Drug Metabolism Reviews, Volume 39, Issue 1 (2007)

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Drug Metabolism Reviews, Volume 39, Issue 1 (2007)

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Research Article

Article
Genomic Structure and Transcriptional Regulation of the Rat, Mouse, and Human Carboxylesterase Genes
Masakiyo Hosokawa, Tomomi Furihata, Yumiko Yaginuma, Naoko Yamamoto, Nao Koyano, Ayako Fujii, Yuko Nagahara, Testuo Satoh & Kan Chiba
Pages: 1-15
Published online: 09 Oct 2008
AbstractforGenomic Structure and Transcriptional Regulation of the Rat, Mouse, and Human Carboxylesterase Genes | Full Text | References | PDF (189.3 KB)
  • 620 Views
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Article
What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs
Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith
Pages: 17-43
Published online: 09 Oct 2008
AbstractforWhat is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs | Full Text | References | PDF (195.1 KB)
  • 2542 Views
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Article
Pharmacogenetic Screening of the Gene Deletion and Duplications of CYP2D6
Irma Meijerman, Linda M. Sanderson, Paul H.M. Smits, Jos H. Beijnen & Jan H.M. Schellens
Pages: 45-60
Published online: 09 Oct 2008
AbstractforPharmacogenetic Screening of the Gene Deletion and Duplications of CYP2D6 | Full Text | References | PDF (205.4 KB)
  • 901 Views
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Article
State-of-the-art Tools for Computational Site of Metabolism Predictions: Comparative Analysis, Mechanistical Insights, and Future Applications
Lovisa Afzelius, Catrin Hasselgren Arnby, Anders Broo, Lars Carlsson, Christine Isaksson, Ulrik Jurva, Britta Kjellander, Karin Kolmodin, Kristina Nilsson, Florian Raubacher & Lars Weidolf
Pages: 61-86
Published online: 09 Oct 2008
AbstractforState-of-the-art Tools for Computational Site of Metabolism Predictions: Comparative Analysis, Mechanistical Insights, and Future Applications | Full Text | References | PDF (1.6 MB)
  • 482 Views
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Article
Carbonyl Reductases and Pluripotent Hydroxysteroid Dehydrogenases of the Short-chain Dehydrogenase/reductase Superfamily
Frank Hoffmann & Edmund Maser
Pages: 87-144
Published online: 09 Oct 2008
AbstractforCarbonyl Reductases and Pluripotent Hydroxysteroid Dehydrogenases of the Short-chain Dehydrogenase/reductase Superfamily | Full Text | References | PDF (629.6 KB)
  • 1022 Views
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Article
Application of Chimeric Mice with Humanized Liver for Predictive ADME
Miki Katoh & Tsuyoshi Yokoi
Pages: 145-157
Published online: 09 Oct 2008
AbstractforApplication of Chimeric Mice with Humanized Liver for Predictive ADME | Full Text | References | PDF (166.8 KB)
  • 428 Views
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Article
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
Nicola J. Hewitt, María José Gómez Lechón, J. Brian Houston, David Hallifax, Hayley S. Brown, Patrick Maurel, J. Gerald Kenna, Lena Gustavsson, Christina Lohmann, Christian Skonberg, Andre Guillouzo, Gregor Tuschl, Albert P. Li, Edward LeCluyse, Geny M. M. Groothuis & Jan G. Hengstler
Pages: 159-234
Published online: 09 Oct 2008
AbstractforPrimary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies | Full Text | References | PDF (1.1 MB)
  • 8083 Views
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Article
The Antioxidant/electrophile Response Element Motif
Donald E. Nerland
Pages: 235-248
Published online: 09 Oct 2008
AbstractforThe Antioxidant/electrophile Response Element Motif | Full Text | References | PDF (129.3 KB)
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Miscellaneous Article

Addendum
Page: 249
Published online: 09 Oct 2008
CitationforAddendum | Full Text | PDF (15.4 KB)
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