Drug Metabolism Reviews, Volume 42, Issue 1 (2010)

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Drug Metabolism Reviews, Volume 42, Issue 1 (2010)

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Miscellany

Preface
Pages: 1-2
Published online: 14 Jan 2010
CitationforPreface | Full Text | PDF (495.7 KB)
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Memorial address for Dr. Kazuta Oguri, emeritus professor
Hideyuki Yamada
Pages: 4-5
Published online: 13 Oct 2009
CitationforMemorial address for Dr. Kazuta Oguri, emeritus professor | Full Text | References | PDF (521.7 KB)
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Review Article

Review Article
UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor–inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors
Karl W. Bock & Barbara S. Bock-Hennig
Pages: 6-13
Published online: 15 Oct 2009
AbstractforUDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor–inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors | Full Text | References | PDF (729.9 KB)
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Review Article
Takashi Iyanagi: UGT1 gene complex: from Gunn rat to human
Shinichi Ikushiro
Pages: 14-22
Published online: 21 Oct 2009
AbstractforTakashi Iyanagi: UGT1 gene complex: from Gunn rat to human | Full Text | References | PDF (785.6 KB)
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Review Article
UGT genomic diversity: beyond gene duplication
Chantal Guillemette, Eric Lévesque, Mario Harvey, Judith Bellemare & Vincent Menard
Pages: 24-44
Published online: 26 Oct 2009
AbstractforUGT genomic diversity: beyond gene duplication | Full Text | References | PDF (1.6 MB)
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Review Article
UGT3A: novel UDP-glycosyltransferases of the UGT superfamily
Robyn Meech & Peter I. Mackenzie
Pages: 45-54
Published online: 14 Jan 2010
AbstractforUGT3A: novel UDP-glycosyltransferases of the UGT superfamily | Full Text | References | PDF (1.1 MB)
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Review Article
Warfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism
Drew R. Jones, Jeffery H. Moran & Grover P. Miller
Pages: 55-61
Published online: 14 Jan 2010
AbstractforWarfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism | Full Text | References | PDF (858.8 KB)
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Review Article
Renal UDP-glucuronosyltransferases and the glucuronidation of xenobiotics and endogenous mediators
Kathleen M. Knights & John O. Miners
Pages: 63-73
Published online: 14 Jan 2010
AbstractforRenal UDP-glucuronosyltransferases and the glucuronidation of xenobiotics and endogenous mediators | Full Text | References | PDF (733.7 KB)
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Review Article
UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function
Jean-Marie Heydel, Elzbieta J Holsztynska, Arièle Legendre, Nicolas Thiebaud, Yves Artur & Anne-Marie Le Bon
Pages: 74-97
Published online: 07 Oct 2009
AbstractforUDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function | Full Text | References | PDF (1.8 MB)
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Review Article
The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors
Peter I. Mackenzie, Dong Gui Hu & Dione A. Gardner-Stephen
Pages: 99-109
Published online: 05 Oct 2009
AbstractforThe regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors | Full Text | References | PDF (940.8 KB)
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Review Article
Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential
Mélanie Verreault, Jenny Kaeding, Patrick Caron, Jocelyn Trottier, Laurent Grosse, Élise Houssin, Sophie Pâquet, Martin Perreault & Olivier Barbier
Pages: 110-122
Published online: 15 Oct 2009
AbstractforRegulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential | Full Text | References | PDF (946.6 KB)
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Review Article
Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies
Zhimin Ou, Min Huang, Lizi Zhao & Wen Xie
Pages: 123-131
Published online: 06 Oct 2009
AbstractforUse of transgenic mice in UDP-glucuronosyltransferase (UGT) studies | Full Text | References | PDF (955.4 KB)
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Review Article
The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families
Anna Radominska-Pandya, Stacie M. Bratton, Matthew R. Redinbo & Michael J. Miley
Pages: 133-144
Published online: 13 Oct 2009
AbstractforThe crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families | Full Text | References | PDF (1.5 MB)
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Review Article
Modulation of UDP-glucuronosyltransferase activity by protein-protein association
Yuji Ishii, Shuso Takeda & Hideyuki Yamada
Pages: 145-158
Published online: 12 Oct 2009
AbstractforModulation of UDP-glucuronosyltransferase activity by protein-protein association | Full Text | References | PDF (801.3 KB)
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Review Article
Insights on membrane topology and structure/function of UDP-glucuronosyltransferases
Jacques Magdalou, Sylvie Fournel-Gigleux & Mohamed Ouzzine
Pages: 159-166
Published online: 06 Oct 2009
AbstractforInsights on membrane topology and structure/function of UDP-glucuronosyltransferases | Full Text | References | PDF (646.7 KB)
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Review Article
Gilbert-Meulengracht’s syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?
Christian P. Strassburg
Pages: 168-181
Published online: 05 Oct 2009
AbstractforGilbert-Meulengracht’s syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? | Full Text | References | PDF (822.7 KB)
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Review Article
Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors
Philip Lazarus & Dongxiao Sun
Pages: 182-194
Published online: 12 Oct 2009
AbstractforPotential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors | Full Text | References | PDF (906.7 KB)
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Review Article
The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro–in vivo extrapolation of drug clearance and drug-drug interaction potential
John O. Miners, Peter I. Mackenzie & Kathleen M. Knights
Pages: 196-208
Published online: 01 Oct 2009
AbstractforThe prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro–in vivo extrapolation of drug clearance and drug-drug interaction potential | Full Text | References | PDF (764.1 KB)
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Review Article
Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system
Michael H. Court
Pages: 209-224
Published online: 13 Oct 2009
AbstractforInterindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system | Full Text | References | PDF (1.4 MB)
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Miscellany

Drug metabolism and disposition: recent advances in regulation, structure function, and pharmacogenomics of UDP-glucuronosyltransferases
Guest editor: Anna Radominska-Pandya
Pages: i-iii
Published online: 20 Oct 2009
First Page PreviewforDrug metabolism and disposition: recent advances in regulation, structure function, and pharmacogenomics of UDP-glucuronosyltransferases
Guest editor: Anna Radominska-Pandya | Full Text | PDF (494.7 KB)
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