARTICLE: LncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis | PDF (7.8 MB)
  • 14 Views
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Open Access
Article
Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer
Jiacheng Wu, Haifei Xu, Hao Ji, Baoqian Zhai, Jinfeng Zhu, Mingde Gao, Haixia Zhu & Xiaolin Wang
Pages: 577-587
Published online: 19 Jan 2021
AbstractforLow Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer | Full Text | References | PDF (3.1 MB)
  • 87 Views
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Open Access

Review

Review Article
Understanding Patterns of Brain Metastasis in Triple-Negative Breast Cancer and Exploring Potential Therapeutic Targets
Yan Lv, Xiao Ma, Yuxin Du & Jifeng Feng
Pages: 589-607
Published online: 22 Jan 2021
AbstractforUnderstanding Patterns of Brain Metastasis in Triple-Negative Breast Cancer and Exploring Potential Therapeutic Targets | Full Text | References | PDF (3.1 MB)
  • 362 Views
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Open Access

Original Research

Article
Identification and Targeting of Thomsen–Friedenreich and IL1RAP Antigens on Chronic Myeloid Leukemia Stem Cells Using Bi-Specific Antibodies
Raghda E Eldesouki, Chengxiang Wu, Fayez M Saleh, Eman Abdel-Moemen Mohammed, Soha Younes, Naglaa Elsayed Hassan, Theresa C Brown, Eckhard U Alt, James E Robinson, Fouad Mohamed Badr & Stephen E Braun
Pages: 609-621
Published online: 22 Jan 2021
AbstractforIdentification and Targeting of Thomsen–Friedenreich and IL1RAP Antigens on Chronic Myeloid Leukemia Stem Cells Using Bi-Specific Antibodies | Full Text | References | PDF (2.9 MB)
  • 117 Views
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Article
Decitabine and Cisplatin are Synergistic to Exert Anti-Tumor Effect on Gastric Cancer via Inducing Sox2 DNA Demethylation
Zhipeng Zhu, Sihao Lin, Xiaofang Wu, Jiuhua Xu, Lulu Li, Weipeng Ye, Jiayi Li & Zhengjie Huang
Pages: 623-636
Published online: 22 Jan 2021
AbstractforDecitabine and Cisplatin are Synergistic to Exert Anti-Tumor Effect on Gastric Cancer via Inducing Sox2 DNA Demethylation | Full Text | References | PDF (5.4 MB)
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Article
Knockdown of NIR Suppresses Breast Cancer Cell Proliferation via Promoting FOXO3
Bolin Chen, Chengcheng Dong, Fang Wang & Jiacai Wu
Pages: 637-651
Published online: 22 Jan 2021
AbstractforKnockdown of NIR Suppresses Breast Cancer Cell Proliferation via Promoting FOXO3 | Full Text | References | PDF (8.6 MB)
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Article
Circular RNA circSEC24A Promotes Cutaneous Squamous Cell Carcinoma Progression by Regulating miR-1193/MAP3K9 Axis
Xiaoyan Lu, Quan Gan & Caibin Gan
Pages: 653-666
Published online: 22 Jan 2021
AbstractforCircular RNA circSEC24A Promotes Cutaneous Squamous Cell Carcinoma Progression by Regulating miR-1193/MAP3K9 Axis | Full Text | References | PDF (10 MB)
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Review

Review Article
Role of Antizyme Inhibitor Proteins in Cancers and Beyond
Vennela Tulluri & Venkatesh V Nemmara
Pages: 667-682
Published online: 25 Jan 2021
AbstractforRole of Antizyme Inhibitor Proteins in Cancers and Beyond | Full Text | References | PDF (6.4 MB)
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Original Research

Article
LINC01278 is Highly Expressed in Osteosarcoma and Participates in the Development of Tumors by Mediating the miR-134-5p/KRAS Axis
Guo-Feng Zhang, Bai-Sui Zhou, Xiao-Chun An, Feng-Min An & Shan-Hui Li
Pages: 683-695
Published online: 26 Jan 2021
AbstractforLINC01278 is Highly Expressed in Osteosarcoma and Participates in the Development of Tumors by Mediating the miR-134-5p/KRAS Axis | Full Text | References | PDF (7.9 MB)
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Corrigendum

Correction
Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells [Corrigendum]
Pages: 697-698
Published online: 26 Jan 2021
CitationforChrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells [Corrigendum] | Full Text | PDF (2 MB)
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Original Research

Article
CPNE1 Enhances Colorectal Cancer Cell Growth, Glycolysis, and Drug Resistance Through Regulating the AKT-GLUT1/HK2 Pathway
Yuexia Wang, Shengli Pan, Xinhong He, Ying Wang, Haozhe Huang, Junxiang Chen, Yuhao Zhang, Zhijin Zhang & Xianju Qin
Pages: 699-710
Published online: 27 Jan 2021
AbstractforCPNE1 Enhances Colorectal Cancer Cell Growth, Glycolysis, and Drug Resistance Through Regulating the AKT-GLUT1/HK2 Pathway | Full Text | References | PDF (6.3 MB)
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Article
Identification of Critical Pathways and Potential Key Genes in Poorly Differentiated Pancreatic Adenocarcinoma
Yuanxiang Lu, Dongxiao Li, Ge Liu, Erwei Xiao, Senmao Mu, Yujin Pan, Fangyuan Qin, Yaping Zhai, Shaofeng Duan, Deyu Li & Guoyi Yan
Pages: 711-723
Published online: 27 Jan 2021
AbstractforIdentification of Critical Pathways and Potential Key Genes in Poorly Differentiated Pancreatic Adenocarcinoma | Full Text | References | PDF (9.3 MB)
  • 108 Views
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Article
LncRNA UCID Promotes Hepatocellular Carcinoma Metastasis via Stabilization of Snail
Shanshan Yuan, Wangli Si, Kun Zhuang, Yijun Li, Yanting Zhang, Jiaming Liu, Li Yang & Xin Zhang
Pages: 725-736
Published online: 28 Jan 2021
AbstractforLncRNA UCID Promotes Hepatocellular Carcinoma Metastasis via Stabilization of Snail | Full Text | References | PDF (9.3 MB)
  • 63 Views
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Article
Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles Promote Proliferation, Invasion and Migration of Osteosarcoma Cells via the lncRNA MALAT1/miR-143/NRSN2/Wnt/β-Catenin Axis
Fujiang Li, Xin Chen, Cong Shang, Qinglong Ying, Xianjun Zhou, Rongkun Zhu, Hongting Lu, Xiwei Hao, Qian Dong & Zhong Jiang
Pages: 737-749
Published online: 02 Feb 2021
AbstractforBone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles Promote Proliferation, Invasion and Migration of Osteosarcoma Cells via the lncRNA MALAT1/miR-143/NRSN2/Wnt/β-Catenin Axis | Full Text | References | PDF (8.9 MB)
  • 111 Views
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Article
LncRNA MCTP1-AS1 Regulates EMT Process in Endometrial Cancer by Targeting the miR-650/SMAD7 Axis
Qin Gao, Qin Huang, Fangbing Li & Fang Luo
Pages: 751-761
Published online: 03 Feb 2021
AbstractforLncRNA MCTP1-AS1 Regulates EMT Process in Endometrial Cancer by Targeting the miR-650/SMAD7 Axis | Full Text | References | PDF (2.9 MB)
  • 68 Views
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Article
Long Noncoding RNA JAKMIP2-AS1 Promotes the Growth of Colorectal Cancer and Indicates Poor Prognosis
Tianyi Ma, Tianyu Qiao, Ziming Yuan, Guiyu Wang, Rui Huang, Meng Wang, Hanqing Hu, Yihao Zhu, Xiaoming Zou & Xishan Wang
Pages: 763-772
Published online: 03 Feb 2021
AbstractforLong Noncoding RNA JAKMIP2-AS1 Promotes the Growth of Colorectal Cancer and Indicates Poor Prognosis | Full Text | References | PDF (3.8 MB)
  • 54 Views
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Article
Hypofractionated Low-Dose Radiotherapy Combined with Immune Checkpoint Inhibition in Metastatic Solid Tumors
Dongqing Li, Wenyu Zhu, Juying Zhou, Mingya Peng, Qian Geng, Xiaolin Pu, Mengjie Wang & Hua Jiang
Pages: 773-783
Published online: 04 Feb 2021
AbstractforHypofractionated Low-Dose Radiotherapy Combined with Immune Checkpoint Inhibition in Metastatic Solid Tumors | Full Text | References | PDF (1 MB)
  • 83 Views
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Article
Development of a Novel Highly Spontaneous Metastatic Model of Esophageal Squamous Cell Carcinoma Using Renal Capsule Technology
Pan Gao, Hongtao Liu, Zhenzhen Yang, Yiran Hui, Zhuangzhuang Shi, Zhen Yang, Min Song, Menghui Yao, Wenfei Fan, Jinhua Yang, Yibin Hao & Tianli Fan
Pages: 785-793
Published online: 04 Feb 2021
AbstractforDevelopment of a Novel Highly Spontaneous Metastatic Model of Esophageal Squamous Cell Carcinoma Using Renal Capsule Technology | Full Text | References | PDF (7.6 MB)
  • 61 Views
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Article
LncRNA FER1L4 Promotes Oral Squamous Cell Carcinoma Progression via Targeting miR-133a-5p/Prx1 Axis
Nan Zhang, Lingfang Zeng, Shouyi Wang, Ronghua Wang, Rui Yang, Zuolin Jin & Hong Tao
Pages: 795-806
Published online: 04 Feb 2021
AbstractforLncRNA FER1L4 Promotes Oral Squamous Cell Carcinoma Progression via Targeting miR-133a-5p/Prx1 Axis | Full Text | References | PDF (9.2 MB)
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Erratum

Correction
Triple Discordances in Receptor Status During Breast Cancer Local Progression and Metastases: Case Report and Literature Review [Erratum]
Page: 807
Published online: 04 Feb 2021
CitationforTriple Discordances in Receptor Status During Breast Cancer Local Progression and Metastases: Case Report and Literature Review [Erratum] | Full Text | PDF (179.2 KB)
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Original Research

Article
Identification of a Six-Gene Signature for Predicting the Overall Survival of Cervical Cancer Patients
Xiao Huo, Xiaoshuang Zhou, Peng Peng, Mei Yu, Ying Zhang, Jiaxin Yang, Dongyan Cao, Hengzi Sun & Keng Shen
Pages: 809-822
Published online: 05 Feb 2021
AbstractforIdentification of a Six-Gene Signature for Predicting the Overall Survival of Cervical Cancer Patients | Full Text | References | PDF (10.3 MB)
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Article
Sinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1
Xiaoyan Qu, Bing Yu, Mengmei Zhu, Xiaomei Li, Lishan Ma, Chuyin Liu, Yixing Zhang & Zhongping Cheng
Pages: 823-834
Published online: 05 Feb 2021
AbstractforSinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1 | Full Text | References | PDF (6 MB)
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Article
Combination Therapy with iRGD-antiCD3 and PD-1 Blockade Enhances Antitumor Potency of Cord Blood-Derived T Cells
Mei Zhu, Hongmei Wang, Shujuan Zhou, Jia Wei, Naiqing Ding, Jie Shao, Lixia Yu, Zhenqing Feng & Baorui Liu
Pages: 835-844
Published online: 05 Feb 2021
AbstractforCombination Therapy with iRGD-antiCD3 and PD-1 Blockade Enhances Antitumor Potency of Cord Blood-Derived T Cells | Full Text | References | PDF (4.8 MB)
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Article
Prognostic Value of Programmed Death Ligand-1 Expression on Tumor-Infiltrating Immune Cells in Patients Treated with Cisplatin-Based Combination Adjuvant Chemotherapy Following Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Retrospective Cohort Study
Dong Hyeon Lee, Jae Yong Jeong & Wan Song
Pages: 845-855
Published online: 05 Feb 2021
AbstractforPrognostic Value of Programmed Death Ligand-1 Expression on Tumor-Infiltrating Immune Cells in Patients Treated with Cisplatin-Based Combination Adjuvant Chemotherapy Following Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Retrospective Cohort Study | Full Text | References | PDF (3.2 MB)
  • 45 Views
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Article
Screening of Therapeutic Candidate Genes of Quercetin for Cervical Cancer and Analysis of Their Regulatory Network
Yuanyuan Li, Jiushe Kou, Tao Wu, Pengsheng Zheng & Xu Chao
Pages: 857-866
Published online: 05 Feb 2021
AbstractforScreening of Therapeutic Candidate Genes of Quercetin for Cervical Cancer and Analysis of Their Regulatory Network | Full Text | References | PDF (5.3 MB)
  • 86 Views
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Article
Expression of p16, p53, and TLR9 in HPV-Associated Head and Neck Squamous Cell Carcinoma: Clinicopathological Correlations and Potential Prognostic Significance
Shu Wang, Xibing Zhuang, Caixia Gao & Tiankui Qiao
Pages: 867-877
Published online: 05 Feb 2021
AbstractforExpression of p16, p53, and TLR9 in HPV-Associated Head and Neck Squamous Cell Carcinoma: Clinicopathological Correlations and Potential Prognostic Significance | Full Text | References | PDF (2 MB)
  • 102 Views
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Article
Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR
Yichao Gu, Fan Wu, Hao Wang, Jiang Chang, Yirui Wang & Xiangcheng Li
Pages: 879-890
Published online: 05 Feb 2021
AbstractforCircular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR | Full Text | References | PDF (10.1 MB)
  • 48 Views
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Article
LncRNA WT1-AS/miR-494-3p Regulates Cell Proliferation, Apoptosis, Migration and Invasion via PTEN/PI3K/AKT Signaling Pathway in Non-Small Cell Lung Cancer
Chaohui Wu, Jiansheng Yang, Rongbin Li, Xianbin Lin, Jiayun Wu & Jingyang Wu
Pages: 891-904
Published online: 09 Feb 2021
AbstractforLncRNA WT1-AS/miR-494-3p Regulates Cell Proliferation, Apoptosis, Migration and Invasion via PTEN/PI3K/AKT Signaling Pathway in Non-Small Cell Lung Cancer | Full Text | References | PDF (15.8 MB)
  • 98 Views
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Article
Baicalein Represses Cervical Cancer Cell Growth, Cell Cycle Progression and Promotes Apoptosis via Blocking AKT/mTOR Pathway by the Regulation of circHIAT1/miR-19a-3p Axis
Jiaojiao Hu, Runkun Wang, Yi Liu, Jianbo Zhou, Ka Shen & Yun Dai
Pages: 905-916
Published online: 09 Feb 2021
AbstractforBaicalein Represses Cervical Cancer Cell Growth, Cell Cycle Progression and Promotes Apoptosis via Blocking AKT/mTOR Pathway by the Regulation of circHIAT1/miR-19a-3p Axis | Full Text | References | PDF (8.1 MB)
  • 115 Views
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Review

Review Article
Research Progress on Regulating LncRNAs of Hepatocellular Carcinoma Stem Cells
Xiaoli Zhang & Ying Zhu
Pages: 917-927
Published online: 10 Feb 2021
AbstractforResearch Progress on Regulating LncRNAs of Hepatocellular Carcinoma Stem Cells | Full Text | References | PDF (984.6 KB)
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Case Report

Case Report
Successful Use of Nivolumab in a Patient with Head and Neck Cancer After Allogeneic Bone Marrow Transplantation
Xiaopei Dong, Ning Lu, Zhongsheng Tong & Yehui Shi
Pages: 929-936
Published online: 10 Feb 2021
AbstractforSuccessful Use of Nivolumab in a Patient with Head and Neck Cancer After Allogeneic Bone Marrow Transplantation | Full Text | References | PDF (590.3 KB)
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Original Research

Article
TEAD4 as a Prognostic Marker Promotes Cell Migration and Invasion of Urinary Bladder Cancer via EMT
Zhengnan Huang, Yilin Yan, Pengfei Tang, Jinming Cai, Xiangqian Cao, Zeyi Wang, Fang Zhang & Bing Shen
Pages: 937-949
Published online: 10 Feb 2021
AbstractforTEAD4 as a Prognostic Marker Promotes Cell Migration and Invasion of Urinary Bladder Cancer via EMT | Full Text | References | PDF (13.7 MB)
  • 66 Views
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Case Report

Case Report
Malignant Acanthosis Nigricans with Recurrent Bladder Cancer: A Case Report and Review of Literature
Rongxin Zhang, Meiya Jiang, Wenyi Lei & Aoxue Wang
Pages: 951-957
Published online: 10 Feb 2021
AbstractforMalignant Acanthosis Nigricans with Recurrent Bladder Cancer: A Case Report and Review of Literature | Full Text | References | PDF (1.2 MB)
  • 111 Views
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Case Report
Extragastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass: Case Report
Shuai Liu, Pan Pan, Bing Han, Jingnan Wang, Meili Sun & Yuping Sun
Pages: 959-965
Published online: 10 Feb 2021
AbstractforExtragastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass: Case Report | Full Text | References | PDF (728.2 KB)
  • 71 Views
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Original Research

Article
IgG Fc Binding Protein (FCGBP) is Down-Regulated in Metastatic Lesions and Predicts Survival in Metastatic Colorectal Cancer Patients
Ziming Yuan, Zhixun Zhao, Hanqing Hu, Yihao Zhu, Weiyuan Zhang, Qingchao Tang, Rui Huang, Feng Gao, Chaoxia Zou, Guiyu Wang & Xishan Wang
Pages: 967-977
Published online: 11 Feb 2021
AbstractforIgG Fc Binding Protein (FCGBP) is Down-Regulated in Metastatic Lesions and Predicts Survival in Metastatic Colorectal Cancer Patients | Full Text | References | PDF (3.3 MB)
  • 93 Views
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Article
Loss of DAB2IP Contributes to Cell Proliferation and Cisplatin Resistance in Gastric Cancer
Guannan Wang, Xu Wang, Meng Han & Xiaoming Wang
Pages: 979-988
Published online: 11 Feb 2021
AbstractforLoss of DAB2IP Contributes to Cell Proliferation and Cisplatin Resistance in Gastric Cancer | Full Text | References | PDF (4.2 MB)
  • 61 Views
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Case Report

Case Report
A Case Report: Cutaneous Metastasis of Advanced Rectal Cancer with BRAF Mutation
Shishi Zhou, Wanfen Tang, Qinghua Wang, Xia Zhang, Xiayun Jin, Xifeng Xu & Jianfei Fu
Pages: 989-993
Published online: 11 Feb 2021
AbstractforA Case Report: Cutaneous Metastasis of Advanced Rectal Cancer with BRAF Mutation | Full Text | References | PDF (3.2 MB)
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Original Research

Article
MicroRNA-140-5p is Downregulated in Osteosarcoma and Overexpression of MicroRNA-140-5p Inhibits Cancer Cell Proliferation by Downregulating GLUT-1
Xiaoling Geng, Haoyu Wang, Lichen Xu, Yazhou Han & Yadong Liu
Pages: 995-1002
Published online: 11 Feb 2021
AbstractforMicroRNA-140-5p is Downregulated in Osteosarcoma and Overexpression of MicroRNA-140-5p Inhibits Cancer Cell Proliferation by Downregulating GLUT-1 | Full Text | References | PDF (2.4 MB)
  • 61 Views
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Retraction

Retraction
The Inhibitive Effect of sh-HIF1A-AS2 on the Proliferation, Invasion, and Pathological Damage of Breast Cancer via Targeting miR-548c-3p Through Regulating HIF-1α/VEGF Pathway in vitro and vivo [Retraction]
Page: 1003
Published online: 11 Feb 2021
CitationforThe Inhibitive Effect of sh-HIF1A-AS2 on the Proliferation, Invasion, and Pathological Damage of Breast Cancer via Targeting miR-548c-3p Through Regulating HIF-1α/VEGF Pathway in vitro and vivo [Retraction] | Full Text | PDF (177.9 KB)
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Retraction
GATA1 Gene Silencing Inhibits Invasion, Proliferation and Migration of Cholangiocarcinoma Stem Cells via Disrupting the PI3K/AKT Pathway [Retraction]
Page: 1005
Published online: 12 Feb 2021
CitationforGATA1 Gene Silencing Inhibits Invasion, Proliferation and Migration of Cholangiocarcinoma Stem Cells via Disrupting the PI3K/AKT Pathway [Retraction] | Full Text | PDF (162.8 KB)
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Original Research

Article
Tandem Mass Tag-Based Proteomic Analysis of Potential Biomarkers for Hepatocellular Carcinoma Differentiation
Wei Wang, Qiang Li, Ge Huang, Bing-yao Lin, Dongzi Lin, Yan Ma, Zhao Zhang, Tao Chen & Jie Zhou
Pages: 1007-1020
Published online: 12 Feb 2021
AbstractforTandem Mass Tag-Based Proteomic Analysis of Potential Biomarkers for Hepatocellular Carcinoma Differentiation | Full Text | References | PDF (5.9 MB)
  • 159 Views
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Article
Comprehensive Analysis of Gene Expression Changes and Validation in Hepatocellular Carcinoma
Hao Zhang, Renzheng Liu, Lin Sun, Weidong Guo, Xiaoyue Ji & Xiao Hu
Pages: 1021-1031
Published online: 15 Feb 2021
AbstractforComprehensive Analysis of Gene Expression Changes and Validation in Hepatocellular Carcinoma | Full Text | References | PDF (9 MB)
  • 166 Views
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Article
Exonuclease 1 (EXO1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma
Chang-shuai Zhou, Ming-tao Feng, Xin Chen, Yang Gao, Lei Chen, Liang-dong Li, De-heng Li & Yi-qun Cao
Pages: 1033-1048
Published online: 15 Feb 2021
AbstractforExonuclease 1 (EXO1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma | Full Text | References | PDF (11.9 MB)
  • 96 Views
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Article
AG-1024 Sensitizes Sorafenib-Resistant Hepatocellular Carcinoma Cells to Sorafenib via Enhancing G1/S Arrest
Wei Zhou, Weiyang Lou, Junru Chen, Bisha Ding, Binjie Chen, Haiyang Xie, Lin Zhou, Shusen Zheng & Donghai Jiang
Pages: 1049-1059
Published online: 15 Feb 2021
AbstractforAG-1024 Sensitizes Sorafenib-Resistant Hepatocellular Carcinoma Cells to Sorafenib via Enhancing G1/S Arrest | Full Text | References | PDF (3.8 MB)
  • 56 Views
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Article
Transiently Elevated TC and sdLDL-C Levels and Falsely Low LDL-C Levels in Patients with Extrahepatic Cholangiocarcinoma
Yi Guo, Yong-Gen Zhang, Hong-Chun Li & Yin-Hai Xu
Pages: 1061-1071
Published online: 15 Feb 2021
AbstractforTransiently Elevated TC and sdLDL-C Levels and Falsely Low LDL-C Levels in Patients with Extrahepatic Cholangiocarcinoma | Full Text | References | PDF (5.3 MB)
  • 59 Views
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Article
Pulmonary Lymphoepithelioma-Like Carcinoma Treated with Immunotherapy or Chemotherapy: A Single Institute Experience
Yang Fu, Yue Zheng, Pei-Pei Wang, Yue-Yun Chen & Zhen-Yu Ding
Pages: 1073-1081
Published online: 16 Feb 2021
AbstractforPulmonary Lymphoepithelioma-Like Carcinoma Treated with Immunotherapy or Chemotherapy: A Single Institute Experience | Full Text | References | PDF (2.9 MB)
  • 79 Views
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Article
Icotinib versus Cisplatin Plus Docetaxel as Adjuvant Chemotherapy in Patients with Stage II (N1+) Non-Small Cell Lung Cancer Harboring Positive EGFR Mutations: A Single-Center Retrospective Study
Saibo Pan, Shijie Wang, Wenshan Li & Ying Chai
Pages: 1083-1091
Published online: 16 Feb 2021
AbstractforIcotinib versus Cisplatin Plus Docetaxel as Adjuvant Chemotherapy in Patients with Stage II (N1+) Non-Small Cell Lung Cancer Harboring Positive EGFR Mutations: A Single-Center Retrospective Study | Full Text | References | PDF (3.5 MB)
  • 62 Views
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Article
Synchronous Multiple Lung Cancers with Lymph Node Metastasis and Different EGFR Mutations: Intrapulmonary Metastasis or Multiple Primary Lung Cancers?
Rirong Qu, Dehao Tu, Wei Ping, Ni Zhang & Xiangning Fu
Pages: 1093-1099
Published online: 16 Feb 2021
AbstractforSynchronous Multiple Lung Cancers with Lymph Node Metastasis and Different EGFR Mutations: Intrapulmonary Metastasis or Multiple Primary Lung Cancers? | Full Text | References | PDF (278.8 KB)
  • 75 Views
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Article
Prognostic Significance of the Combination of Fibrinogen and Tumor Marker Index in Esophageal Squamous Cell Carcinoma Patients
Yufeng Qiao, Mingquan Ma, Hongdian Zhang, Zhentao Yu & Peng Tang
Pages: 1101-1111
Published online: 17 Feb 2021
AbstractforPrognostic Significance of the Combination of Fibrinogen and Tumor Marker Index in Esophageal Squamous Cell Carcinoma Patients | Full Text | References | PDF (1.7 MB)
  • 59 Views
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Case Report

Case Report
Poor Prognosis of Pulmonary Adenosquamous Carcinoma with NRAS and HRAS Double Mutation
Jidong Zhao, Xiangmei Zhang, Ming He, Xin Chen, Xing Cui, Tian Qin, Xueliang Niu & Liyan Zhao
Pages: 1113-1116
Published online: 17 Feb 2021
AbstractforPoor Prognosis of Pulmonary Adenosquamous Carcinoma with NRAS and HRAS Double Mutation | Full Text | References | PDF (1.7 MB)
  • 59 Views
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Original Research

Article
Circular RNA circDNM3OS Functions as a miR-145-5p Sponge to Accelerate Cholangiocarcinoma Growth and Glutamine Metabolism by Upregulating MORC2
Yongfeng Su, Ting Yu, Yaqi Wang, Xianming Huang & Xiaoyong Wei
Pages: 1117-1129
Published online: 17 Feb 2021
AbstractforCircular RNA circDNM3OS Functions as a miR-145-5p Sponge to Accelerate Cholangiocarcinoma Growth and Glutamine Metabolism by Upregulating MORC2 | Full Text | References | PDF (7.9 MB)
  • 67 Views
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Article
Identification and Functional Validation of Radioresistance-Related Genes AHNAK2 and EVPL in Esophageal Squamous Cell Carcinoma by Exome and Transcriptome Sequencing Analyses
Qiang Hou, Zhenzhen Jiang, Ziwei Li & Mingfeng Jiang
Pages: 1131-1145
Published online: 18 Feb 2021
AbstractforIdentification and Functional Validation of Radioresistance-Related Genes AHNAK2 and EVPL in Esophageal Squamous Cell Carcinoma by Exome and Transcriptome Sequencing Analyses | Full Text | References | PDF (8.5 MB)
  • 63 Views
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Article
LINC00466 Impacts Cell Proliferation, Metastasis and Sensitivity to Temozolomide of Glioma by Sponging miR-137 to Regulate PPP1R14B Expression
Mingfei Zhao, Yijie Shao, Jinfang Xu, Buyi Zhang, Chenguang Li & Jie Gong
Pages: 1147-1159
Published online: 19 Feb 2021
AbstractforLINC00466 Impacts Cell Proliferation, Metastasis and Sensitivity to Temozolomide of Glioma by Sponging miR-137 to Regulate PPP1R14B Expression | Full Text | References | PDF (7.6 MB)
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Article
miR-744-5p Inhibits Multiple Myeloma Proliferation, Epithelial Mesenchymal Transformation and Glycolysis by Targeting SOX12/Wnt/β-Catenin Signaling
Bingling Guo, Chunyan Xiao, Yumin Liu, Ning Zhang, Hao Bai, Tao Yang, Ying Xiang, Yingyu Nan, Qiying Li, Wenjun Zhang & Dehong Huang
Pages: 1161-1172
Published online: 22 Feb 2021
AbstractformiR-744-5p Inhibits Multiple Myeloma Proliferation, Epithelial Mesenchymal Transformation and Glycolysis by Targeting SOX12/Wnt/β-Catenin Signaling | Full Text | References | PDF (5.2 MB)
  • 74 Views
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Article
Novel lncRNA LINC00941 Promotes Proliferation and Invasion of Colon Cancer Through Activation of MYC
Lin Chang, Dongmin Zhou & Suxia Luo
Pages: 1173-1186
Published online: 22 Feb 2021
AbstractforNovel lncRNA LINC00941 Promotes Proliferation and Invasion of Colon Cancer Through Activation of MYC | Full Text | References | PDF (9.2 MB)
  • 53 Views
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Article
RETRACTED ARTICLE: KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a
Quan Zhang, Lei Xu, Jianjun Wang, Xiaoming Zhu, Zeheng Ma, Junfeng Yang, Jiwei Li, Xiangbo Jia & Li Wei
Pages: 1187-1204
Published online: 22 Feb 2021
AbstractforRETRACTED ARTICLE: KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a | PDF (15.7 MB)
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Article
Cancer-Associated Fibroblasts Positively Correlate with Dedifferentiation and Aggressiveness of Thyroid Cancer
Shishuai Wen, Ning Qu, Ben Ma, Xiao Wang, Yi Luo, Weibo Xu, Hongyi Jiang, Yan Zhang, Yu Wang & Qinghai Ji
Pages: 1205-1217
Published online: 22 Feb 2021
AbstractforCancer-Associated Fibroblasts Positively Correlate with Dedifferentiation and Aggressiveness of Thyroid Cancer | Full Text | References | PDF (7.2 MB)
  • 134 Views
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Article
TRPM2-AS Promotes Bladder Cancer by Targeting miR-22-3p and Regulating GINS2 mRNA Expression
Yudong Tian, Yanbin Guan, Yang Su, Tao Yang & Haizhou Yu
Pages: 1219-1237
Published online: 23 Feb 2021
AbstractforTRPM2-AS Promotes Bladder Cancer by Targeting miR-22-3p and Regulating GINS2 mRNA Expression | Full Text | References | PDF (13.8 MB)
  • 99 Views
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Article
Actinidia eriantha Polysaccharide and PD1-Antibody Combination Therapy Enhances Antitumor Efficacy in Colorectal Cancer–Xenograft Mice
Jinxia Li, Yiping Wang, Weiyang Jin & Li Shen
Pages: 1239-1248
Published online: 24 Feb 2021
AbstractforActinidia eriantha Polysaccharide and PD1-Antibody Combination Therapy Enhances Antitumor Efficacy in Colorectal Cancer–Xenograft Mice | Full Text | References | PDF (10.2 MB)
  • 68 Views
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Article
MicroRNA-1249 Targets G Protein Subunit Alpha 11 and Facilitates Gastric Cancer Cell Proliferation, Motility and Represses Cell Apoptosis
Hongzhu Zhang, Tingting Fu & Cuiping Zhang
Pages: 1249-1259
Published online: 24 Feb 2021
AbstractforMicroRNA-1249 Targets G Protein Subunit Alpha 11 and Facilitates Gastric Cancer Cell Proliferation, Motility and Represses Cell Apoptosis | Full Text | References | PDF (6.4 MB)
  • 67 Views
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Article
Ouabain Exhibited Strong Anticancer Effects in Melanoma Cells via Induction of Apoptosis, G2/M Phase Arrest, and Migration Inhibition
Lei Wang, Wei Cai, Bing Han, Jue Zhang, Bing Yu & Ming Chen
Pages: 1261-1273
Published online: 25 Feb 2021
AbstractforOuabain Exhibited Strong Anticancer Effects in Melanoma Cells via Induction of Apoptosis, G2/M Phase Arrest, and Migration Inhibition | Full Text | References | PDF (12.9 MB)
  • 77 Views
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Article
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC)
Guang-zhao Huang, Qing-qing Wu, Ze-nan Zheng, Ting-ru Shao, Fei Li, Xin-yan Lu, Heng-yu Ye, Gao-xiang Chen, Yu-xing Song, Wei-sen Zeng, Yi-long Ai & Xiao-zhi Lv
Pages: 1275-1289
Published online: 25 Feb 2021
AbstractforBioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC) | Full Text | References | PDF (15.4 MB)
  • 142 Views
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Article
Anti-Proliferative, Pro-Apoptotic, Anti-Migrative and Tumor-Inhibitory Effects and Pleiotropic Mechanism of Theaflavin on B16F10 Melanoma Cells
Lei Zhang, Shijie Meng, Bo Yan, Jie Chen, Li Zhou, Letian Shan & Ying Wang
Pages: 1291-1304
Published online: 25 Feb 2021
AbstractforAnti-Proliferative, Pro-Apoptotic, Anti-Migrative and Tumor-Inhibitory Effects and Pleiotropic Mechanism of Theaflavin on B16F10 Melanoma Cells | Full Text | References | PDF (10.5 MB)
  • 93 Views
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Article
Increased HSF1 Promotes Infiltration and Metastasis in Cervical Cancer via Enhancing MTDH-VEGF-C Expression
Xueyan Shi, Zhenghao Deng, Shouman Wang, Shuai Zhao, Lan Xiao, Jiang Zou, Tao Li, Sichuang Tan, SipAin Tan & Xianzhong Xiao
Pages: 1305-1315
Published online: 26 Feb 2021
AbstractforIncreased HSF1 Promotes Infiltration and Metastasis in Cervical Cancer via Enhancing MTDH-VEGF-C Expression | Full Text | References | PDF (6.3 MB)
  • 53 Views
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Article
Near-Infrared Light-Triggered Thermosensitive Liposomes Modified with Membrane Peptides for the Local Chemo/Photothermal Therapy of Melanoma
Xinxin Li, Chunsheng Yang, Yingkai Tao, Xiaoyang Hou, Yanqun Liu, Hong Sang & Guan Jiang
Pages: 1317-1329
Published online: 25 Feb 2021
AbstractforNear-Infrared Light-Triggered Thermosensitive Liposomes Modified with Membrane Peptides for the Local Chemo/Photothermal Therapy of Melanoma | Full Text | References | PDF (6.8 MB)
  • 77 Views
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Article
Downregulation of LncRNA DARS-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3
Jinming Zhu & Shichao Han
Pages: 1331-1340
Published online: 25 Feb 2021
AbstractforDownregulation of LncRNA DARS-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3 | Full Text | References | PDF (5.9 MB)
  • 62 Views
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Review

Review Article
Promising Molecular Targets for the Targeted Therapy of Biliary Tract Cancers: An Overview
Wenwei Yang & Yongkun Sun
Pages: 1341-1366
Published online: 25 Feb 2021
AbstractforPromising Molecular Targets for the Targeted Therapy of Biliary Tract Cancers: An Overview | Full Text | References | PDF (550.2 KB)
  • 117 Views
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Case Report

Case Report
Secondary Nasopharyngeal Mixed Adenoneuroendocrine Carcinoma After Radical Radiotherapy for Nasopharyngeal Carcinoma: A Rare Case and Literature Review
Donglan Huang, Chunyue Huang, Hongmei Wang, Lizhen He, Jian Zhang, Xi Zhong, Ziqian Guo, Yawei Yuan & Weijun Zhang
Pages: 1367-1376
Published online: 25 Feb 2021
AbstractforSecondary Nasopharyngeal Mixed Adenoneuroendocrine Carcinoma After Radical Radiotherapy for Nasopharyngeal Carcinoma: A Rare Case and Literature Review | Full Text | References | PDF (10.4 MB)
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Original Research

Article
Expression and Prognostic Value of Tumor-Infiltrating Lymphocytes and PD-L1 in Hepatocellular Carcinoma
Hanxiao Nie, Tao He, Li Wang & Ling Zhang
Pages: 1377-1385
Published online: 25 Feb 2021
AbstractforExpression and Prognostic Value of Tumor-Infiltrating Lymphocytes and PD-L1 in Hepatocellular Carcinoma | Full Text | References | PDF (4.1 MB)
  • 83 Views
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Article
Expression and Functional Relevance of ANXA1 in Hypopharyngeal Carcinoma with Lymph Node Metastasis
Lei Li, Zhihai Wang, Tao Lu, Yanshi Li, Min Pan, Dan Yu & Guohua Hu
Pages: 1387-1399
Published online: 25 Feb 2021
AbstractforExpression and Functional Relevance of ANXA1 in Hypopharyngeal Carcinoma with Lymph Node Metastasis | Full Text | References | PDF (8.8 MB)
  • 67 Views
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Article
Renal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais
Weihua Wang, ZhanJiang Han, Dongqi Guo & Yanju Xiang
Pages: 1401-1416
Published online: 25 Feb 2021
AbstractforRenal Transcriptomics Reveals the Carcinogenic Mechanism of Ethyl Carbamate in Musalais | Full Text | References | PDF (10.6 MB)
  • 64 Views
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Review

Review Article
Research Trends and Regulation of CCL5 in Prostate Cancer
Renlun Huang, Lang Guo, Menghan Gao, Jing Li & Songtao Xiang
Pages: 1417-1427
Published online: 25 Feb 2021
AbstractforResearch Trends and Regulation of CCL5 in Prostate Cancer | Full Text | References | PDF (3.4 MB)
  • 136 Views
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Original Research

Article
TRIM11 Promotes Proliferation, Migration, Invasion and EMT of Gastric Cancer by Activating β-Catenin Signaling
Qingzhi Lan, Xiaoping Tan, Pengzhan He, Wei Li, Shan Tian & Weiguo Dong
Pages: 1429-1440
Published online: 25 Feb 2021
AbstractforTRIM11 Promotes Proliferation, Migration, Invasion and EMT of Gastric Cancer by Activating β-Catenin Signaling | Full Text | References | PDF (7.3 MB)
  • 113 Views
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Article
Serum Exosomal miRNA-1226 as Potential Biomarker of Pancreatic Ductal Adenocarcinoma
Cheng Wang, Jianhua Wang, Wenjing Cui, Yongkang Liu, Hao Zhou, Yajie Wang, Xin Chen, Xiao Chen & Zhongqiu Wang
Pages: 1441-1451
Published online: 26 Feb 2021
AbstractforSerum Exosomal miRNA-1226 as Potential Biomarker of Pancreatic Ductal Adenocarcinoma | Full Text | References | PDF (4.5 MB)
  • 187 Views
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Article
Small Proline-Rich Protein 2B Facilitates Gastric Adenocarcinoma Proliferation via MDM2-p53/p21 Signaling Pathway
Ling Yao, Jinhua Yan, Fei Cheng, Lihong Gan, Yaqin Huang, Li Zheng & Nian Fang
Pages: 1453-1463
Published online: 26 Feb 2021
AbstractforSmall Proline-Rich Protein 2B Facilitates Gastric Adenocarcinoma Proliferation via MDM2-p53/p21 Signaling Pathway | Full Text | References | PDF (7.3 MB)
  • 65 Views
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Article
A Functional Food Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Inflammatory Colorectal Cancer in Mice
Jie Zhang, Zhewen Chen, Yanwen Lu, Daoyuan Tu, Fengqian Zou, Shouwen Lin, Weinan Yu, Mingyong Miao & Hanping Shi
Pages: 1465-1477
Published online: 26 Feb 2021
AbstractforA Functional Food Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Inflammatory Colorectal Cancer in Mice | Full Text | References | PDF (8.5 MB)
  • 92 Views
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Article
FLT3-ITD Mutation and FLT3 Ligand Plasma Level Were Not Associated with One-Year Survival of Indonesian Acute Myeloid Leukemia Patients
Ikhwan Rinaldi, Melva Louisa, Resti Mulya Sari & Elly Arwanih
Pages: 1479-1486
Published online: 26 Feb 2021
AbstractforFLT3-ITD Mutation and FLT3 Ligand Plasma Level Were Not Associated with One-Year Survival of Indonesian Acute Myeloid Leukemia Patients | Full Text | References | PDF (859.3 KB)
  • 77 Views
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Article
FAST1 Predicts Poor Survival of Renal Carcinoma and Promotes Its Progression Through the TGF-β/Smad Pathway
Tao Tian, Xiangyang Fu, Liangliang Hu, Xiaofeng Yang, Peng Sun & Fengfeng Sun
Pages: 1487-1499
Published online: 26 Feb 2021
AbstractforFAST1 Predicts Poor Survival of Renal Carcinoma and Promotes Its Progression Through the TGF-β/Smad Pathway | Full Text | References | PDF (7.7 MB)
  • 53 Views
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Review

Review Article
Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application
Feifei Pu, Fengxia Chen, Jianxiang Liu, Zhicai Zhang & Zengwu Shao
Pages: 1501-1516
Published online: 01 Mar 2021
AbstractforImmune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application | Full Text | References | PDF (1.5 MB)
  • 327 Views
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Original Research

Article
The Significance of HOXC11 and LSH in Survival Prediction in Gastric Adenocarcinoma
Xin Peng, Jingyue Sun, Yao Long, Desheng Xiao, Jianhua Zhou, Yongguang Tao & Shuang Liu
Pages: 1517-1529
Published online: 01 Mar 2021
AbstractforThe Significance of HOXC11 and LSH in Survival Prediction in Gastric Adenocarcinoma | Full Text | References | PDF (7.6 MB)
  • 59 Views
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Article
Biological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase
Zhendong Qiu, Wenhong Deng, Yupu Hong, Liang Zhao, Man Li, Yongjun Guan, Yingru Su, Chen Chen, Qiao Shi, Jia Yu & Weixing Wang
Pages: 1531-1542
Published online: 01 Mar 2021
AbstractforBiological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase | Full Text | References | PDF (8.7 MB)
  • 89 Views
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Article
Circulating Tumor Cells Undergoing the Epithelial–Mesenchymal Transition: Influence on Prognosis in Cytokeratin 19-Positive Hepatocellular Carcinoma
Qian Zhang, Wanting Xing, Jie Zhang, Junwen Hu, Lunan Qi & Bangde Xiang
Pages: 1543-1552
Published online: 02 Mar 2021
AbstractforCirculating Tumor Cells Undergoing the Epithelial–Mesenchymal Transition: Influence on Prognosis in Cytokeratin 19-Positive Hepatocellular Carcinoma | Full Text | References | PDF (3.3 MB)
  • 64 Views
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Article
MiRNA-223-3p Affects Mantle Cell Lymphoma Development by Regulating the CHUK/NF-ƘB2 Signaling Pathway
Jingjing Yuan, Qing Zhang, Shengsheng Wu, Suran Yan, Ran Zhao, Yajuan Sun, Xiaoxu Tian & Keshu Zhou
Pages: 1553-1564
Published online: 02 Mar 2021
AbstractforMiRNA-223-3p Affects Mantle Cell Lymphoma Development by Regulating the CHUK/NF-ƘB2 Signaling Pathway | Full Text | References | PDF (6.9 MB)
  • 62 Views
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Article
Clinical Significance and Oncogenic Activity of GRWD1 Overexpression in the Development of Colon Carcinoma
Xin Zhou, Jin Shang, Xing Liu, Jin-Fu Zhuang, Yuan-Feng Yang, Yi-Yi Zhang & Guo-Xian Guan
Pages: 1565-1580
Published online: 02 Mar 2021
AbstractforClinical Significance and Oncogenic Activity of GRWD1 Overexpression in the Development of Colon Carcinoma | Full Text | References | PDF (15.1 MB)
  • 61 Views
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Case Report

Case Report
Partial Response to Pyrotinib Plus Capecitabine in an Advanced Breast Cancer Patient with HER2 Amplification and R157W Mutation After Anti-HER2 Treatment: A Case Report and Literature Review
Yanchun Qu, Yufeng Liu, Kailin Ding, Yong Li, Xiaoyu Hong & Haibo Zhang
Pages: 1581-1588
Published online: 02 Mar 2021
AbstractforPartial Response to Pyrotinib Plus Capecitabine in an Advanced Breast Cancer Patient with HER2 Amplification and R157W Mutation After Anti-HER2 Treatment: A Case Report and Literature Review | Full Text | References | PDF (1.9 MB)
  • 57 Views
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Original Research

Article
An Apoptotic Gene Signature for the Prognosis of Hepatocellular Carcinoma
Kunlun Chen, Pengfei Zhu, Yuan Liao, Lei Yan, Ruo Feng & Wenlong Zhai
Pages: 1589-1604
Published online: 02 Mar 2021
AbstractforAn Apoptotic Gene Signature for the Prognosis of Hepatocellular Carcinoma | Full Text | References | PDF (8.4 MB)
  • 65 Views
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Article
REG4 is a Potential Biomarker for Radiochemotherapy Sensitivity in Colorectal Cancer
Lei Gao, Xingjun Wu, Libo Zhang, Yang Dai, Zhe Zhu, Yunqing Zhi & Kaijing Wang
Pages: 1605-1611
Published online: 02 Mar 2021
AbstractforREG4 is a Potential Biomarker for Radiochemotherapy Sensitivity in Colorectal Cancer | Full Text | References | PDF (3.6 MB)
  • 65 Views
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Case Report

Case Report
Antiangiogenesis Combined with Immunotherapy to Treat Advanced Small-Cell Carcinoma of the Esophagus Resistant to Chemotherapy: According to the Guidance of Next-Generation Sequencing
Man Jiang & Xiaochun Zhang
Pages: 1613-1621
Published online: 02 Mar 2021
AbstractforAntiangiogenesis Combined with Immunotherapy to Treat Advanced Small-Cell Carcinoma of the Esophagus Resistant to Chemotherapy: According to the Guidance of Next-Generation Sequencing | Full Text | References | PDF (2.5 MB)
  • 42 Views
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Original Research

Article
Estimating Survival in Patients with Non-Small-Cell Lung Cancer and Brain Metastases: A Verification of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA)
Ji Li, Wang Jing, Xiaoyang Zhai, Wenxiao Jia, Hui Zhu & Jinming Yu
Pages: 1623-1631
Published online: 02 Mar 2021
AbstractforEstimating Survival in Patients with Non-Small-Cell Lung Cancer and Brain Metastases: A Verification of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA) | Full Text | References | PDF (1.2 MB)
  • 71 Views
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Article
High VCAM-1 Predicts Poor Prognosis and is Associated with Chemotherapy Resistance in Nasopharyngeal Carcinoma
Yu Huang, Hongbin Miao, Chenxi Xia, Huajun Feng, Shengen Xu, Zhuoping Liang, Yuanyuan Wang, Chong Zhao, Gang Qin, Xiaoyi Ou & Feipeng Zhao
Pages: 1633-1641
Published online: 02 Mar 2021
AbstractforHigh VCAM-1 Predicts Poor Prognosis and is Associated with Chemotherapy Resistance in Nasopharyngeal Carcinoma | Full Text | References | PDF (6 MB)
  • 51 Views
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Article
RPN2 Predicts Poor Prognosis and Promotes Bladder Cancer Growth and Metastasis via the PI3K-Akt Pathway
Chenglin Han, Shuxiao Chen, Haiyang Ma, Xiangchuan Wen, Zilong Wang, Yingkun Xu, Xunbo Jin, Xiao Yu & Muwen Wang
Pages: 1643-1657
Published online: 03 Mar 2021
AbstractforRPN2 Predicts Poor Prognosis and Promotes Bladder Cancer Growth and Metastasis via the PI3K-Akt Pathway | Full Text | References | PDF (11.9 MB)
  • 65 Views
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Article
LncRNA KCNQ1OT1 Promotes Proliferation, Invasion and Metastasis of Prostate Cancer by Regulating miR-211-5p/CHI3L1 Pathway
Hailong Hao, Huiqing Chen, Liwu Xie, Hongyu Liu & Dongwen Wang
Pages: 1659-1671
Published online: 03 Mar 2021
AbstractforLncRNA KCNQ1OT1 Promotes Proliferation, Invasion and Metastasis of Prostate Cancer by Regulating miR-211-5p/CHI3L1 Pathway | Full Text | References | PDF (13.5 MB)
  • 83 Views
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Article
Targeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma
Qiaoping Zheng, Guifang Gan, Xianfu Gao, Qingqiong Luo & Fuxiang Chen
Pages: 1673-1687
Published online: 04 Mar 2021
AbstractforTargeting the IDO-BCL2A1-Cytochrome c Pathway Promotes Apoptosis in Oral Squamous Cell Carcinoma | Full Text | References | PDF (17.1 MB)
  • 81 Views
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Article
Prognostic Value and Biological Functions of RNA Binding Proteins in Stomach Adenocarcinoma
Junqing Li, Wenjie Zhou, Jitao Wei, Xing Xiao, Tailai An, Wenhui Wu & Yulong He
Pages: 1689-1705
Published online: 04 Mar 2021
AbstractforPrognostic Value and Biological Functions of RNA Binding Proteins in Stomach Adenocarcinoma | Full Text | References | PDF (11.9 MB)
  • 66 Views
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Article
Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells
Guanzhang Li, Ting-Wei Chen, Ann-Christin Nickel, Sajjad Muhammad, Hans-Jakob Steiger, Theophilos Tzaridis, Daniel Hänggi, Reinhard Zeidler, Wei Zhang & Ulf Dietrich Kahlert
Pages: 1707-1718
Published online: 04 Mar 2021
AbstractforCarbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells | Full Text | References | PDF (7.9 MB)
  • 141 Views
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Article
Early Study of Tumor Abnormal Protein in Gastric Adenocarcinoma
Ming Zhang, Xiaoyu Wang & Zhenghua Wang
Pages: 1719-1726
Published online: 05 Mar 2021
AbstractforEarly Study of Tumor Abnormal Protein in Gastric Adenocarcinoma | Full Text | References | PDF (561.5 KB)
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Review

Review Article
Biological Function of HYOU1 in Tumors and Other Diseases
Shan Rao, Linda Oyang, Jiaxin Liang, Pin Yi, Yaqian Han, Xia Luo, Longzheng Xia, Jinguan Lin, Shiming Tan, Jiaqi Hu, Hui Wang, Lu Tang, Qing Pan, Yanyan Tang, Yujuan Zhou & Qianjin Liao
Pages: 1727-1735
Published online: 05 Mar 2021
AbstractforBiological Function of HYOU1 in Tumors and Other Diseases | Full Text | References | PDF (530.4 KB)
  • 217 Views
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Original Research

Article
Prognostic Implications of the Complement Protein C1Q and Its Correlation with Immune Infiltrates in Osteosarcoma
Hanji Huang, Manli Tan, Li Zheng, Guohua Yan, Kanglu Li, Dejie Lu, Xiaofei Cui, Si He, Danqing Lei, Bo Zhu & Jinmin Zhao
Pages: 1737-1751
Published online: 05 Mar 2021
AbstractforPrognostic Implications of the Complement Protein C1Q and Its Correlation with Immune Infiltrates in Osteosarcoma | Full Text | References | PDF (12.7 MB)
  • 115 Views
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Article
High Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7
Xiuli Jin, Weixin Fu, Dan Li, Ningning Wang, Jiayu Chen, Zilu Zeng, Jiaqi Guo, Hao Liu, Xinping Zhong, Hu Peng, Xin Yu, Jing Sun, Xinhe Zhang, Xue Wang, Beibei Xu, Yingbo Lin, Jianping Liu, Claudia Kutter & Yiling Li
Pages: 1753-1769
Published online: 08 Mar 2021
AbstractforHigh Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7 | Full Text | References | PDF (11.6 MB)
  • 76 Views
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Article
P4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization
Qiyan Wang, Junwen Zhang, Sheng Fang, Jialin Wang, Xiangming Han, Fusheng Liu & Guishan Jin
Pages: 1771-1782
Published online: 08 Mar 2021
AbstractforP4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization | Full Text | References | PDF (10 MB)
  • 75 Views
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Case Series

Case Report
A Retrospective Case Study of 13 Uterine Perivascular Epithelioid Cell Neoplasm (PEComa) Patients
Jiahui Gu, Wantong Wang & Shizhuo Wang
Pages: 1783-1790
Published online: 09 Mar 2021
AbstractforA Retrospective Case Study of 13 Uterine Perivascular Epithelioid Cell Neoplasm (PEComa) Patients | Full Text | References | PDF (278 KB)
  • 91 Views
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Case Report

Case Report
Complete Response to Pembrolizumab in Advanced Colon Cancer Harboring Somatic POLE F367S Mutation with Microsatellite Stability Status: A Case Study
Jianxin Chen & Haizhou Lou
Pages: 1791-1796
Published online: 09 Mar 2021
AbstractforComplete Response to Pembrolizumab in Advanced Colon Cancer Harboring Somatic POLE F367S Mutation with Microsatellite Stability Status: A Case Study | Full Text | References | PDF (1.7 MB)
  • 89 Views
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Review

Review Article
Current and Emerging Therapeutic Options for Hairy Cell Leukemia Variant
Qiuying Liu, Nicholas Harris, Narendranath Epperla & Leslie A Andritsos
Pages: 1797-1805
Published online: 09 Mar 2021
AbstractforCurrent and Emerging Therapeutic Options for Hairy Cell Leukemia Variant | Full Text | References | PDF (306.3 KB)
  • 81 Views
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Original Research

Article
Circ-PITX1 Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1248/CCND2 Axis
Qianyu Yue, Yanyan Xu, Xiaoli Deng, Shenglan Wang, Jingman Qiu, Baojiang Qian & Yunhui Zhang
Pages: 1807-1819
Published online: 09 Mar 2021
AbstractforCirc-PITX1 Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1248/CCND2 Axis | Full Text | References | PDF (8.8 MB)
  • 71 Views
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Review

Review Article
Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
Bashir Ahmad, Yaser Gamallat, Muhammad Fiaz Khan, Syed Riaz Din, Muhammad Israr, Manzoor Ahmad, Naeem Tahir, Nasir Azam, Khalil Ur Rahman, Wang Xin, Wang Zexu, Peng Linjie, Pengyu Su & Wang Liang
Pages: 1821-1841
Published online: 10 Mar 2021
AbstractforNatural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis | Full Text | References | PDF (7.3 MB)
  • 157 Views
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Article
ARID4B Knockdown Suppresses PI3K/AKT Signaling and Induces Apoptosis in Human Glioma Cells
Siou-Min Luo, Wen-Chiuan Tsai, Chia-Kuang Tsai, Ying Chen & Dueng-Yuan Hueng
Pages: 1843-1855
Published online: 10 Mar 2021
AbstractforARID4B Knockdown Suppresses PI3K/AKT Signaling and Induces Apoptosis in Human Glioma Cells | Full Text | References | PDF (10.2 MB)
  • 99 Views
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Retraction

Retraction
C-Terminal of E1A Binding Protein 1 Enhances the Migration of Gastric Epithelial Cells and Has a Clinicopathologic Significance in Human Gastric Carcinoma [Retraction]
Page: 1857
Published online: 10 Mar 2021
CitationforC-Terminal of E1A Binding Protein 1 Enhances the Migration of Gastric Epithelial Cells and Has a Clinicopathologic Significance in Human Gastric Carcinoma [Retraction] | Full Text | PDF (166.3 KB)
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Retraction
MiR-126 Regulates Proliferation and Invasion in the Bladder Cancer BLS Cell Line by Targeting the PIK3R2-Mediated PI3K/Akt Signaling Pathway [Retraction]
Page: 1859
Published online: 10 Mar 2021
CitationforMiR-126 Regulates Proliferation and Invasion in the Bladder Cancer BLS Cell Line by Targeting the PIK3R2-Mediated PI3K/Akt Signaling Pathway [Retraction] | Full Text | PDF (169.5 KB)
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Original Research

Article
LncRNA ILF3-AS1 Promotes the Progression of Colon Adenocarcinoma Cells Through the miR-619-5p/CAMK1D Axis
Wei Liu & Shan Li
Pages: 1861-1872
Published online: 12 Mar 2021
AbstractforLncRNA ILF3-AS1 Promotes the Progression of Colon Adenocarcinoma Cells Through the miR-619-5p/CAMK1D Axis | Full Text | References | PDF (7.3 MB)
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Review

Review Article
Current Progress and Future Perspectives of Immune Checkpoint Inhibitors in Biliary Tract Cancer
Poshita-Kumari Seesaha, Kang-Xin Wang, Guo-Qun Wang, Ting-Yun Cui, Feng-Jiao Zhao, Lan-Lan Pan, Xiang-Cheng Li, Yong-Qian Shu & Xiao-Feng Chen
Pages: 1873-1882
Published online: 12 Mar 2021
AbstractforCurrent Progress and Future Perspectives of Immune Checkpoint Inhibitors in Biliary Tract Cancer | Full Text | References | PDF (316.3 KB)
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Original Research

Article
LncRNA HOTAIR Promotes Cancer Stem-Like Cells Properties by Sponging miR-34a to Activate the JAK2/STAT3 Pathway in Pancreatic Ductal Adenocarcinoma
Shikang Deng, Junfeng Wang, Li Zhang, Jiao Li & Yan Jin
Pages: 1883-1893
Published online: 12 Mar 2021
AbstractforLncRNA HOTAIR Promotes Cancer Stem-Like Cells Properties by Sponging miR-34a to Activate the JAK2/STAT3 Pathway in Pancreatic Ductal Adenocarcinoma | Full Text | References | PDF (8.3 MB)
  • 114 Views
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Review

Review Article
Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research
Hao Wang, Die Meng, Haoyue Guo, Chenglong Sun, Peixin Chen, Minlin Jiang, Yi Xu, Jia Yu, Qiyu Fang, Jun Zhu, Wencheng Zhao, Shengyu Wu, Sha Zhao, Wei Li, Bin Chen, Lei Wang & Yayi He
Pages: 1895-1909
Published online: 16 Mar 2021
AbstractforSingle-Cell Sequencing, an Advanced Technology in Lung Cancer Research | Full Text | References | PDF (2.3 MB)
  • 101 Views
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Original Research

Article
Irradiation-Induced Activated Microglia Affect Brain Metastatic Colonization of NSCLC Cells via miR-9/CDH1 Axis
Yu Jin, Yalin Kang, Xiaohong Peng, Li Yang, Qianxia Li, Qi Mei, Xinyi Chen, Guangyuan Hu, Yang Tang & Xianglin Yuan
Pages: 1911-1922
Published online: 16 Mar 2021
AbstractforIrradiation-Induced Activated Microglia Affect Brain Metastatic Colonization of NSCLC Cells via miR-9/CDH1 Axis | Full Text | References | PDF (5.9 MB)
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Retraction

Retraction
Propofol Suppresses Proliferation, Migration, Invasion and Promotes Apoptosis by Upregulating microRNA-140-5p in Gastric Cancer Cells [Retraction]
Page: 1923
Published online: 16 Mar 2021
CitationforPropofol Suppresses Proliferation, Migration, Invasion and Promotes Apoptosis by Upregulating microRNA-140-5p in Gastric Cancer Cells [Retraction] | Full Text | PDF (162.8 KB)
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Original Research

Article
Anti-Lung Cancer Targets of Radix Paeoniae Rubra and Biological Molecular Mechanism: Network Pharmacological Analyses and Experimental Validation
Yunfei Ma, Guangda Li, Mingwei Yu, Kexin Cao, Qiwei Li, Xu Sun, Guowang Yang & Xiaomin Wang
Pages: 1925-1936
Published online: 16 Mar 2021
AbstractforAnti-Lung Cancer Targets of Radix Paeoniae Rubra and Biological Molecular Mechanism: Network Pharmacological Analyses and Experimental Validation | Full Text | References | PDF (12 MB)
  • 78 Views
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Article
Assessment of the Circulating Tumor Cells and Microsatellite Instability in Colorectal Cancer Patients: Prognostic and Diagnostic Value
Aya Alsayed, Salem E Salem, Mostafa M El Serafi, Mona S Abdellateif, Abdel-Rahman N Zekri, Marwa Mohanad & Abeer A Bahnassy
Pages: 1937-1951
Published online: 16 Mar 2021
AbstractforAssessment of the Circulating Tumor Cells and Microsatellite Instability in Colorectal Cancer Patients: Prognostic and Diagnostic Value | Full Text | References | PDF (3.8 MB)
  • 65 Views
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Article
Lack of Synergy Between β-Agonist Treatment and a Blockage of Sarcoplasmic Calcium Flow in a Rat Cancer Cachexia Model
Silvia Busquets, Marta Castillejo, Queralt Jové, Baptiste Jude, Patricia Mejías, Francisco J López-Soriano & Josep M Argilés
Pages: 1953-1959
Published online: 17 Mar 2021
AbstractforLack of Synergy Between β-Agonist Treatment and a Blockage of Sarcoplasmic Calcium Flow in a Rat Cancer Cachexia Model | Full Text | References | PDF (797.8 KB)
  • 60 Views
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Article
Anti–PD-1 Monotherapy for Advanced NSCLC Patients with Older Age or Those with Poor Performance Status
Taichi Matsubara, Takashi Seto, Shinkichi Takamori, Takatoshi Fujishita, Ryo Toyozawa, Kensaku Ito, Masafumi Yamaguchi & Tatsuro Okamoto
Pages: 1961-1968
Published online: 17 Mar 2021
AbstractforAnti–PD-1 Monotherapy for Advanced NSCLC Patients with Older Age or Those with Poor Performance Status | Full Text | References | PDF (2.6 MB)
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Review

Review Article
Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT
Jian Sun, Weiwei Sheng, Yuteng Ma & Ming Dong
Pages: 1969-1980
Published online: 17 Mar 2021
AbstractforPotential Role of Musashi-2 RNA-Binding Protein in Cancer EMT | Full Text | References | PDF (3 MB)
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Original Research

Article
Organ-Specific Tumor Response to Pembrolizumab in Advanced Urothelial Carcinoma After Platinum-Based Chemotherapy
Nobuki Furubayashi, Takahito Negishi, Naotaka Sakamoto, Hozumi Shimokawa, Futoshi Morokuma, Yoohyun Song, Yoshifumi Hori, Toshihisa Tomoda, Noriaki Tokuda, Narihito Seki, Kentaro Kuroiwa & Motonobu Nakamura
Pages: 1981-1988
Published online: 18 Mar 2021
AbstractforOrgan-Specific Tumor Response to Pembrolizumab in Advanced Urothelial Carcinoma After Platinum-Based Chemotherapy | Full Text | References | PDF (1.1 MB)
  • 105 Views
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Case Report

Case Report
Apatinib Combined with Irinotecan in the Treatment of Advanced Small-Cell Esophageal Carcinoma: A Case Report
Longhua Guo, Xiaofang Zou, Yinfang Gu, Lilan Yi, Jingjing Zhao & Guowu Wu
Pages: 1989-1995
Published online: 18 Mar 2021
AbstractforApatinib Combined with Irinotecan in the Treatment of Advanced Small-Cell Esophageal Carcinoma: A Case Report | Full Text | References | PDF (7.7 MB)
  • 51 Views
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Case Report
A Case of Solid Variant of Adenoid Cystic Carcinoma from Trachea: A Case Report and Review of Literature
Feng Gao, Lijuan Zang, Jin He & Weiqing Xu
Pages: 1997-2002
Published online: 18 Mar 2021
AbstractforA Case of Solid Variant of Adenoid Cystic Carcinoma from Trachea: A Case Report and Review of Literature | Full Text | References | PDF (1.1 MB)
  • 88 Views
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Original Research

Article
DNASE1L3 as a Prognostic Biomarker Associated with Immune Cell Infiltration in Cancer
Zenghua Deng, Mengmeng Xiao, Dexiao Du, Nan Luo, Dongfang Liu, Tingting Liu, Dongbo Lian & Jirun Peng
Pages: 2003-2017
Published online: 18 Mar 2021
AbstractforDNASE1L3 as a Prognostic Biomarker Associated with Immune Cell Infiltration in Cancer | Full Text | References | PDF (13.1 MB)
  • 131 Views
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Review

Review Article
Role and Therapeutic Potential of Melatonin in Various Type of Cancers
Sangiliyandi Gurunathan, Muhammad Qasim, Min-Hee Kang & Jin-Hoi Kim
Pages: 2019-2052
Published online: 18 Mar 2021
AbstractforRole and Therapeutic Potential of Melatonin in Various Type of Cancers | Full Text | References | PDF (6.3 MB)
  • 488 Views
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Review Article
The Association Between Inflammation and Immunosuppression: Implications for ICI Biomarker Development
Danielle Benedict Sacdalan & Josephine Anne Lucero
Pages: 2053-2064
Published online: 18 Mar 2021
AbstractforThe Association Between Inflammation and Immunosuppression: Implications for ICI Biomarker Development | Full Text | References | PDF (911.9 KB)
  • 90 Views
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Original Research

Article
Helicobacter pylori Regulates the Apoptosis of Human Megakaryocyte Cells via NF-κB/IL-17 Signaling
Huyi Lei, Yongyong Ma, Jie Tan & Qifa Liu
Pages: 2065-2074
Published online: 19 Mar 2021
AbstractforHelicobacter pylori Regulates the Apoptosis of Human Megakaryocyte Cells via NF-κB/IL-17 Signaling | Full Text | References | PDF (4.5 MB)
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Article
Evaluation of Cervical High-Grade Squamous Intraepithelial Lesions-Correlated Markers as Triage Strategy for Colposcopy After Co-Testing
Xiao Huo, Hengzi Sun, Dongyan Cao, Jiaxin Yang, Peng Peng, Linghua Kong, Fei Chen, Keng Shen & Shuhong Li
Pages: 2075-2084
Published online: 19 Mar 2021
AbstractforEvaluation of Cervical High-Grade Squamous Intraepithelial Lesions-Correlated Markers as Triage Strategy for Colposcopy After Co-Testing | Full Text | References | PDF (2.2 MB)
  • 84 Views
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Article
Global Characterization of Immune Infiltration in Clear Cell Renal Cell Carcinoma
Yan Zheng, Yibo Wen, Huixia Cao, Yue Gu, Lei Yan, Yanliang Wang, Limeng Wang, Lina Zhang & Fengmin Shao
Pages: 2085-2100
Published online: 22 Mar 2021
AbstractforGlobal Characterization of Immune Infiltration in Clear Cell Renal Cell Carcinoma | Full Text | References | PDF (11.5 MB)
  • 81 Views
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Case Report

Case Report
A Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases
Shiyun Li, Fuqiang Gan, Manling Luo & Puying Luo
Pages: 2101-2107
Published online: 23 Mar 2021
AbstractforA Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases | Full Text | References | PDF (815 KB)
  • 76 Views
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Review

Review Article
Oral PI3K-δ,γ Inhibitor for the Management of People with Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: A Narrative Review on Duvelisib
Ankit Shah & Jacqueline C Barrientos
Pages: 2109-2119
Published online: 25 Mar 2021
AbstractforOral PI3K-δ,γ Inhibitor for the Management of People with Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: A Narrative Review on Duvelisib | Full Text | References | PDF (1 MB)
  • 81 Views
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Review Article
Recent Advances in Our Knowledge of mCRC Tumor Biology and Genetics: A Focus on Targeted Therapy Development
William H Gmeiner
Pages: 2121-2130
Published online: 25 Mar 2021
AbstractforRecent Advances in Our Knowledge of mCRC Tumor Biology and Genetics: A Focus on Targeted Therapy Development | Full Text | References | PDF (1 MB)
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Case Report

Case Report
Identification of Novel Alectinib-Resistant ALK Mutation G1202K with Sensitization to Lorlatinib: A Case Report and in silico Structural Modelling
Ping Yang, Ran Cao, Hua Bao, Xue Wu, Lingling Yang, Dongqin Zhu, Lu Zhang, Liming Peng, Yuefei Cai, Weijun Zhang & Yang Shao
Pages: 2131-2138
Published online: 25 Mar 2021
AbstractforIdentification of Novel Alectinib-Resistant ALK Mutation G1202K with Sensitization to Lorlatinib: A Case Report and in silico Structural Modelling | Full Text | References | PDF (4.8 MB)
  • 87 Views
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Original Research

Article
Primary Tumor Radiotherapy During EGFR-TKI Disease Control Improves Survival of Treatment Naïve Advanced EGFR-Mutant Lung Adenocarcinoma Patients
Kuo-Hsuan Hsu, Jing-Wen Huang, Jeng-Sen Tseng, Kuan-Wen Chen, Yih-Chyang Weng, Sung-Liang Yu, Tsung-Ying Yang, Yen-Hsiang Huang, Jeremy J W Chen, Kun-Chieh Chen & Gee-Chen Chang
Pages: 2139-2148
Published online: 25 Mar 2021
AbstractforPrimary Tumor Radiotherapy During EGFR-TKI Disease Control Improves Survival of Treatment Naïve Advanced EGFR-Mutant Lung Adenocarcinoma Patients | Full Text | References | PDF (1.9 MB)
  • 78 Views
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Article
CD8+CD39+ T Cells Mediate Anti-Tumor Cytotoxicity in Bladder Cancer
Wenjie Zhu, Zihan Zhao, Baofu Feng, Wenhao Yu, Ji Li, Hongqian Guo & Rong Yang
Pages: 2149-2161
Published online: 25 Mar 2021
AbstractforCD8+CD39+ T Cells Mediate Anti-Tumor Cytotoxicity in Bladder Cancer | Full Text | References | PDF (7.5 MB)
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Article
Upregulated MicroRNA-483-3p is an Early Event in Pancreatic Ductal Adenocarcinoma (PDAC) and as a Powerful Liquid Biopsy Biomarker in PDAC
Huilin Shao, Yue Zhang, Jie Yan, Xinchao Ban, Xiaojie Fan, Xiaoyan Chang, Zhaohui Lu, Yan Wu, Liju Zong, Shengwei Mo, Shuangni Yu & Jie Chen
Pages: 2163-2175
Published online: 25 Mar 2021
AbstractforUpregulated MicroRNA-483-3p is an Early Event in Pancreatic Ductal Adenocarcinoma (PDAC) and as a Powerful Liquid Biopsy Biomarker in PDAC | Full Text | References | PDF (8 MB)
  • 109 Views
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Case Report

Case Report
Dramatic Responses of Recurrent Upper Urinary Tract Urothelial Carcinoma Harboring FGFR3 and TP53 Activating Mutations to Pembrolizumab in Combination with Erdafitinib: A Case Report
Xinjia Ding, Jianguo Zong, Xiang Li, Xiaoyan Bai, Bowen Tan, Weibing Sun, Ruoyu Wang & Yan Ding
Pages: 2177-2183
Published online: 25 Mar 2021
AbstractforDramatic Responses of Recurrent Upper Urinary Tract Urothelial Carcinoma Harboring FGFR3 and TP53 Activating Mutations to Pembrolizumab in Combination with Erdafitinib: A Case Report | Full Text | References | PDF (803.6 KB)
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Review

Review Article
A Review of Chimeric Antigen Receptor T-Cell Therapy for Myeloma and Lymphoma
Shebli Atrash & Tamara K Moyo
Pages: 2185-2201
Published online: 26 Mar 2021
AbstractforA Review of Chimeric Antigen Receptor T-Cell Therapy for Myeloma and Lymphoma | Full Text | References | PDF (3.1 MB)
  • 162 Views
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Original Research

Article
Analysis of the Clinicopathological Characteristics of Stage I–III Colorectal Cancer Patients Deficient in Mismatch Repair Proteins
Yichao Liang, Xinling Cai, Xu Zheng & Hongzhuan Yin
Pages: 2203-2212
Published online: 26 Mar 2021
AbstractforAnalysis of the Clinicopathological Characteristics of Stage I–III Colorectal Cancer Patients Deficient in Mismatch Repair Proteins | Full Text | References | PDF (1.3 MB)
  • 87 Views
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Article
Long Non-Coding RNA LINC00313 Accelerates Cervical Carcinoma Progression by miR-4677-3p/CDK6 Axis
Yongning Zhai, Yang Liu, Zhen Wang, Wei Wang, Juan Zhou & Jingyuan Lu
Pages: 2213-2226
Published online: 29 Mar 2021
AbstractforLong Non-Coding RNA LINC00313 Accelerates Cervical Carcinoma Progression by miR-4677-3p/CDK6 Axis | Full Text | References | PDF (897.8 KB)
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Case Report

Case Report
Case Report: SMARCB1 (INI-1)-Deficient Carcinoma of the Nasal Cavity with Pure Yolk Sac Tumor Differentiation and Elevated Serum AFP Levels
Chun-Yu Li, Ya-mei Han, Ke Xu, Shu-yue Wu, Xu-Yong Lin & Hong-yi Cao
Pages: 2227-2233
Published online: 29 Mar 2021
AbstractforCase Report: SMARCB1 (INI-1)-Deficient Carcinoma of the Nasal Cavity with Pure Yolk Sac Tumor Differentiation and Elevated Serum AFP Levels | Full Text | References | PDF (530.1 KB)
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Retraction

Retraction
LncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis [Retraction]
Page: 2235
Published online: 30 Mar 2021
CitationforLncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis [Retraction] | Full Text | PDF (164.4 KB)
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Corrigendum

Correction
MicroRNA-769-5p Promotes the Growth of Glioma Cells by Targeting Lysine Methyltransferase 2A [Corrigendum]
Page: 2237
Published online: 29 Mar 2021
CitationforMicroRNA-769-5p Promotes the Growth of Glioma Cells by Targeting Lysine Methyltransferase 2A [Corrigendum] | Full Text | PDF (162.7 KB)
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Correction
Long Noncoding RNA LINC00460 Facilitates Colorectal Cancer Progression by Negatively Regulating miR-613 [Corrigendum]
Pages: 2239-2240
Published online: 30 Mar 2021
CitationforLong Noncoding RNA LINC00460 Facilitates Colorectal Cancer Progression by Negatively Regulating miR-613 [Corrigendum] | Full Text | PDF (2 MB)
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Case Report

Case Report
Bronchiolar Adenoma Transforming to Invasive Mucinous Adenocarcinoma: A Case Report
Xu Han, Jialin Hao, Suling Ding, En-Hua Wang & Liang Wang
Pages: 2241-2246
Published online: 30 Mar 2021
AbstractforBronchiolar Adenoma Transforming to Invasive Mucinous Adenocarcinoma: A Case Report | Full Text | References | PDF (9.6 MB)
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Original Research

Article
Remodels the Immunosuppressive Tumor Microenvironment by Combination of Bacillus Calmette–Guérin and Anti-PD-L1 in an Orthotopic Triple-Negative Breast Cancer Mouse Model
Yuan Lu, Xin Huang, Xiaoke Liu, Yu He, Zhe Hu, Weize Xu, Gang Cao & Wenbo He
Pages: 2247-2258
Published online: 30 Mar 2021
AbstractforRemodels the Immunosuppressive Tumor Microenvironment by Combination of Bacillus Calmette–Guérin and Anti-PD-L1 in an Orthotopic Triple-Negative Breast Cancer Mouse Model | Full Text | References | PDF (6.9 MB)
  • 79 Views
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Article
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma
Yanfen Cui, Baoai Han, He Zhang, Hui Liu, Fei Zhang & Ruifang Niu
Pages: 2259-2277
Published online: 31 Mar 2021
AbstractforIdentification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma | Full Text | References | PDF (17 MB)
  • 103 Views
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Article
LINC00460 Promotes Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Head and Neck Squamous Cell Carcinoma via miR-320a/BGN Axis
Yifan Yang, Ru Wang, Ling Feng, Hongzhi Ma & Jugao Fang
Pages: 2279-2291
Published online: 30 Mar 2021
AbstractforLINC00460 Promotes Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Head and Neck Squamous Cell Carcinoma via miR-320a/BGN Axis | Full Text | References | PDF (9 MB)
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Article
LncRNA LHFPL3-AS1 Promotes Oral Squamous Cell Carcinoma Growth and Cisplatin Resistance Through Targeting miR-362-5p/CHSY1 Pathway
Jiandong Li, Xiaohu Xu, Dandan Zhang, Han Lv & Xin Lei
Pages: 2293-2300
Published online: 31 Mar 2021
AbstractforLncRNA LHFPL3-AS1 Promotes Oral Squamous Cell Carcinoma Growth and Cisplatin Resistance Through Targeting miR-362-5p/CHSY1 Pathway | Full Text | References | PDF (4.8 MB)
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Article
PD-L1 Expression and Outcome in Patients with Metastatic Non-Small Cell Lung Cancer and EGFR Mutations Receiving EGFR-TKI as Frontline Treatment
Cheng-Yu Chang, Yi-Chun Lai, Yu-Feng Wei, Chung-Yu Chen & Shih-Chieh Chang
Pages: 2301-2309
Published online: 31 Mar 2021
AbstractforPD-L1 Expression and Outcome in Patients with Metastatic Non-Small Cell Lung Cancer and EGFR Mutations Receiving EGFR-TKI as Frontline Treatment | Full Text | References | PDF (293.1 KB)
  • 48 Views
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Article
miR-944 Suppresses EGF-Induced EMT in Colorectal Cancer Cells by Directly Targeting GATA6
JingTong Tang, Wei Gao, Gang Liu, WeiWei Sheng, JianPing Zhou, Qi Dong & Ming Dong
Pages: 2311-2325
Published online: 31 Mar 2021
AbstractformiR-944 Suppresses EGF-Induced EMT in Colorectal Cancer Cells by Directly Targeting GATA6 | Full Text | References | PDF (14.4 MB)
  • 73 Views
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Article
Serum Exosomal miRNA Might Be a Novel Liquid Biopsy to Identify Leptomeningeal Metastasis in Non-Small Cell Lung Cancer
Qiuli Xu, Liang Ye, Litang Huang, Li Zhou, Xi Chen, Mingxiang Ye, Guannan Wu, Ping Zhan, Tangfeng Lv & Yong Song
Pages: 2327-2335
Published online: 01 Apr 2021
AbstractforSerum Exosomal miRNA Might Be a Novel Liquid Biopsy to Identify Leptomeningeal Metastasis in Non-Small Cell Lung Cancer | Full Text | References | PDF (2.9 MB)
  • 106 Views
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Corrigendum

Correction
LHX6 Affects Erlotinib Resistance and Migration of EGFR-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling [Corrigendum]
Page: 2337
Published online: 06 Apr 2021
CitationforLHX6 Affects Erlotinib Resistance and Migration of EGFR-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling [Corrigendum] | Full Text | PDF (179.1 KB)
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Original Research

Article
XBP1s Acts as a Tumor Suppressor to Inhibit the EMT Process and Metastasis of Papillary Thyroid Cancer
Wen Yang, Xia Xu, Ming Xu, Jun Zhou, Zihan Xi, Hui Guo, Jie Ming & Tao Huang
Pages: 2339-2348
Published online: 06 Apr 2021
AbstractforXBP1s Acts as a Tumor Suppressor to Inhibit the EMT Process and Metastasis of Papillary Thyroid Cancer | Full Text | References | PDF (6.7 MB)
  • 69 Views
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Article
Evaluation of the UK Myeloma Research Alliance Risk Profile in Chinese Patients with Newly Diagnosed Multiple Myeloma without Autologous Stem Cell Transplantation
Kewa Ma, Jiannan Ye, Lingling Wang, Chao Sun & Xin Zhou
Pages: 2349-2361
Published online: 06 Apr 2021
AbstractforEvaluation of the UK Myeloma Research Alliance Risk Profile in Chinese Patients with Newly Diagnosed Multiple Myeloma without Autologous Stem Cell Transplantation | Full Text | References | PDF (549.3 KB)
  • 51 Views
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Article
Construction of miRNA-mRNA Regulatory Network and Prognostic Signature in Endometrial Cancer
Rui Sun, Jinhui Liu, Sipei Nie, Siyue Li, Jing Yang, Yi Jiang & Wenjun Cheng
Pages: 2363-2378
Published online: 06 Apr 2021
AbstractforConstruction of miRNA-mRNA Regulatory Network and Prognostic Signature in Endometrial Cancer | Full Text | References | PDF (13.4 MB)
  • 72 Views
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Review

Review Article
Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
Tan Li, Hong-chun Xian, Li Dai, Ya-ling Tang & Xin-hua Liang
Pages: 2379-2395
Published online: 07 Apr 2021
AbstractforTip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis | Full Text | References | PDF (580.2 KB)
  • 100 Views
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Review Article
Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
Mengwei Wang, Tianwei Xu, Wenyan Feng, Junxia Liu & Zhaoxia Wang
Pages: 2397-2415
Published online: 07 Apr 2021
AbstractforAdvances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer | Full Text | References | PDF (3.9 MB)
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Case Report

Case Report
Rapid Disease Progression in a Patient with Advanced NSCLC Harboring a Germline MET Exon 14 Skipping Mutation: A Case Report
Yang Jiao, Chen Fang, Yuchen Yang, Lin Shao, Yi Huang, Qinying Sun & Yuchao Dong
Pages: 2417-2421
Published online: 07 Apr 2021
AbstractforRapid Disease Progression in a Patient with Advanced NSCLC Harboring a Germline MET Exon 14 Skipping Mutation: A Case Report | Full Text | References | PDF (344 KB)
  • 58 Views
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Original Research

Article
Development and Analytical Validation of a Targeted Next-Generation Sequencing Panel to Detect Actionable Mutations for Targeted Therapy
Dandan Wang, Kai Ma, Wei Deng, Jingyu Li, Shaohua Xiang, Yang Zhang, Ying Fu, Heng Dai & Bingding Huang
Pages: 2423-2431
Published online: 07 Apr 2021
AbstractforDevelopment and Analytical Validation of a Targeted Next-Generation Sequencing Panel to Detect Actionable Mutations for Targeted Therapy | Full Text | References | PDF (829 KB)
  • 92 Views
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Article
Integrated Profiling Identifies CCNA2 as a Potential Biomarker of Immunotherapy in Breast Cancer
Yichao Wang, Qianyi Zhong, Zhaoyun Li, Zhu Lin, Hanjun Chen & Pan Wang
Pages: 2433-2448
Published online: 09 Apr 2021
AbstractforIntegrated Profiling Identifies CCNA2 as a Potential Biomarker of Immunotherapy in Breast Cancer | Full Text | References | PDF (21.3 MB)
  • 131 Views
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Open Access
Article
Lipid–Polymer Hybrid Nanoparticle-Based Combination Treatment with Cisplatin and EGFR/HER2 Receptor-Targeting Afatinib to Enhance the Treatment of Nasopharyngeal Carcinoma
Dehui Fu, Chao Li & Yongwang Huang
Pages: 2449-2461
Published online: 09 Apr 2021
AbstractforLipid–Polymer Hybrid Nanoparticle-Based Combination Treatment with Cisplatin and EGFR/HER2 Receptor-Targeting Afatinib to Enhance the Treatment of Nasopharyngeal Carcinoma | Full Text | References | PDF (6.6 MB)
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Article
Actin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway
Shaoxia Fan, Shen Yan, Yang Yang, Jian Shang & Min Hao
Pages: 2463-2473
Published online: 12 Apr 2021
AbstractforActin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway | Full Text | References | PDF (10.1 MB)
  • 104 Views
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Article
Circ_0006168 Promotes the Migration, Invasion and Proliferation of Esophageal Squamous Cell Carcinoma Cells via miR-516b-5p-Dependent Regulation of XBP1
Yunhe Huang, Lei Jiang & Guangxia Wei
Pages: 2475-2488
Published online: 12 Apr 2021
AbstractforCirc_0006168 Promotes the Migration, Invasion and Proliferation of Esophageal Squamous Cell Carcinoma Cells via miR-516b-5p-Dependent Regulation of XBP1 | Full Text | References | PDF (9.8 MB)
  • 48 Views
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Case Report

Case Report
Promising Response to Lenalidomide-Combination Therapy in a Discordant Lymphoma Consisting of EBV-Positive Diffuse Large B-Cell Lymphoma and Angioimmunoblastic T-Cell Lymphoma: A Case Report
Pan Hu, Yu Ben, Juan Liu, Weicheng Zheng, Xiyue Yan, Yaping Zhang & Wenyu Shi
Pages: 2489-2495
Published online: 12 Apr 2021
AbstractforPromising Response to Lenalidomide-Combination Therapy in a Discordant Lymphoma Consisting of EBV-Positive Diffuse Large B-Cell Lymphoma and Angioimmunoblastic T-Cell Lymphoma: A Case Report | Full Text | References | PDF (3.1 MB)
  • 77 Views
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Case Report
Hodgkin Lymphoma as a Secondary Neoplasm During Therapy for Chronic Myeloid Leukaemia: Case Report and Review of the Literature
Edyta Paczkowska, Michał Janowski, Katarzyna Karpińska, Małgorzata Ryłów, Barbara Zdziarska, Wojciech Poncyljusz & Bogusław Machaliński
Pages: 2497-2503
Published online: 12 Apr 2021
AbstractforHodgkin Lymphoma as a Secondary Neoplasm During Therapy for Chronic Myeloid Leukaemia: Case Report and Review of the Literature | Full Text | References | PDF (1.4 MB)
  • 62 Views
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Original Research

Article
Calycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-κB Pathway
Yu Zhang, Jian-Qiang Zhang, Tong Zhang, Hui Xue, Wen-Bo Zuo, Yan-Nan Li, Yue Zhao, Geng Sun, Zhong-Ren Fu, Qing Zhang, Xue Zhao, Yue Teng, An-Qi Wang, Jia-Zhu Li, Ying Wang & Cheng-Hao Jin
Pages: 2505-2517
Published online: 12 Apr 2021
AbstractforCalycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-κB Pathway | Full Text | References | PDF (10.9 MB)
  • 141 Views
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Article
GDC-0326 Enhances the Effects of 5-Fu in Colorectal Cancer Cells by Inducing Necroptotic Death
Zizhen Zhang, Fangyu Ju, Fei Chen, Haoyue Wu, Jingyu Chen, Jing Zhong, Liming Shao, Sheng Zheng, Liangjing Wang & Meng Xue
Pages: 2519-2530
Published online: 13 Apr 2021
AbstractforGDC-0326 Enhances the Effects of 5-Fu in Colorectal Cancer Cells by Inducing Necroptotic Death | Full Text | References | PDF (9.4 MB)
  • 72 Views
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Review

Review Article
Consequences of Mutations and Abnormal Expression of SMAD4 in Tumors and T Cells
Rongxue Wan, Jianguo Feng & Liling Tang
Pages: 2531-2540
Published online: 13 Apr 2021
AbstractforConsequences of Mutations and Abnormal Expression of SMAD4 in Tumors and T Cells | Full Text | References | PDF (709.4 KB)
  • 123 Views
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Original Research

Article
MicroRNA-302s Might Regulate ARL4C-Mediated Gastric Cancer Progression via p53 Signaling: Bioinformatics Analysis and Experiments Validation
Ning Xie, Yifei Pan, Jian Wu, Yunfan Bai, Cailan Xiao, Xiaoliang Gao, Jinhai Wang & Na Liu
Pages: 2541-2553
Published online: 13 Apr 2021
AbstractforMicroRNA-302s Might Regulate ARL4C-Mediated Gastric Cancer Progression via p53 Signaling: Bioinformatics Analysis and Experiments Validation | Full Text | References | PDF (7.7 MB)
  • 64 Views
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Case Report

Case Report
Complete Pathologic Response After Concurrent Treatment with Pembrolizumab and Radiotherapy in Metastatic Colorectal Cancer: A Case Report
Jian Yang, Feng Bi & Hongfeng Gou
Pages: 2555-2561
Published online: 13 Apr 2021
AbstractforComplete Pathologic Response After Concurrent Treatment with Pembrolizumab and Radiotherapy in Metastatic Colorectal Cancer: A Case Report | Full Text | References | PDF (660.6 KB)
  • 116 Views
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Review

Review Article
Dihydroartemisinin as a Sensitizing Agent in Cancer Therapies
Qingrong Li, Qiang Ma, Jibing Cheng, Xi Zhou, Wenjie Pu, Xiaowu Zhong & Xiaolan Guo
Pages: 2563-2573
Published online: 13 Apr 2021
AbstractforDihydroartemisinin as a Sensitizing Agent in Cancer Therapies | Full Text | References | PDF (2.4 MB)
  • 171 Views
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Case Report

Case Report
Coexistence of Lung Squamous Cell Carcinoma and Pulmonary Tuberculosis Within a Single Lesion: A Case Report
Ming-Jing Yu, Pei-Jun Li & Zong-An Liang
Pages: 2575-2578
Published online: 13 Apr 2021
AbstractforCoexistence of Lung Squamous Cell Carcinoma and Pulmonary Tuberculosis Within a Single Lesion: A Case Report | Full Text | References | PDF (1.6 MB)
  • 84 Views
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Original Research

Article
A Novel Transcription Factor-Based Prognostic Signature in Endometrial Cancer: Establishment and Validation
Xiao Yang, Yuan Cheng, Xingchen Li, Jingyi Zhou, Yangyang Dong, Boqiang Shen, Lijun Zhao & Jianliu Wang
Pages: 2579-2598
Published online: 13 Apr 2021
AbstractforA Novel Transcription Factor-Based Prognostic Signature in Endometrial Cancer: Establishment and Validation | Full Text | References | PDF (30.3 MB)
  • 79 Views
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Article
Construction of the Prediction Model for Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy Based on Pretreatment Tumor-Infiltrating Macrophage-Associated Biomarkers
Xing Liu, Shuping Zheng, Yong Peng, Jinfu Zhuang, Yuanfeng Yang, Yunlu Xu & Guoxian Guan
Pages: 2599-2610
Published online: 13 Apr 2021
AbstractforConstruction of the Prediction Model for Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy Based on Pretreatment Tumor-Infiltrating Macrophage-Associated Biomarkers | Full Text | References | PDF (4 MB)
  • 66 Views
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Review

Review Article
Role of G Protein-Coupled Estrogen Receptor in Digestive System Carcinomas: A Minireview
Yu-an Qiu, Jianping Xiong & Tenghua Yu
Pages: 2611-2622
Published online: 14 Apr 2021
AbstractforRole of G Protein-Coupled Estrogen Receptor in Digestive System Carcinomas: A Minireview | Full Text | References | PDF (1.4 MB)
  • 83 Views
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Original Research

Article
A Combination of RNA-Seq Analysis and Use of TCGA Database for Determining the Molecular Mechanism and Identifying Potential Drugs for GJB1 in Ovarian Cancer
Jie Yang, Yaqin Fan, Beibei Xie & Dan Yang
Pages: 2623-2633
Published online: 14 Apr 2021
AbstractforA Combination of RNA-Seq Analysis and Use of TCGA Database for Determining the Molecular Mechanism and Identifying Potential Drugs for GJB1 in Ovarian Cancer | Full Text | References | PDF (7.3 MB)
  • 102 Views
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Article
Bioinformatics Analysis of the SIRT Family Members and Assessment of Their Potential Clinical Value
Mingjiang Liu, Jingjing Yu, Hu Jin, Sifan Wang, Jin Ding, Hao Xing, Songqing He & Yonglian Zeng
Pages: 2635-2649
Published online: 15 Apr 2021
AbstractforBioinformatics Analysis of the SIRT Family Members and Assessment of Their Potential Clinical Value | Full Text | References | PDF (20.6 MB)
  • 76 Views
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Article
Desmoplastic Melanoma: A Clinicopathological Analysis of Three Cases in the Chinese Population
Yaqi Fan, Mingyuan Xu, Yulin Liang, Nanhui Wu, Feiyan Wang, Qian Du, Yun Bai & Yeqiang Liu
Pages: 2651-2660
Published online: 15 Apr 2021
AbstractforDesmoplastic Melanoma: A Clinicopathological Analysis of Three Cases in the Chinese Population | Full Text | References | PDF (772.1 KB)
  • 234 Views
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Article
GDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2+ Macrophage Infiltration in Mice
Min Li, Tianqing Huang, Xiaolan Li, Zhiwei Shi, Yue Sheng, Mimi Hu & Kui Song
Pages: 2661-2672
Published online: 15 Apr 2021
AbstractforGDC-0575, a CHK1 Inhibitor, Impairs the Development of Colitis and Colitis-Associated Cancer by Inhibiting CCR2+ Macrophage Infiltration in Mice | Full Text | References | PDF (901.1 KB)
  • 68 Views
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Article
3D Culture of Circulating Tumor Cells for Evaluating Early Recurrence and Metastasis in Patients with Hepatocellular Carcinoma
Cong-Li Hu, Yan-Jun Zhang, Xiao-Feng Zhang, Xiang Fei, Hai Zhang, Chun-Guang Li & Bin Sun
Pages: 2673-2688
Published online: 16 Apr 2021
Abstractfor3D Culture of Circulating Tumor Cells for Evaluating Early Recurrence and Metastasis in Patients with Hepatocellular Carcinoma | Full Text | References | PDF (11 MB)
  • 168 Views
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Article
Expression and Prognosis of Sperm-Associated Antigen 1 in Human Breast Cancer
Shuangyan Lin, Yanbo Lv, Luoning Zheng, Genxiang Mao & Fang Peng
Pages: 2689-2698
Published online: 16 Apr 2021
AbstractforExpression and Prognosis of Sperm-Associated Antigen 1 in Human Breast Cancer | Full Text | References | PDF (613 KB)
  • 66 Views
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Article
Long Noncoding RNA ZEB1-AS1 Downregulates miR-23a, Promotes Tumor Progression, and Predicts the Survival of Oral Squamous Cell Carcinoma Patients
Xue Wang, Yan Guo, Chunyu Wang, Qiang Wang & Guangqi Yan
Pages: 2699-2710
Published online: 16 Apr 2021
AbstractforLong Noncoding RNA ZEB1-AS1 Downregulates miR-23a, Promotes Tumor Progression, and Predicts the Survival of Oral Squamous Cell Carcinoma Patients | Full Text | References | PDF (7.4 MB)
  • 70 Views
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Article
LINC00184 Promotes Ovarian Cancer Cells Proliferation and Cisplatin Resistance by Elevating CNTN1 Expression via Sponging miR-1305
Yuwen Han, Jun You, Yun Han, Yinglei Liu, Menghui Huang, Xiaoyan Lu, Jingjing Chen & Yanli Zheng
Pages: 2711-2726
Published online: 19 Apr 2021
AbstractforLINC00184 Promotes Ovarian Cancer Cells Proliferation and Cisplatin Resistance by Elevating CNTN1 Expression via Sponging miR-1305 | Full Text | References | PDF (9.3 MB)
  • 72 Views
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Article
Exosomes Derived from Pancreatic Cancer Cells Induce Osteoclast Differentiation Through the miR125a-5p/TNFRSF1B Pathway
Yizhao Zhou, Yi Zhu, Xin Dong, Guodong Cao, Yongzhou Li, Yiqun Fan, Qing Chen, Haolei Cai & Yulian Wu
Pages: 2727-2739
Published online: 19 Apr 2021
AbstractforExosomes Derived from Pancreatic Cancer Cells Induce Osteoclast Differentiation Through the miR125a-5p/TNFRSF1B Pathway | Full Text | References | PDF (7.4 MB)
  • 137 Views
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Case Report

Case Report
A Remarkable and Durable Response to Sintilimab and Anlotinib in the First-Line Treatment of an Anaplastic Thyroid Carcinoma without Targetable Genomic Alterations: A Case Report
Lin Gui, Shaoyan Liu, Ye Zhang & Yuankai Shi
Pages: 2741-2746
Published online: 20 Apr 2021
AbstractforA Remarkable and Durable Response to Sintilimab and Anlotinib in the First-Line Treatment of an Anaplastic Thyroid Carcinoma without Targetable Genomic Alterations: A Case Report | Full Text | References | PDF (1,018 KB)
  • 72 Views
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Original Research

Article
lncRNA GSEC Promotes the Progression of Triple Negative Breast Cancer (TNBC) by Targeting the miR-202-5p/AXL Axis
Jianhua Zhang, Chuang Du, Linfeng Zhang, Yan Wang, Yingying Zhang & Jingruo Li
Pages: 2747-2759
Published online: 20 Apr 2021
AbstractforlncRNA GSEC Promotes the Progression of Triple Negative Breast Cancer (TNBC) by Targeting the miR-202-5p/AXL Axis | Full Text | References | PDF (739.1 KB)
  • 86 Views
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Review

Review Article
A Concise Review: The Role of Stem Cells in Cancer Progression and Therapy
Hasaan Hayat, Hanaan Hayat, Bennett Francis Dwan, Mithil Gudi, Jack Owen Bishop & Ping Wang
Pages: 2761-2772
Published online: 20 Apr 2021
AbstractforA Concise Review: The Role of Stem Cells in Cancer Progression and Therapy | Full Text | References | PDF (921.7 KB)
  • 176 Views
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Original Research

Article
Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis
Haifeng Gao, Jiajia Xu, Fen Qiao & Liangjun Xue
Pages: 2773-2787
Published online: 20 Apr 2021
AbstractforDepletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis | Full Text | References | PDF (971.2 KB)
  • 68 Views
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Article
Downregulation of Chemokine CCL20 Involved in Myeloma Cells Resistant to Elotuzumab and Lenalidomide
Huihan Wang, Hua Shi, Xiaowei He & Aijun Liao
Pages: 2789-2795
Published online: 21 Apr 2021
AbstractforDownregulation of Chemokine CCL20 Involved in Myeloma Cells Resistant to Elotuzumab and Lenalidomide | Full Text | References | PDF (2.6 MB)
  • 81 Views
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Case Series

Case Report
Maintenance Long-Term Multiple Cycles Treatment with Docetaxel in Metastatic Castration-Resistant Prostate Cancer: A Report of Three Cases
Jian-zhou Cao, Jin-feng Pan, Derry Mingyao Ng, Meng-qi Ying, Jun-hui Jiang & Qi Ma
Pages: 2797-2803
Published online: 21 Apr 2021
AbstractforMaintenance Long-Term Multiple Cycles Treatment with Docetaxel in Metastatic Castration-Resistant Prostate Cancer: A Report of Three Cases | Full Text | References | PDF (2.1 MB)
  • 59 Views
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Original Research

Article
Expression Profiles of tRNA-Derived Fragments and Their Potential Roles in Multiple Myeloma
Cong Xu & Yunfeng Fu
Pages: 2805-2814
Published online: 22 Apr 2021
AbstractforExpression Profiles of tRNA-Derived Fragments and Their Potential Roles in Multiple Myeloma | Full Text | References | PDF (564 KB)
  • 72 Views
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Case Report

Case Report
Olaparib Treatment in a Patient with Advanced Gallbladder Cancer Harboring BRCA1 Mutation
Xiaofen Li, Limin Gao, Meng Qiu & Dan Cao
Pages: 2815-2819
Published online: 22 Apr 2021
AbstractforOlaparib Treatment in a Patient with Advanced Gallbladder Cancer Harboring BRCA1 Mutation | Full Text | References | PDF (315.9 KB)
  • 90 Views
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Erratum

Correction
Coexistence of Lung Squamous Cell Carcinoma and Pulmonary Tuberculosis Within a Single Lesion: A Case Report [Erratum]
Page: 2821
Published online: 23 Apr 2021
CitationforCoexistence of Lung Squamous Cell Carcinoma and Pulmonary Tuberculosis Within a Single Lesion: A Case Report [Erratum] | Full Text | PDF (152.4 KB)
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Case Report

Case Report
EGFR (p. G719A+L747V)/EML4-ALK Co-alterations in Lung Adenocarcinoma with Leptomeningeal Metastasis Responding to Afatinib Treatment: A Case Report
Zhiqin Lu, Xia Wang, Yuxi Luo, Jianping Wei, Zhimin Zeng, Qiang Xiong, Jing Cai & Anwen Liu
Pages: 2823-2828
Published online: 23 Apr 2021
AbstractforEGFR (p. G719A+L747V)/EML4-ALK Co-alterations in Lung Adenocarcinoma with Leptomeningeal Metastasis Responding to Afatinib Treatment: A Case Report | Full Text | References | PDF (428.3 KB)
  • 57 Views
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Original Research

Article
A Novel Circular RNA circCSPP1 Promotes Liver Cancer Progression by Sponging miR-1182
Nan Jia, Zhe Song, Baosheng Chen, Jinsheng Cheng & Wenyong Zhou
Pages: 2829-2838
Published online: 23 Apr 2021
AbstractforA Novel Circular RNA circCSPP1 Promotes Liver Cancer Progression by Sponging miR-1182 | Full Text | References | PDF (6 MB)
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Case Report

Case Report
Genetic Analysis and Targeted Therapy Using Buparlisib and MK2206 in a Patient with Triple Metachronous Cancers of the Kidney, Prostate, and Squamous Cell Carcinoma of the Lung: A Case Report
Tong Zhao, Yuqin Tian, Xinjia Ding, Lin Liu, Bowen Tan, Bin Yang, Jianlin Wu, Ting Lei, Ruoyu Wang & Yan Ding
Pages: 2839-2845
Published online: 28 Apr 2021
AbstractforGenetic Analysis and Targeted Therapy Using Buparlisib and MK2206 in a Patient with Triple Metachronous Cancers of the Kidney, Prostate, and Squamous Cell Carcinoma of the Lung: A Case Report | Full Text | References | PDF (4.9 MB)
  • 77 Views
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Case Report
Combination of Osimertinib and Anlotinib May Overcome the Resistance Mediated by in cis EGFR T790M-C797S in NSCLC: A Case Report
Rengui Zhou, Lei Song, Wenwen Zhang, Lin Shao, Xi Li & Xiangyong Li
Pages: 2847-2851
Published online: 28 Apr 2021
AbstractforCombination of Osimertinib and Anlotinib May Overcome the Resistance Mediated by in cis EGFR T790M-C797S in NSCLC: A Case Report | Full Text | References | PDF (1.9 MB)
  • 110 Views
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Original Research

Article
TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer
Yufeng Wang, Chuanhui Miao & Xiang Gao
Pages: 2853-2865
Published online: 28 Apr 2021
AbstractforTCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer | Full Text | References | PDF (767.3 KB)
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Article
LncRNA EGOT/miR-211-5p Affected Radiosensitivity of Rectal Cancer by Competitively Regulating ErbB4
Chunxiang Li, Hengchang Liu, Ran Wei, Zheng Liu, Haipeng Chen, Xu Guan, Zhixun Zhao, Xishan Wang & Zheng Jiang
Pages: 2867-2878
Published online: 28 Apr 2021
AbstractforLncRNA EGOT/miR-211-5p Affected Radiosensitivity of Rectal Cancer by Competitively Regulating ErbB4 | Full Text | References | PDF (7.3 MB)
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Article
MiR-140-3p Impedes Gastric Cancer Progression and Metastasis by Regulating BCL2/BECN1-Mediated Autophagy
Jianliang Chen, Shengqiang Cai, Tianchun Gu, Fei Song, Yingchun Xue & Di Sun
Pages: 2879-2892
Published online: 29 Apr 2021
AbstractforMiR-140-3p Impedes Gastric Cancer Progression and Metastasis by Regulating BCL2/BECN1-Mediated Autophagy | Full Text | References | PDF (871.6 KB)
  • 91 Views
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Article
Exploration of the Associations of lncRNA Expression Patterns with Tumor Mutation Burden and Prognosis in Colon Cancer
Chengsheng Ding, Zezhi Shan, Mengcheng Li, Yang Xia & Zhiming Jin
Pages: 2893-2909
Published online: 29 Apr 2021
AbstractforExploration of the Associations of lncRNA Expression Patterns with Tumor Mutation Burden and Prognosis in Colon Cancer | Full Text | References | PDF (3.7 MB)
  • 85 Views
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Case Report

Case Report
Alectinib for Miliary Lung Metastasis in ALK-Positive Lung Adenocarcinoma
Hironori Satoh, Yusuke Okuma, Jumpei Kashima, Aya Konnno-Yamamoto, Yasushi Yatabe & Yuichiro Ohe
Pages: 2911-2915
Published online: 30 Apr 2021
AbstractforAlectinib for Miliary Lung Metastasis in ALK-Positive Lung Adenocarcinoma | Full Text | References | PDF (1.5 MB)
  • 48 Views
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Original Research

Article
Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma
Wanli Gu, Peng Chen, Peng Ren, Yanhai Wang, Xiaobing Li & Mingzhi Gong
Pages: 2917-2927
Published online: 30 Apr 2021
AbstractforDownregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma | Full Text | References | PDF (6.6 MB)
  • 51 Views
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Review

Review Article
Advances in Therapy for Hormone Receptor (HR)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Advanced Breast Cancer Patients Who Have Experienced Progression After Treatment with CDK4/6 Inhibitors
Chao Li & Xujun Li
Pages: 2929-2939
Published online: 03 May 2021
AbstractforAdvances in Therapy for Hormone Receptor (HR)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Advanced Breast Cancer Patients Who Have Experienced Progression After Treatment with CDK4/6 Inhibitors | Full Text | References | PDF (467.2 KB)
  • 100 Views
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Original Research

Article
Gαi1 Promoted Proliferation, Migration and Invasion via Activating the Akt-mTOR/Erk-MAPK Signaling Pathway in Renal Cell Carcinoma
Zhan Chen, Yong Zhang, Xiang Wu, Ji Zhang, Wei Xu, Cheng Shen & Bing Zheng
Pages: 2941-2952
Published online: 04 May 2021
AbstractforGαi1 Promoted Proliferation, Migration and Invasion via Activating the Akt-mTOR/Erk-MAPK Signaling Pathway in Renal Cell Carcinoma | Full Text | References | PDF (8.7 MB)
  • 55 Views
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Article
Tumor Mutation Burden and Differentially Mutated Genes Among Immune Phenotypes in Patients with Lung Adenocarcinoma
Hao Wang, Shanhao Chen, Die Meng, Chunyan Wu, Junjie Zhu, Minlin Jiang, Jing Ning, Shengyu Wu, Lijia Wu, Jingjie Li, Bin Chen, Sha Zhao, Wei Li, Jia Yu, Qiyu Fang, Jun Zhu, Wencheng Zhao, Yayi He & Caicun Zhou
Pages: 2953-2965
Published online: 04 May 2021
AbstractforTumor Mutation Burden and Differentially Mutated Genes Among Immune Phenotypes in Patients with Lung Adenocarcinoma | Full Text | References | PDF (4.7 MB)
  • 77 Views
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Review

Review Article
Treatment Strategies for Metastatic Castration-Sensitive Prostate Cancer: From “All-Comers” to “Personalized” Approach
Kenichi Harada, Masaki Shiota, Akinori Minato, Masahiro Matsumoto, Ikko Tomisaki, Masato Fujisawa & Naohiro Fujimoto
Pages: 2967-2974
Published online: 05 May 2021
AbstractforTreatment Strategies for Metastatic Castration-Sensitive Prostate Cancer: From “All-Comers” to “Personalized” Approach | Full Text | References | PDF (587 KB)
  • 140 Views
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Original Research

Article
High Expression of SLC41A3 Correlates with Poor Prognosis in Hepatocellular Carcinoma
Qian Li, Dan-Lei Xiong, Heng Wang, Wei-Li Jin, Ying-Yu Ma & Xiao-Ming Fan
Pages: 2975-2988
Published online: 05 May 2021
AbstractforHigh Expression of SLC41A3 Correlates with Poor Prognosis in Hepatocellular Carcinoma | Full Text | References | PDF (9.1 MB)
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Corrigendum

Correction
MIIP is Downregulated in Gastric Cancer and Its Forced Expression Inhibits Proliferation and Invasion of Gastric Cancer Cells in vitro and in vivo [Corrigendum]
Pages: 2989-2990
Published online: 06 May 2021
CitationforMIIP is Downregulated in Gastric Cancer and Its Forced Expression Inhibits Proliferation and Invasion of Gastric Cancer Cells in vitro and in vivo [Corrigendum] | Full Text | PDF (2.1 MB)
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Original Research

Article
Increased Collagen Type V α2 (COL5A2) in Colorectal Cancer is Associated with Poor Prognosis and Tumor Progression
Jie Wang, Ying-Hua Jiang, Peng-Yuan Yang & Feng Liu
Pages: 2991-3002
Published online: 05 May 2021
AbstractforIncreased Collagen Type V α2 (COL5A2) in Colorectal Cancer is Associated with Poor Prognosis and Tumor Progression | Full Text | References | PDF (920.7 KB)
  • 102 Views
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Case Report

Case Report
A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review
Mei Er Tu He Ta Mi Shi, Ning Wang, Qing Yao, Shuang-Shuang Dong, Xiao Feng, Jin Zhao, Hong Zou, Li-Juan Pang & Yan Qi
Pages: 3003-3011
Published online: 06 May 2021
AbstractforA Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review | Full Text | References | PDF (1.2 MB)
  • 87 Views
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Review

Review Article
Emerging Mechanisms and Treatment Progress on Liver Metastasis of Colorectal Cancer
Wubin Zheng, Fan Wu, Kai Fu, Guangshun Sun, Guoqiang Sun, Xiao Li, Wei Jiang, Hongyong Cao, Hanjin Wang & Weiwei Tang
Pages: 3013-3036
Published online: 06 May 2021
AbstractforEmerging Mechanisms and Treatment Progress on Liver Metastasis of Colorectal Cancer | Full Text | References | PDF (1.1 MB)
  • 156 Views
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Clinical Trial Report

Case Report
A Phase I Trial of the MET/ALK/ROS1 Inhibitor Crizotinib Combined with the VEGF Inhibitor Pazopanib in Patients with Advanced Solid Malignancies
Sarina A Piha-Paul, Ecaterina E Dumbrava, Binoj C Nair, Wendy Xiong, Li Xu, Rosa Mostorino, Vivek Subbiah, Nizar Tannir, Siqing Fu, Aung Naing, Filip Janku, Daniel D Karp, Shreyaskumar Patel, Najat C Daw, David Hong, Funda Meric-Bernstam & Ralph Zinner
Pages: 3037-3049
Published online: 07 May 2021
AbstractforA Phase I Trial of the MET/ALK/ROS1 Inhibitor Crizotinib Combined with the VEGF Inhibitor Pazopanib in Patients with Advanced Solid Malignancies | Full Text | References | PDF (368.9 KB)
  • 87 Views
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Original Research

Article
IFNγ/PD-L1 Signaling Improves the Responsiveness of Anti-PD-1 Therapy in Colorectal Cancer: An in vitro Study
Wenli Yuan, Deyao Deng, Hanyu Li, Xinghui Hu, Xueqin Shang, Xia Hou, Hongchao Jiang & Hongchun He
Pages: 3051-3062
Published online: 07 May 2021
AbstractforIFNγ/PD-L1 Signaling Improves the Responsiveness of Anti-PD-1 Therapy in Colorectal Cancer: An in vitro Study | Full Text | References | PDF (685.7 KB)
  • 74 Views
  • 1 CrossRef citations
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Open Access

Case Report

Case Report
Significant Benefits of Afatinib and Apatinib in a Refractory Advanced NSCLC Patient Resistant to Osimertinib: A Case Report
Yuanyang Zhao, Yuxing Chen, Huaying Huang, Xi Li, Lin Shao & Hao Ding
Pages: 3063-3067
Published online: 07 May 2021
AbstractforSignificant Benefits of Afatinib and Apatinib in a Refractory Advanced NSCLC Patient Resistant to Osimertinib: A Case Report | Full Text | References | PDF (395.6 KB)
  • 70 Views
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Open Access

Original Research

Article
Effect of GLUT1 Inhibition and Autophagy Modulation on the Growth and Migration of Laryngeal Carcinoma Stem Cells Under Hypoxic and Low-Glucose Conditions
Xiao-Hong Chen, Jia Liu, Jiang-Tao Zhong, Shui-Hong Zhou & Jun Fan
Pages: 3069-3081
Published online: 11 May 2021
AbstractforEffect of GLUT1 Inhibition and Autophagy Modulation on the Growth and Migration of Laryngeal Carcinoma Stem Cells Under Hypoxic and Low-Glucose Conditions | Full Text | References | PDF (13.6 MB)
  • 91 Views
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Open Access
Article
Long Noncoding RNA CCDC26 Promotes Thyroid Cancer Malignant Progression via miR-422a/EZH2/Sirt6 Axis
Xiao Ma, Yanyan Li, Yuntao Song & Guohui Xu
Pages: 3083-3094
Published online: 11 May 2021
AbstractforLong Noncoding RNA CCDC26 Promotes Thyroid Cancer Malignant Progression via miR-422a/EZH2/Sirt6 Axis | Full Text | References | PDF (7.6 MB)
  • 72 Views
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Open Access
Article
Inhibition of circRNA circVPS33B Reduces Warburg Effect and Tumor Growth Through Regulating the miR-873-5p/HNRNPK Axis in Infiltrative Gastric Cancer
Yizhuo Lu, Jia Cheng, Wangyu Cai, Huiqin Zhuo, Guoyang Wu & Jianchun Cai
Pages: 3095-3108
Published online: 12 May 2021
AbstractforInhibition of circRNA circVPS33B Reduces Warburg Effect and Tumor Growth Through Regulating the miR-873-5p/HNRNPK Axis in Infiltrative Gastric Cancer | Full Text | References | PDF (874.6 KB)
  • 45 Views
  • 3 CrossRef citations
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Open Access
Article
MiR-17 and miR-93 Promote Tumor Progression by Targeting p21 in Patients with Chordoma
Wei Dong, Jingwu Li, Xiaoliu Dong, Wenjian Shi, Yu Zhang & Yongliang Liu
Pages: 3109-3118
Published online: 12 May 2021
AbstractforMiR-17 and miR-93 Promote Tumor Progression by Targeting p21 in Patients with Chordoma | Full Text | References | PDF (559 KB)
  • 68 Views
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Open Access
Article
Identification of the EMT-Related Genes Signature for Predicting Occurrence and Progression in Thyroid Cancer
Qiang Li, Sheng Jiang, Tienan Feng, Tengteng Zhu & Biyun Qian
Pages: 3119-3131
Published online: 12 May 2021
AbstractforIdentification of the EMT-Related Genes Signature for Predicting Occurrence and Progression in Thyroid Cancer | Full Text | References | PDF (837.7 KB)
  • 77 Views
  • 3 CrossRef citations
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Article
Epigenetic Study of Esophageal Carcinoma Based on Methylation, Gene Integration and Weighted Correlation Network Analysis
Yanzhao Xu, Na Wang, Rongfeng Liu, Huilai Lv, Zhenhua Li, Fan Zhang, Chunyue Gai & Ziqiang Tian
Pages: 3133-3149
Published online: 13 May 2021
AbstractforEpigenetic Study of Esophageal Carcinoma Based on Methylation, Gene Integration and Weighted Correlation Network Analysis | Full Text | References | PDF (8.2 MB)
  • 77 Views
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Article
CircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway
Yang Cao, Xin Xie, Mingzhu Li & Yuhua Gao
Pages: 3151-3165
Published online: 13 May 2021
AbstractforCircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway | Full Text | References | PDF (1.2 MB)
  • 92 Views
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Open Access

Case Report

Case Report
Diagnosis and Individualized Treatment of Secondary Central Nervous System Lymphoma: A Case Report
Qian Li, Wei Liu, Kai Li, Yifu Tian & Huan Li
Pages: 3167-3175
Published online: 13 May 2021
AbstractforDiagnosis and Individualized Treatment of Secondary Central Nervous System Lymphoma: A Case Report | Full Text | References | PDF (585.3 KB)
  • 63 Views
  • 1 CrossRef citations
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Open Access

Retraction

Retraction
MiR-502-3P Suppresses Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Targeting SET [Retraction]
Page: 3177
Published online: 18 May 2021
CitationforMiR-502-3P Suppresses Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Targeting SET [Retraction] | Full Text | PDF (165.2 KB)
  • 51 Views
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Open Access

Original Research

Article
Regional Brain Glucose Metabolism and Its Prognostic Value in Pretreatment Extranodal Natural Killer/T-Cell Lymphoma Patients
Ziwei Zhou, Zhe Guo, Qingqiao Hu, Wei Ding, Chongyang Ding & Lijun Tang
Pages: 3179-3191
Published online: 14 May 2021
AbstractforRegional Brain Glucose Metabolism and Its Prognostic Value in Pretreatment Extranodal Natural Killer/T-Cell Lymphoma Patients | Full Text | References | PDF (723.9 KB)
  • 61 Views
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Case Report

Case Report
Case Report of a Breast Mass with Three Types of Malignant Tumors—Squamous Cell Carcinoma, Invasive Ductal Carcinoma, and Breast Sarcoma
Chao Li, Hongfei Fang & Hongfeng Lu
Pages: 3193-3197
Published online: 14 May 2021
AbstractforCase Report of a Breast Mass with Three Types of Malignant Tumors—Squamous Cell Carcinoma, Invasive Ductal Carcinoma, and Breast Sarcoma | Full Text | References | PDF (411.5 KB)
  • 75 Views
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Original Research

Article
Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway
Feng Cheng, Jintao Dou, Yong Zhang, Xiang Wang, Huijun Wei, Zhijian Zhang, Yuxiang Cao & Zhihao Wu
Pages: 3199-3208
Published online: 17 May 2021
AbstractforUrolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway | Full Text | References | PDF (557.3 KB)
  • 146 Views
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Open Access
Article
LncRNA ST8SIA6-AS1 Promotes Cholangiocarcinoma Progression by Suppressing the miR-145-5p/MAL2 Axis
Junchuang He, Hongxian Yan, Sidong Wei & Guoyong Chen
Pages: 3209-3223
Published online: 17 May 2021
AbstractforLncRNA ST8SIA6-AS1 Promotes Cholangiocarcinoma Progression by Suppressing the miR-145-5p/MAL2 Axis | Full Text | References | PDF (984.6 KB)
  • 61 Views
  • 4 CrossRef citations
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Open Access
Article
Long Noncoding RNA LINC01410 Suppresses Tumorigenesis and Enhances Radiosensitivity in Neuroblastoma Cells Through Regulating miR-545-3p/HK2 Axis
Liping Mou, Lili Wang, Shaoming Zhang & Qinghua Wang
Pages: 3225-3238
Published online: 18 May 2021
AbstractforLong Noncoding RNA LINC01410 Suppresses Tumorigenesis and Enhances Radiosensitivity in Neuroblastoma Cells Through Regulating miR-545-3p/HK2 Axis | Full Text | References | PDF (9.2 MB)
  • 58 Views
  • 8 CrossRef citations
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Open Access
Article
MicroRNA-29b-3p Inhibits the Migration and Invasion of Gastric Cancer Cells by Regulating the Autophagy-Associated Protein MAZ
Xiaomeng Zhao, Nan Ye, Xueke Feng, Haiyan Ju, Ruixia Liu & Wenyu Lu
Pages: 3239-3249
Published online: 18 May 2021
AbstractforMicroRNA-29b-3p Inhibits the Migration and Invasion of Gastric Cancer Cells by Regulating the Autophagy-Associated Protein MAZ | Full Text | References | PDF (5.7 MB)
  • 87 Views
  • 11 CrossRef citations
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Open Access
Article
Comprehensive Analysis of the Relationship Between Metabolic Reprogramming and Immune Function in Prostate Cancer
Weijie Xie, Huan Guo, Jiawei Zhang, Li Hu, Yuqi Wu & Xiangwei Wang
Pages: 3251-3266
Published online: 18 May 2021
AbstractforComprehensive Analysis of the Relationship Between Metabolic Reprogramming and Immune Function in Prostate Cancer | Full Text | References | PDF (11.8 MB)
  • 90 Views
  • 6 CrossRef citations
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Open Access
Article
Artificial Intelligence Based on Blood Biomarkers Including CTCs Predicts Outcomes in Epithelial Ovarian Cancer: A Prospective Study
Jun Ma, Jiani Yang, Yue Jin, Shanshan Cheng, Shan Huang, Nan Zhang & Yu Wang
Pages: 3267-3280
Published online: 18 May 2021
AbstractforArtificial Intelligence Based on Blood Biomarkers Including CTCs Predicts Outcomes in Epithelial Ovarian Cancer: A Prospective Study | Full Text | References | PDF (737.6 KB)
  • 344 Views
  • 15 CrossRef citations
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Article
Circular RNA circWDR27 Promotes Papillary Thyroid Cancer Progression by Regulating miR-215-5p/TRIM44 Axis
Weilan Wang, Chengmin Huang, Peng Luo, Jiang Yao, Jie Li, Wenxia Wang & Fengqin Liu
Pages: 3281-3293
Published online: 19 May 2021
AbstractforCircular RNA circWDR27 Promotes Papillary Thyroid Cancer Progression by Regulating miR-215-5p/TRIM44 Axis | Full Text | References | PDF (786 KB)
  • 47 Views
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Open Access

Retraction

Retraction
MiR-144 Suppresses Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Targeting SMAD4 [Retraction]
Pages: 3295-3296
Published online: 19 May 2021
CitationforMiR-144 Suppresses Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Targeting SMAD4 [Retraction] | Full Text | PDF (177.8 KB)
  • 55 Views
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Open Access

Original Research

Article
Banxia Xiexin Decoction Inhibits the Expression of PD-L1 Through Multi-Target and Multi-Pathway Regulation of Major Oncogenes in Gastric Cancer
Xuan Feng, Feng Xue, Guihua He, Suiping Huang & Qing Ni
Pages: 3297-3307
Published online: 19 May 2021
AbstractforBanxia Xiexin Decoction Inhibits the Expression of PD-L1 Through Multi-Target and Multi-Pathway Regulation of Major Oncogenes in Gastric Cancer | Full Text | References | PDF (852.7 KB)
  • 80 Views
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Open Access
Article
High Expression of Cyclin D1 is an Independent Marker for Favorable Prognosis in Middle Eastern Breast Cancer
Abdul K Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Saeeda O Ahmed, Nabil Siraj, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim & Khawla S Al-Kuraya
Pages: 3309-3318
Published online: 19 May 2021
AbstractforHigh Expression of Cyclin D1 is an Independent Marker for Favorable Prognosis in Middle Eastern Breast Cancer | Full Text | References | PDF (413 KB)
  • 95 Views
  • 1 CrossRef citations
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Open Access
Article
Sevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA
Suqing Sun, Peng Wang, Lijie Ren, Hongli Wang, Yanli Zhan & Shimin Shan
Pages: 3319-3333
Published online: 20 May 2021
AbstractforSevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA | Full Text | References | PDF (1,012.7 KB)
  • 81 Views
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Open Access

Review

Review Article
Functions and Targets of miR-335 in Cancer
Lingling Ye, Fen Wang, Hao Wu, Hui Yang, Yan Yang, Yajun Ma, Aili Xue, Jing Zhu, Meili Chen, Jinyan Wang & Quan an Zhang
Pages: 3335-3349
Published online: 20 May 2021
AbstractforFunctions and Targets of miR-335 in Cancer | Full Text | References | PDF (654.4 KB)
  • 122 Views
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Open Access

Retraction

Retraction
miR-488 Inhibits Cell Growth and Metastasis in Renal Cell Carcinoma by Targeting HMGN5 [Retraction]
Page: 3351
Published online: 20 May 2021
CitationformiR-488 Inhibits Cell Growth and Metastasis in Renal Cell Carcinoma by Targeting HMGN5 [Retraction] | Full Text | PDF (159.1 KB)
  • 41 Views
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Original Research

Article
The ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation
Qiwen Kuang, Yuxiang Liang, Yangjia Zhuo, Zhiduan Cai, Funeng Jiang, Jianjiang Xie, Yu Zheng & Weide Zhong
Pages: 3353-3366
Published online: 24 May 2021
AbstractforThe ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation | Full Text | References | PDF (11.6 MB)
  • 102 Views
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Open Access

Case Report

Case Report
Successful Management of a Patient with Refractory Primary Central Nervous System Lymphoma by Zanubrutinib
Qiansong Cheng, Jing Wang, Chenglan Lv & Jingyan Xu
Pages: 3367-3372
Published online: 24 May 2021
AbstractforSuccessful Management of a Patient with Refractory Primary Central Nervous System Lymphoma by Zanubrutinib | Full Text | References | PDF (426.6 KB)
  • 91 Views
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Open Access

Original Research

Article
Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma
Galina Kireeva, Ekaterina Gubareva, Mikhail Maydin, Vladislav Osetnik, Stepan Kruglov, Andrey Panchenko, Anastasia Dorofeeva, Margarita Tyndyk, Elena Fedoros & Vladimir Anisimov
Pages: 3373-3381
Published online: 24 May 2021
AbstractforEfficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma | Full Text | References | PDF (479.9 KB)
  • 71 Views
  • 3 CrossRef citations
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Open Access
Article
SOX17 Antagonizes the WNT Signaling Pathway and is Epigenetically Inactivated in Clear-Cell Renal Cell Carcinoma
Lu Wang, Zhe Wang, Yuze Zhu, Shutao Tan, Xiaonan Chen & Xianghong Yang
Pages: 3383-3394
Published online: 24 May 2021
AbstractforSOX17 Antagonizes the WNT Signaling Pathway and is Epigenetically Inactivated in Clear-Cell Renal Cell Carcinoma | Full Text | References | PDF (4.9 MB)
  • 62 Views
  • 1 CrossRef citations
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Open Access
Article
RETRACTED ARTICLE: LINC00894 Enhances the Progression of Breast Cancer by Sponging miR-429 to Regulate ZEB1 Expression
De-feng Meng, Hua Shao & Chuan-bo Feng
Pages: 3395-3407
Published online: 25 May 2021
AbstractforRETRACTED ARTICLE: LINC00894 Enhances the Progression of Breast Cancer by Sponging miR-429 to Regulate ZEB1 Expression | PDF (860.9 KB)
  • 85 Views
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Case Report

Case Report
Successful Treatment with Ensartinib After Alectinib-induced Hyperbilirubinemia in ALK-Positive NSCLC
Ling Peng, Kui Xiao, Jian Cui, Xiang-Hua Ye, Yong-Chang Zhang, Li Mao, Giovanni Selvaggi, Jennifer Yen & Justin Stebbing
Pages: 3409-3415
Published online: 25 May 2021
AbstractforSuccessful Treatment with Ensartinib After Alectinib-induced Hyperbilirubinemia in ALK-Positive NSCLC | Full Text | References | PDF (506.6 KB)
  • 74 Views
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Open Access

Review

Review Article
Platelets: The Emerging Clinical Diagnostics and Therapy Selection of Cancer Liquid Biopsies
Yiming Meng, Jing Sun, Yang Zheng, Guirong Zhang, Tao Yu & Haozhe Piao
Pages: 3417-3428
Published online: 25 May 2021
AbstractforPlatelets: The Emerging Clinical Diagnostics and Therapy Selection of Cancer Liquid Biopsies | Full Text | References | PDF (341.7 KB)
  • 125 Views
  • 6 CrossRef citations
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Open Access

Original Research

Article
Preparation, Biocompatibility and Antitumor Activity of Nanodelivery System Targeting Breast Cancer Base on a Silica Nanoparticle
Jiuzhou Liu, Shasha Ren, Xiangyu Zhang, Yun Feng, Zhenglun Qiu, Li Ma & Jingwen Huang
Pages: 3429-3442
Published online: 25 May 2021
AbstractforPreparation, Biocompatibility and Antitumor Activity of Nanodelivery System Targeting Breast Cancer Base on a Silica Nanoparticle | Full Text | References | PDF (924.3 KB)
  • 59 Views
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Open Access
Article
NUSAP1 Accelerates Osteosarcoma Cell Proliferation and Cell Cycle Progression via Upregulating CDC20 and Cyclin A2
Haoran Wang, Zixiang Liu, Peng Wu, Hanqing Wang & Weiwei Ren
Pages: 3443-3454
Published online: 25 May 2021
AbstractforNUSAP1 Accelerates Osteosarcoma Cell Proliferation and Cell Cycle Progression via Upregulating CDC20 and Cyclin A2 | Full Text | References | PDF (801.3 KB)
  • 72 Views
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Open Access

Case Report

Case Report
Targeted Sequencing Facilitated Diagnosis of an Uncommon Patient Harboring Both Multiple Primary and Intrapulmonary Metastatic Lung Cancer: A Case Report
Hefei Li, Shaoyong Dong, Duo Zhang, Zhimin Guo, Ce Li, Jianxing Xiang, Xiao Zou, Li Yan, Ying Sun & Wei Li
Pages: 3455-3459
Published online: 26 May 2021
AbstractforTargeted Sequencing Facilitated Diagnosis of an Uncommon Patient Harboring Both Multiple Primary and Intrapulmonary Metastatic Lung Cancer: A Case Report | Full Text | References | PDF (872.8 KB)
  • 69 Views
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Original Research

Article
Clinical Significance of the D-Loop Gene Mutation in Mitochondrial DNA in Laryngeal Cancer
Lei Wang, He-Xiang Cheng, Yan-Hui Zhou & Min Ma
Pages: 3461-3466
Published online: 26 May 2021
AbstractforClinical Significance of the D-Loop Gene Mutation in Mitochondrial DNA in Laryngeal Cancer | Full Text | References | PDF (1.6 MB)
  • 71 Views
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Open Access
Article
Silencing HIPPI Suppresses Tumor Progression in Non-Small-Cell Lung Cancer by Inhibiting DNA Replication
Guanghui Xie, Yongwen Li, Yongjun Jiang, Xian Ye, Jianfeng Tang & Jun Chen
Pages: 3467-3480
Published online: 27 May 2021
AbstractforSilencing HIPPI Suppresses Tumor Progression in Non-Small-Cell Lung Cancer by Inhibiting DNA Replication | Full Text | References | PDF (11.6 MB)
  • 62 Views
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Open Access

Case Report

Case Report
Androgen Deprivation Therapy for Patients with Androgen-Receptor-Positive Metastatic Salivary Duct Carcinoma: A Case Report and Review of the Literature
Yongfei You, Panpan Wang, Xi Wan, Liping Xu, Yi Gong & Weihua Zhang
Pages: 3481-3486
Published online: 28 May 2021
AbstractforAndrogen Deprivation Therapy for Patients with Androgen-Receptor-Positive Metastatic Salivary Duct Carcinoma: A Case Report and Review of the Literature | Full Text | References | PDF (298.1 KB)
  • 83 Views
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Original Research

Article
Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling
Ruiqi Xu, Mengnan Zeng, Yuanyuan Wu, Shengchao Wang, Beibei Zhang, Jingke Zhang, Yuxuan Kan, Benke Li, Bing Cao, Xiaoke Zheng & Weisheng Feng
Pages: 3487-3501
Published online: 28 May 2021
AbstractforAcetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling | Full Text | References | PDF (909 KB)
  • 68 Views
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Open Access
Article
Development and Validation of an Autophagy-Stroma-Based Microenvironment Gene Signature for Risk Stratification in Colorectal Cancer
Lin Chen, Kunzi Zhang, Jian Sun, Jingtong Tang & Jianping Zhou
Pages: 3503-3515
Published online: 31 May 2021
AbstractforDevelopment and Validation of an Autophagy-Stroma-Based Microenvironment Gene Signature for Risk Stratification in Colorectal Cancer | Full Text | References | PDF (713.6 KB)
  • 50 Views
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Open Access
Article
Comparative Analysis and in vitro Experiments of Signatures and Prognostic Value of Immune Checkpoint Genes in Colorectal Cancer
Rui Ma, Xiujuan Qu, Xiaofang Che, Bowen Yang, Ce Li, Kezuo Hou, Tianshu Guo, Jiawen Xiao & Yunpeng Liu
Pages: 3517-3534
Published online: 31 May 2021
AbstractforComparative Analysis and in vitro Experiments of Signatures and Prognostic Value of Immune Checkpoint Genes in Colorectal Cancer | Full Text | References | PDF (1.3 MB)
  • 85 Views
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Open Access

Retraction

Retraction
LINC00665 Promotes the Progression of Multiple Myeloma by Adsorbing miR-214-3p and Positively Regulating the Expression of PSMD10 and ASF1B [Retraction]
Page: 3535
Published online: 01 Jun 2021
CitationforLINC00665 Promotes the Progression of Multiple Myeloma by Adsorbing miR-214-3p and Positively Regulating the Expression of PSMD10 and ASF1B [Retraction] | Full Text | PDF (152.4 KB)
  • 49 Views
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Open Access

Case Report

Case Report
Near Complete Pathologic Response to PD-1 Inhibitor and Radiotherapy in a Patient with Locally Advanced Pancreatic Ductal Adenocarcinoma
Patrick M McCarthy, Matthew J Rendo, Matthew D Uy, Alexandra M Adams, Anne E O’Shea, Daniel William Nelson, Joshua L Fenderson, Katherine M Cebe, Robert W Krell, Guy T Clifton, George E Peoples & Timothy J Vreeland
Pages: 3537-3544
Published online: 01 Jun 2021
AbstractforNear Complete Pathologic Response to PD-1 Inhibitor and Radiotherapy in a Patient with Locally Advanced Pancreatic Ductal Adenocarcinoma | Full Text | References | PDF (531.7 KB)
  • 97 Views
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Original Research

Article
Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma
Changbao Chen, Hua Zhou, Zhongjun Liu & Xinlong Ma
Pages: 3545-3553
Published online: 01 Jun 2021
AbstractforDysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma | Full Text | References | PDF (2.4 MB)
  • 76 Views
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Open Access
Article
LncRNA PVT1 Facilitates Proliferation, Migration and Invasion of NSCLC Cells via miR-551b/FGFR1 Axis
Xi Wang, Zhe Cheng, Lingling Dai, Tianci Jiang, Pengfei Li, Liuqun Jia, Xiaogang Jing, Lin An, Meng Liu, Shujun Wu & Yu Wang
Pages: 3555-3565
Published online: 02 Jun 2021
AbstractforLncRNA PVT1 Facilitates Proliferation, Migration and Invasion of NSCLC Cells via miR-551b/FGFR1 Axis | Full Text | References | PDF (715.6 KB)
  • 67 Views
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Open Access

Case Report

Case Report
Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review
Zhitao Chen, Lele Zhang, Jiacheng Huang, Chenchen Ding, Ting Zhang, Dalong Wan & Liang Xue
Pages: 3567-3581
Published online: 03 Jun 2021
AbstractforTargeted-Gene Sequencing and Bioinformatics Analysis of Patients with Pancreatic Mucoepidermoid Carcinoma: A Case Report and Literature Review | Full Text | References | PDF (1.1 MB)
  • 88 Views
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Original Research

Article
ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway
Wei Huang, Ju Zhu, Haoming Shi, Qingchen Wu & Cheng Zhang
Pages: 3583-3596
Published online: 03 Jun 2021
AbstractforITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway | Full Text | References | PDF (1 MB)
  • 94 Views
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Open Access

Retraction

Retraction
miR-622 Suppresses Tumor Formation by Directly Targeting VEGFA in Papillary Thyroid Carcinoma [Retraction]
Page: 3597
Published online: 03 Jun 2021
CitationformiR-622 Suppresses Tumor Formation by Directly Targeting VEGFA in Papillary Thyroid Carcinoma [Retraction] | Full Text | PDF (157.8 KB)
  • 49 Views
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Original Research

Article
β-Elemene Enhances the Sensitivity of Osteosarcoma Cells to Doxorubicin via Downregulation of Peroxiredoxin-1
Shaochun Zhang & Weichun Guo
Pages: 3599-3609
Published online: 03 Jun 2021
Abstractforβ-Elemene Enhances the Sensitivity of Osteosarcoma Cells to Doxorubicin via Downregulation of Peroxiredoxin-1 | Full Text | References | PDF (676.7 KB)
  • 74 Views
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Open Access
Article
Identification of Ten Mitosis Genes Associated with Tamoxifen Resistance in Breast Cancer
Xi Sun, Shuning Ding, Shuangshuang Lu, Zheng Wang, Xiaosong Chen & Kunwei Shen
Pages: 3611-3624
Published online: 04 Jun 2021
AbstractforIdentification of Ten Mitosis Genes Associated with Tamoxifen Resistance in Breast Cancer | Full Text | References | PDF (5.4 MB)
  • 92 Views
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Open Access
Article
Identification of Susceptible Genes for Chronic Obstructive Pulmonary Disease with Lung Adenocarcinoma by Weighted Gene Co-Expression Network Analysis
Ping Li, Youyu Wang, Xiaoli Wang, Lin Liu & Lei Chen
Pages: 3625-3634
Published online: 04 Jun 2021
AbstractforIdentification of Susceptible Genes for Chronic Obstructive Pulmonary Disease with Lung Adenocarcinoma by Weighted Gene Co-Expression Network Analysis | Full Text | References | PDF (6.9 MB)
  • 58 Views
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Open Access
Article
miR-340 Promotes Retinoblastoma Cell Proliferation, Migration and Invasion Through Targeting WIF1
Kun Li, Fengmei Han, Yanping Wu & Xue Wang
Pages: 3635-3648
Published online: 04 Jun 2021
AbstractformiR-340 Promotes Retinoblastoma Cell Proliferation, Migration and Invasion Through Targeting WIF1 | Full Text | References | PDF (903.2 KB)
  • 56 Views
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Article
miR-183-5p Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis
Yaqian Niu, Fang Liu, Xiuyue Wang, Yuling Chang, Yanmei Song, Huiyuan Chu, Shisan Bao & Che Chen
Pages: 3649-3658
Published online: 04 Jun 2021
AbstractformiR-183-5p Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis | Full Text | References | PDF (7.1 MB)
  • 64 Views
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Article
Construction and Analysis of a circRNA-Mediated ceRNA Network in Lung Adenocarcinoma
Zhaojun Wang, Hanzhong Pei, Hongsen Liang, Qiwei Zhang, Li Wei, Donglei Shi, Yun Chen & Junhang Zhang
Pages: 3659-3669
Published online: 08 Jun 2021
AbstractforConstruction and Analysis of a circRNA-Mediated ceRNA Network in Lung Adenocarcinoma | Full Text | References | PDF (7.1 MB)
  • 117 Views
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Article
circHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326
Liqiang Qi, Bo Sun, Beibei Yang & Su Lu
Pages: 3671-3685
Published online: 09 Jun 2021
AbstractforcircHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326 | Full Text | References | PDF (13.1 MB)
  • 100 Views
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Article
miR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3
Qian Chen, Hongyu Zhang, Jianyin Zhang, Le Shen, Jing Yang, Yan Wang, JinXiu Ma & Bing Zhuan
Pages: 3687-3700
Published online: 09 Jun 2021
AbstractformiR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3 | Full Text | References | PDF (9.2 MB)
  • 98 Views
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Case Report

Case Report
Durable Clinical Response to Immune and Targeted Therapies in an Elderly Man with Synchronous Gastric (HER2+) and Bladder Cancers: Case Report and Literature Review
Xin Tian, Qiuxia Zhu & Zhenyong Zhang
Pages: 3701-3708
Published online: 09 Jun 2021
AbstractforDurable Clinical Response to Immune and Targeted Therapies in an Elderly Man with Synchronous Gastric (HER2+) and Bladder Cancers: Case Report and Literature Review | Full Text | References | PDF (2.4 MB)
  • 49 Views
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Review

Review Article
Current Perspectives and Novel Strategies of NRAS-Mutant Melanoma
Alejandro Garcia-Alvarez, Carolina Ortiz & Eva Muñoz-Couselo
Pages: 3709-3719
Published online: 09 Jun 2021
AbstractforCurrent Perspectives and Novel Strategies of NRAS-Mutant Melanoma | Full Text | References | PDF (285 KB)
  • 203 Views
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Original Research

Article
G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer
Yunfen Li, Zhengting Chen, Ke Cao, Lan Zhang, Yuhui Ma, Shuhui Yu, Hanyu Jin, Xiaoling Liu & Wenhui Li
Pages: 3721-3728
Published online: 10 Jun 2021
AbstractforG9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer | Full Text | References | PDF (6.3 MB)
  • 70 Views
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Article
miR-593-3p Promotes Proliferation and Invasion in Prostate Cancer Cells by Targeting ADIPOR1
Qiang Huang, Long Peng, Yuxiang Sun, Jiayu Huang, Tong Han, Yongjie Li & Hui Peng
Pages: 3729-3737
Published online: 14 Jun 2021
AbstractformiR-593-3p Promotes Proliferation and Invasion in Prostate Cancer Cells by Targeting ADIPOR1 | Full Text | References | PDF (6 MB)
  • 52 Views
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Case Report

Case Report
A Novel KIF5B-EGFR Fusion Variant in Non-Small-Cell Lung Cancer and Response to Afatinib: A Case Report
Xia Wang, Long Huang, Jing Cai & Anwen Liu
Pages: 3739-3744
Published online: 14 Jun 2021
AbstractforA Novel KIF5B-EGFR Fusion Variant in Non-Small-Cell Lung Cancer and Response to Afatinib: A Case Report | Full Text | References | PDF (2.7 MB)
  • 61 Views
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Original Research

Article
m6A-Induced LncRNA MEG3 Suppresses the Proliferation, Migration and Invasion of Hepatocellular Carcinoma Cell Through miR-544b/BTG2 Signaling
Jian Wu, Runhua Pang, Minan Li, Bin Chen, Junhai Huang & Yaqing Zhu
Pages: 3745-3755
Published online: 15 Jun 2021
Abstractform6A-Induced LncRNA MEG3 Suppresses the Proliferation, Migration and Invasion of Hepatocellular Carcinoma Cell Through miR-544b/BTG2 Signaling | Full Text | References | PDF (7 MB)
  • 86 Views
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Article
Progesterone Receptor Together with PKCα Expression as Prognostic Factors for Astrocytomas Malignancy
Denisse Arcos-Montoya, Talia Wegman-Ostrosky, Sonia Mejía-Pérez, Marisol De la Fuente-Granada, Ignacio Camacho-Arroyo, Alejandro García-Carrancá, Marco A Velasco-Velázquez, Joaquín Manjarrez-Marmolejo & Aliesha González-Arenas
Pages: 3757-3768
Published online: 16 Jun 2021
AbstractforProgesterone Receptor Together with PKCα Expression as Prognostic Factors for Astrocytomas Malignancy | Full Text | References | PDF (6.7 MB)
  • 72 Views
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Article
Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis
Zhongfang Zhao & Nong Liao
Pages: 3769-3781
Published online: 17 Jun 2021
AbstractforBergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis | Full Text | References | PDF (9.1 MB)
  • 95 Views
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Article
Epigenetic Mechanism of Enrichment of A549 Lung Cancer Stem Cells with 5-Fu
Fangyuan Cao, Mumu Shi, Bo Yu, Xiangrong Cheng, Xin Li & Xinshan Jia
Pages: 3783-3794
Published online: 18 Jun 2021
AbstractforEpigenetic Mechanism of Enrichment of A549 Lung Cancer Stem Cells with 5-Fu | Full Text | References | PDF (3.4 MB)
  • 87 Views
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Case Report

Case Report
A New Treatment Strategy for Early T‐Cell Precursor Acute Lymphoblastic Leukemia: A Case Report and Literature Review
Jianping Mao, Lianguo Xue, Haiqing Wang, Yuanxin Zhu, Juan Wang & Lidong Zhao
Pages: 3795-3802
Published online: 18 Jun 2021
AbstractforA New Treatment Strategy for Early T‐Cell Precursor Acute Lymphoblastic Leukemia: A Case Report and Literature Review | Full Text | References | PDF (2.9 MB)
  • 147 Views
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Review

Review Article
Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy
Huixian Zhang, Wencheng Zhao, Xingya Li & Yayi He
Pages: 3803-3812
Published online: 21 Jun 2021
AbstractforCholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy | Full Text | References | PDF (2.3 MB)
  • 155 Views
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Original Research

Article
Identification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells
John Lee, Rongbing Chen, T Mohanakumar, Ross Bremner, Sumeet Mittal & Timothy P Fleming
Pages: 3813-3820
Published online: 21 Jun 2021
AbstractforIdentification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells | Full Text | References | PDF (2.5 MB)
  • 57 Views
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Article
Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing
Chengzhou Lv, Wei Sun, Jiapeng Huang, Yuan Qin, Xiaoyu Ji & Hao Zhang
Pages: 3821-3832
Published online: 21 Jun 2021
AbstractforExpression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing | Full Text | References | PDF (6.8 MB)
  • 66 Views
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Article
RETRACTED ARTICLE: Identification of Enzalutamide Resistance-Related circRNA-miRNA-mRNA Regulatory Networks in Patients with Prostate Cancer
JunJie Yu, Si Sun, WeiPu Mao, Bin Xu & Ming Chen
Pages: 3833-3848
Published online: 21 Jun 2021
AbstractforRETRACTED ARTICLE: Identification of Enzalutamide Resistance-Related circRNA-miRNA-mRNA Regulatory Networks in Patients with Prostate Cancer | PDF (14 MB)
  • 62 Views
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Article
Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation
Mahmoud Youns, Momen Askoura, Hisham A Abbas, Gouda H Attia, Ahdab N Khayyat, Reham M Goda, Ahmad J Almalki, El-Sayed Khafagy & Wael A H Hegazy
Pages: 3849-3860
Published online: 23 Jun 2021
AbstractforCelastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation | Full Text | References | PDF (8.4 MB)
  • 182 Views
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Article
Down-Regulation of an Autophagy-Related Gene SERPINA1 as a Superior Prognosis Biomarker Associates with Relapse and Distant Metastasis in Colon Adenocarcinoma
Chen Fu, Zhaojin Yu, Ying He, Jian Ding & Minjie Wei
Pages: 3861-3872
Published online: 22 Jun 2021
AbstractforDown-Regulation of an Autophagy-Related Gene SERPINA1 as a Superior Prognosis Biomarker Associates with Relapse and Distant Metastasis in Colon Adenocarcinoma | Full Text | References | PDF (9.1 MB)
  • 92 Views
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Case Report

Case Report
Complete Response of Hepatocellular Carcinoma with Macroscopic Vascular Invasion and Pulmonary Metastasis to the Combination of Drug-Eluting Beads Transarterial Chemoembolization and Huaier Granule: A Case Report
Tan-Yang Zhou, Guo-Fang Tao, Sheng-Qun Chen, Hong-Liang Wang, Yue-Lin Zhang, Guan-Hui Zhou, Chun-Hui Nie, Tong-Yin Zhu, Bao-Quan Wang, Zi-Niu Yu, Li Jing, Feng Chen & Jun-Hui Sun
Pages: 3873-3880
Published online: 23 Jun 2021
AbstractforComplete Response of Hepatocellular Carcinoma with Macroscopic Vascular Invasion and Pulmonary Metastasis to the Combination of Drug-Eluting Beads Transarterial Chemoembolization and Huaier Granule: A Case Report | Full Text | References | PDF (1 MB)
  • 64 Views
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Original Research

Article
HS3ST2 and Its Related Molecules as Potential Biomarkers for Predicting Lymph Node Metastasis in Patients with Colorectal Cancer
Guangyu Gao, Xinya Shi & Jiaofeng Shen
Pages: 3881-3894
Published online: 25 Jun 2021
AbstractforHS3ST2 and Its Related Molecules as Potential Biomarkers for Predicting Lymph Node Metastasis in Patients with Colorectal Cancer | Full Text | References | PDF (9.9 MB)
  • 58 Views
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Case Report

Case Report
Remarkable Response to Olaparib in a Patient with Combined Hepatocellular-Cholangiocarcinoma Harboring a Biallelic BRCA2 Mutation
Yu-Li Su, Ca Tung Ng, Yi-Hua Jan, Yi-Lin Hsieh, Chia-Ling Wu & Kien Thiam Tan
Pages: 3895-3901
Published online: 29 Jun 2021
AbstractforRemarkable Response to Olaparib in a Patient with Combined Hepatocellular-Cholangiocarcinoma Harboring a Biallelic BRCA2 Mutation | Full Text | References | PDF (2.1 MB)
  • 135 Views
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Original Research

Article
Bioinformatics Analysis of Choriocarcinoma-Related MicroRNA-Transcription Factor-Target Gene Regulatory Networks and Validation of Key miRNAs
Xiaotong Peng, Zhirong Zhang, Yanqun Mo, Junliang Liu, Shuo Wang & Huining Liu
Pages: 3903-3919
Published online: 29 Jun 2021
AbstractforBioinformatics Analysis of Choriocarcinoma-Related MicroRNA-Transcription Factor-Target Gene Regulatory Networks and Validation of Key miRNAs | Full Text | References | PDF (13.5 MB)
  • 60 Views
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Case Report

Case Report
PD-L1 Expressing Recurrent Clear Cell Carcinoma of the Vulva with Durable Partial Response to Pembrolizumab: A Case Report
Manavi Sachdeva, Natalie Y L Ngoi, Diana Lim, Michelle L M Poon, Yee Liang Thian, Yi Wan Lim, Siew Eng Lim, Pearl Tong, Jeffrey H Y Lum, Joseph Ng, Arunachalam Ilancheran, Efren J Domingo, Jeffrey J H Low & David S P Tan
Pages: 3921-3928
Published online: 29 Jun 2021
AbstractforPD-L1 Expressing Recurrent Clear Cell Carcinoma of the Vulva with Durable Partial Response to Pembrolizumab: A Case Report | Full Text | References | PDF (1.4 MB)
  • 82 Views
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Original Research

Article
Fatty Acid–Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway
Zimeng Wu, Ji-Hak Jeong, Chenchen Ren, Li Yang, Leilei Ding, Feiyan Li, Dongyuan Jiang, Yuanhang Zhu & Jie Lu
Pages: 3929-3942
Published online: 29 Jun 2021
AbstractforFatty Acid–Binding Protein 4 (FABP4) Suppresses Proliferation and Migration of Endometrial Cancer Cells via PI3K/Akt Pathway | Full Text | References | PDF (13.1 MB)
  • 104 Views
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Retraction

Retraction
Nuclear Factor-Kappa B1 Inhibits Early Apoptosis of Glioma Cells by Promoting the Expression of Bcl-2 [Retraction]
Page: 3943
Published online: 29 Jun 2021
CitationforNuclear Factor-Kappa B1 Inhibits Early Apoptosis of Glioma Cells by Promoting the Expression of Bcl-2 [Retraction] | Full Text | PDF (127.4 KB)
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Case Report

Case Report
Intravascular Papillary Endothelial Hyperplasia Mimicking Vaginal Malignant Tumor in a Post-Radiotherapy Patient: A Case Report and Literature Review
Ying-Xin Gong, Yu Xie, Limei Chen & Long Sui
Pages: 3945-3948
Published online: 29 Jun 2021
AbstractforIntravascular Papillary Endothelial Hyperplasia Mimicking Vaginal Malignant Tumor in a Post-Radiotherapy Patient: A Case Report and Literature Review | Full Text | References | PDF (569 KB)
  • 66 Views
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Case Report
Durable Response to Crizotinib in a Patient with Pulmonary Adenocarcinoma Harboring MET Intron 14 Mutation: A Case Report
Brice Leyrat, Xavier Durando, Hugo Veyssiere & Maureen Bernadach
Pages: 3949-3958
Published online: 29 Jun 2021
AbstractforDurable Response to Crizotinib in a Patient with Pulmonary Adenocarcinoma Harboring MET Intron 14 Mutation: A Case Report | Full Text | References | PDF (841.3 KB)
  • 74 Views
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Original Research

Article
The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAFV600E Mutation
Tauangtham Anekpuritanang, Maythad Uataya, Apichaya Claimon, Natthawadee Laokulrath, Warut Pongsapich & Paveena Pithuksurachai
Pages: 3959-3969
Published online: 29 Jun 2021
AbstractforThe Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAFV600E Mutation | Full Text | References | PDF (3.1 MB)
  • 98 Views
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Article
Demographic Characteristics and Treatment Patterns Among Patients Receiving Palbociclib for HR+/HER2− Advanced Breast Cancer: A Nationwide Real-World Experience
Katalin Boér, Gábor Rubovszky, György Rokszin, Zsolt Abonyi-Tóth, Csenge Földesi & Magdolna Dank
Pages: 3971-3981
Published online: 01 Jul 2021
AbstractforDemographic Characteristics and Treatment Patterns Among Patients Receiving Palbociclib for HR+/HER2− Advanced Breast Cancer: A Nationwide Real-World Experience | Full Text | References | PDF (260 KB)
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Case Report

Case Report
Sustained Clinical Benefit of Pyrotinib Combined with Capecitabine Rescue Therapy After Trastuzumab Resistance in HER2-Positive Advanced Gastric Cancer: A Case Report
Xin Li, Xiaoqiang Gu, Jiahua Xu, Ling Chen, Hongwei Li, Dan Meng, Haoran Bai, Jinzu Yang & Jianxin Qian
Pages: 3983-3989
Published online: 01 Jul 2021
AbstractforSustained Clinical Benefit of Pyrotinib Combined with Capecitabine Rescue Therapy After Trastuzumab Resistance in HER2-Positive Advanced Gastric Cancer: A Case Report | Full Text | References | PDF (3.5 MB)
  • 55 Views
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Original Research

Article
Knockdown of LINC00504 Inhibits the Proliferation and Invasion of Breast Cancer via the Downregulation of miR-140-5p
Tieying Hou, Long Ye & Shulin Wu
Pages: 3991-4003
Published online: 02 Jul 2021
AbstractforKnockdown of LINC00504 Inhibits the Proliferation and Invasion of Breast Cancer via the Downregulation of miR-140-5p | Full Text | References | PDF (8.9 MB)
  • 75 Views
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Review

Review Article
Circular RNAs Regulate Glucose Metabolism in Cancer Cells
Xiaoyu Ji, Wei Sun, Chengzhou Lv, Jiapeng Huang & Hao Zhang
Pages: 4005-4021
Published online: 02 Jul 2021
AbstractforCircular RNAs Regulate Glucose Metabolism in Cancer Cells | Full Text | References | PDF (4.2 MB)
  • 95 Views
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Original Research

Article
Anti-CD22 CAR-T Cell Therapy as a Salvage Treatment in B Cell Malignancies Refractory or Relapsed After Anti-CD19 CAR-T therapy
Haibo Zhu, Haobin Deng, Juan Mu, Cuicui Lyu, Yanyu Jiang & Qi Deng
Pages: 4023-4037
Published online: 02 Jul 2021
AbstractforAnti-CD22 CAR-T Cell Therapy as a Salvage Treatment in B Cell Malignancies Refractory or Relapsed After Anti-CD19 CAR-T therapy | Full Text | References | PDF (10.1 MB)
  • 246 Views
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Article
Expression and Clinical Value of LncRNA GAPLINC in Esophageal Squamous Cell Carcinoma
Peng Wang, Song Yang, Shengbin Dai, Qingtao Ni, Huilan Liu, Lei Yu, Kaijin Lu, Gaohua Han & Junxing Huang
Pages: 4039-4045
Published online: 05 Jul 2021
AbstractforExpression and Clinical Value of LncRNA GAPLINC in Esophageal Squamous Cell Carcinoma | Full Text | References | PDF (1.7 MB)
  • 58 Views
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Article
A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway
Yuchen Xia, Guihua Wang, Manli Jiang, Xueting Liu, Yan Zhao, Yinghui Song, Binyuan Jiang, Demao Zhu, Ling Hu, Zhao Zhang, Ting Cao, Ji Ming Wang & Jinyue Hu
Pages: 4047-4060
Published online: 05 Jul 2021
AbstractforA Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway | Full Text | References | PDF (12.5 MB)
  • 121 Views
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Article
Chidamide-Induced Accumulation of Reactive Oxygen Species Increases Lenalidomide Sensitivity Against Multiple Myeloma Cells
Duanfeng Jiang, Kaixuan Zhang, Yinghong Zhu, Yan Zhu, Lang Zou, Jian Hu, Yajuan Cui, Wen Zhou, Fangping Chen & Yanjuan He
Pages: 4061-4075
Published online: 06 Jul 2021
AbstractforChidamide-Induced Accumulation of Reactive Oxygen Species Increases Lenalidomide Sensitivity Against Multiple Myeloma Cells | Full Text | References | PDF (11.5 MB)
  • 87 Views
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Article
A Comparative Study of Self-Expandable Metallic Stent Combined with Double 125I Seeds Strands or Single 125I Seeds Strand in the Treatment of Advanced Perihilar Cholangiocarcinoma with Malignant Obstructive Jaundice
Zhaonan Li, Dechao Jiao, Xinwei Han & Zaoqu Liu
Pages: 4077-4086
Published online: 06 Jul 2021
AbstractforA Comparative Study of Self-Expandable Metallic Stent Combined with Double 125I Seeds Strands or Single 125I Seeds Strand in the Treatment of Advanced Perihilar Cholangiocarcinoma with Malignant Obstructive Jaundice | Full Text | References | PDF (2.7 MB)
  • 47 Views
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Review

Review Article
Progress in Treatment of Non-Small Cell Lung Cancer Harboring HER2 Aberrations
Jun Ni & Li Zhang
Pages: 4087-4098
Published online: 06 Jul 2021
AbstractforProgress in Treatment of Non-Small Cell Lung Cancer Harboring HER2 Aberrations | Full Text | References | PDF (285.4 KB)
  • 94 Views
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Original Research

Article
FSTL3 is a Prognostic Biomarker in Gastric Cancer and is Correlated with M2 Macrophage Infiltration
Yuan-Jie Liu, Jie-Pin Li, Ying Zhang, Meng-Jun Nie, Yong-Hua Zhang, Shen-Lin Liu & Xi Zou
Pages: 4099-4117
Published online: 06 Jul 2021
AbstractforFSTL3 is a Prognostic Biomarker in Gastric Cancer and is Correlated with M2 Macrophage Infiltration | Full Text | References | PDF (18.1 MB)
  • 87 Views
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Case Report

Case Report
Primary Synchronous Ipsilateral Renal Fibrosarcoma and Renal Pelvic Carcinoma: A Case Report and Literature Review
Hua Jiang, Lulu Liu & Ganhong Li
Pages: 4119-4125
Published online: 07 Jul 2021
AbstractforPrimary Synchronous Ipsilateral Renal Fibrosarcoma and Renal Pelvic Carcinoma: A Case Report and Literature Review | Full Text | References | PDF (990.7 KB)
  • 67 Views
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Review

Review Article
The Role and Mechanism of MALAT1 Long Non-Coding RNA in the Diagnosis and Treatment of Head and Neck Squamous Cell Carcinoma
Dong Ye, Yongqin Deng & Zhisen Shen
Pages: 4127-4136
Published online: 08 Jul 2021
AbstractforThe Role and Mechanism of MALAT1 Long Non-Coding RNA in the Diagnosis and Treatment of Head and Neck Squamous Cell Carcinoma | Full Text | References | PDF (1.9 MB)
  • 88 Views
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Original Research

Article
Preoperative Serum Hypersensitive-c-Reactive-Protein (Hs-CRP) to Albumin Ratio Predicts Survival in Patients with Luminal B Subtype Breast Cancer
Xiujun Liu, Xiuchun Guo & Zhiqiang Zhang
Pages: 4137-4148
Published online: 09 Jul 2021
AbstractforPreoperative Serum Hypersensitive-c-Reactive-Protein (Hs-CRP) to Albumin Ratio Predicts Survival in Patients with Luminal B Subtype Breast Cancer | Full Text | References | PDF (4.2 MB)
  • 101 Views
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Review

Review Article
Recent Advances in Systemic Treatments for HER-2 Positive Advanced Gastric Cancer
Seda Kahraman & Suayib Yalcin
Pages: 4149-4162
Published online: 13 Jul 2021
AbstractforRecent Advances in Systemic Treatments for HER-2 Positive Advanced Gastric Cancer | Full Text | References | PDF (443.4 KB)
  • 202 Views
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Original Research

Article
Key Role of MCUR1 in Malignant Progression of Breast Cancer
Peipei Gao, Ting Peng, Shitong Lin, Wenhua Zhi, Canhui Cao, Ping Wu, Ling Xi, Peng Wu, Qin Yang & Wencheng Ding
Pages: 4163-4175
Published online: 13 Jul 2021
AbstractforKey Role of MCUR1 in Malignant Progression of Breast Cancer | Full Text | References | PDF (10.7 MB)
  • 69 Views
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Review

Review Article
The Emerging Role of Circ-SHPRH in Cancer
Xinyue Ju, Yan Tang, Rongfeng Qu & Shuhong Hao
Pages: 4177-4188
Published online: 13 Jul 2021
AbstractforThe Emerging Role of Circ-SHPRH in Cancer | Full Text | References | PDF (1.5 MB)
  • 78 Views
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Original Research

Article
Expression and Diagnostic Value of tRNA-Derived Fragments Secreted by Extracellular Vesicles in Hypopharyngeal Carcinoma
Jian Xi, Zhiming Zeng, Xin Li, Xin Zhang & Jing Xu
Pages: 4189-4199
Published online: 14 Jul 2021
AbstractforExpression and Diagnostic Value of tRNA-Derived Fragments Secreted by Extracellular Vesicles in Hypopharyngeal Carcinoma | Full Text | References | PDF (4.1 MB)
  • 57 Views
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Case Report

Case Report
Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report
Yu Cheng, Gang Wu, Simeng Zhang, Yunpeng Liu, Jinglei Qu & Xiujuan Qu
Pages: 4201-4209
Published online: 15 Jul 2021
AbstractforComplete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report | Full Text | References | PDF (6.4 MB)
  • 55 Views
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Original Research

Article
CDH11 Regulates Adhesion and Transcellular Migration of Tongue Squamous Cell Carcinoma
Bi-Tan Zheng, Qing-Ling Li, Ting Lan, Jian Xie, You-Guang Lu, Da-Li Zheng & Bo-Hua Su
Pages: 4211-4222
Published online: 16 Jul 2021
AbstractforCDH11 Regulates Adhesion and Transcellular Migration of Tongue Squamous Cell Carcinoma | Full Text | References | PDF (8.2 MB)
  • 77 Views
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Review

Review Article
The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition
Wenjiao Du, Xinchang Liu, Man Yang, Weipeng Wang & Jing Sun
Pages: 4223-4229
Published online: 16 Jul 2021
AbstractforThe Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition | Full Text | References | PDF (2.2 MB)
  • 132 Views
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Case Report

Case Report
A Case of Pulmonary Embolism with Sarcomatoid Malignant Pleural Mesothelioma with Long-Term Pleural Effusion
Rumeng Gu, Luxi Jiang, Ting Duan, Chun Chen, Shengchang Wu & Deguang Mu
Pages: 4231-4237
Published online: 16 Jul 2021
AbstractforA Case of Pulmonary Embolism with Sarcomatoid Malignant Pleural Mesothelioma with Long-Term Pleural Effusion | Full Text | References | PDF (813.9 KB)
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Original Research

Article
ILT4 in Colorectal Cancer Cells Induces Suppressive T Cell Contexture and Disease Progression
Zijiang Yang, Aiqin Gao, Wenjing Shi, Jingnan Wang, Xianchao Zhang, Zhengyan Xu, Tingting Xu, Yan Zheng, Yuping Sun & Fei Yang
Pages: 4239-4254
Published online: 20 Jul 2021
AbstractforILT4 in Colorectal Cancer Cells Induces Suppressive T Cell Contexture and Disease Progression | Full Text | References | PDF (10.6 MB)
  • 84 Views
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Case Report

Case Report
Perirenal Perivascular Epithelioid Cell Tumor (PEcoma) with Pulmonary Micro Invasive Adenocarcinoma: A Case Report and Literature Review
Zhaoxun Li, Nan Hu, Yan Liao & Jingmei Liu
Pages: 4255-4260
Published online: 21 Jul 2021
AbstractforPerirenal Perivascular Epithelioid Cell Tumor (PEcoma) with Pulmonary Micro Invasive Adenocarcinoma: A Case Report and Literature Review | Full Text | References | PDF (775.7 KB)
  • 60 Views
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Case Report
NGS-Based ctDNA Profiling After the Resistance of Second-Line Osimertinib for Patient with EGFR-Mutated Pulmonary Adenocarcinoma
Dan Li, DaFu Yang, SaiQiong Cui, Evenki Pan, Peng Yang & ZhaoXia Dai
Pages: 4261-4265
Published online: 21 Jul 2021
AbstractforNGS-Based ctDNA Profiling After the Resistance of Second-Line Osimertinib for Patient with EGFR-Mutated Pulmonary Adenocarcinoma | Full Text | References | PDF (665.8 KB)
  • 79 Views
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Retraction

Retraction
Long Noncoding RNA RGMB-AS1 Acts as a microRNA-574 Sponge Thereby Enhancing the Aggressiveness of Gastric Cancer via HDAC4 Upregulation [Retraction]
Page: 4267
Published online: 22 Jul 2021
CitationforLong Noncoding RNA RGMB-AS1 Acts as a microRNA-574 Sponge Thereby Enhancing the Aggressiveness of Gastric Cancer via HDAC4 Upregulation [Retraction] | Full Text | PDF (149.4 KB)
  • 52 Views
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Case Report

Case Report
Heterochronous Metastases of Lung Adenocarcinoma to Pancreas and Liver: A Case Report from Pathological Perspectives
Bo Zhang, Qida Hu, Jiajie Yu, Junsen Wang, Hanjin Yang, Jiongbo Lou, Guoying Cai, Haifeng Huang, Mengqiu Xu, Zhaoying Xiao & Yun Zhang
Pages: 4269-4273
Published online: 22 Jul 2021
AbstractforHeterochronous Metastases of Lung Adenocarcinoma to Pancreas and Liver: A Case Report from Pathological Perspectives | Full Text | References | PDF (936.9 KB)
  • 43 Views
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Original Research

Article
Expression of B7-H3 Correlates with PD-L1 and Poor Prognosis in Patients with Cervical Cancer
Qianqian Zhang, Liju Zong, Hui Zhang, Wei Xie, Fan Yang, Wenwen Sun, Baoxia Cui & Youzhong Zhang
Pages: 4275-4283
Published online: 23 Jul 2021
AbstractforExpression of B7-H3 Correlates with PD-L1 and Poor Prognosis in Patients with Cervical Cancer | Full Text | References | PDF (1.8 MB)
  • 76 Views
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Open Access
Article
SQLE Mediates Metabolic Reprogramming to Promote LN Metastasis in Castration-Resistant Prostate Cancer
Zhenzhou Xu, Liang Huang, Tao Dai, Xiaming Pei, Longzheng Xia, Gongqian Zeng, Mingji Ye, Kan Liu, Fuhua Zeng, Weiqing Han & Shusuan Jiang
Pages: 4285-4295
Published online: 24 Jul 2021
AbstractforSQLE Mediates Metabolic Reprogramming to Promote LN Metastasis in Castration-Resistant Prostate Cancer | Full Text | References | PDF (8.1 MB)
  • 85 Views
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Retraction

Retraction
LINC00152 Promotes the Growth and Invasion of Oral Squamous Cell Carcinoma by Regulating miR-139-5p [Retraction]
Page: 4297
Published online: 29 Jul 2021
CitationforLINC00152 Promotes the Growth and Invasion of Oral Squamous Cell Carcinoma by Regulating miR-139-5p [Retraction] | Full Text | PDF (143.8 KB)
  • 39 Views
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Case Report

Case Report
Gallbladder Adenosquamous Cancer with Situs Inversus Totalis: A Case Report and Literature Review
Junming Huang, Hanjin Yang, Meng Wang, Xinyu Zhao, Shiyi Shao, Fu Zhang, Risheng Que, Qida Hu & Tingbo Liang
Pages: 4299-4304
Published online: 28 Jul 2021
AbstractforGallbladder Adenosquamous Cancer with Situs Inversus Totalis: A Case Report and Literature Review | Full Text | References | PDF (2.1 MB)
  • 58 Views
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Open Access

Short Report

Brief Report
Sorafenib in the Treatment of Virus-Related HCC: Differences Between HCV and HBV
Serena De Matteis, Martina Ghetti, Laura Gramantieri, Giorgia Marisi & Andrea Casadei-Gardini
Pages: 4305-4308
Published online: 30 Jul 2021
AbstractforSorafenib in the Treatment of Virus-Related HCC: Differences Between HCV and HBV | Full Text | References | PDF (1.3 MB)
  • 43 Views
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Original Research

Article
Glypican-1 Overexpression in Different Types of Breast Cancers
Fatemah O F O Alshammari, Yousef M Al-Saraireh, Ahmed M M Youssef, Yahya M AL-sarayra & Hamzeh Mohammad Alrawashdeh
Pages: 4309-4318
Published online: 30 Jul 2021
AbstractforGlypican-1 Overexpression in Different Types of Breast Cancers | Full Text | References | PDF (1.2 MB)
  • 76 Views
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Corrigendum

Correction
LncRNA MIR205HG Drives Esophageal Squamous Cell Carcinoma Progression by Regulating miR-214/SOX4 Axis [Corrigendum]
Pages: 4319-4320
Published online: 02 Aug 2021
CitationforLncRNA MIR205HG Drives Esophageal Squamous Cell Carcinoma Progression by Regulating miR-214/SOX4 Axis [Corrigendum] | Full Text | PDF (2.4 MB)
  • 48 Views
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Case Report

Case Report
Immunotherapy-Related Cystitis: Case Report and Review of the Literature
Liping Zhu, Zhiqiang Wang, Justin Stebbing, Zibing Wang & Ling Peng
Pages: 4321-4328
Published online: 31 Jul 2021
AbstractforImmunotherapy-Related Cystitis: Case Report and Review of the Literature | Full Text | References | PDF (2.6 MB)
  • 131 Views
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Case Report
Acquired ALK Resistance Mutations Identified from Liquid Biopsy in an ALK-Rearranged Squamous Cell Lung Cancer Patient Treated with Sequential ALK TKI Therapy: A Case Report
Bin Yao, Xue Han, Linrong Pang, Caihong Xu, Sisi Liu, Xiaochun Cheng & Jun Chen
Pages: 4329-4333
Published online: 03 Aug 2021
AbstractforAcquired ALK Resistance Mutations Identified from Liquid Biopsy in an ALK-Rearranged Squamous Cell Lung Cancer Patient Treated with Sequential ALK TKI Therapy: A Case Report | Full Text | References | PDF (1.5 MB)
  • 62 Views
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Original Research

Article
RETRACTED ARTICLE: miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer
Jiying Wang, Li Wang & Congjun Zhang
Pages: 4335-4343
Published online: 04 Aug 2021
AbstractforRETRACTED ARTICLE: miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer | PDF (4 MB)
  • 60 Views
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Open Access
Article
The Anti-Cancer Effect of Four Curcumin Analogues on Human Glioma Cells
Siou-Min Luo, Yi-Ping Wu, Li-Chun Huang, Shih-Ming Huang & Dueng-Yuan Hueng
Pages: 4345-4359
Published online: 04 Aug 2021
AbstractforThe Anti-Cancer Effect of Four Curcumin Analogues on Human Glioma Cells | Full Text | References | PDF (16.6 MB)
  • 313 Views
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Review

Review Article
Rapidly Evolving Treatment Landscape for Metastatic Esophagogastric Carcinoma: Review of Recent Data
Lionel Aurelien Kankeu Fonkoua & Harry H Yoon
Pages: 4361-4381
Published online: 05 Aug 2021
AbstractforRapidly Evolving Treatment Landscape for Metastatic Esophagogastric Carcinoma: Review of Recent Data | Full Text | References | PDF (1.8 MB)
  • 76 Views
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Original Research

Article
Targeting c-MET to Enhance the Efficacy of Olaparib in Prostate Cancer
Zhenwei Wang, Zhihong Dai, Bingwei Wang, Yuren Gao, Xiang Gao, Liang Wang, Sihai Zhou, Liqin Yang, Xiaofu Qiu & Zhiyu Liu
Pages: 4383-4389
Published online: 04 Aug 2021
AbstractforTargeting c-MET to Enhance the Efficacy of Olaparib in Prostate Cancer | Full Text | References | PDF (4 MB)
  • 85 Views
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Article
High Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma
Na Liu, Liang Zhong, Guangcheng Ni, Jiao Lin, Liang Xie, Taiwen Li, Hongxia Dan & Qianming Chen
Pages: 4391-4406
Published online: 10 Aug 2021
AbstractforHigh Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma | Full Text | References | PDF (12.1 MB)
  • 63 Views
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Case Report

Case Report
Choriocarcinoma Masquerading as Lung Abscess or Lung Cancer: A Case with Atypical Imaging Findings
Qianqian Gu, Shuangquan Yan, Jiang Lin, Xiaomai Wu, Lanxi Chen, Meifu Gan, Huarong Luo, Dongqing Lv & Ling Lin
Pages: 4407-4414
Published online: 10 Aug 2021
AbstractforChoriocarcinoma Masquerading as Lung Abscess or Lung Cancer: A Case with Atypical Imaging Findings | Full Text | References | PDF (1 MB)
  • 73 Views
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Original Research

Article
RETRACTED ARTICLE: Long Non-Coding RNA TRG-AS1 Promoted Proliferation and Invasion of Lung Cancer Cells Through the miR-224-5p/SMAD4 Axis
Mengyan Zhang, Weiguo Zhu, Mansour Haeryfar, Sumei Jiang, Xiang Jiang, Wei Chen & Jiancheng Li
Pages: 4415-4426
Published online: 10 Aug 2021
AbstractforRETRACTED ARTICLE: Long Non-Coding RNA TRG-AS1 Promoted Proliferation and Invasion of Lung Cancer Cells Through the miR-224-5p/SMAD4 Axis | PDF (7.2 MB)
  • 76 Views
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Article
TP53 Mutation Related and Directly Regulated lncRNA Prognosis Markers in Hepatocellular Carcinoma
Xiulei Zhang, Zhihao Fu & Xiao Zhang
Pages: 4427-4437
Published online: 10 Aug 2021
AbstractforTP53 Mutation Related and Directly Regulated lncRNA Prognosis Markers in Hepatocellular Carcinoma | Full Text | References | PDF (4.9 MB)
  • 64 Views
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Open Access
Article
Subgroup Analysis by Liver Metastasis in the FRESCO Trial Comparing Fruquintinib versus Placebo Plus Best Supportive Care in Chinese Patients with Metastatic Colorectal Cancer
Shukui Qin, Rui-Hua Xu, Lin Shen, Jianming Xu, Yuxian Bai, Lei Yang, Yanhong Deng, Zhen-dong Chen, Haijun Zhong, Hongming Pan, Weijian Guo, Yongqian Shu, Ying Yuan, Jianfeng Zhou, Nong Xu, Tianshu Liu, Dong Ma, Changping Wu, Ying Cheng, Donghui Chen, Wei Li, Sanyuan Sun, Zhuang Yu, Peiguo Cao, Haihui Chen, Jiejun Wang, Shubin Wang, Hongbing Wang, Ning Wang, Bin Zhang, Qiang Zhang, Weiguo Su, Xiaojun Guo & Jin Li
Pages: 4439-4450
Published online: 11 Aug 2021
AbstractforSubgroup Analysis by Liver Metastasis in the FRESCO Trial Comparing Fruquintinib versus Placebo Plus Best Supportive Care in Chinese Patients with Metastatic Colorectal Cancer | Full Text | References | PDF (7.7 MB)
  • 102 Views
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Review

Review Article
A Comprehensive Understanding of Choroidal Metastasis from Lung Cancer
Zihan Qu, Jiewei Liu, Lingling Zhu & Qinghua Zhou
Pages: 4451-4465
Published online: 12 Aug 2021
AbstractforA Comprehensive Understanding of Choroidal Metastasis from Lung Cancer | Full Text | References | PDF (3 MB)
  • 162 Views
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Original Research

Article
Prognostic Value of miR-1826 in Prostate Cancer and Its Regulatory Effect on Tumor Progression
Yongguo Liu, Jing Liu, Xiancheng Han & Linkai Mou
Pages: 4467-4475
Published online: 13 Aug 2021
AbstractforPrognostic Value of miR-1826 in Prostate Cancer and Its Regulatory Effect on Tumor Progression | Full Text | References | PDF (4.6 MB)
  • 73 Views
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Review

Review Article
Advances in Immunotherapy of Malignant Pleural Mesothelioma
Dongying Liao, Yongchao Yu, Qingyun Mei, Ziwei Wang, Xiaojiang Li, Yingjie Jia & Fanming Kong
Pages: 4477-4484
Published online: 14 Aug 2021
AbstractforAdvances in Immunotherapy of Malignant Pleural Mesothelioma | Full Text | References | PDF (297.5 KB)
  • 90 Views
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Original Research

Article
Endometrial Tumors with MSI-H and dMMR Share a Similar Tumor Immune Microenvironment
Yunfeng Song, Ye Gu, Xiang Hu, Mengfei Wang, Qizhi He & Yiran Li
Pages: 4485-4497
Published online: 16 Aug 2021
AbstractforEndometrial Tumors with MSI-H and dMMR Share a Similar Tumor Immune Microenvironment | Full Text | References | PDF (8.3 MB)
  • 119 Views
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Open Access

Clinical Trial Report

Case Report
Efficacy and Safety of Apatinib for Elderly Patients with Advanced or Metastatic Gastric Cancer After Failure of at Least First-Line Chemotherapy: A Multi-Center, Single-Arm, Phase II Study
Dengfeng Ren, Guoxiu Wang, Yu Zhang, Jie Kan, Qiuxia Dong, Junhui Zhao, Faxiang Ji, Hao Li, Yushuang Luo, Mingzhe Lin, Guoyuan Li, Zhibo Liu, Xinfu Ma, Qijing Guo, Fuxing Zhao, Guoshuang Shen & Jiuda Zhao
Pages: 4499-4508
Published online: 18 Aug 2021
AbstractforEfficacy and Safety of Apatinib for Elderly Patients with Advanced or Metastatic Gastric Cancer After Failure of at Least First-Line Chemotherapy: A Multi-Center, Single-Arm, Phase II Study | Full Text | References | PDF (2.5 MB)
  • 79 Views
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Review

Review Article
Clinical Utility of Fedratinib in Myelofibrosis
Julian A Waksal, Douglas Tremblay & John Mascarenhas
Pages: 4509-4521
Published online: 21 Aug 2021
AbstractforClinical Utility of Fedratinib in Myelofibrosis | Full Text | References | PDF (3.3 MB)
  • 125 Views
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Original Research

Article
Tetrandrine Inhibits Epithelial-Mesenchymal Transition in IL-6-Induced HCT116 Human Colorectal Cancer Cells
Shih-Chang Tsai, Wei-Chei Wu & Jai-Sing Yang
Pages: 4523-4536
Published online: 21 Aug 2021
AbstractforTetrandrine Inhibits Epithelial-Mesenchymal Transition in IL-6-Induced HCT116 Human Colorectal Cancer Cells | Full Text | References | PDF (7.3 MB)
  • 68 Views
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Case Report

Case Report
Undifferentiated Small Round Cell Sarcoma of the Postcricoid Region of the Hypopharynx: A Rare Case Report and Review of the Literature
Jiao Zhu, Bo Li, Juan Juan Hu, Weiping Liu, Dan Lu & Jun Liu
Pages: 4537-4544
Published online: 24 Aug 2021
AbstractforUndifferentiated Small Round Cell Sarcoma of the Postcricoid Region of the Hypopharynx: A Rare Case Report and Review of the Literature | Full Text | References | PDF (669.5 KB)
  • 103 Views
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Open Access
Case Report
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions
Junhui Xu, Liang Gao, Miao Yan, Bingjie Wang, Zhengyang Song, Huihui Liu, Kunyan Sun, Lin Nong, Mangju Wang & Xinan Cen
Pages: 4545-4550
Published online: 24 Aug 2021
AbstractforPotential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions | Full Text | References | PDF (517.5 KB)
  • 56 Views
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Case Report
Simultaneous Follicular Lymphoma and Myelofibrosis: Report of a Case with Review of the Literature
Ling-zhijie Kong, Jing Li, Rui-Cang Wang, Lin Kang, Qiang Wei & Yan Li
Pages: 4551-4559
Published online: 24 Aug 2021
AbstractforSimultaneous Follicular Lymphoma and Myelofibrosis: Report of a Case with Review of the Literature | Full Text | References | PDF (3.8 MB)
  • 54 Views
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Original Research

Article
A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer
Suxing Liu, Di Li, Jian Liu, Huiyun Wang, Ivana Horecny, Ru Shen, Rumin Zhang, Heping Wu, Qiyue Hu, Peng Zhao, Fengqi Zhang, Yinfa Yan, Jun Feng, Linghang Zhuang, Jing Li, Lianshan Zhang & Weikang Tao
Pages: 4561-4574
Published online: 24 Aug 2021
AbstractforA Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer | Full Text | References | PDF (3.4 MB)
  • 135 Views
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Case Report

Case Report
Surgical Resection of Pancreatic Hepatoid Carcinoma Followed by Combined Transarterial Chemoembolization and Immunotherapy: A Case Report
Jintong He, Qinying Zhao, Qiang Liu, Fei Li, Long He, Mengyi Liu & Xiong Yan
Pages: 4575-4578
Published online: 26 Aug 2021
AbstractforSurgical Resection of Pancreatic Hepatoid Carcinoma Followed by Combined Transarterial Chemoembolization and Immunotherapy: A Case Report | Full Text | References | PDF (473.4 KB)
  • 49 Views
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Review

Review Article
Osimertinib in EGFR-Mutated Lung Cancer: A Review of the Existing and Emerging Clinical Data
Chung-Shien Lee, Matthew Milone & Nagashree Seetharamu
Pages: 4579-4597
Published online: 26 Aug 2021
AbstractforOsimertinib in EGFR-Mutated Lung Cancer: A Review of the Existing and Emerging Clinical Data | Full Text | References | PDF (1.9 MB)
  • 269 Views
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Case Report

Case Report
A Case Report of Targeted Therapy with Anlotinib in a Patient with Advanced Breast Metaplastic Carcinoma
Jieya Zou, Xiaojuan Yang, Jiajun Duan, Ji Wang, Zhuangqing Yang, Dan Luo, Lihua Liu, Junyao Chen & Jianyun Nie
Pages: 4599-4607
Published online: 27 Aug 2021
AbstractforA Case Report of Targeted Therapy with Anlotinib in a Patient with Advanced Breast Metaplastic Carcinoma | Full Text | References | PDF (1.4 MB)
  • 69 Views
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Original Research

Article
Daam1 Overexpression Promotes Gastric Cancer Progression and Regulates ERK and AKT Signaling Pathways
Yue Zhang, Xue Bai, Yi Zhang & Yan Li
Pages: 4609-4619
Published online: 27 Aug 2021
AbstractforDaam1 Overexpression Promotes Gastric Cancer Progression and Regulates ERK and AKT Signaling Pathways | Full Text | References | PDF (7.8 MB)
  • 60 Views
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Case Report

Case Report
Diagnosis of NUT Carcinoma Despite False-Negative Next-Generation Sequencing Results: A Case Report and Literature Review
Xi Wang, Jinping Wang, Xue Luo, Jinxi Lu, Liang Wang, Qingchang Li & En-Hua Wang
Pages: 4621-4633
Published online: 27 Aug 2021
AbstractforDiagnosis of NUT Carcinoma Despite False-Negative Next-Generation Sequencing Results: A Case Report and Literature Review | Full Text | References | PDF (976.8 KB)
  • 134 Views
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Open Access

Retraction

Retraction
circPDSS1 Stimulates the Development of Colorectal Cancer via Activating the Wnt/β-Catenin Signaling [Retraction]
Pages: 4635-4636
Published online: 30 Aug 2021
CitationforcircPDSS1 Stimulates the Development of Colorectal Cancer via Activating the Wnt/β-Catenin Signaling [Retraction] | Full Text | PDF (154.9 KB)
  • 53 Views
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Retraction
MicroRNA-200b Acts as a Tumor Suppressor in Osteosarcoma via Targeting ZEB1 [Retraction]
Pages: 4637-4638
Published online: 30 Aug 2021
CitationforMicroRNA-200b Acts as a Tumor Suppressor in Osteosarcoma via Targeting ZEB1 [Retraction] | Full Text | PDF (134 KB)
  • 53 Views
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Retraction
Effect of Long Non-Coding RNA AOC4P on Gastrointestinal Stromal Tumor Cells [Retraction]
Pages: 4639-4640
Published online: 30 Aug 2021
CitationforEffect of Long Non-Coding RNA AOC4P on Gastrointestinal Stromal Tumor Cells [Retraction] | Full Text | PDF (135.3 KB)
  • 59 Views
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Open Access

Corrigendum

Correction
ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer [Corrigendum]
Pages: 4641-4643
Published online: 31 Aug 2021
First Page PreviewforACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer [Corrigendum] | Full Text | PDF (3.7 MB)
  • 43 Views
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Original Research

Article
A Preliminary Study on the Pathogenesis of Colorectal Cancer by Constructing a Hsa-circRNA-0067835-miRNA-mRNA Regulatory Network
Ning Liu, Fan Jiang & Zhiju Chen
Pages: 4645-4658
Published online: 31 Aug 2021
AbstractforA Preliminary Study on the Pathogenesis of Colorectal Cancer by Constructing a Hsa-circRNA-0067835-miRNA-mRNA Regulatory Network | Full Text | References | PDF (10.5 MB)
  • 70 Views
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Article
Occurrence, Related Factors and Prognostic Value of Vascular Lake in Hepatocellular Carcinoma Patients Treated with Drug-Eluting Bead Transarterial Chemoembolization
Hao Li, Manzhou Wang, Pengfei Chen, Fangzheng Li, Donglin Kuang, Xinwei Han, Jianzhuang Ren & Xuhua Duan
Pages: 4659-4670
Published online: 31 Aug 2021
AbstractforOccurrence, Related Factors and Prognostic Value of Vascular Lake in Hepatocellular Carcinoma Patients Treated with Drug-Eluting Bead Transarterial Chemoembolization | Full Text | References | PDF (1.7 MB)
  • 49 Views
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Review

Review Article
Testing for EGFR Mutations and ALK Rearrangements in Advanced Non-Small-Cell Lung Cancer: Considerations for Countries in Emerging Markets
Mercedes L Dalurzo, Alejandro Avilés-Salas, Fernando Augusto Soares, Yingyong Hou, Yuan Li, Anna Stroganova, Büge Öz, Arif Abdillah, Hui Wan & Yoon-La Choi
Pages: 4671-4692
Published online: 01 Sep 2021
AbstractforTesting for EGFR Mutations and ALK Rearrangements in Advanced Non-Small-Cell Lung Cancer: Considerations for Countries in Emerging Markets | Full Text | References | PDF (754.3 KB)
  • 200 Views
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Original Research

Article
Long Non-Coding RNA Duxap8 Facilitates Cell Proliferation and Induces Apoptosis in Colorectal Cancer via miR-519b/ZNF277 Axis
Hailiang Liang, Jin Wang, Peng Zhang, Wei Yang, Yang Yang, Yin Zhi, Wei Wu & Xiaoqiang Dong
Pages: 4693-4703
Published online: 01 Sep 2021
AbstractforLong Non-Coding RNA Duxap8 Facilitates Cell Proliferation and Induces Apoptosis in Colorectal Cancer via miR-519b/ZNF277 Axis | Full Text | References | PDF (9.3 MB)
  • 49 Views
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Open Access

Retraction

Retraction
miR-30d Induced Apoptosis by Targeting Sox4 to Inhibit the Proliferation, Invasion and Migration of Nephroblastoma [Retraction]
Pages: 4705-4706
Published online: 06 Sep 2021
CitationformiR-30d Induced Apoptosis by Targeting Sox4 to Inhibit the Proliferation, Invasion and Migration of Nephroblastoma [Retraction] | Full Text | PDF (131.9 KB)
  • 33 Views
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Original Research

Article
Identification of microRNA Signature and Key Genes Between Adenoma and Adenocarcinomas Using Bioinformatics Analysis
Xinya Shi, Guang Yu Gao & Jiaofeng Shen
Pages: 4707-4720
Published online: 04 Sep 2021
AbstractforIdentification of microRNA Signature and Key Genes Between Adenoma and Adenocarcinomas Using Bioinformatics Analysis | Full Text | References | PDF (7.6 MB)
  • 76 Views
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Open Access
Article
Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer
Jing Ye, Xiaojing Chen & Weiguo Lu
Pages: 4721-4734
Published online: 07 Sep 2021
AbstractforIdentification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer | Full Text | References | PDF (11.7 MB)
  • 98 Views
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Retraction

Retraction
Long Noncoding RNA DLEU1 Aggravates Glioma Progression via the miR-421/MEF2D Axis [Retraction]
Pages: 4735-4736
Published online: 09 Sep 2021
CitationforLong Noncoding RNA DLEU1 Aggravates Glioma Progression via the miR-421/MEF2D Axis [Retraction] | Full Text | PDF (135.9 KB)
  • 40 Views
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Retraction
microRNA-493 Inhibits Tongue Squamous Cell Carcinoma Oncogenicity via Directly Targeting HMGA2 [Retraction]
Pages: 4737-4738
Published online: 09 Sep 2021
CitationformicroRNA-493 Inhibits Tongue Squamous Cell Carcinoma Oncogenicity via Directly Targeting HMGA2 [Retraction] | Full Text | PDF (138.7 KB)
  • 39 Views
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Retraction
microRNA-605 Directly Targets SOX9 to Alleviate the Aggressive Phenotypes of Glioblastoma Multiforme Cell Lines by Deactivating the PI3K/Akt Pathway [Retraction]
Pages: 4739-4740
Published online: 09 Sep 2021
CitationformicroRNA-605 Directly Targets SOX9 to Alleviate the Aggressive Phenotypes of Glioblastoma Multiforme Cell Lines by Deactivating the PI3K/Akt Pathway [Retraction] | Full Text | PDF (140 KB)
  • 40 Views
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Open Access
Retraction
Long Noncoding RNA SNHG7, a Molecular Sponge for microRNA-485, Promotes the Aggressive Behavior of Cervical Cancer by Regulating PAK4 [Retraction]
Pages: 4741-4742
Published online: 09 Sep 2021
CitationforLong Noncoding RNA SNHG7, a Molecular Sponge for microRNA-485, Promotes the Aggressive Behavior of Cervical Cancer by Regulating PAK4 [Retraction] | Full Text | PDF (141.1 KB)
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Retraction
Long Non-Coding RNA ASB16-AS1 Functions as a miR-760 Sponge to Facilitate the Malignant Phenotype of Osteosarcoma by Increasing HDGF Expression [Retraction]
Pages: 4743-4744
Published online: 09 Sep 2021
CitationforLong Non-Coding RNA ASB16-AS1 Functions as a miR-760 Sponge to Facilitate the Malignant Phenotype of Osteosarcoma by Increasing HDGF Expression [Retraction] | Full Text | PDF (146 KB)
  • 40 Views
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Retraction
microRNA-612 Suppresses the Malignant Development of Non-Small-Cell Lung Cancer by Directly Targeting Bromodomain-Containing Protein 4 [Retraction]
Pages: 4745-4746
Published online: 09 Sep 2021
CitationformicroRNA-612 Suppresses the Malignant Development of Non-Small-Cell Lung Cancer by Directly Targeting Bromodomain-Containing Protein 4 [Retraction] | Full Text | PDF (143.5 KB)
  • 38 Views
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Open Access
Retraction
LncRNA SNHG16 Drives Proliferation and Invasion of Papillary Thyroid Cancer Through Modulation of miR-497 [Retraction]
Pages: 4747-4748
Published online: 09 Sep 2021
CitationforLncRNA SNHG16 Drives Proliferation and Invasion of Papillary Thyroid Cancer Through Modulation of miR-497 [Retraction] | Full Text | PDF (133.6 KB)
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Open Access

Original Research

Article
Carbon-Ion Beam Irradiation and the miR-200c Mimic Effectively Eradicate Pancreatic Cancer Stem Cells Under in vitro and in vivo Conditions
Sei Sai, Eun Ho Kim, Woong Sub Koom, Guillaume Vares, Masao Suzuki, Shigeru Yamada & Mitsuhiro Hayashi
Pages: 4749-4760
Published online: 16 Sep 2021
AbstractforCarbon-Ion Beam Irradiation and the miR-200c Mimic Effectively Eradicate Pancreatic Cancer Stem Cells Under in vitro and in vivo Conditions | Full Text | References | PDF (7.1 MB)
  • 68 Views
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Open Access
Article
TFF-1 Functions to Suppress Multiple Phenotypes Associated with Lung Cancer Progression
Kentaro Minegishi, Yoh Dobashi, Hiroyoshi Tsubochi, Koichi Hagiwara, Yuko Ishibashi, Sachiyo Nomura, Ritsuko Nakamura, Yasukazu Ohmoto & Shunsuke Endo
Pages: 4761-4777
Published online: 10 Sep 2021
AbstractforTFF-1 Functions to Suppress Multiple Phenotypes Associated with Lung Cancer Progression | Full Text | References | PDF (8.6 MB)
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Open Access
Article
CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p
ZhenYu Shen & ShengHua Sun
Pages: 4779-4789
Published online: 10 Sep 2021
AbstractforCircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p | Full Text | References | PDF (8.6 MB)
  • 65 Views
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Open Access
Article
A c-Met Inhibitor Suppresses Osteosarcoma Progression via the ERK1/2 Pathway in Human Osteosarcoma Cells
Weijie Chen, Su Wu, Yang Huang, Tingting Zhang, Hao Dong, Xing Zheng, Tao Chen, Xiaokang Gong, Gang Liu & Xing Zhao
Pages: 4791-4804
Published online: 10 Sep 2021
AbstractforA c-Met Inhibitor Suppresses Osteosarcoma Progression via the ERK1/2 Pathway in Human Osteosarcoma Cells | Full Text | References | PDF (15.3 MB)
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Open Access

Case Report

Case Report
Clinical and Pathologic Complete Response to Gefitinib in a Patient with SqCLC Harboring EGFR p.E746_S752delinsV Mutation
Weitao Zhuang, Chao Zhang, Yong Tang, Dan Tian, Zihua Lan, Cheng Zeng & Guibin Qiao
Pages: 4805-4808
Published online: 15 Sep 2021
AbstractforClinical and Pathologic Complete Response to Gefitinib in a Patient with SqCLC Harboring EGFR p.E746_S752delinsV Mutation | Full Text | References | PDF (1.2 MB)
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Open Access

Original Research

Article
High Tumor Mutation Burden and DNA Repair Gene Mutations are Associated with Primary Resistance to Crizotinib in ALK-Rearranged Lung Cancer
Dakai Xiao, Qiuhua Deng, Dongyun He, Ying Huang, Wenchi Liang, Fengnan Wang & Haihong Yang
Pages: 4809-4817
Published online: 15 Sep 2021
AbstractforHigh Tumor Mutation Burden and DNA Repair Gene Mutations are Associated with Primary Resistance to Crizotinib in ALK-Rearranged Lung Cancer | Full Text | References | PDF (4.6 MB)
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Open Access

Review

Review Article
Clinical Utility of Olaparib in the Treatment of Metastatic Castration-Resistant Prostate Cancer: A Review of Current Evidence and Patient Selection
Alexis LeVee, Ching Ying Lin, Edwin Posadas, Robert Figlin, Neil A Bhowmick, Dolores Di Vizio, Leigh Ellis, Charlos J Rosser, Michael R Freeman, Dan Theodorescu, Stephen J Freedland & Jun Gong
Pages: 4819-4832
Published online: 15 Sep 2021
AbstractforClinical Utility of Olaparib in the Treatment of Metastatic Castration-Resistant Prostate Cancer: A Review of Current Evidence and Patient Selection | Full Text | References | PDF (416.7 KB)
  • 240 Views
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Open Access

Case Report

Case Report
A Metastatic Cervical Adenocarcinoma Patient Carrying HER2 G292R Achieved Complete Response Upon Pyrotinib Treatment
Jing Liu, Yanhong Zhuo, Feng Wang, Zirong Li, Yibin Lin, Li Li, Junping Pan, Yanwen Song, Haiwei Du, Chanhe Li & Qin Xu
Pages: 4833-4836
Published online: 16 Sep 2021
AbstractforA Metastatic Cervical Adenocarcinoma Patient Carrying HER2 G292R Achieved Complete Response Upon Pyrotinib Treatment | Full Text | References | PDF (2.3 MB)
  • 66 Views
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Open Access

Review

Review Article
Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
Qing-Kang Zheng, Chao Ma, Irfan ullah, Kang Hu, Rui-Jie Ma, Nan Zhang & Zhi-Gang Sun
Pages: 4837-4846
Published online: 16 Sep 2021
AbstractforRoles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression | Full Text | References | PDF (2.1 MB)
  • 161 Views
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Open Access

Retraction

Retraction
microRNA-628 Inhibits the Proliferation of Acute Myeloid Leukemia Cells by Directly Targeting IGF-1R [Retraction]
Pages: 4847-4848
Published online: 19 Sep 2021
CitationformicroRNA-628 Inhibits the Proliferation of Acute Myeloid Leukemia Cells by Directly Targeting IGF-1R [Retraction] | Full Text | PDF (146.8 KB)
  • 53 Views
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Open Access
Retraction
miRNA-641 Inhibits the Proliferation, Migration, and Invasion and Induces Apoptosis of Cervical Cancer Cells by Directly Targeting ZEB1 [Retraction]
Pages: 4849-4850
Published online: 19 Sep 2021
CitationformiRNA-641 Inhibits the Proliferation, Migration, and Invasion and Induces Apoptosis of Cervical Cancer Cells by Directly Targeting ZEB1 [Retraction] | Full Text | PDF (147.7 KB)
  • 51 Views
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Open Access
Retraction
microRNA-769 is Downregulated in Colorectal Cancer and Inhibits Cancer Progression by Directly Targeting Cyclin-Dependent Kinase 1 [Retraction]
Pages: 4851-4852
Published online: 19 Sep 2021
CitationformicroRNA-769 is Downregulated in Colorectal Cancer and Inhibits Cancer Progression by Directly Targeting Cyclin-Dependent Kinase 1 [Retraction] | Full Text | PDF (140.6 KB)
  • 35 Views
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Open Access

Case Report

Case Report
Rapid Response to Pembrolizumab in a Chemo-Refractory Testicular Germ Cell Cancer with Microsatellite Instability-High
Koji Kawai, Akinobu Tawada, Mizuki Onozawa, Takamitsu Inoue, Hiromichi Sakurai, Ichiro Mori, Yuichi Takiguchi & Jun Miyazaki
Pages: 4853-4858
Published online: 21 Sep 2021
AbstractforRapid Response to Pembrolizumab in a Chemo-Refractory Testicular Germ Cell Cancer with Microsatellite Instability-High | Full Text | References | PDF (1.6 MB)
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Open Access

Study Protocol

Brief Report
Study on Efficacy and Safety of Low-Dose Apatinib Combined with Camrelizumab and SOX Regimen as First-Line Treatment of Locally Advanced and Unresectable Gastric/Gastroesophageal Junction Cancer: A Protocol for an Open-Label, Dose Escalation and Extension Phase Ib Clinical Trial
Kang-Xin Wang, Ting-Yun Cui, Xu-Dong Yang, Guo-Qun Wang, Qiu-Sheng Jiang, Hui Sun, Nan-Yuan Jiang, Xiao-Min Yong, Chuan-Bing Shi, Yong-Bin Ding, Xiao-Feng Chen & Yue-Yu Fang
Pages: 4859-4865
Published online: 21 Sep 2021
AbstractforStudy on Efficacy and Safety of Low-Dose Apatinib Combined with Camrelizumab and SOX Regimen as First-Line Treatment of Locally Advanced and Unresectable Gastric/Gastroesophageal Junction Cancer: A Protocol for an Open-Label, Dose Escalation and Extension Phase Ib Clinical Trial | Full Text | References | PDF (291.9 KB)
  • 64 Views
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Open Access

Original Research

Article
Elevated RGMA Expression Predicts Poor Prognosis in Patients with Glioblastoma
Thi Le Phan, Hyun-Jin Kim, Suk Jun Lee, Moon-Chang Choi & Sung-Hak Kim
Pages: 4867-4878
Published online: 21 Sep 2021
AbstractforElevated RGMA Expression Predicts Poor Prognosis in Patients with Glioblastoma | Full Text | References | PDF (10.6 MB)
  • 79 Views
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Open Access
Article
Raloxifene Protects Cisplatin-Induced Renal Injury in Mice via Inhibiting Oxidative Stress
Jian-Hong An, Chun-Yan Li, Chun-Ya Chen, Jian-Bin Wu & Hong Shen
Pages: 4879-4890
Published online: 22 Sep 2021
AbstractforRaloxifene Protects Cisplatin-Induced Renal Injury in Mice via Inhibiting Oxidative Stress | Full Text | References | PDF (12.3 MB)
  • 78 Views
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Open Access

Case Report

Case Report
Multimodal Treatment Combining Salvage Surgery-Assisted Chemotherapy and Checkpoints Blockade Immunotherapy Achieves Complete Remission on a Recurrent Penile Cancer Patient: A Case Report
Linjun Hu, Xingli Shan, Dongdong Han, Zhaoxia Guo, Huina Wang & Zejun Xiao
Pages: 4891-4896
Published online: 22 Sep 2021
AbstractforMultimodal Treatment Combining Salvage Surgery-Assisted Chemotherapy and Checkpoints Blockade Immunotherapy Achieves Complete Remission on a Recurrent Penile Cancer Patient: A Case Report | Full Text | References | PDF (2.6 MB)
  • 57 Views
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Open Access

Retraction

Retraction
microRNA-564 Inhibits the Aggressive Phenotypes of Papillary Thyroid Cancer by Directly Targeting Astrocyte-Elevated Gene-1 [Retraction]
Pages: 4897-4898
Published online: 24 Sep 2021
CitationformicroRNA-564 Inhibits the Aggressive Phenotypes of Papillary Thyroid Cancer by Directly Targeting Astrocyte-Elevated Gene-1 [Retraction] | Full Text | PDF (140.8 KB)
  • 38 Views
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Open Access
Retraction
MicroRNA-559 Plays an Inhibitory Role in the Malignant Progression of Glioblastoma Cells by Directly Targeting Metadherin [Retraction]
Pages: 4899-4900
Published online: 24 Sep 2021
CitationforMicroRNA-559 Plays an Inhibitory Role in the Malignant Progression of Glioblastoma Cells by Directly Targeting Metadherin [Retraction] | Full Text | PDF (139.6 KB)
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Open Access

Original Research

Article
RETRACTED ARTICLE: Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP
Ling Zhang, Bijay Khadka, Jieying Wu, Yashu Feng, Bing Long, Ruozhi Xiao & Jiajun Liu
Pages: 4901-4914
Published online: 24 Sep 2021
AbstractforRETRACTED ARTICLE: Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP | PDF (10.9 MB)
  • 14 Views
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Open Access

Case Report

Case Report
Identification of a Novel SLC8A1-ALK Fusion and Non-Canonical Expression Significantly Responding to ALK-TKIs in Lung Adenocarcinoma: A Case Report
Xingyu Zhu, Yuqi He, Yin Wang, Yan Lei, Xiaoxing Su, Yifan Liu, Shuangxiu Wu & Zhengfu He
Pages: 4915-4920
Published online: 27 Sep 2021
AbstractforIdentification of a Novel SLC8A1-ALK Fusion and Non-Canonical Expression Significantly Responding to ALK-TKIs in Lung Adenocarcinoma: A Case Report | Full Text | References | PDF (3.3 MB)
  • 63 Views
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Open Access

Original Research

Article
A Radiomic Approach to Access Tumor Immune Status by CD8+TRMs on Surgically Resected Non-Small-Cell Lung Cancer
Jie Min, Fei Dong, Pin Wu, Xiaopei Xu, Yimin Wu, Yanbin Tan, Fan Yang & Ying Chai
Pages: 4921-4931
Published online: 27 Sep 2021
AbstractforA Radiomic Approach to Access Tumor Immune Status by CD8+TRMs on Surgically Resected Non-Small-Cell Lung Cancer | Full Text | References | PDF (4.7 MB)
  • 54 Views
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Open Access

Retraction

Retraction
microRNA-605 Inhibits the Oncogenicity of Non-Small-Cell Lung Cancer by Directly Targeting Forkhead Box P1 [Retraction]
Pages: 4933-4934
Published online: 28 Sep 2021
CitationformicroRNA-605 Inhibits the Oncogenicity of Non-Small-Cell Lung Cancer by Directly Targeting Forkhead Box P1 [Retraction] | Full Text | PDF (140.8 KB)
  • 48 Views
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Open Access
Retraction
MicroRNA-652 Suppresses Malignant Phenotypes in Glioblastoma Multiforme via FOXK1-Mediated AKT/mTOR Signaling Pathway [Retraction]
Pages: 4935-4936
Published online: 28 Sep 2021
CitationforMicroRNA-652 Suppresses Malignant Phenotypes in Glioblastoma Multiforme via FOXK1-Mediated AKT/mTOR Signaling Pathway [Retraction] | Full Text | PDF (140.7 KB)
  • 62 Views
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Open Access
Retraction
MicroRNA-761 Targets FGFR1 to Suppress the Malignancy of Osteosarcoma by Deactivating PI3K/Akt Pathway [Retraction]
Pages: 4937-4938
Published online: 28 Sep 2021
CitationforMicroRNA-761 Targets FGFR1 to Suppress the Malignancy of Osteosarcoma by Deactivating PI3K/Akt Pathway [Retraction] | Full Text | PDF (144 KB)
  • 48 Views
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Open Access
Retraction
LINC01224 Exhibits Cancer-Promoting Activity in Epithelial Ovarian Cancer Through microRNA-485-5p-Mediated PAK4 Upregulation [Retraction]
Pages: 4939-4940
Published online: 30 Sep 2021
CitationforLINC01224 Exhibits Cancer-Promoting Activity in Epithelial Ovarian Cancer Through microRNA-485-5p-Mediated PAK4 Upregulation [Retraction] | Full Text | PDF (139.2 KB)
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Open Access

Review

Review Article
Efficacy and Toxicity Profile of Carfilzomib-Based Regimens for Treatment of Newly Diagnosed Multiple Myeloma: A Systematic Review
Hassaan Imtiaz, Maimoona Khan, Hamid Ehsan, Ahsan Wahab, Abdul Rafae, Ali Y Khan, Abdur Jamil, Muhammad Khawar Sana, Abdullah Jamal, Taimoor Jaffar Ali, Iqraa Ansar, Muzammil M Khan, Jack Khouri & Faiz Anwer
Pages: 4941-4960
Published online: 01 Oct 2021
AbstractforEfficacy and Toxicity Profile of Carfilzomib-Based Regimens for Treatment of Newly Diagnosed Multiple Myeloma: A Systematic Review | Full Text | References | PDF (835.8 KB)
  • 96 Views
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Open Access

Retraction

Retraction
MicroRNA-936 Targets FGF2 to Inhibit Epithelial Ovarian Cancer Aggressiveness by Deactivating the PI3K/Akt Pathway [Retraction]
Pages: 4961-4962
Published online: 04 Oct 2021
CitationforMicroRNA-936 Targets FGF2 to Inhibit Epithelial Ovarian Cancer Aggressiveness by Deactivating the PI3K/Akt Pathway [Retraction] | Full Text | PDF (144.1 KB)
  • 56 Views
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Open Access
Retraction
MicroRNA-618 Directly Targets Metadherin mRNA to Suppress the Malignant Phenotype of Osteosarcoma Cells by Reducing PTEN-AKT Pathway Output [Retraction]
Pages: 4963-4964
Published online: 01 Oct 2021
CitationforMicroRNA-618 Directly Targets Metadherin mRNA to Suppress the Malignant Phenotype of Osteosarcoma Cells by Reducing PTEN-AKT Pathway Output [Retraction] | Full Text | PDF (144.4 KB)
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Open Access
Retraction
MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1 [Retraction]
Pages: 4965-4966
Published online: 01 Oct 2021
CitationforMicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1 [Retraction] | Full Text | PDF (144 KB)
  • 53 Views
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Open Access

Original Research

Article
TP53 Co-Mutational Features and NGS-Calibrated Immunohistochemistry Threshold in Gastric Cancer
Ruili Yu, Tingyi Sun, Xianwei Zhang, Zhen Li, Yang Xu, Kaihua Liu, Yuqian Shi, Xue Wu, Yang Shao & Lingfei Kong
Pages: 4967-4978
Published online: 01 Oct 2021
AbstractforTP53 Co-Mutational Features and NGS-Calibrated Immunohistochemistry Threshold in Gastric Cancer | Full Text | References | PDF (5.6 MB)
  • 67 Views
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Open Access
Article
Clinical Significance of ADAMTS19, BMP7, SIM1, and SFRP1 Promoter Methylation in Renal Clear Cell Carcinoma
Raimonda Kubiliute, Algirdas Zalimas, Arnas Bakavicius, Albertas Ulys, Feliksas Jankevicius & Sonata Jarmalaite
Pages: 4979-4990
Published online: 05 Oct 2021
AbstractforClinical Significance of ADAMTS19, BMP7, SIM1, and SFRP1 Promoter Methylation in Renal Clear Cell Carcinoma | Full Text | References | PDF (4.4 MB)
  • 65 Views
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Open Access

Retraction

Retraction
MicroRNA-937 Inhibits the Malignant Phenotypes of Breast Cancer by Directly Targeting and Downregulating Forkhead Box Q1 [Retraction]
Pages: 4991-4992
Published online: 04 Oct 2021
CitationforMicroRNA-937 Inhibits the Malignant Phenotypes of Breast Cancer by Directly Targeting and Downregulating Forkhead Box Q1 [Retraction] | Full Text | PDF (137.5 KB)
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Open Access
Retraction
SNHG8 is Upregulated in Esophageal Squamous Cell Carcinoma and Directly Sponges microRNA-411 to Increase Oncogenicity by Upregulating KPNA2 [Retraction]
Pages: 4993-4994
Published online: 04 Oct 2021
CitationforSNHG8 is Upregulated in Esophageal Squamous Cell Carcinoma and Directly Sponges microRNA-411 to Increase Oncogenicity by Upregulating KPNA2 [Retraction] | Full Text | PDF (142 KB)
  • 39 Views
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Open Access
Retraction
MicroRNA-675 Directly Targets MAPK1 to Suppress the Oncogenicity of Papillary Thyroid Cancer and is Sponged by Long Non-Coding RNA RMRP [Retraction]
Pages: 4995-4996
Published online: 04 Oct 2021
CitationforMicroRNA-675 Directly Targets MAPK1 to Suppress the Oncogenicity of Papillary Thyroid Cancer and is Sponged by Long Non-Coding RNA RMRP [Retraction] | Full Text | PDF (138.7 KB)
  • 48 Views
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Open Access
Retraction
Long Non-Coding RNA HAND2-AS1 Inhibits Growth and Migration of Gastric Cancer Cells Through Regulating the miR-590-3p/KCNT2 Axis [Retraction]
Pages: 4997-4998
Published online: 04 Oct 2021
CitationforLong Non-Coding RNA HAND2-AS1 Inhibits Growth and Migration of Gastric Cancer Cells Through Regulating the miR-590-3p/KCNT2 Axis [Retraction] | Full Text | PDF (139.9 KB)
  • 48 Views
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Open Access
Retraction
Long Noncoding RNA X-Inactive Specific Transcript Facilitates Cellular Functions in Melanoma via miR-139-5p/ROCK1 Pathway [Retraction]
Pages: 4999-5000
Published online: 05 Oct 2021
CitationforLong Noncoding RNA X-Inactive Specific Transcript Facilitates Cellular Functions in Melanoma via miR-139-5p/ROCK1 Pathway [Retraction] | Full Text | PDF (138.9 KB)
  • 51 Views
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Open Access
Retraction
MicroRNA-939 Directly Targets HDGF to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway [Retraction]
Pages: 5001-5002
Published online: 05 Oct 2021
CitationforMicroRNA-939 Directly Targets HDGF to Inhibit the Aggressiveness of Prostate Cancer via Deactivation of the WNT/β-Catenin Pathway [Retraction] | Full Text | PDF (156.4 KB)
  • 36 Views
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Open Access
Retraction
Long Noncoding RNA Sox2 Overlapping Transcript (SOX2OT) Promotes Non-Small-Cell Lung Cancer Migration and Invasion via Sponging microRNA 132 (miR-132) [Retraction]
Pages: 5003-5004
Published online: 05 Oct 2021
CitationforLong Noncoding RNA Sox2 Overlapping Transcript (SOX2OT) Promotes Non-Small-Cell Lung Cancer Migration and Invasion via Sponging microRNA 132 (miR-132) [Retraction] | Full Text | PDF (140.5 KB)
  • 44 Views
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Open Access

Original Research

Article
ET-1 Promotes Epithelial–Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells via the microRNA-489-3p /TWIST Axis
Huey-En Tzeng, Chih-Hsin Tang, Chun-Hao Tsai, Chih-Hui Chiu, Min-Huan Wu & Yun Yen
Pages: 5005-5018
Published online: 06 Oct 2021
AbstractforET-1 Promotes Epithelial–Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells via the microRNA-489-3p /TWIST Axis | Full Text | References | PDF (10.9 MB)
  • 67 Views
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Open Access
Article
Early Prediction of Objective Response of Fibrinogen in a Real-World Cohort of Hepatocellular Carcinoma Cases Treated by Programmed Cell Death Receptor-1 and Lenvatinib
Yanjun Shen, Huige Wang, Jianying Wei & Wendong Li
Pages: 5019-5026
Published online: 07 Oct 2021
AbstractforEarly Prediction of Objective Response of Fibrinogen in a Real-World Cohort of Hepatocellular Carcinoma Cases Treated by Programmed Cell Death Receptor-1 and Lenvatinib | Full Text | References | PDF (1.3 MB)
  • 63 Views
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Open Access

Case Report

Case Report
First Report of Severe Autoimmune Hemolytic Anemia During Eltrombopag Therapy in Waldenström Macroglobulinemia-Associated Thrombocytopenia
Yingying Shen, Fanhua Yu, Hangping Ge, Keding Shao, Yuhong Zhou, Baodong Ye, Yiping Shen & Dijiong Wu
Pages: 5027-5033
Published online: 09 Oct 2021
AbstractforFirst Report of Severe Autoimmune Hemolytic Anemia During Eltrombopag Therapy in Waldenström Macroglobulinemia-Associated Thrombocytopenia | Full Text | References | PDF (4.3 MB)
  • 84 Views
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Open Access

Original Research

Article
RPARP-AS1/miR125a-5p Axis Promotes Cell Proliferation, Migration and Invasion in Colon Cancer
Yongjun Ren, Caixia Zhao, Yi He, Xuli Min, Hao Xu & Xiao Hu
Pages: 5035-5043
Published online: 12 Oct 2021
AbstractforRPARP-AS1/miR125a-5p Axis Promotes Cell Proliferation, Migration and Invasion in Colon Cancer | Full Text | References | PDF (5.9 MB)
  • 84 Views
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Open Access

Case Report

Case Report
Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome
Haruka Kitano, Fumihiro Yamaguchi, Kenji Atarashi, Mina Hiraiwa, Yo Shiratori, Shota Onozaki & Yusuke Shikama
Pages: 5045-5049
Published online: 12 Oct 2021
AbstractforCorrelation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome | Full Text | References | PDF (2.9 MB)
  • 108 Views
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Open Access

Corrigendum

Correction
ITPKA1 Promotes Growth, Migration and Invasion of Renal Cell Carcinoma via Activation of mTOR Signaling Pathway [Corrigendum]
Pages: 5051-5053
Published online: 15 Oct 2021
First Page PreviewforITPKA1 Promotes Growth, Migration and Invasion of Renal Cell Carcinoma via Activation of mTOR Signaling Pathway [Corrigendum] | Full Text | PDF (2.1 MB)
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Open Access

Expression of Concern

Expression of Concern
Long Non-Coding RNA LINC00239 Functions as a Competitive Endogenous RNA by Sponging microRNA-484 and Enhancing KLF12 Expression to Promote the Oncogenicity of Colorectal Cancer [Expression of Concern]
Pages: 5055-5056
Published online: 20 Oct 2021
CitationforLong Non-Coding RNA LINC00239 Functions as a Competitive Endogenous RNA by Sponging microRNA-484 and Enhancing KLF12 Expression to Promote the Oncogenicity of Colorectal Cancer [Expression of Concern] | Full Text | PDF (136.8 KB)
  • 55 Views
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Open Access
Expression of Concern
Long Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression [Expression of Concern]
Pages: 5057-5058
Published online: 20 Oct 2021
CitationforLong Noncoding RNA CCDC144NL-AS1 Promotes the Oncogenicity of Osteosarcoma by Acting as a Molecular Sponge for microRNA-490-3p and Thereby Increasing HMGA2 Expression [Expression of Concern] | Full Text | PDF (135.2 KB)
  • 46 Views
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Open Access
Expression of Concern
Long Noncoding RNA ST7-AS1 Upregulates TRPM7 Expression by Sponging microRNA-543 to Promote Cervical Cancer Progression [Expression of Concern]
Pages: 5059-5060
Published online: 20 Oct 2021
CitationforLong Noncoding RNA ST7-AS1 Upregulates TRPM7 Expression by Sponging microRNA-543 to Promote Cervical Cancer Progression [Expression of Concern] | Full Text | PDF (135 KB)
  • 59 Views
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Open Access
Expression of Concern
Long Intergenic Non-Protein Coding RNA 519 Promotes the Biological Activities of Tongue Squamous Cell Carcinoma by Sponging microRNA-876-3p and Consequently Upregulating MACC1 [Expression of Concern]
Pages: 5061-5062
Published online: 20 Oct 2021
CitationforLong Intergenic Non-Protein Coding RNA 519 Promotes the Biological Activities of Tongue Squamous Cell Carcinoma by Sponging microRNA-876-3p and Consequently Upregulating MACC1 [Expression of Concern] | Full Text | PDF (136.7 KB)
  • 39 Views
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Expression of Concern
Long Noncoding RNA LINC00525 Promotes the Aggressive Phenotype of Chordoma Through Acting as a microRNA-505-3p Sponge and Consequently Raising HMGB1 Expression [Expression of Concern]
Pages: 5063-5064
Published online: 20 Oct 2021
CitationforLong Noncoding RNA LINC00525 Promotes the Aggressive Phenotype of Chordoma Through Acting as a microRNA-505-3p Sponge and Consequently Raising HMGB1 Expression [Expression of Concern] | Full Text | PDF (136.9 KB)
  • 55 Views
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Original Research

Article
A Immune-Related Signature Associated with TME Can Serve as a Potential Biomarker for Survival and Sorafenib Resistance in Liver Cancer
Mingyi Ju, Longyang Jiang, Qian Wei, Lifeng Yu, Lianze Chen, Yan Wang, Baohui Hu, Ping Qian, Ming Zhang, Chenyi Zhou, Zinan Li, Minjie Wei, Lin Zhao & Jiali Han
Pages: 5065-5083
Published online: 20 Oct 2021
AbstractforA Immune-Related Signature Associated with TME Can Serve as a Potential Biomarker for Survival and Sorafenib Resistance in Liver Cancer | Full Text | References | PDF (16.3 MB)
  • 76 Views
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Review

Review Article
Clinical Application of Tumor Vascular Disrupting Therapy: A Systematic Review and Meta-Analysis
Wen Tsang, Lu Gan, Zhikun Zhang, Tong Li, Yiqun Luo, Liping Zhong & Yong Huang
Pages: 5085-5093
Published online: 20 Oct 2021
AbstractforClinical Application of Tumor Vascular Disrupting Therapy: A Systematic Review and Meta-Analysis | Full Text | References | PDF (6.5 MB)
  • 52 Views
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Open Access

Retraction

Retraction
LncRNA NEAT1 Promotes Proliferation, Migration and Invasion via Regulating miR-296-5p/CNN2 Axis in Hepatocellular Carcinoma Cells [Retraction]
Pages: 5095-5096
Published online: 21 Oct 2021
CitationforLncRNA NEAT1 Promotes Proliferation, Migration and Invasion via Regulating miR-296-5p/CNN2 Axis in Hepatocellular Carcinoma Cells [Retraction] | Full Text | PDF (135.1 KB)
  • 60 Views
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Original Research

Article
Serum Reactive Oxygen Species Modulator 1 as a Novel Predictive Biomarker for Resected Lung Adenocarcinoma: A Retrospective Pilot Study
Boksoon Chang, In Kyung Hwang & Seung Hyeun Lee
Pages: 5097-5106
Published online: 21 Oct 2021
AbstractforSerum Reactive Oxygen Species Modulator 1 as a Novel Predictive Biomarker for Resected Lung Adenocarcinoma: A Retrospective Pilot Study | Full Text | References | PDF (1.3 MB)
  • 53 Views
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Open Access

Case Report

Case Report
Feasibility and Safety of Neoadjuvant Alectinib in Pulmonary Invasive Mucinous Adenocarcinoma with ALK Rearrangement: Case Report and Literature Review
Rumeng Gu, Ziling Shi, Ting Duan & Meijun Song
Pages: 5107-5113
Published online: 21 Oct 2021
AbstractforFeasibility and Safety of Neoadjuvant Alectinib in Pulmonary Invasive Mucinous Adenocarcinoma with ALK Rearrangement: Case Report and Literature Review | Full Text | References | PDF (1.1 MB)
  • 78 Views
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Open Access

Review

Review Article
Interaction of Gut Microbiome and Host microRNAs with the Occurrence of Colorectal and Breast Cancer and Their Impact on Patient Immunity
Sumadee De Silva, Kamani Hemamala Tennekoon & Eric Hamilton Karunanayake
Pages: 5115-5129
Published online: 22 Oct 2021
AbstractforInteraction of Gut Microbiome and Host microRNAs with the Occurrence of Colorectal and Breast Cancer and Their Impact on Patient Immunity | Full Text | References | PDF (2.4 MB)
  • 228 Views
  • 7 CrossRef citations
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Original Research

Article
18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells
Ying-Hua Luo, Cheng Wang, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Yan-Nan Li, Zhong-Ren Fu, Ying Wang & Cheng-Hao Jin
Pages: 5131-5144
Published online: 22 Oct 2021
Abstractfor18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells | Full Text | References | PDF (12.5 MB)
  • 147 Views
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Review

Review Article
Targeted Therapy for Advanced or Metastatic Cholangiocarcinoma: Focus on the Clinical Potential of Infigratinib
James Yu, Amit Mahipal & Richard Kim
Pages: 5145-5160
Published online: 23 Oct 2021
AbstractforTargeted Therapy for Advanced or Metastatic Cholangiocarcinoma: Focus on the Clinical Potential of Infigratinib | Full Text | References | PDF (517.9 KB)
  • 174 Views
  • 13 CrossRef citations
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Open Access

Case Report

Case Report
ALK Rearrangement in Small-Cell Lung Cancer and Durable Response to Alectinib: A Case Report
Ning Sun, Yan Zhuang, Junling Zhang, Shiqing Chen, Yuwen Dai & Renhong Guo
Pages: 5161-5166
Published online: 24 Oct 2021
AbstractforALK Rearrangement in Small-Cell Lung Cancer and Durable Response to Alectinib: A Case Report | Full Text | References | PDF (6.7 MB)
  • 46 Views
  • 1 CrossRef citations
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Open Access

Corrigendum

Correction
Clinical Utility of Olaparib in the Treatment of Metastatic Castration-Resistant Prostate Cancer: A Review of Current Evidence and Patient Selection [Corrigendum]
Pages: 5167-5168
Published online: 26 Oct 2021
CitationforClinical Utility of Olaparib in the Treatment of Metastatic Castration-Resistant Prostate Cancer: A Review of Current Evidence and Patient Selection [Corrigendum] | Full Text | PDF (130.8 KB)
  • 33 Views
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Original Research

Article
Comparative Transcriptome Provides a Systematic Perspective on Epstein–Barr Virus-Associated Gastric Carcinoma Cell Lines
Jun-Ting Huang, Jian-Ning Chen, Yuan-Hua Bi, Li-Ping Gong, Jing-Yue Zhang, Yu DU & Chun-Kui Shao
Pages: 5169-5182
Published online: 23 Oct 2021
AbstractforComparative Transcriptome Provides a Systematic Perspective on Epstein–Barr Virus-Associated Gastric Carcinoma Cell Lines | Full Text | References | PDF (10.6 MB)
  • 71 Views
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Open Access
Article
Identification of HOXD10 as a Marker of Poor Prognosis in Glioblastoma Multiforme
Yanxin Li, Ke Ma, Qi Xie, Xianwei Zhang, Xiulei Zhang, Kui Chen, Lingfei Kong & Rongjun Qian
Pages: 5183-5195
Published online: 27 Oct 2021
AbstractforIdentification of HOXD10 as a Marker of Poor Prognosis in Glioblastoma Multiforme | Full Text | References | PDF (8.2 MB)
  • 104 Views
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Open Access

Case Series

Case Report
MRD-Negative Remission Induced in EP300-ZNF384 Positive B-ALL Patients by Tandem CD19/CD22 CAR T-Cell Therapy Bridging to Allogeneic Stem Cell Transplantation
Xin-Yue Zhang, Hai-Ping Dai, Ling Zhang, Si-Ning Liu, Yin Dai, De-Pei Wu & Xiao-Wen Tang
Pages: 5197-5204
Published online: 29 Oct 2021
AbstractforMRD-Negative Remission Induced in EP300-ZNF384 Positive B-ALL Patients by Tandem CD19/CD22 CAR T-Cell Therapy Bridging to Allogeneic Stem Cell Transplantation | Full Text | References | PDF (3.9 MB)
  • 62 Views
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Open Access

Original Research

Article
Targeting Endoglin Expressing Cells in the Tumor Microenvironment Does Not Inhibit Tumor Growth in a Pancreatic Cancer Mouse Model
Mark J A Schoonderwoerd, Sarah K Hakuno, Martijn Sassen, Eleonore B Kuhlemaijer, Madelon Paauwe, Marije Slingerland, Marieke F Fransen & Lukas J A C Hawinkels
Pages: 5205-5220
Published online: 29 Oct 2021
AbstractforTargeting Endoglin Expressing Cells in the Tumor Microenvironment Does Not Inhibit Tumor Growth in a Pancreatic Cancer Mouse Model | Full Text | References | PDF (7.8 MB)
  • 121 Views
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Open Access

Case Report

Case Report
Long-Term Survival After Salvage Thoracic Surgery on a Patient with ALK-Rearranged Metastatic Lung Adenocarcinoma After Progression on Targeted Therapy
Kangqi Ren, Guanggui Ding, Shuying Xie & Lin Yang
Pages: 5221-5225
Published online: 02 Nov 2021
AbstractforLong-Term Survival After Salvage Thoracic Surgery on a Patient with ALK-Rearranged Metastatic Lung Adenocarcinoma After Progression on Targeted Therapy | Full Text | References | PDF (2 MB)
  • 64 Views
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Open Access
Case Report
Anti-γ-Aminobutyric Acid Type β Receptor Antibody-Associated Encephalitis After 2 Cycles of Durvalumab Therapy in a Patient with Small Cell Lung Cancer: A Case Report
Jiamo Li, Jianing Jiang, Jinyan Lv, Ru Zhang, Wenting Chen, Shiyi Li, Qianchen Jin & Gang Wang
Pages: 5227-5236
Published online: 03 Nov 2021
AbstractforAnti-γ-Aminobutyric Acid Type β Receptor Antibody-Associated Encephalitis After 2 Cycles of Durvalumab Therapy in a Patient with Small Cell Lung Cancer: A Case Report | Full Text | References | PDF (2.8 MB)
  • 73 Views
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Original Research

Article
AATF is Overexpressed in Human Head and Neck Squamous Cell Carcinoma and Regulates STAT3/Survivin Signaling
Lin Fu, Quanxiu Jin, Qianze Dong & Qingchang Li
Pages: 5237-5248
Published online: 09 Nov 2021
AbstractforAATF is Overexpressed in Human Head and Neck Squamous Cell Carcinoma and Regulates STAT3/Survivin Signaling | Full Text | References | PDF (8.8 MB)
  • 59 Views
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Open Access
Article
Cytochrome 4Z1 Expression is Associated with Poor Prognosis in Colon Cancer Patients
Yousef M Al-saraireh, Fatemah O F O Alshammari, Ahmed M M youssef, Sameeh Al-Sarayreh, Ghadeer H Almuhaisen, Nedal Alnawaiseh, Jehad M Al-Shuneigat & Hamzeh M Alrawashdeh
Pages: 5249-5260
Published online: 12 Nov 2021
AbstractforCytochrome 4Z1 Expression is Associated with Poor Prognosis in Colon Cancer Patients | Full Text | References | PDF (1.4 MB)
  • 65 Views
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Open Access

Retraction

Retraction
Circular RNA SMARCA5 Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer by miR-19b-3p/HOXA9 Axis [Retraction]
Pages: 5261-5262
Published online: 15 Nov 2021
CitationforCircular RNA SMARCA5 Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer by miR-19b-3p/HOXA9 Axis [Retraction] | Full Text | PDF (134.2 KB)
  • 37 Views
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Original Research

Article
The Study of Mucosal-Associated Invariant T Cells in Colon Cancer and Roles in Immune Activities
Juanfen Mo, Li Zheng, Zhenzhen Gao, Jiayuan Wu & Yi Bao
Pages: 5263-5273
Published online: 16 Nov 2021
AbstractforThe Study of Mucosal-Associated Invariant T Cells in Colon Cancer and Roles in Immune Activities | Full Text | References | PDF (8.1 MB)
  • 104 Views
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Open Access

Review

Review Article
Potential Biomarkers for the Efficacy of PD-1-PD-L Blockade in Cancer
Miruna Grecea, Olga Soritau, Daniel Dulf, Tudor Eliade Ciuleanu & Mihnea Zdrenghea
Pages: 5275-5291
Published online: 17 Nov 2021
AbstractforPotential Biomarkers for the Efficacy of PD-1-PD-L Blockade in Cancer | Full Text | References | PDF (1.5 MB)
  • 69 Views
  • 3 CrossRef citations
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Open Access

Corrigendum

Correction
Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation [Corrigendum]
Pages: 5293-5294
Published online: 16 Nov 2021
CitationforOverexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation [Corrigendum] | Full Text | PDF (3 MB)
  • 51 Views
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Open Access
Correction
Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation [Corrigendum]
Pages: 5295-5296
Published online: 16 Nov 2021
CitationforDown-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation [Corrigendum] | Full Text | PDF (1.1 MB)
  • 40 Views
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Original Research

Article
HER2 Amplification in Advanced NSCLC Patients After Progression on EGFR-TKI and Clinical Response to EGFR-TKI Plus Pyrotinib Combination Therapy
Jiadi Gan, Yihua Huang, Jun Liao, Lanlan Pang & Wenfeng Fang
Pages: 5297-5307
Published online: 18 Nov 2021
AbstractforHER2 Amplification in Advanced NSCLC Patients After Progression on EGFR-TKI and Clinical Response to EGFR-TKI Plus Pyrotinib Combination Therapy | Full Text | References | PDF (4.9 MB)
  • 109 Views
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Open Access

Case Report

Case Report
Immunotherapy-Related Cardiotoxicity Re-Emergence in Non-Small Cell Lung Cancer – A Case Report
Yuanxiang Li, Yang Hu, Bin Yang, Caibao Jin, Hui Ren, Jingyi Wu, Zhijun Wang, Youying Wei, Ling Yang & Yanping Hu
Pages: 5309-5314
Published online: 23 Nov 2021
AbstractforImmunotherapy-Related Cardiotoxicity Re-Emergence in Non-Small Cell Lung Cancer – A Case Report | Full Text | References | PDF (425.1 KB)
  • 56 Views
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Open Access
Case Report
Efficacy with Trastuzumab Deruxtecan for Non-Small-Cell Lung Cancer Harboring HER2 Exon 20 Insertion Mutation in a Patient with a Poor Performance Status: A Case Report
Yuki Kato, Yasuhiro Kato, Yuji Minegishi, Takahiro Suzuki, Shinji Nakamichi, Masaru Matsumoto, Akihiko Miyanaga, Rintaro Noro, Kaoru Kubota, Yasuhiro Terasaki, Masahiro Seike & Akihiko Gemma
Pages: 5315-5319
Published online: 23 Nov 2021
AbstractforEfficacy with Trastuzumab Deruxtecan for Non-Small-Cell Lung Cancer Harboring HER2 Exon 20 Insertion Mutation in a Patient with a Poor Performance Status: A Case Report | Full Text | References | PDF (2.3 MB)
  • 80 Views
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Open Access

Review

Review Article
Targeted Treatment of Non-Small Cell Lung Cancer: Focus on Capmatinib with Companion Diagnostics
Matthew Z Guo, Kristen A Marrone, Alexander Spira, David M Waterhouse & Susan C Scott
Pages: 5321-5331
Published online: 23 Nov 2021
AbstractforTargeted Treatment of Non-Small Cell Lung Cancer: Focus on Capmatinib with Companion Diagnostics | Full Text | References | PDF (1.4 MB)
  • 74 Views
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Open Access

Corrigendum

Correction
Dehydrocorydaline Inhibits Cell Proliferation, Migration and Invasion via Suppressing MEK1/2-ERK1/2 Cascade in Melanoma [Corrigendum]
Pages: 5333-5334
Published online: 23 Nov 2021
CitationforDehydrocorydaline Inhibits Cell Proliferation, Migration and Invasion via Suppressing MEK1/2-ERK1/2 Cascade in Melanoma [Corrigendum] | Full Text | PDF (2.7 MB)
  • 41 Views
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Review

Review Article
The Controversial Role of Polyploidy in Hepatocellular Carcinoma
Nan Wang, Fengjie Hao, Yan Shi & Junqing Wang
Pages: 5335-5344
Published online: 27 Nov 2021
AbstractforThe Controversial Role of Polyploidy in Hepatocellular Carcinoma | Full Text | References | PDF (1.8 MB)
  • 108 Views
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Open Access

Original Research

Article
Durable Response to Vemurafenib and Cobimetinib for the Treatment of BRAF-Mutated Metastatic Melanoma in Routine Clinical Practice
Mª del Carmen Álamo, Sebastian Ochenduszko, Guillermo Crespo, Mónica Corral, Juana Oramas, Pilar Sancho, Javier Medina, Fernando Garicano, Pedro López, Begoña Campos Balea, Analia Rodríguez Garzotto & Eva Muñoz-Couselo
Pages: 5345-5352
Published online: 27 Nov 2021
AbstractforDurable Response to Vemurafenib and Cobimetinib for the Treatment of BRAF-Mutated Metastatic Melanoma in Routine Clinical Practice | Full Text | References | PDF (321.4 KB)
  • 96 Views
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Open Access

Case Report

Case Report
Favorable Response to Olaparib in a Patient with Cancer of Unknown Primary Carrying a Germline BRCA1 R71K Mutation
Xiaomeng Jia, Shanshan Zhao, Xiang Li, Li Lv, Xin Chen, Evenki Pan, Qiuxiang Ou, Chen Song, Siwen Sun, Jinbo Zhao, Lingzhi Xu & Man Li
Pages: 5353-5360
Published online: 27 Nov 2021
AbstractforFavorable Response to Olaparib in a Patient with Cancer of Unknown Primary Carrying a Germline BRCA1 R71K Mutation | Full Text | References | PDF (4 MB)
  • 68 Views
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Open Access

Corrigendum

Correction
Expression of B7-H3 Correlates with PD-L1 and Poor Prognosis in Patients with Cervical Cancer [Corrigendum]
Pages: 5361-5362
Published online: 30 Nov 2021
CitationforExpression of B7-H3 Correlates with PD-L1 and Poor Prognosis in Patients with Cervical Cancer [Corrigendum] | Full Text | PDF (134 KB)
  • 62 Views
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Open Access

Case Report

Case Report
Endostar Plus Apatinib Successfully Achieved Long Term Progression-Free Survival in Refractory Ovarian Cancer: A Case Report and Literature Review
Chunmei Xiao, Fangye Xu, Rong Wang, Qi Liang, Kai Shen, Jiali Xu & Lianke Liu
Pages: 5363-5372
Published online: 01 Dec 2021
AbstractforEndostar Plus Apatinib Successfully Achieved Long Term Progression-Free Survival in Refractory Ovarian Cancer: A Case Report and Literature Review | Full Text | References | PDF (3.5 MB)
  • 51 Views
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Original Research

Article
Identification and Validation a Necroptosis‑related Prognostic Signature and Associated Regulatory Axis in Stomach Adenocarcinoma
Ning Wang & Dingsheng Liu
Pages: 5373-5383
Published online: 02 Dec 2021
AbstractforIdentification and Validation a Necroptosis‑related Prognostic Signature and Associated Regulatory Axis in Stomach Adenocarcinoma | Full Text | References | PDF (8.9 MB)
  • 97 Views
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Case Report

Case Report
Efficacy and Drug Resistance Analysis of ALK Inhibitors in Combination with Stereotactic Body Radiation Therapy for Treating Lung Squamous Carcinoma Patient Harboring EML4-ALK Rearrangement
Long Liang, Mian Mao, Lei Wu, Taiyu Chen, Jiahua Lyu, Qifeng Wang & Tao Li
Pages: 5385-5389
Published online: 03 Dec 2021
AbstractforEfficacy and Drug Resistance Analysis of ALK Inhibitors in Combination with Stereotactic Body Radiation Therapy for Treating Lung Squamous Carcinoma Patient Harboring EML4-ALK Rearrangement | Full Text | References | PDF (1.6 MB)
  • 67 Views
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Original Research

Article
M2-Type Macrophages Induce Tregs Generation by Activating the TGF-β/Smad Signalling Pathway to Promote Colorectal Cancer Development
Xueqian Ma, Yu Gao, Yanlei Chen, Jinhao Liu, Chunyu Yang, Cuifen Bao, Yanping Wang, Yang Feng, Xiaoyu Song & Shifeng Qiao
Pages: 5391-5402
Published online: 07 Dec 2021
AbstractforM2-Type Macrophages Induce Tregs Generation by Activating the TGF-β/Smad Signalling Pathway to Promote Colorectal Cancer Development | Full Text | References | PDF (5.7 MB)
  • 133 Views
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Open Access
Article
Fibrinogen/Albumin Ratio (FAR) in Patients with Triple Negative Breast Cancer and Its Relationship with Epidermal Growth Factor Receptor Expression
Wenbo Gao, Ming Li & Yunhao Zhang
Pages: 5403-5415
Published online: 07 Dec 2021
AbstractforFibrinogen/Albumin Ratio (FAR) in Patients with Triple Negative Breast Cancer and Its Relationship with Epidermal Growth Factor Receptor Expression | Full Text | References | PDF (6 MB)
  • 63 Views
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Open Access

Retraction

Retraction
Promotion of miR-221-5p on the Sensitivity of Gastric Cancer Cells to Cisplatin and Its Effects on Cell Proliferation and Apoptosis by Regulating DDR1 [Retraction]
Pages: 5417-5418
Published online: 07 Dec 2021
CitationforPromotion of miR-221-5p on the Sensitivity of Gastric Cancer Cells to Cisplatin and Its Effects on Cell Proliferation and Apoptosis by Regulating DDR1 [Retraction] | Full Text | PDF (135.7 KB)
  • 53 Views
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Open Access
Retraction
Hsa_circ_0006916 Knockdown Represses the Development of Hepatocellular Carcinoma via Modulating miR-599/SRSF2 Axis [Retraction]
Pages: 5419-5420
Published online: 07 Dec 2021
CitationforHsa_circ_0006916 Knockdown Represses the Development of Hepatocellular Carcinoma via Modulating miR-599/SRSF2 Axis [Retraction] | Full Text | PDF (134.9 KB)
  • 45 Views
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Open Access
Retraction
LncRNA SNHG16 Regulates the Progress of Acute Myeloid Leukemia Through miR183-5p–FOXO1 Axis [Retraction]
Pages: 5421-5422
Published online: 07 Dec 2021
CitationforLncRNA SNHG16 Regulates the Progress of Acute Myeloid Leukemia Through miR183-5p–FOXO1 Axis [Retraction] | Full Text | PDF (141.3 KB)
  • 40 Views
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Open Access

Case Report

Case Report
Efficient Everolimus Treatment for Metastatic Castration Resistant Prostate Cancer with AKT1 Mutation: A Case Report
Zhe Yu, Wei Wei, Hongruo Liu, Evenki Pan, Peng Yang & Kui Jiang
Pages: 5423-5428
Published online: 08 Dec 2021
AbstractforEfficient Everolimus Treatment for Metastatic Castration Resistant Prostate Cancer with AKT1 Mutation: A Case Report | Full Text | References | PDF (3.1 MB)
  • 63 Views
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Open Access
Case Report
Effective Disease Control After Combinatorial Treatment with a PD-1 Antibody and an mTOR Inhibitor for Recurrent Ovarian Clear Cell Carcinomas: A Case Report and Literature Review
Yue Li, wentao Liu, Xiaoyan Zhang, Yu Fang, Xiaolong Yue, Xin Zhang, Qifan He, Na Fu, Sizhen Wang, Tonghui Ma & Dalin Li
Pages: 5429-5434
Published online: 09 Dec 2021
AbstractforEffective Disease Control After Combinatorial Treatment with a PD-1 Antibody and an mTOR Inhibitor for Recurrent Ovarian Clear Cell Carcinomas: A Case Report and Literature Review | Full Text | References | PDF (1.6 MB)
  • 66 Views
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Open Access

Original Research

Article
High Red Cell Distribution Width Independently Predicts Adverse Survival in Patients with Newly Diagnosed Skull Base Chordoma
Mingxuan Li, Yutao Shen, Yujia Xiong, Jiwei Bai, Shuai Wang, Chuzhong Li & Yazhuo Zhang
Pages: 5435-5445
Published online: 11 Dec 2021
AbstractforHigh Red Cell Distribution Width Independently Predicts Adverse Survival in Patients with Newly Diagnosed Skull Base Chordoma | Full Text | References | PDF (4.9 MB)
  • 61 Views
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Open Access

Case Series

Case Report
Complete Response to PD-1 Inhibitor in Primary Hepatocellular Carcinoma Patients Post-Progression on Bi-Specific Antibody Conjugated CIK Cell Treatment: A Report of Two Cases
Tong Wu, Linzhi Zhang, Zhen Zeng, Tao Yan, Jiamin Cheng, Xiaojie Miao & Yinying Lu
Pages: 5447-5453
Published online: 18 Dec 2021
AbstractforComplete Response to PD-1 Inhibitor in Primary Hepatocellular Carcinoma Patients Post-Progression on Bi-Specific Antibody Conjugated CIK Cell Treatment: A Report of Two Cases | Full Text | References | PDF (2.6 MB)
  • 68 Views
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Open Access

Original Research

Article
Identification of NUTF2 as a Candidate Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Head and Neck Squamous Cell Carcinoma
Rui Zhang & Ying Gao
Pages: 5455-5467
Published online: 22 Dec 2021
AbstractforIdentification of NUTF2 as a Candidate Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Head and Neck Squamous Cell Carcinoma | Full Text | References | PDF (8.2 MB)
  • 60 Views
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Open Access

Retraction

Retraction
Overexpressed Long Noncoding RNA TUG1 Affects the Cell Cycle, Proliferation, and Apoptosis of Pancreatic Cancer Partly Through Suppressing RND3 and MT2A [Retraction]
Pages: 5469-5470
Published online: 23 Dec 2021
CitationforOverexpressed Long Noncoding RNA TUG1 Affects the Cell Cycle, Proliferation, and Apoptosis of Pancreatic Cancer Partly Through Suppressing RND3 and MT2A [Retraction] | Full Text | PDF (142.6 KB)
  • 52 Views
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Open Access

Case Report

Case Report
Clinical Impact of Switching to Ceritinib After Severe AEs Related to Crizotinib/Alectinib in a Novel PTH2R-ALK Fusion Lung Adenocarcinoma: A Case Report
Gang Shen, Yinping Du, Jifang Shen, Junling Zhang, Xihua Xia, Mengli Huang & Wenxiang Shen
Pages: 5471-5475
Published online: 23 Dec 2021
AbstractforClinical Impact of Switching to Ceritinib After Severe AEs Related to Crizotinib/Alectinib in a Novel PTH2R-ALK Fusion Lung Adenocarcinoma: A Case Report | Full Text | References | PDF (2.7 MB)
  • 46 Views
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Original Research

Article
CBX7, a Potential Prognostic Biomarker in Lung Adenocarcinoma
Yanlong Yang, Zaoxiu Hu, Hongwen Sun, Qinghe Yu, Linzhu Yang, Fang Yin, Yongmen Sun, Lisha Pu, Xingming Zhu, Shen Li, Xiaobo Chen & Yunping Zhao
Pages: 5477-5492
Published online: 24 Dec 2021
AbstractforCBX7, a Potential Prognostic Biomarker in Lung Adenocarcinoma | Full Text | References | PDF (9.4 MB)
  • 60 Views
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Open Access
Article
AATF is Overexpressed in Human Bladder Cancer and Regulates Chemo-Sensitivity Through Survivin
Shutao Tan, Lin Fu & Qianze Dong
Pages: 5493-5505
Published online: 29 Dec 2021
AbstractforAATF is Overexpressed in Human Bladder Cancer and Regulates Chemo-Sensitivity Through Survivin | Full Text | References | PDF (9.4 MB)
  • 65 Views
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Open Access

Review

Review Article
Targeted Treatment of Chronic Lymphocytic Leukemia: Clinical Utility of Acalabrutinib
Candida Vitale, Jamie Lynn Gibbons & Alessandra Ferrajoli
Pages: 5507-5519
Published online: 29 Dec 2021
AbstractforTargeted Treatment of Chronic Lymphocytic Leukemia: Clinical Utility of Acalabrutinib | Full Text | References | PDF (1.1 MB)
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Open Access
Review Article
Clinical Evaluation of Ramucirumab for the Treatment of Hepatocellular Carcinoma (HCC): Place in Therapy
Khalil Choucair, Syed Kamran & Anwaar Saeed
Pages: 5521-5532
Published online: 29 Dec 2021
AbstractforClinical Evaluation of Ramucirumab for the Treatment of Hepatocellular Carcinoma (HCC): Place in Therapy | Full Text | References | PDF (428.5 KB)
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Original Research

Article
Alectinib Together with Intracranial Therapies Improved Survival Outcomes in Untreated ALK-Positive Patients with Non-Small-Cell Lung Cancer and Symptomatic and Synchronic Brain Metastases: A Retrospective Study
Qiang Yin, Peng Li, Peng Wang, Zhen Zhang, Qun Liu, Zengfeng Sun, Wenliang Li, Li Ma & Xiaoguang Wang
Pages: 5533-5542
Published online: 30 Dec 2021
AbstractforAlectinib Together with Intracranial Therapies Improved Survival Outcomes in Untreated ALK-Positive Patients with Non-Small-Cell Lung Cancer and Symptomatic and Synchronic Brain Metastases: A Retrospective Study | Full Text | References | PDF (3.5 MB)
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