Drug and Chemical Toxicology, Volume 46, Issue 2 (2023)

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Drug and Chemical Toxicology, Volume 46, Issue 2 (2023)

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Research Articles

Article
Effects of caffeic acid phenethyl ester use and inhibition of p42/44 MAP kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of rats
Yilmaz Cigremis, Hasan Ozen, Merve Durhan, Selahattin Tunc & Evren Kose
Pages: 197-208
Published online: 27 Dec 2021
AbstractforEffects of caffeic acid phenethyl ester use and inhibition of p42/44 MAP kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of rats | Full Text | References | PDF (3.4 MB) | EPUB
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Article
The protective effects of vitamins A, C, and E on zinc oxide nanoparticles (ZnO NPs)-induced liver oxidative stress in male Wistar rats
Mojtaba Bayat, Sajedeh Daei, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir & Alireza Nourian
Pages: 209-218
Published online: 16 Dec 2021
AbstractforThe protective effects of vitamins A, C, and E on zinc oxide nanoparticles (ZnO NPs)-induced liver oxidative stress in male Wistar rats | Full Text | References | PDF (2.5 MB) | EPUB
  • 260 Views
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Article
Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation
Anne A. Adeyanju, Omolola R. Oyenihi, Oluwafemi O. Oguntibeju & Oreoluwa Ojomu
Pages: 219-225
Published online: 29 Dec 2021
AbstractforSildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation | Full Text | References | PDF (1.2 MB) | EPUB
  • 146 Views
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Article
B-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling
Zhiyong Xiao, Feng Liu, Junping Cheng, Ying Wang, Wenxia Zhou & Yongxiang Zhang
Pages: 226-235
Published online: 05 Jan 2022
AbstractforB-Raf inhibitor vemurafenib counteracts sulfur mustard-induced epidermal impairment through MAPK/ERK signaling | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 203 Views
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Article
Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model
Adedayo Oluwaseun Ademiluyi, Opeyemi Babatunde Ogunsuyi, Josephine Oluwaseun Akinduro, Olayemi Philemon Aro & Ganiyu Oboh
Pages: 236-246
Published online: 22 Mar 2022
AbstractforEvaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model | Full Text | References | PDF (2.3 MB) | EPUB
  • 158 Views
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Article
Intestinal epithelial damage due to herbal compounds – an in vitro study
Susan M. Britza, Ian F. Musgrave, Rachael Farrington & Roger W. Byard
Pages: 247-255
Published online: 03 Jan 2022
AbstractforIntestinal epithelial damage due to herbal compounds – an in vitro study | Full Text | References | PDF (1.9 MB) | EPUB
  • 218 Views
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Review

Review
The effect of preconditioning agents on cardiotoxicity and neurotoxicity of carbon monoxide poisoning in animal studies: a systematic review
Hamed Baharara, Hanieh Ghasemi, Sara Samadi, Bahar Roohshad, Vahid Jomehzadeh, Khosrow Ravankhah Moghaddam, Amir Hooshang Mohammadpour & Omid Arasteh
Pages: 256-270
Published online: 26 May 2022
AbstractforThe effect of preconditioning agents on cardiotoxicity and neurotoxicity of carbon monoxide poisoning in animal studies: a systematic review | Full Text | References | PDF (1.4 MB) | EPUB
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Research Articles

Article
The inhibitory effects of pimozide, an antipsychotic drug, on voltage-gated K+ channels in rabbit coronary arterial smooth muscle cells
Mi Seon Seo, Jin Ryeol An, Ryeon Heo, Minji Kang, Seojin Park, Seo-Yeong Mun, Hongzoo Park, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Geehyun Song & Won Sun Park
Pages: 271-280
Published online: 23 Mar 2022
AbstractforThe inhibitory effects of pimozide, an antipsychotic drug, on voltage-gated K+ channels in rabbit coronary arterial smooth muscle cells | Full Text | References | PDF (1.7 MB) | EPUB
  • 132 Views
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Article
Ginsenoside Re attenuates 8-OH-DPAT-induced serotonergic behaviors in mice via interactive modulation between PKCδ gene and Nrf2
Eun-Joo Shin, Ji Hoon Jeong, Bao-Trong Nguyen, Naveen Sharma, Cuong Ngoc Kim Tran, Seung-Yeol Nah, Yi Lee, Jae Kyung Byun, Sung Kwon Ko & Hyoung-Chun Kim
Pages: 281-296
Published online: 16 Jun 2022
AbstractforGinsenoside Re attenuates 8-OH-DPAT-induced serotonergic behaviors in mice via interactive modulation between PKCδ gene and Nrf2 | Full Text | References | PDF (3.3 MB) | EPUB
  • 142 Views
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Article
Assessment of the genotoxic effects of antihypertensive drug active ingredient indapamide in human lymphocytes
Ece Avuloglu-Yilmaz, Deniz Yuzbasioglu & Fatma Unal
Pages: 297-303
Published online: 11 Jan 2022
AbstractforAssessment of the genotoxic effects of antihypertensive drug active ingredient indapamide in human lymphocytes | Full Text | References | PDF (938.1 KB) | EPUB
  • 399 Views
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Article
Salvianolic acid A suppresses CCl4-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways
Shengnan Li, Rong Wang, Fuxing Song, Panpan Chen, Yanqiu Gu, Chun Chen & Yongfang Yuan
Pages: 304-313
Published online: 20 Jan 2022
AbstractforSalvianolic acid A suppresses CCl4-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways | Full Text | References | PDF (2.3 MB) | EPUB
  • 297 Views
  • 9 CrossRef citations
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Article
Comparative evaluation of the effects of bisphenol derivatives on oxidative stress parameters in HepG2 cells
Busra Ozyurt, Gizem Ozkemahli, Anil Yirun, Aylin Balci Ozyurt, Merve Bacanli, Nursen Basaran, Belma Kocer-Gumusel & Pinar Erkekoglu
Pages: 314-322
Published online: 19 Jan 2022
AbstractforComparative evaluation of the effects of bisphenol derivatives on oxidative stress parameters in HepG2 cells | Full Text | References | PDF (1.9 MB) | EPUB
  • 396 Views
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Article
Inhibition of methotrexate induced toxicity in the adult rat spleen by adalimumab
İlkay Bahceci, Levent Tumkaya, Tolga Mercantepe, Nuray Aslan, Ömer Faruk Duran, Umut Serkan Soztanaci & Zihni Acar Yazıcı
Pages: 323-329
Published online: 20 Jan 2022
AbstractforInhibition of methotrexate induced toxicity in the adult rat spleen by adalimumab | Full Text | References | PDF (3.6 MB) | EPUB
  • 391 Views
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Article
Phytochemical analysis, in silico study and toxicity profile of Cycas pectinata Buch.-Ham seed in mice
Chuckles Ch. Marak, Brilliant N. Marak, Ved Prakash Singh, Guruswami Gurusubramanian & Vikas Kumar Roy
Pages: 330-342
Published online: 03 Feb 2022
AbstractforPhytochemical analysis, in silico study and toxicity profile of Cycas pectinata Buch.-Ham seed in mice | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 258 Views
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Article
28-day repeated dose toxicological evaluation of Coronil in Sprague Dawley rats: Behavioral, hematological, biochemical and histopathological assessments under GLP compliance
Acharya Balkrishna, Sandeep Sinha & Anurag Varshney
Pages: 343-356
Published online: 09 Feb 2022
Abstractfor28-day repeated dose toxicological evaluation of Coronil in Sprague Dawley rats: Behavioral, hematological, biochemical and histopathological assessments under GLP compliance | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 563 Views
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Article
L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling
Neven Hassan, Maha Rashad, Ebtihal Elleithy, Zainab Sabry, Ghada Ali & Sherif Elmosalamy
Pages: 357-368
Published online: 17 Feb 2022
AbstractforL-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 218 Views
  • 12 CrossRef citations
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Article
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells
Yanji Qu, Shimin Zong, Zhe Wang, Peiyu Du, Yingying Wen, Hao Li, Nan Wu & Hongjun Xiao
Pages: 369-379
Published online: 17 Feb 2022
AbstractforThe PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 174 Views
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Article
Antiandrogen enzalutamide induced genetic, cellular, and hepatic damages: amelioration by triterpene Lupeol
Mohammad A. Khan, Deepti Singh, Homa Fatma, Kafil Akhtar, Farruk Arjmand, Santosh Maurya & Hifzur R. Siddique
Pages: 380-391
Published online: 21 Feb 2022
AbstractforAntiandrogen enzalutamide induced genetic, cellular, and hepatic damages: amelioration by triterpene Lupeol | Full Text | References | PDF (3.5 MB) | EPUB
  • 288 Views
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Article
Subacute oral toxicology and toxicokinetics of pterostilbene, a novel Top1/Tdp1 inhibiting anti-tumor reagent
Changcheng Sun, Ying Li, Yutian Zhang, Haoyan Huang, Huili Chen, Jiaqin Chen, Luyao Han, Xiang Chen, Xijing Chen & Yongjie Zhang
Pages: 392-399
Published online: 07 Mar 2022
AbstractforSubacute oral toxicology and toxicokinetics of pterostilbene, a novel Top1/Tdp1 inhibiting anti-tumor reagent | Full Text | References | PDF (1.7 MB) | EPUB
  • 164 Views
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Article
Fluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressions
Gökçe Ceren Kuşçu, Çevik Gürel, Aylin Buhur, Nefise Ülkü Karabay Yavaşoğlu, Timur Köse, Altuğ Yavaşoğlu & Fatih Oltulu
Pages: 400-411
Published online: 24 Feb 2022
AbstractforFluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressions | Full Text | References | PDF (5.5 MB) | EPUB
  • 378 Views
  • 4 CrossRef citations
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