Drug and Chemical Toxicology, Volume 46, Issue 4 (2023)

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Drug and Chemical Toxicology, Volume 46, Issue 4 (2023)

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Research Articles

Article
The role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder
Farzaneh Motafeghi, Parham Mortazavi, Amir Hossein Salman Mahiny, Mohammad Mehdi Abtahi & Mohammad Shokrzadeh
Pages: 617-624
Published online: 16 May 2022
AbstractforThe role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Assessment of Toxicity and Wound Healing Activity of Selaginella Bryopteris Extract
Shravan Kumar Paswan, Pritt Verma, Sajal Srivastava & Chandana Venkateswara Rao
Pages: 625-633
Published online: 29 May 2022
AbstractforAssessment of Toxicity and Wound Healing Activity of Selaginella Bryopteris Extract | Full Text | References | PDF (1.6 MB) | EPUB
  • 136 Views
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Article
Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test
Dennis Franckenstein, Melanie K. Bothe, Sara B. Hurtado & Martin Westphal
Pages: 634-639
Published online: 23 May 2022
AbstractforHydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test | Full Text | References | PDF (597.6 KB) | EPUB
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Open Access
Article
Hypolipidemic potential and safety profile of the ethanolic extract and flour of the peel of Passiflora Cincinnata Mast. (Passifloraceae) in mice
Ana Ediléia Barbosa Pereira Leal, Érica Martins de Lavor, Ana Paula de Oliveira, Lívia Macedo Dutra, Jackson de Menezes Barbosa, Cristiane dos Santos Cerqueira Alves, Roxana Braga de Andrade Teles, Raira Feitosa dos Santos, Ricardo Santana de Lima, Mário Adriano Ávila Queiroz, Julianeli Tolentino de Lima & Jackson Roberto Guedes da Silva Almeida
Pages: 640-649
Published online: 19 May 2022
AbstractforHypolipidemic potential and safety profile of the ethanolic extract and flour of the peel of Passiflora Cincinnata Mast. (Passifloraceae) in mice | Full Text | References | PDF (2.3 MB) | EPUB
  • 115 Views
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Article
Metabonomic and transcriptomic analyses of Tripterygium glycosides tablet-induced hepatotoxicity in rats
Zhuoling An, Yuan Sun, Chen Shi & Lihong Liu
Pages: 650-664
Published online: 23 May 2022
AbstractforMetabonomic and transcriptomic analyses of Tripterygium glycosides tablet-induced hepatotoxicity in rats | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 188 Views
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Article
Unusual dimeric flavonoids (brachydins) induce ultrastructural membrane alterations associated with antitumor activity in cancer cell lines
Vera Lucia Maciel-Silva, Claudia Quintino da Rocha, Luciana Magalhães Rebelo Alencar, Patrícia Valéria Castelo-Branco, Israel Higino de Sousa, Ana Paula Azevedo-Santos, André Alvares Marques Vale, Silvio Gomes Monteiro, Rossy-Eric Pereira Soares, Sulayne Janayna Araujo Guimarães, Jessyane Rodrigues do Nascimento & Silma Regina Ferreira Pereira
Pages: 665-676
Published online: 29 May 2022
AbstractforUnusual dimeric flavonoids (brachydins) induce ultrastructural membrane alterations associated with antitumor activity in cancer cell lines | Full Text | References | PDF (3.8 MB) | EPUB
  • 177 Views
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Article
Asparagus falcatus L. (Asparagaceae) leaf extracts attenuate doxorubicin-induced renal toxicity via antioxidant, anti-inflammatory, and anti-apoptotic pathways
Sachinthi S. Amarasiri, Anoja P. Attanayake, Lakmini K. B. Mudduwa & Kamani A. P. W. Jayatilaka
Pages: 677-691
Published online: 30 May 2022
AbstractforAsparagus falcatus L. (Asparagaceae) leaf extracts attenuate doxorubicin-induced renal toxicity via antioxidant, anti-inflammatory, and anti-apoptotic pathways | Full Text | References | PDF (2.7 MB) | EPUB
  • 95 Views
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Article
Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases
Omid Mehrpour, Christopher Hoyte, Foster Goss, Farshad M. Shirazi & Samaneh Nakhaee
Pages: 692-698
Published online: 07 Jun 2022
AbstractforDecision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases | Full Text | References | PDF (898.7 KB) | EPUB
  • 185 Views
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Article
In vitro cytogenetic analysis of two different anti-phosphates (sevelamer hydrochloride and calcium carbonate) agents used by patients with hyperphosphatemia
Goulzar Ulaya & Hasan Basri İla
Pages: 699-707
Published online: 07 Jun 2022
AbstractforIn vitro cytogenetic analysis of two different anti-phosphates (sevelamer hydrochloride and calcium carbonate) agents used by patients with hyperphosphatemia | Full Text | References | PDF (1.3 MB) | EPUB
  • 134 Views
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Article
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats
Mukaddes Gürler, Engin Burak Selçuk, Beyza Güzide Özerol, Kevser Tanbek, Elif Taşlıdere, Azibe Yıldız, Fatma Hilal Yağın & Elif Gürel
Pages: 708-716
Published online: 02 Jun 2022
AbstractforProtective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats | Full Text | References | PDF (2.7 MB) | EPUB
  • 750 Views
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Article
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate
Ayan Pradhan, Shilpa Sengupta, Ritika Sengupta & Mitali Chatterjee
Pages: 717-725
Published online: 14 Jun 2022
AbstractforAttenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate | Full Text | References | PDF (1.6 MB) | EPUB
  • 320 Views
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Article
Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells
Ana Paula de Souza, Raíne Fogliati Schardosim, Juliana Escouto Al Kateeb, Mauricio Lehmann, Ivana Grivicich & Rafael Rodrigues Dihl
Pages: 726-735
Published online: 14 Jun 2022
AbstractforModulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells | Full Text | References | PDF (1.8 MB) | EPUB
  • 145 Views
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Article
Orally administered zingerone does not mitigate alcohol-induced hepatic oxidative stress in growing Sprague Dawley rat pups
Bernice Asiedu, Busisani Wiseman Lembede, Trevor Tapiwa Nyakudya & Eliton Chivandi
Pages: 736-745
Published online: 23 Jun 2022
AbstractforOrally administered zingerone does not mitigate alcohol-induced hepatic oxidative stress in growing Sprague Dawley rat pups | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 118 Views
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Article
D-ribose-L-cysteine exhibits neuroprotective activity through inhibition of oxido-behavioral dysfunctions and modulated activities of neurotransmitters in the cerebellum of Juvenile mice exposed to ethanol
Damilare Adedayo Adekomi, Olamide Janet Olajide, Omowumi Oyeronke Adewale, Akeem Ayodeji Okesina, John Olabode Fatoki, Benedict Abiola Falana, Temidayo Daniel Adeniyi, Adebiyi Aderinola Adegoke, Waliu Adetunji Ojo & Sheriffdeen Oluwabusayo Alabi
Pages: 746-756
Published online: 20 Jun 2022
AbstractforD-ribose-L-cysteine exhibits neuroprotective activity through inhibition of oxido-behavioral dysfunctions and modulated activities of neurotransmitters in the cerebellum of Juvenile mice exposed to ethanol | Full Text | References | PDF (1.1 MB) | EPUB
  • 91 Views
  • 2 CrossRef citations
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Article
Screening the immunotoxicity of different food preservative agents on the model organism Galleria mellonella L. (Lepidoptera: Pyralidae) larvae
Emine Duman Erbaş, Rehemah Gwokyalya, Hülya Altuntaş & Bilal Kutrup
Pages: 757-767
Published online: 27 Jun 2022
AbstractforScreening the immunotoxicity of different food preservative agents on the model organism Galleria mellonella L. (Lepidoptera: Pyralidae) larvae | Full Text | References | PDF (2.1 MB) | EPUB
  • 356 Views
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Article
Genotoxic potential of different nano-silver halides in cultured human lymphocyte cells
Devrim Güzel, Merve Güneş, Burçin Yalçın, Esin Akarsu, Eyyüp Rencüzoğulları & Bülent Kaya
Pages: 768-780
Published online: 08 Jul 2022
AbstractforGenotoxic potential of different nano-silver halides in cultured human lymphocyte cells | Full Text | References | PDF (2.3 MB) | EPUB
  • 214 Views
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Article
Lethal toxicity induced by combined ingestion of dietary acetic acid and carbamazepine
Iuliu Fulga, Oana-Maria Dragostin, Carmen Chitescu, Ioana Irimia, Alin Pîrăianu, Elena Stamate & Ana Fulga
Pages: 781-785
Published online: 11 Aug 2022
AbstractforLethal toxicity induced by combined ingestion of dietary acetic acid and carbamazepine | Full Text | References | PDF (1.3 MB) | EPUB
  • 107 Views
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Article
Comparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines
Ashley L. Ball, Megan E. Solan, Marco E. Franco & Ramon Lavado
Pages: 786-794
Published online: 19 Jul 2022
AbstractforComparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines | Full Text | References | PDF (1.2 MB) | EPUB
  • 210 Views
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Article
Acute and sub-acute oral toxicity assessment of 5-hydroxy-1,4-naphthoquinone in mice
Dievya Gohil, Girish Ch. Panigrahi, Saurabh Kumar Gupta, Khushboo A. Gandhi, Poonam Gera, Preeti Chavan, Deepak Sharma, Santosh Sandur & Vikram Gota
Pages: 795-808
Published online: 28 Jul 2022
AbstractforAcute and sub-acute oral toxicity assessment of 5-hydroxy-1,4-naphthoquinone in mice | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 211 Views
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Review

Review
Pesticides analysis in alternative biological matrices
Luana C. Crocoli, Rafael A. Menck & Sidnei Moura
Pages: 809-824
Published online: 23 Jun 2022
AbstractforPesticides analysis in alternative biological matrices | Full Text | References | PDF (1.7 MB) | EPUB
  • 217 Views
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