Drug Metabolism Reviews, Volume 20, Issue 2-4 (1989)

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Drug Metabolism Reviews, Volume 20, Issue 2-4 (1989)

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Introduction

Introduction
Pages: 153-154
Published online: 22 Sep 2008
CitationforIntroduction | PDF (79.5 KB)
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Research Article

Article
Chemical Strategies for the Inactivation of Bay-Region Diol Epoxides. Ultimate Carcinogens Derived from Polycyclic Aromatic Hydrocarbons'
Jane M. Sayer, Dale L. Whalen & Donald M. Jerina
Pages: 155-182
Published online: 22 Sep 2008
First Page PreviewforChemical Strategies for the Inactivation of Bay-Region Diol Epoxides. Ultimate Carcinogens Derived from Polycyclic Aromatic Hydrocarbons' | References | PDF (1.3 MB)
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Article
Radical Intermediates in the Cytochrome P-450-Catalyzed Oxidation of Aliphatic Hydrocarbons
Paul R. Ortiz De Montellano & Ralph A. Stearns
Pages: 183-191
Published online: 22 Sep 2008
First Page PreviewforRadical Intermediates in the Cytochrome P-450-Catalyzed Oxidation of Aliphatic Hydrocarbons | References | PDF (355 KB)
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Article
Ca2+ Activated Mechanisms in Cell Killing
Pierluigi Nicotera, David J. Mc Conkey, Jeannette M. Dypbukt, Dean P. Jones & Sten Orrenius
Pages: 193-201
Published online: 22 Sep 2008
First Page PreviewforCa2+ Activated Mechanisms in Cell Killing | References | PDF (349.1 KB)
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Article
Neoantigens Associated with Halothane Hepatitis
Lance R. Pohl, J. G. Kenna, Hiroko Satoh, David Christ & Jackie L. Martin
Pages: 203-217
Published online: 22 Sep 2008
First Page PreviewforNeoantigens Associated with Halothane Hepatitis | References | PDF (1.1 MB)
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Article
Ethanol Promotes Oxygen-Radical Attack on Proteins But Not on Lipids
H. Remmer, W. Kessler, H. Einsele, Th. Hintze, G. Diaz De Toranzo, A. M. Gharaibeh & H. Frank
Pages: 219-232
Published online: 22 Sep 2008
First Page PreviewforEthanol Promotes Oxygen-Radical Attack on Proteins But Not on Lipids | References | PDF (528.1 KB)
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Article
Effects of Cysteine Isomers and Derivatives on Acute Acrylonitrile Toxicity
Donald E. Nerland, Frederick W. Benz & Christine Babiuk
Pages: 233-246
Published online: 22 Sep 2008
First Page PreviewforEffects of Cysteine Isomers and Derivatives on Acute Acrylonitrile Toxicity | References | PDF (589.6 KB)
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Article
Drug Metabolism and Toxicity During Hypoxia
Dean P. Jones, Tak Yee Aw & Xiaoqin Shan
Pages: 247-260
Published online: 22 Sep 2008
First Page PreviewforDrug Metabolism and Toxicity During Hypoxia | References | PDF (699.7 KB)
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Article
Mechanism of Dimethylsulfoxide Protection Against Acetaminophen Hepatotoxicit
K. Arndt, W. M. Haschek & E. H. Jeffery
Pages: 261-269
Published online: 22 Sep 2008
First Page PreviewforMechanism of Dimethylsulfoxide Protection Against Acetaminophen Hepatotoxicit | References | PDF (384.6 KB)
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Symposium

Symposium Scenes
Pages: 271-273
Published online: 22 Sep 2008
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Research Article

Article
Cytochrome P-450, Reductive Metabolism, And Cell Injury
Herbert De Groot & Helmut Sies
Pages: 275-284
Published online: 22 Sep 2008
First Page PreviewforCytochrome P-450, Reductive Metabolism, And Cell Injury | References | PDF (394.3 KB)
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Article
Dietary Heterocyclic Amines and Human Cancer
N. J. Gooderham, S. Murray, J. C. Rice, A. R. Boobis & D. S. Davies
Pages: 285-305
Published online: 22 Sep 2008
First Page PreviewforDietary Heterocyclic Amines and Human Cancer | References | PDF (745.7 KB)
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Article
Mines as Intermediates in Oxidative Aralkylamine Metabolism
J. W. Gorrod & A. Raman
Pages: 307-339
Published online: 22 Sep 2008
First Page PreviewforMines as Intermediates in Oxidative Aralkylamine Metabolism | References | PDF (1.1 MB)
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Article
Acetaminophen Peroxidation Reactions
David W. Potter & Jack A. Hinson
Pages: 341-358
Published online: 22 Sep 2008
First Page PreviewforAcetaminophen Peroxidation Reactions | References | PDF (778.6 KB)
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Symposium

Symposium Scenes
Pages: 359-364
Published online: 22 Sep 2008
First Page PreviewforSymposium Scenes | PDF (1.6 MB)
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Research Article

Article
Mechanistic Aspects of Cytochrome P450-Hydroperoxide Interactions: Substituent Effects on Degradative Pathways
John A. Thompson & Nathan P. Yumibe
Pages: 365-378
Published online: 22 Sep 2008
First Page PreviewforMechanistic Aspects of Cytochrome P450-Hydroperoxide Interactions: Substituent Effects on Degradative Pathways | References | PDF (506.4 KB)
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Article
The Use of Human Liver for Foreign Compound Metabolism and Toxicity Studies
Garth Powis
Pages: 379-394
Published online: 22 Sep 2008
First Page PreviewforThe Use of Human Liver for Foreign Compound Metabolism and Toxicity Studies | References | PDF (755.2 KB)
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Article
Interaction of Anticancer Drugs with Hepatic Monooxygenase Enzymes
Gerald A. Le Blanc & David J. Waxman
Pages: 395-439
Published online: 22 Sep 2008
First Page PreviewforInteraction of Anticancer Drugs with Hepatic Monooxygenase Enzymes | References | PDF (2 MB)
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Article
What Can the Use of Unmetabolizable Lipophilic Compounds Tell About the Importance of Drug Metabolism?
M. H. Bickel
Pages: 441-447
Published online: 22 Sep 2008
First Page PreviewforWhat Can the Use of Unmetabolizable Lipophilic Compounds Tell About the Importance of Drug Metabolism? | References | PDF (294.3 KB)
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Article
Human Liver Mephenytoin 4 -Hydroxylase Cytochrome P-450 Proteins and Genes
William R. Brian, Cecile Gedt, Teresa M. Bellew, Pramod K. Srivastava, Richard W. Bork, Diane R. Umbenhauer, R. Stephen Lloyd & F. Peter Guengerich
Pages: 449-465
Published online: 22 Sep 2008
First Page PreviewforHuman Liver Mephenytoin 4 -Hydroxylase Cytochrome P-450 Proteins and Genes | References | PDF (1.5 MB)
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Article
Structure-Function Relationships of Cytochrome P-450 Laurate (ω-1)-Hydroxylase
Yoshio Imai, Tomohide Uno, Masahiko Nakamura & Hiroshi Yokota
Pages: 467-478
Published online: 22 Sep 2008
First Page PreviewforStructure-Function Relationships of Cytochrome P-450 Laurate (ω-1)-Hydroxylase | References | PDF (593.8 KB)
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Article
Warfarin as A Probe of Cytochromes P 450 Function
Laurence S. Kaminsky
Pages: 479-487
Published online: 22 Sep 2008
First Page PreviewforWarfarin as A Probe of Cytochromes P 450 Function | References | PDF (315.3 KB)
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Article
Stereochemistry of Cytochrome P-450 Reactions
William F. Trager
Pages: 489-496
Published online: 22 Sep 2008
AbstractforStereochemistry of Cytochrome P-450 Reactions | References | PDF (311.6 KB)
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Article
Orientation of Microsomal Membrane Porteins
Juris Ozols
Pages: 497-510
Published online: 22 Sep 2008
AbstractforOrientation of Microsomal Membrane Porteins | References | PDF (491.3 KB)
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Article
Human Aromatase
Shiuan Chen, Marc J. Besman, John E. Shively, Kazutoshi Yanagibashi & Peter F. Hall
Pages: 511-517
Published online: 22 Sep 2008
AbstractforHuman Aromatase | References | PDF (479 KB)
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Article
Cytochrome P-450: Cytochrome P-450 Reductase Interactions
Henry W. Strobel, Steven G. Nadler & David R. Nelson
Pages: 519-533
Published online: 22 Sep 2008
First Page PreviewforCytochrome P-450: Cytochrome P-450 Reductase Interactions | References | PDF (962.4 KB)
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Article
Metabolism of the B-Ring of Testosterone by the Rat Cytochrome P-450 System
Kenneth Korzekwa, Kiyoshi Nagata, William F. Trager & James r. Gillette
Pages: 535-539
Published online: 22 Sep 2008
AbstractforMetabolism of the B-Ring of Testosterone by the Rat Cytochrome P-450 System | References | PDF (229 KB)
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Article
The Utility of p-Mtrophenol Hydroxylation in P450iie1 Analysis
Dennis R. Koop, Carmen L. Laethem & Daniel J. Tierney
Pages: 541-551
Published online: 22 Sep 2008
First Page PreviewforThe Utility of p-Mtrophenol Hydroxylation in P450iie1 Analysis | References | PDF (457.2 KB)
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Symposium

Symposium Scenes
Pages: 553-555
Published online: 22 Sep 2008
First Page PreviewforSymposium Scenes | PDF (1.3 MB)
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Research Article

Article
Physiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P450
John b. Schenkman, Kenneth e. Thummel & Leonard v. Favreau
Pages: 557-584
Published online: 22 Sep 2008
First Page PreviewforPhysiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P450 | References | PDF (2.1 MB)
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Article
Modulation of the Polycycuc Aromatic Hydrocarbon-Dependent Induction of Cytochrome P450ia1 By Glucocorticoids
R. A. Prough, A. J. Sherratt, D. E. Banet, M. W. Linder, J. M. Mathis & E. R. Simpson
Pages: 585-599
Published online: 22 Sep 2008
First Page PreviewforModulation of the Polycycuc Aromatic Hydrocarbon-Dependent Induction of Cytochrome P450ia1 By Glucocorticoids | References | PDF (944.4 KB)
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Article
Use of Bile Fistulas to Solve Problems of Drug Metabolism
David y. Cooper, Sidney s. Levin, Heinz Schleyer, Wieslawa Maniara, Rong Huang, Biswanath Mukherji & Henry A. Sloviter
Pages: 601-613
Published online: 22 Sep 2008
First Page PreviewforUse of Bile Fistulas to Solve Problems of Drug Metabolism | References | PDF (455.6 KB)
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Article
Degradation of Rat Hepatic Cytochrome P-450p
Maria Almira Correia, Katsumi Sugiyama & Kunquan Yao
Pages: 615-628
Published online: 22 Sep 2008
AbstractforDegradation of Rat Hepatic Cytochrome P-450p | References | PDF (850.1 KB)
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Article
Does Cytochrome P-450 Mediate the Effects of Norepinephrine in the Hepatocyte?
Jordan l. Holtzman, Jargarlapudi S. Prasad, Richard r. Erickson, Neng-Qain Chen, Yu-Xiu Liu & Sri Prakash Srivastava
Pages: 629-643
Published online: 22 Sep 2008
First Page PreviewforDoes Cytochrome P-450 Mediate the Effects of Norepinephrine in the Hepatocyte? | References | PDF (618.5 KB)
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Article
Design of Specific Mechanism Based Inactivators of Hepatic and Adrenal Microsomal Cytochromes P-450 Responsible for Progesterone 21-Hydroxylation
James r. Halpert, John-Yan Jaw & Eric F. Johnson
Pages: 645-655
Published online: 22 Sep 2008
First Page PreviewforDesign of Specific Mechanism Based Inactivators of Hepatic and Adrenal Microsomal Cytochromes P-450 Responsible for Progesterone 21-Hydroxylation | References | PDF (480.3 KB)
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Article
Cutaneous Cytochrome P-450
Hasan Mukhtar & Wasiuddin A. Khan
Pages: 657-673
Published online: 22 Sep 2008
First Page PreviewforCutaneous Cytochrome P-450 | References | PDF (875.8 KB)
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Symposium

Symposium Scenes
Pages: 675-677
Published online: 22 Sep 2008
First Page PreviewforSymposium Scenes | PDF (886.4 KB)
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Research Article

Article
New Perspectives in Catalase Dependent Ethanol Metabolism
Ronald g. Thurman & Jeffrey a. Handler
Pages: 679-688
Published online: 22 Sep 2008
First Page PreviewforNew Perspectives in Catalase Dependent Ethanol Metabolism | References | PDF (490.1 KB)
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Article
Udp-Glucuronosyltrans-Ferases in the Metabolic Disposition of Xenobiotics
Thomas r. Tephly, Marcy Townsend & Mitchell D. Green
Pages: 689-695
Published online: 22 Sep 2008
First Page PreviewforUdp-Glucuronosyltrans-Ferases in the Metabolic Disposition of Xenobiotics | References | PDF (277.7 KB)
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Article
Xen0biotic Oxidation Catalyzed by Aldehyde Dehydrogenases
N. E. Sladek.C. L. Manthey, P. A. Maki, Z. Zhang & G. J. Landkamer
Pages: 697-720
Published online: 22 Sep 2008
First Page PreviewforXen0biotic Oxidation Catalyzed by Aldehyde Dehydrogenases | References | PDF (833.2 KB)
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Article
Cellular and Molecular Aspects of Udp-Glucuronosyltransferases
Gerard Siest, Sylvie Fournel-Gigleux, Jacques Magdalou & Denyse Bagrel
Pages: 721-731
Published online: 22 Sep 2008
First Page PreviewforCellular and Molecular Aspects of Udp-Glucuronosyltransferases | References | PDF (518.8 KB)
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Article
Similarities Between Catalase and Cyt0s0lic Epoxide Hydrolase
Thomas m. Guenthner, Mazen Qato, Robert Whalen & Sallie Glomb
Pages: 733-748
Published online: 22 Sep 2008
First Page PreviewforSimilarities Between Catalase and Cyt0s0lic Epoxide Hydrolase | References | PDF (1.6 MB)
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Symposium

Symposium Scenes
Pages: 749-751
Published online: 22 Sep 2008
First Page PreviewforSymposium Scenes | PDF (701.4 KB)
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Research Article

Article
Prostaglandin Metabolism by Hepatic Cytochrome P-450
David Kupfer & Karsten A. Holm
Pages: 753-764
Published online: 22 Sep 2008
First Page PreviewforProstaglandin Metabolism by Hepatic Cytochrome P-450 | References | PDF (480.4 KB)
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Article
Developmental Aspects of P450iiia: Prenatal Activity and Inducibility
J. E. Hulla & M. R. Juchau
Pages: 765-779
Published online: 22 Sep 2008
First Page PreviewforDevelopmental Aspects of P450iiia: Prenatal Activity and Inducibility | References | PDF (762.8 KB)
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Article
Induction of the Alcohol Inducible Form of Cytochrome P-450 By Nitrogen-Containing Heterocycles: Effects on Pyridine It-Oxide Production
Raymond f. Novak, Karen l. Kaul & Sang Geon Kim
Pages: 781-792
Published online: 22 Sep 2008
First Page PreviewforInduction of the Alcohol Inducible Form of Cytochrome P-450 By Nitrogen-Containing Heterocycles: Effects on Pyridine It-Oxide Production | References | PDF (549.1 KB)
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Article
Induction of Cytochromes P-450b/E By Phenobarbital in Primary Culture of Adult Rat Hepatocytes: Test of Differentiated Uver Gene Expression
Philip s. Guzelian, Donna Li & Erin G. Schuetz
Pages: 793-809
Published online: 22 Sep 2008
First Page PreviewforInduction of Cytochromes P-450b/E By Phenobarbital in Primary Culture of Adult Rat Hepatocytes: Test of Differentiated Uver Gene Expression | References | PDF (1.3 MB)
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Article
Cytochrome P-450 Membrane Signals
Byron Kemper & Elzbieta Szczesna-Skorupa
Pages: 811-820
Published online: 22 Sep 2008
First Page PreviewforCytochrome P-450 Membrane Signals | References | PDF (496.9 KB)
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Article
Regulatory Mechanism of Gene Expression of Methylcholanthrene-Inducible Cytochrome P-450
Y. Fujii-Kuriyama, A. Fujisawa-Sehara & K. Sogawa
Pages: 821-826
Published online: 22 Sep 2008
First Page PreviewforRegulatory Mechanism of Gene Expression of Methylcholanthrene-Inducible Cytochrome P-450 | References | PDF (342.9 KB)
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Article
Structure and Regulation of P450s in the Rat P450iia Gene Subfamily
Frank j. Gonzalez, Tamihide Matsunaga & Kiyoshi Nagata
Pages: 827-837
Published online: 22 Sep 2008
First Page PreviewforStructure and Regulation of P450s in the Rat P450iia Gene Subfamily | References | PDF (609.4 KB)
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Article
Regulation of Cytochrome P1-450 Gene Expression in Mouse Hepatoma Cells by 2,3,7,8-Tetrachloflodibenzo-p-Dioxin
James p. Whitlock, Michael s. Denison, Linda k. Durrin, Joan m. Fisher, Donna r. Galeazzi & Phillip b. C. Jones
Pages: 839-846
Published online: 22 Sep 2008
First Page PreviewforRegulation of Cytochrome P1-450 Gene Expression in Mouse Hepatoma Cells by 2,3,7,8-Tetrachloflodibenzo-p-Dioxin | References | PDF (331 KB)
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Article
Cytochrome p-450 dynamics: a tribute to g. J. Mannering
E. H. Jeffery
Pages: 847-849
Published online: 22 Sep 2008
First Page PreviewforCytochrome p-450 dynamics: a tribute to g. J. Mannering | References | PDF (114.8 KB)
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Symposium

Symposium Scenes
Pages: 851-853
Published online: 22 Sep 2008
First Page PreviewforSymposium Scenes | PDF (967.1 KB)
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Acknowledgment

Acknowledgment
Pages: xi-xii
Published online: 22 Sep 2008
CitationforAcknowledgment | PDF (785.7 KB)
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