Drug Metabolism Reviews, Volume 34, Issue 3 (2002)

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Drug Metabolism Reviews, Volume 34, Issue 3 (2002)

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Research Article

Article
N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION
Peter Hlavica
Pages: 451-477
Published online: 25 Jul 2002
AbstractforN-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION | Full Text | References | PDF (418.9 KB)
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Article
ELECTRON SUPPLY AND CATALYTIC OXIDATION OF NITROGEN BY CYTOCHROME P450 AND NITRIC OXIDE SYNTHASE
Clinton R. Nishida, Giselle Knudsen, Wesley Straub & Paul R. Ortiz de Montellano
Pages: 479-501
Published online: 25 Jul 2002
AbstractforELECTRON SUPPLY AND CATALYTIC OXIDATION OF NITROGEN BY CYTOCHROME P450 AND NITRIC OXIDE SYNTHASE | Full Text | References | PDF (588.1 KB)
  • 87 Views
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Article
AN OVERVIEW OF THE MECHANISM, SUBSTRATE SPECIFICITIES, AND STRUCTURE OF FMOs
Daniel M. Ziegler
Pages: 503-511
Published online: 25 Jul 2002
AbstractforAN OVERVIEW OF THE MECHANISM, SUBSTRATE SPECIFICITIES, AND STRUCTURE OF FMOs | Full Text | References | PDF (312.8 KB)
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Article
HUMAN AND PLANT FLAVIN-CONTAINING MONOOXYGENASE N-OXYGENATION OF AMINES: DETOXICATION VS. BIOACTIVATION
John R. Cashman
Pages: 513-521
Published online: 25 Jul 2002
AbstractforHUMAN AND PLANT FLAVIN-CONTAINING MONOOXYGENASE N-OXYGENATION OF AMINES: DETOXICATION VS. BIOACTIVATION | Full Text | References | PDF (126.8 KB)
  • 173 Views
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Article
GENETIC POLYMORPHISMS OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)
Sharon K. Krueger, David E. Williams, Mei-Fei Yueh, Sarah R. Martin, Ronald N. Hines, Judy L. Raucy, Colin T. Dolphin, Elizabeth A. Shephard & Ian R. Phillips
Pages: 523-532
Published online: 25 Jul 2002
AbstractforGENETIC POLYMORPHISMS OF FLAVIN-CONTAINING MONOOXYGENASE (FMO) | Full Text | References | PDF (288.4 KB)
  • 341 Views
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Article
STUDIES ON THE OXIDATION OF 1,4-DISUBSTITUTED-1,2,3,6-TETRAHYDROPYRIDINES
Neal Castagnoli Jr., Kay Castagnoli, Géraldine Magnin, Simon Kuttab & Jackie Shang
Pages: 533-547
Published online: 25 Jul 2002
AbstractforSTUDIES ON THE OXIDATION OF 1,4-DISUBSTITUTED-1,2,3,6-TETRAHYDROPYRIDINES | Full Text | References | PDF (428.4 KB)
  • 63 Views
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Article
N-OXIDATION OF AROMATIC AMINES BY INTRACELLULAR OXIDASES
Arno G. Siraki, Tom S. Chan, Giuseppe Galati, Shirley Teng & Peter J. O'Brien
Pages: 549-564
Published online: 25 Jul 2002
AbstractforN-OXIDATION OF AROMATIC AMINES BY INTRACELLULAR OXIDASES | Full Text | References | PDF (220.9 KB)
  • 301 Views
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Article
REDUCTION OF N-HYDROXYLATED COMPOUNDS: AMIDOXIMES (N-HYDROXYAMIDINES) AS PRO-DRUGS OF AMIDINES
Bernd Clement
Pages: 565-579
Published online: 25 Jul 2002
AbstractforREDUCTION OF N-HYDROXYLATED COMPOUNDS: AMIDOXIMES (N-HYDROXYAMIDINES) AS PRO-DRUGS OF AMIDINES | Full Text | References | PDF (319.9 KB)
  • 683 Views
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Article
BIOREDUCTIVELY ACTIVATED ANTITUMOR N-OXIDES: THE CASE OF AQ4N, A UNIQUE APPROACH TO HYPOXIA-ACTIVATED CANCER CHEMOTHERAPY
Laurence H. Patterson
Pages: 581-592
Published online: 25 Jul 2002
AbstractforBIOREDUCTIVELY ACTIVATED ANTITUMOR N-OXIDES: THE CASE OF AQ4N, A UNIQUE APPROACH TO HYPOXIA-ACTIVATED CANCER CHEMOTHERAPY | Full Text | References | PDF (252.5 KB)
  • 356 Views
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Article
OXIDATION OF N-HYDROXYGUANIDINES BY CYTOCHROMES P450 AND NO-SYNTHASES AND FORMATION OF NITRIC OXIDE
Daniel Mansuy & Jean-Luc Boucher
Pages: 593-606
Published online: 25 Jul 2002
AbstractforOXIDATION OF N-HYDROXYGUANIDINES BY CYTOCHROMES P450 AND NO-SYNTHASES AND FORMATION OF NITRIC OXIDE | Full Text | References | PDF (261.4 KB)
  • 91 Views
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Article
N-HYDROXYARYLAMINES
F. Peter Guengerich
Pages: 607-623
Published online: 25 Jul 2002
AbstractforN-HYDROXYARYLAMINES | Full Text | References | PDF (438.1 KB)
  • 203 Views
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Article
HETEROCYCLIC AROMATIC AMINE METABOLISM, DNA ADDUCT FORMATION, MUTAGENESIS, AND CARCINOGENESIS
Robert J. Turesky
Pages: 625-650
Published online: 25 Jul 2002
AbstractforHETEROCYCLIC AROMATIC AMINE METABOLISM, DNA ADDUCT FORMATION, MUTAGENESIS, AND CARCINOGENESIS | Full Text | References | PDF (413.5 KB)
  • 589 Views
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Article
N-OXIDATION OF DRUGS ASSOCIATED WITH IDIOSYNCRATIC DRUG REACTIONS
Jack Uetrecht
Pages: 651-665
Published online: 25 Jul 2002
AbstractforN-OXIDATION OF DRUGS ASSOCIATED WITH IDIOSYNCRATIC DRUG REACTIONS | Full Text | References | PDF (326 KB)
  • 316 Views
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Article
ROLE OF HUMAN CYTOCHROME P450 (CYP) IN THE METABOLIC ACTIVATION OF NITROSAMINE DERIVATIVES: APPLICATION OF GENETICALLY ENGINEERED SALMONELLA EXPRESSING HUMAN CYP
Tetsuya Kamataki, Ken-ichi Fujita, Kazuo Nakayama, Yoshiyuki Yamazaki, Masami Miyamoto & Noritaka Ariyoshi
Pages: 667-676
Published online: 25 Jul 2002
AbstractforROLE OF HUMAN CYTOCHROME P450 (CYP) IN THE METABOLIC ACTIVATION OF NITROSAMINE DERIVATIVES: APPLICATION OF GENETICALLY ENGINEERED SALMONELLA EXPRESSING HUMAN CYP | Full Text | References | PDF (268.3 KB)
  • 378 Views
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