Drug Delivery, Volume 26, Issue 1 (2019)

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Drug Delivery, Volume 26, Issue 1 (2019)

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Research Article

Article
Galactose-modified selenium nanoparticles for targeted delivery of doxorubicin to hepatocellular carcinoma
Yu Xia, Jiayu Zhong, Mingqi Zhao, Ying Tang, Ning Han, Liang Hua, Tiantian Xu, Changbing Wang & Bing Zhu
Pages: 1-11
Published online: 02 Jan 2019
AbstractforGalactose-modified selenium nanoparticles for targeted delivery of doxorubicin to hepatocellular carcinoma | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Open Access
Article
Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid
Qin Wang, Yinan Zhong, Wenting Liu, Zemin Wang, Liqin Gu, Xuejiao Li, Jiqing Zheng, Huan Du, Zhiyuan Zhong & Fang Xie
Pages: 12-22
Published online: 28 Jan 2019
AbstractforEnhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 3715 Views
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Open Access
Article
Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity
Nikola Plenagl, Lili Duse, Benjamin Sebastian Seitz, Nathalie Goergen, Shashank Reddy Pinnapireddy, Jarmila Jedelska, Jana Brüßler & Udo Bakowsky
Pages: 23-33
Published online: 28 Jan 2019
AbstractforPhotodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 3409 Views
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Open Access
Article
Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy
Zhenkun Zong, Lei Hua, Zhen Wang, Haoyue Xu, Chengkun Ye, Bomin Pan, Zongren Zhao, Longzhen Zhang, Jun Lu, Hongmei Liu & Rutong Yu
Pages: 34-44
Published online: 11 Feb 2019
AbstractforSelf-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 3075 Views
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Open Access
Article
Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction
Wenqi Sun, Zhelong Li, Xueying Zhou, Guodong Yang & Lijun Yuan
Pages: 45-50
Published online: 11 Feb 2019
AbstractforEfficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction | Full Text | References | PDF (810.2 KB) | EPUB
  • 7798 Views
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Open Access
Article
Rhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo
Zhengbin Fei, Shiyu Li, Jiajia Wang, Yuzhe Wang, Zhenyou Jiang, Wenhua Huang & Hanxiao Sun
Pages: 51-62
Published online: 11 Feb 2019
AbstractforRhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2026 Views
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Open Access

Articles

Article
Stereoselectivity evaluation of chiral chitosan microspheres delivery system containing rac-KET in vitro and in vivo
Li-Na Yin, Ya-Wen Zhang, Wen-Hai Huang, Sheng-Hao Wang & Gao-Li Zheng
Pages: 63-69
Published online: 11 Feb 2019
AbstractforStereoselectivity evaluation of chiral chitosan microspheres delivery system containing rac-KET in vitro and in vivo | Full Text | References | PDF (728 KB) | EPUB | Supplemental
  • 1446 Views
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Open Access

Research Article

Article
Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome
Yujia Zhang, Nan Zhang, Hui Song, He Li, Jin Wen, Xiaochuan Tan & Wensheng Zheng
Pages: 70-77
Published online: 11 Feb 2019
AbstractforDesign, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome | Full Text | References | PDF (998.4 KB) | EPUB
  • 3217 Views
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Open Access
Article
Intranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye
Ye Tao, Chong Li, Anhui Yao, Yingxin Qu, Limin Qin, Zuojun Xiong, Jianbin Zhang & Weiwen Wang
Pages: 78-88
Published online: 11 Feb 2019
AbstractforIntranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye | Full Text | References | PDF (1.4 MB) | EPUB
  • 2360 Views
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Open Access
Article
Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles
Haipeng Wang, Shuilin Sun, Yu Zhang, Jiayi Wang, Shouhua Zhang, Xuebing Yao, Ling Chen, Zhen Gao & Baogang Xie
Pages: 89-97
Published online: 11 Feb 2019
AbstractforImproved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 4256 Views
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Open Access

Review

ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20
Kenneth W. Locke, Daniel C. Maneval & Michael J. LaBarre
Pages: 98-106
Published online: 11 Feb 2019
AbstractforENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20 | Full Text | References | PDF (913.8 KB) | EPUB
  • 11582 Views
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Open Access

Research Article

Article
Permeation-enhancing effects and mechanisms of O-acylterpineol on isosorbide dinitrate: mechanistic insights based on ATR-FTIR spectroscopy, molecular modeling, and CLSM images
Yan Li, Chunyan Wang, Jian Wang, Tianzhe Chu, Linlin Zhao & Ligang Zhao
Pages: 107-119
Published online: 11 Feb 2019
AbstractforPermeation-enhancing effects and mechanisms of O-acylterpineol on isosorbide dinitrate: mechanistic insights based on ATR-FTIR spectroscopy, molecular modeling, and CLSM images | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1883 Views
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Open Access
Article
Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet
Mohammad K. D. Manshadi, Mahsa Saadat, Mehdi Mohammadi, Reza Kamali, Milad Shamsi, Mozhgan Naseh & Amir Sanati-Nezhad
Pages: 120-128
Published online: 23 Feb 2019
AbstractforMagnetic aerosol drug targeting in lung cancer therapy using permanent magnet | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3450 Views
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Open Access
Article
Cetuximab-modified silica nanoparticle loaded with ICG for tumor-targeted combinational therapy of breast cancer
Xiaoxue Zhang, Yinyan Li, Minjie Wei, Chang Liu, Tao Yu & Jun Yang
Pages: 129-136
Published online: 23 Feb 2019
AbstractforCetuximab-modified silica nanoparticle loaded with ICG for tumor-targeted combinational therapy of breast cancer | Full Text | References | PDF (1 MB) | EPUB
  • 3350 Views
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Open Access
Article
Electrosprayed naringin-loaded microsphere/SAIB hybrid depots enhance bone formation in a mouse calvarial defect model
Xue Yang, Huthayfa N.S Almassri, Qiongyue Zhang, Yihui Ma, Dan Zhang, Mingsheng Chen & Xiaohong Wu
Pages: 137-146
Published online: 23 Feb 2019
AbstractforElectrosprayed naringin-loaded microsphere/SAIB hybrid depots enhance bone formation in a mouse calvarial defect model | Full Text | References | PDF (1.2 MB) | EPUB
  • 1932 Views
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Open Access
Article
Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases
Scott K. Ferguson, David I. Pak, Justin L. Hopkins, Julie W. Harral, Katherine M. Redinius, Zoe Loomis, Kurt R. Stenmark, Mark A. Borden, Thies Schroeder & David C. Irwin
Pages: 147-157
Published online: 01 Mar 2019
AbstractforPre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases | Full Text | References | PDF (1.7 MB) | EPUB
  • 2037 Views
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Open Access
Article
Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation
Yuzhen Hou, Fan Zhang, Jie Lan, Fengyuan Sun, Jun Li, Mengshuang Li, Kaichao Song & Xianggen Wu
Pages: 158-167
Published online: 01 Mar 2019
AbstractforUltra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2621 Views
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Open Access
Article
A thermosensitive gel based on w1/o/w2 multiple microemulsions for the vaginal delivery of small nucleic acid
Jiu Wang, Yajing Wang, Ziqiang Wang, Fan Wang, Jie He, Xiaoyun Yang, Weidong Xie, Ying Liu & Yaou Zhang
Pages: 168-178
Published online: 01 Mar 2019
AbstractforA thermosensitive gel based on w1/o/w2 multiple microemulsions for the vaginal delivery of small nucleic acid | Full Text | References | PDF (1.4 MB) | EPUB
  • 1816 Views
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Open Access
Article
Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation
Jie Mou, Zongxiang Liu, Jie Liu, Jianwu Lu, Wentao Zhu & Dongsheng Pei
Pages: 179-187
Published online: 01 Mar 2019
AbstractforHydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 4834 Views
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Open Access
Article
A more efficient ocular delivery system of triamcinolone acetonide as eye drop to the posterior segment of the eye
Jin Li, Tongjie Cheng, Qiang Tian, Ying Cheng, Lixia Zhao, Xingzhen Zhang & Yi Qu
Pages: 188-198
Published online: 05 Mar 2019
AbstractforA more efficient ocular delivery system of triamcinolone acetonide as eye drop to the posterior segment of the eye | Full Text | References | PDF (1.4 MB) | EPUB
  • 2750 Views
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Open Access
Article
Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles
Xiao Que, Jing Su, Pengcheng Guo, Zul Kamal, Enge Xu, Siyu Liu, Jieyu Chen & Mingfeng Qiu
Pages: 199-207
Published online: 05 Mar 2019
AbstractforStudy on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 3617 Views
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Open Access
Article
The improved antitumor efficacy of continuous intratumoral chemotherapy with cisplatin-loaded implants for the treatment of sarcoma 180 tumor-bearing mice
Li Gao, Shang Cai, Awei Cai, Yang Zhao, Tangbing Xu, Yan Ma, Yan Xu, Yuan Wang, Hao Wang & Yong Hu
Pages: 208-215
Published online: 05 Mar 2019
AbstractforThe improved antitumor efficacy of continuous intratumoral chemotherapy with cisplatin-loaded implants for the treatment of sarcoma 180 tumor-bearing mice | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2479 Views
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Open Access
Article
Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability
Jong Chan Byeon, Sang-Eun Lee, Tae-Hyeon Kim, Jung Bin Ahn, Dong-Hyun Kim, Jin-Seok Choi & Jeong-Sook Park
Pages: 216-225
Published online: 07 Mar 2019
AbstractforDesign of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 5430 Views
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Open Access
Article
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model
Imke Rudnik-Jansen, Karin Schrijver, Nina Woike, Anna Tellegen, Sabine Versteeg, Pieter Emans, George Mihov, Jens Thies, Niels Eijkelkamp, Marianna Tryfonidou & Laura Creemers
Pages: 226-236
Published online: 07 Mar 2019
AbstractforIntra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 4947 Views
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Open Access
Article
Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa
Chiara Bianca Maria Platania, Michele Dei Cas, Simona Cianciolo, Annamaria Fidilio, Francesca Lazzara, Rita Paroni, Rosario Pignatello, Enrica Strettoi, Riccardo Ghidoni, Filippo Drago & Claudio Bucolo
Pages: 237-243
Published online: 11 Mar 2019
AbstractforNovel ophthalmic formulation of myriocin: implications in retinitis pigmentosa | Full Text | References | PDF (952.3 KB) | EPUB | Supplemental
  • 3226 Views
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Open Access
Article
Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging
Kristoffer K. Hendel, Charlotte Bagger, Uffe H. Olesen, Christian Janfelt, Steen H. Hansen, Merete Haedersdal & Catharina M. Lerche
Pages: 244-251
Published online: 12 Mar 2019
AbstractforFractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging | Full Text | References | PDF (1.6 MB) | EPUB
  • 2202 Views
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Open Access

Review Article

Preparation and drug delivery of dextran-drug complex
Shiyu Huang & Gangliang Huang
Pages: 252-261
Published online: 11 Mar 2019
AbstractforPreparation and drug delivery of dextran-drug complex | Full Text | References | PDF (1.1 MB) | EPUB
  • 5142 Views
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Open Access

Research Article

Article
Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance
Meng Lei, Guanglan Ma, Sijia Sha, Xueyuan Wang, Haiting Feng, Yongqiang Zhu & Xiao Du
Pages: 262-272
Published online: 11 Mar 2019
AbstractforDual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 4443 Views
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Open Access
Article
Exploitation of enrofloxacin-loaded docosanoic acid solid lipid nanoparticle suspension as oral and intramuscular sustained release formulations for pig
Yanfei Tao, Fei Yang, Kuiyu Meng, Dongmei Chen, Yujuan Yang, Kaixiang Zhou, Wanhe Luo, Wei Qu, Yuanhu Pan, Zonghui Yuan & Shuyu Xie
Pages: 273-280
Published online: 16 Mar 2019
AbstractforExploitation of enrofloxacin-loaded docosanoic acid solid lipid nanoparticle suspension as oral and intramuscular sustained release formulations for pig | Full Text | References | PDF (964.9 KB) | EPUB
  • 2128 Views
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Open Access
Article
Combined using of paclitaxel and salinomycin active targeting nanostructured lipid carriers against non-small cell lung cancer and cancer stem cells
Jianwen Zhou, Mingshuang Sun, Shanshan Jin, Li Fan, Wenquan Zhu, Xiaoyu Sui, Lixin Cao, Chunrong Yang & Cuiyan Han
Pages: 281-289
Published online: 16 Mar 2019
AbstractforCombined using of paclitaxel and salinomycin active targeting nanostructured lipid carriers against non-small cell lung cancer and cancer stem cells | Full Text | References | PDF (1.4 MB) | EPUB
  • 2667 Views
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Open Access
Article
Development and effects of tacrolimus-loaded nanoparticles on the inhibition of corneal allograft rejection
Qianni Wu, Dong Liu, Xulin Zhang, Dongni Wang, Meimei DongYe, Wan Chen, Duoru Lin, Fangming Zhu, Weirong Chen & Haotian Lin
Pages: 290-299
Published online: 21 Mar 2019
AbstractforDevelopment and effects of tacrolimus-loaded nanoparticles on the inhibition of corneal allograft rejection | Full Text | References | PDF (1.4 MB) | EPUB
  • 2940 Views
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Open Access
Article
pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin
Leran Bu, Hena Zhang, Kang Xu, Baixiang Du, Caihong Zhu & Yuling Li
Pages: 300-308
Published online: 21 Mar 2019
AbstractforpH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 2105 Views
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Open Access
Article
Preparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study
Lili Ren, Jingjing Wang & Guoguang Chen
Pages: 309-317
Published online: 21 Mar 2019
AbstractforPreparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2252 Views
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Open Access
Article
Poly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer
Ionut Cristian Radu, Ariana Hudita, Catalin Zaharia, Bianca Galateanu, Horia Iovu, Eugenia (Vasile) Tanasa, Sabina Georgiana Nitu, Octav Ginghina, Carolina Negrei, Aristidis Tsatsakis, Kelly Velonia, Mikhail Shtilman & Marieta Costache
Pages: 318-327
Published online: 21 Mar 2019
AbstractforPoly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer | Full Text | References | PDF (1.3 MB) | EPUB
  • 2844 Views
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Open Access

Review Article

Improving cellular uptake of therapeutic entities through interaction with components of cell membrane
Renshuai Zhang, Xiaofei Qin, Fandong Kong, Pengwei Chen & Guojun Pan
Pages: 328-342
Published online: 24 Mar 2019
AbstractforImproving cellular uptake of therapeutic entities through interaction with components of cell membrane | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 14563 Views
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Research Article

Article
A biocompatible reverse thermoresponsive polymer for ocular drug delivery
Asitha Balachandra, Elsa C. Chan, Joseph P. Paul, Sze Ng, Vicki Chrysostomou, Steven Ngo, Roshan Mayadunne & Peter van Wijngaarden
Pages: 343-353
Published online: 24 Mar 2019
AbstractforA biocompatible reverse thermoresponsive polymer for ocular drug delivery | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 2241 Views
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Open Access
Article
PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy
Jun Zeng, Chen Li, Xing Duan, Fuyue Liu, Anqin Li, Chunhan Luo, Li Jia, Yifang Gan, Lu Yan & Yaxin Zheng
Pages: 354-362
Published online: 26 Mar 2019
AbstractforPEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy | Full Text | References | PDF (1.2 MB) | EPUB
  • 2203 Views
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Open Access

Review Article

Recent progress in LyP-1-based strategies for targeted imaging and therapy
Ningning Song, Lingzhou Zhao, Meilin Zhu & Jinhua Zhao
Pages: 363-375
Published online: 24 Mar 2019
AbstractforRecent progress in LyP-1-based strategies for targeted imaging and therapy | Full Text | References | PDF (1.5 MB) | EPUB
  • 3193 Views
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Open Access

Research Article

Article
Transdermal metformin hydrochloride-loaded cubic phases: in silico formulation optimization, preparation, properties, and application for local treatment of melanoma
Xiang Yu, Wei Zhou, Hongmei Wang, Sheng Lu, Yiguang Jin & Junhui Fu
Pages: 376-383
Published online: 24 Mar 2019
AbstractforTransdermal metformin hydrochloride-loaded cubic phases: in silico formulation optimization, preparation, properties, and application for local treatment of melanoma | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2132 Views
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Open Access

Critical Review

A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience
Bart J. F. van den Bemt, Lynda Gettings, Barbara Domańska, Richard Bruggraber, Irina Mountian & Lars E. Kristensen
Pages: 384-392
Published online: 24 Mar 2019
AbstractforA portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience | Full Text | References | PDF (841.4 KB) | EPUB
  • 5951 Views
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Open Access

Research Article

Article
The involvement of perivascular spaces or tissues in the facial intradermal brain-targeted delivery
Wei Yang, Bing-Hui Jin, Ya-Jing Chen, Chang Cao, Jia-Zhen Zhu, Ying-Zheng Zhao, Xi-Chong Yu & Fan-Zhu Li
Pages: 393-403
Published online: 31 Mar 2019
AbstractforThe involvement of perivascular spaces or tissues in the facial intradermal brain-targeted delivery | Full Text | References | PDF (2.2 MB) | EPUB
  • 1880 Views
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Open Access
Article
A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy
Margo Steuperaert, Charlotte Debbaut, Charlotte Carlier, Olivier De Wever, Benedicte Descamps, Christian Vanhove, Wim Ceelen & Patrick Segers
Pages: 404-415
Published online: 31 Mar 2019
AbstractforA 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy | Full Text | References | PDF (2 MB) | EPUB
  • 2618 Views
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Review Article

Application and design of esterase-responsive nanoparticles for cancer therapy
Haonan Dong, Long Pang, Hailin Cong, Youqing Shen & Bing Yu
Pages: 416-432
Published online: 31 Mar 2019
AbstractforApplication and design of esterase-responsive nanoparticles for cancer therapy | Full Text | References | PDF (2.8 MB) | EPUB
  • 6927 Views
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Research Article

Article
Doxorubicin-loaded red blood cells reduced cardiac toxicity and preserved anticancer activity
Alfredo Lucas, Dawn Lam & Pedro Cabrales
Pages: 433-442
Published online: 31 Mar 2019
AbstractforDoxorubicin-loaded red blood cells reduced cardiac toxicity and preserved anticancer activity | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3362 Views
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Article
Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers
Livia P. Mendes, Can Sarisozen, Ed Luther, Jiayi Pan & Vladimir P. Torchilin
Pages: 443-458
Published online: 31 Mar 2019
AbstractforSurface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 3011 Views
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Open Access
Article
Transient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity
Shirley Sharabi, Yael Bresler, Orly Ravid, Chen Shemesh, Dana Atrakchi, Michal Schnaider-Beeri, Fabien Gosselet, Lucie Dehouck, David Last, David Guez, Dianne Daniels, Yael Mardor & Itzik Cooper
Pages: 459-469
Published online: 08 Apr 2019
AbstractforTransient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 3103 Views
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Open Access
Article
pH sensitive peptide functionalized nanoparticles for co-delivery of erlotinib and DAPT to restrict the progress of triple negative breast cancer
Xu Wan, Chaoqian Liu, Yinan Lin, Jie Fu, Guohong Lu & Zhengmao Lu
Pages: 470-480
Published online: 08 Apr 2019
AbstractforpH sensitive peptide functionalized nanoparticles for co-delivery of erlotinib and DAPT to restrict the progress of triple negative breast cancer | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 2483 Views
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Open Access
Article
Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery
Mengshuang Li, Jie Lan, Xuefei Li, Meng Xin, Hui Wang, Fan Zhang, Xiaohong Lu, Zengfang Zhuang & Xianggen Wu
Pages: 481-489
Published online: 08 Apr 2019
AbstractforNovel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2466 Views
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Open Access
Article
Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide
Qian-Qian Shan, Xiao-Jing Jiang, Fang-Yuan Wang, Zi-Xuan Shu & Shuang-Ying Gui
Pages: 490-498
Published online: 12 May 2019
AbstractforCubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2750 Views
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Open Access
Article
Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells
Liangping Li, Suoju He, Lizhen Yu, Ezzat H Elshazly, Hui Wang, Kuanmin Chen, Song Zhang, Lixia Ke & Renmin Gong
Pages: 499-508
Published online: 29 Apr 2019
AbstractforCodelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells | Full Text | References | PDF (1.7 MB) | EPUB
  • 2255 Views
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Article
Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study
Alaa Emad Eldeeb, Salwa Salah & Mahmoud Ghorab
Pages: 509-521
Published online: 15 May 2019
AbstractforProniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization
Dong Liu, Qianni Wu, Yuqiong Zhu, Yijun Liu, Xiuli Xie, Sihan Li, Haotian Lin, Weirong Chen & Fangming Zhu
Pages: 522-531
Published online: 15 May 2019
AbstractforCo-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals
Stine Harloff-Helleberg, Lies A. L. Fliervoet, Mathias Fanø, Mechthild Schmitt, Maxim Antopolski, Arto Urtti & Hanne Mørck Nielsen
Pages: 532-541
Published online: 15 May 2019
AbstractforExploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Co-encapsulation of docetaxel and cyclosporin A into SNEDDS to promote oral cancer chemotherapy
Weiping Cui, Hanqing Zhao, Chen Wang, Yao Chen, Cong Luo, Shenwu Zhang, Bingjun Sun & Zhonggui He
Pages: 542-550
Published online: 15 May 2019
AbstractforCo-encapsulation of docetaxel and cyclosporin A into SNEDDS to promote oral cancer chemotherapy | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment
Da Wang, Chao Wang, Liang Wang & Yue Chen
Pages: 551-565
Published online: 16 May 2019
AbstractforA comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Use of magnoflorine-phospholipid complex to permeate blood-brain barrier and treat depression in the CUMS animal model
Bingjie Li, Linmeng Han, Bingyan Cao, Xiaoying Yang, Xuehui Zhu, Bing Yang, Haodong Zhao & Wei Qiao
Pages: 566-574
Published online: 20 May 2019
AbstractforUse of magnoflorine-phospholipid complex to permeate blood-brain barrier and treat depression in the CUMS animal model | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Articles

Article
New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment
Fengyuan Sun, Zhou Zheng, Jie Lan, Xuefei Li, Mengshuang Li, Kaichao Song & Xianggen Wu
Pages: 575-585
Published online: 07 Jun 2019
AbstractforNew micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Reviews

Development of an intravaginal ring delivering simultaneously anastrozole and levonorgestrel: a pharmacokinetic perspective
Rüdiger Nave
Pages: 586-594
Published online: 07 Jun 2019
AbstractforDevelopment of an intravaginal ring delivering simultaneously anastrozole and levonorgestrel: a pharmacokinetic perspective | Full Text | References | PDF (926.7 KB) | EPUB | Supplemental
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Research Article

Article
Multifunctional nanoplatform based on star-shaped copolymer for liver cancer targeting therapy
Xianling Gong, Yi Zheng, Guangzhi He, Kebing Chen, Xiaowei Zeng & Zhihong Chen
Pages: 595-603
Published online: 14 Jun 2019
AbstractforMultifunctional nanoplatform based on star-shaped copolymer for liver cancer targeting therapy | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Articles

Article
Biophysical and chemical stability of surfactant/budesonide and the pulmonary distribution following intra-tracheal administration
Chung-Ming Chen, Chien-Hsiang Chang, Chih-Hua Chao, Mei-Hui Wang & Tsu-Fu Yeh
Pages: 604-611
Published online: 17 Jun 2019
AbstractforBiophysical and chemical stability of surfactant/budesonide and the pulmonary distribution following intra-tracheal administration | Full Text | References | PDF (930.6 KB) | EPUB
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Research Article

Article
Inhibition of microRNA-183 expression resists human umbilical vascular endothelial cells injury by upregulating expression of IRS1
Yingying Zhang, Yefei Zhan, Dandan Liu & Bo Yu
Pages: 612-621
Published online: 18 Jun 2019
AbstractforInhibition of microRNA-183 expression resists human umbilical vascular endothelial cells injury by upregulating expression of IRS1 | Full Text | References | PDF (1.3 MB) | EPUB
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Original Paper

Article
Optimization of formulation for enhanced intranasal delivery of insulin with translationally controlled tumor protein-derived protein transduction domain
Hae-Duck Bae, Ji-Sun Lee, Haejun Pyun, Moonhee Kim & Kyunglim Lee
Pages: 622-628
Published online: 18 Jun 2019
AbstractforOptimization of formulation for enhanced intranasal delivery of insulin with translationally controlled tumor protein-derived protein transduction domain | Full Text | References | PDF (889.1 KB) | EPUB
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Research Article

Article
Polydopamine-tailored paclitaxel-loaded polymeric microspheres with adhered NIR-controllable gold nanoparticles for chemo-phototherapy of pancreatic cancer
Asmita Banstola, Tung Thanh Pham, Jee-Heon Jeong & Simmyung Yook
Pages: 629-640
Published online: 25 Jun 2019
AbstractforPolydopamine-tailored paclitaxel-loaded polymeric microspheres with adhered NIR-controllable gold nanoparticles for chemo-phototherapy of pancreatic cancer | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Original Paper

Article
Up-regulation of MIAT aggravates the atherosclerotic damage in atherosclerosis mice through the activation of PI3K/Akt signaling pathway
Guoqiang Sun, Yubo Li & Zhiyong Ji
Pages: 641-649
Published online: 25 Jun 2019
AbstractforUp-regulation of MIAT aggravates the atherosclerotic damage in atherosclerosis mice through the activation of PI3K/Akt signaling pathway | Full Text | References | PDF (1.1 MB) | EPUB
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Research Article

Article
Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation
Yun Xia, Yipeng Su, Qiyue Wang, Chen Yang, Baoqiang Tang, Yue Zhang, Jiasheng Tu & Yan Shen
Pages: 650-660
Published online: 01 Jul 2019
AbstractforPreparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Synergistic photothermal/photodynamic suppression of prostatic carcinoma by targeted biodegradable MnO2 nanosheets
Dewang Zeng, Lei Wang, Lu Tian, Shili Zhao, Xianfeng Zhang & Hongyan Li
Pages: 661-672
Published online: 01 Jul 2019
AbstractforSynergistic photothermal/photodynamic suppression of prostatic carcinoma by targeted biodegradable MnO2 nanosheets | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 3095 Views
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Article
Preparation and in vitro and in vivo evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate
Ting Zhou, Xin Tang, Wei Zhang, Jianfang Feng & Wei Wu
Pages: 673-679
Published online: 02 Jul 2019
AbstractforPreparation and in vitro and in vivo evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate | Full Text | References | PDF (899.5 KB) | EPUB | Supplemental
  • 1537 Views
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Article
Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model
S. T. Christensen, A. S. Grell, S. E. Johansson, C. M. Andersson, L. Edvinsson & K. A. Haanes
Pages: 680-688
Published online: 05 Jul 2019
AbstractforSynergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
In-vitro and in-vivo respiratory deposition of a developed metered dose inhaler formulation of an anti-migraine drug
Ebtsam M. Abdou, Soha M. Kandil, Amany Morsi & Maysa W. Sleem
Pages: 689-699
Published online: 05 Jul 2019
AbstractforIn-vitro and in-vivo respiratory deposition of a developed metered dose inhaler formulation of an anti-migraine drug | Full Text | References | PDF (1,020.3 KB) | EPUB
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Article
Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease
Shengnan Tang, Aiping Wang, Xiuju Yan, Liuxiang Chu, Xiucheng Yang, Yina Song, Kaoxiang Sun, Xin Yu, Rongxia Liu, Zimei Wu & Peng Xue
Pages: 700-707
Published online: 10 Jul 2019
AbstractforBrain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Articles

Article
Development of synthetic high-density lipoprotein-based ApoA-I mimetic peptide-loaded docetaxel as a drug delivery nanocarrier for breast cancer chemotherapy
Miaomiao Gong, Qi Zhang, Qi Zhao, Jiani Zheng, Yue Li, Siling Wang & Yue Yuan
Pages: 708-716
Published online: 10 Jul 2019
AbstractforDevelopment of synthetic high-density lipoprotein-based ApoA-I mimetic peptide-loaded docetaxel as a drug delivery nanocarrier for breast cancer chemotherapy | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
A novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy
Yongmei Zhao, Gang Chen, Zhengjie Meng, Guangming Gong, Wei Zhao, Kaikai Wang & Tianqing Liu
Pages: 717-723
Published online: 11 Jul 2019
AbstractforA novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Article
Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
Wen Lin, Xiaoxing Ma, Chaopei Zhou, Hong Yang, Yang Yang, Xiangyang Xie, Chunrong Yang & Cuiyan Han
Pages: 724-731
Published online: 11 Jul 2019
AbstractforDevelopment and characteristics of novel sonosensitive liposomes for vincristine bitartrate | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Zinc oxide end-capped Fe3O4@mSiO2 core-shell nanocarriers as targeted and responsive drug delivery system for chemo-/ions synergistic therapeutics
Minchao Liu, Xiangyu Sun, Zhihui Liao, Yahui Li, Xiaoliang Qi, Yuna Qian, Hicham Fenniri, Ping Zhao & Jianliang Shen
Pages: 732-743
Published online: 25 Jul 2019
AbstractforZinc oxide end-capped Fe3O4@mSiO2 core-shell nanocarriers as targeted and responsive drug delivery system for chemo-/ions synergistic therapeutics | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma
Tao Liu, Jingzhen Li, Xidong Wu, Siyi Zhang, Zhongming Lu, Guanxue Li, Junzheng Li & Shaohua Chen
Pages: 744-755
Published online: 25 Jul 2019
AbstractforTransferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment
Guofei Li & Limei Zhao
Pages: 756-764
Published online: 29 Jul 2019
AbstractforSorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 1600 Views
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Article
Lipid-chitosan hybrid nanoparticles for controlled delivery of cisplatin
Muhammad Muzamil Khan, Asadullah Madni, Vladimir Torchilin, Nina Filipczak, Jiayi Pan, Nayab Tahir & Hassan Shah
Pages: 765-772
Published online: 29 Jul 2019
AbstractforLipid-chitosan hybrid nanoparticles for controlled delivery of cisplatin | Full Text | References | PDF (1 MB) | EPUB
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Article
Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery
Wenbo Zhan, Ferdinando Rodriguez y Baena & Daniele Dini
Pages: 773-781
Published online: 30 Jul 2019
AbstractforEffect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3927 Views
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Article
Ganoderic acid loaded nano-lipidic carriers improvise treatment of hepatocellular carcinoma
Mahfoozur Rahman, Shareefa Abdullah Al-Ghamdi, Khalid S Alharbi, Sarwar Beg, Kalicharan Sharma, Firoz Anwar, Fahad A Al-Abbasi & Vikas Kumar
Pages: 782-793
Published online: 30 Jul 2019
AbstractforGanoderic acid loaded nano-lipidic carriers improvise treatment of hepatocellular carcinoma | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo
Weijie Li, Ruicong Yan, Yong Liu, Chuanchuan He, Xiaojuan Zhang, Yao Lu, Muhammad Waseem Khan, Chuanrui Xu, Tan Yang & Guangya Xiang
Pages: 794-802
Published online: 01 Aug 2019
AbstractforCo-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Targeting murine alveolar macrophages by the intratracheal administration of locked nucleic acid containing antisense oligonucleotides
Yasunori Uemura & Katsuya Kobayashi
Pages: 803-811
Published online: 06 Aug 2019
AbstractforTargeting murine alveolar macrophages by the intratracheal administration of locked nucleic acid containing antisense oligonucleotides | Full Text | References | PDF (1.1 MB) | EPUB
  • 1840 Views
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Article
Effects of rosiglitazone/PHBV drug delivery system on postoperative fibrosis in rabbit glaucoma filtration surgery model
Feng Zhang, Ke Liu, Zheng Pan, Mengdan Cao, Dengming Zhou, Hairong Liu, Yuting Huang & Xuanchu Duan
Pages: 812-819
Published online: 07 Aug 2019
AbstractforEffects of rosiglitazone/PHBV drug delivery system on postoperative fibrosis in rabbit glaucoma filtration surgery model | Full Text | References | PDF (1.4 MB) | EPUB
  • 1683 Views
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Article
Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis
Hailing Yang, Zhenjie Liu, Yonglong Song & Changjiang Hu
Pages: 820-830
Published online: 07 Aug 2019
AbstractforHyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2170 Views
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Article
Dehydration affects drug transport over nasal mucosa
Abdullah Ali, Marie Wahlgren, Birgitta Rembratt-Svensson, Ameena Daftani, Peter Falkman, Per Wollmer & Johan Engblom
Pages: 831-840
Published online: 10 Aug 2019
AbstractforDehydration affects drug transport over nasal mucosa | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Intraocular administration of tetramethylpyrazine hydrochloride to rats: a direct delivery pathway for brain targeting?
Dan Mao, Fang Li, Qun Ma, Manman Dai, Huimin Zhang, Luyu Bai & Ning He
Pages: 841-848
Published online: 10 Aug 2019
AbstractforIntraocular administration of tetramethylpyrazine hydrochloride to rats: a direct delivery pathway for brain targeting? | Full Text | References | PDF (875.8 KB) | EPUB
  • 1469 Views
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Article
Design and optimization of crocetin loaded PLGA nanoparticles against diabetic nephropathy via suppression of inflammatory biomarkers: a formulation approach to preclinical study
Xiaodong Yang
Pages: 849-859
Published online: 14 Sep 2019
AbstractforDesign and optimization of crocetin loaded PLGA nanoparticles against diabetic nephropathy via suppression of inflammatory biomarkers: a formulation approach to preclinical study | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Review Article

Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine
Liang Zhang
Pages: 860-869
Published online: 14 Sep 2019
AbstractforPharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine | Full Text | References | PDF (992.7 KB) | EPUB
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Research Article

Article
Biomaterial-engineered intra-articular drug delivery systems for osteoarthritis therapy
Longfa Kou, Shuyi Xiao, Rui Sun, Shihui Bao, Qing Yao & Ruijie Chen
Pages: 870-885
Published online: 14 Sep 2019
AbstractforBiomaterial-engineered intra-articular drug delivery systems for osteoarthritis therapy | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
SYL3C aptamer-anchored microemulsion co-loading β-elemene and PTX enhances the treatment of colorectal cancer
Xiaorong Zhou, Chuanpei Cao, Nan Li & Shaofei Yuan
Pages: 886-897
Published online: 14 Sep 2019
AbstractforSYL3C aptamer-anchored microemulsion co-loading β-elemene and PTX enhances the treatment of colorectal cancer | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1955 Views
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Article
Numerical modeling of high-intensity focused ultrasound-mediated intraperitoneal delivery of thermosensitive liposomal doxorubicin for cancer chemotherapy
Mohsen Rezaeian, Amir Sedaghatkish & M. Soltani
Pages: 898-917
Published online: 16 Sep 2019
AbstractforNumerical modeling of high-intensity focused ultrasound-mediated intraperitoneal delivery of thermosensitive liposomal doxorubicin for cancer chemotherapy | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2796 Views
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Article
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma
Wenguang Gu, Tao Zhang, Junsheng Gao, Yi Wang, Dejian Li, Ziwen Zhao, Bo Jiang, Zhiwei Dong & Hui Liu
Pages: 918-927
Published online: 16 Sep 2019
AbstractforAlbumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma | Full Text | References | PDF (1.5 MB) | EPUB
  • 1890 Views
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Article
Electrochemical generation of microbubbles by carbon nanotube interdigital electrodes to increase the permeability and material uptakes of cancer cells
Mohammad Ali Khayamian, Shahriar Shalileh, Shohreh Vanaei, Mohammad Salemizadeh Parizi, Saeid Ansaryan, Mohammad Saghafi, Fereshteh Abbasvandi, Amirali Ebadi, Pouya Soltan Khamsi & Mohammad Abdolahad
Pages: 928-934
Published online: 16 Sep 2019
AbstractforElectrochemical generation of microbubbles by carbon nanotube interdigital electrodes to increase the permeability and material uptakes of cancer cells | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field
Yusuke Kono, Serika Gogatsubo, Takeshi Ohba & Takuya Fujita
Pages: 935-943
Published online: 18 Sep 2019
AbstractforEnhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field | Full Text | References | PDF (1.1 MB) | EPUB
  • 1568 Views
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Article
Evaluation of therapeutic effect of targeting nanobubbles conjugated with NET-1 siRNA by shear wave elastography: an in vivo study of hepatocellular carcinoma bearing mice model
Haitao Shang, Bolin Wu, Xitian Liang, Yixin Sun, Xue Han, Lei Zhang, Qiucheng Wang & Wen Cheng
Pages: 944-951
Published online: 23 Sep 2019
AbstractforEvaluation of therapeutic effect of targeting nanobubbles conjugated with NET-1 siRNA by shear wave elastography: an in vivo study of hepatocellular carcinoma bearing mice model | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Cubic and hexagonal liquid crystal gels for ocular delivery with enhanced effect of pilocarpine nitrate on anti-glaucoma treatment
Wang Xingqi, Zhang Yong, Li Xing, Wang Yang, Huang Jie, Hu Rongfeng, Gui Shuangying & Chu Xiaoqin
Pages: 952-964
Published online: 23 Sep 2019
AbstractforCubic and hexagonal liquid crystal gels for ocular delivery with enhanced effect of pilocarpine nitrate on anti-glaucoma treatment | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide
Shuang Yang, Dandan Wang, Yaojun Sun & Bin Zheng
Pages: 965-974
Published online: 23 Sep 2019
AbstractforDelivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Fabrication and characterization of solid lipid nano-formulation of astraxanthin against DMBA-induced breast cancer via Nrf-2-Keap1 and NF-kB and mTOR/Maf-1/PTEN pathway
Tao Sun, Jun Gao, Dan Han, Hongyan Shi & Xianqiang Liu
Pages: 975-988
Published online: 26 Sep 2019
AbstractforFabrication and characterization of solid lipid nano-formulation of astraxanthin against DMBA-induced breast cancer via Nrf-2-Keap1 and NF-kB and mTOR/Maf-1/PTEN pathway | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 4085 Views
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Article
A novel dendrimer-based complex co-modified with cyclic RGD hexapeptide and penetratin for noninvasive targeting and penetration of the ocular posterior segment
Xiucheng Yang, Lihua Wang, Lin Li, Meishan Han, Shengnan Tang, Tengteng Wang, Junping Han, Xiaoyan He, Xiuting He, Aiping Wang & Kaoxiang Sun
Pages: 989-1001
Published online: 01 Oct 2019
AbstractforA novel dendrimer-based complex co-modified with cyclic RGD hexapeptide and penetratin for noninvasive targeting and penetration of the ocular posterior segment | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy
Mengna Liu, Bingjie Wang, Chunjing Guo, Xiaoya Hou, Ziting Cheng & Daquan Chen
Pages: 1002-1016
Published online: 01 Oct 2019
AbstractforNovel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Enhancement of curcumin antitumor efficacy and further photothermal ablation of tumor growth by single-walled carbon nanotubes delivery system in vivo
Haixia Li, Nan Zhang, Yongwei Hao, Yali Wang, Shasha Jia & Hongling Zhang
Pages: 1017-1026
Published online: 03 Oct 2019
AbstractforEnhancement of curcumin antitumor efficacy and further photothermal ablation of tumor growth by single-walled carbon nanotubes delivery system in vivo | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Dual functional matrix metalloproteinase-responsive curcumin-loaded nanoparticles for tumor-targeted treatment
Fangyuan Guo, Qiafan Fu, Chenhao Jin, Xugang Ji, Qinying Yan, Qingliang Yang, Danjun Wu, Ying Gao, Weiyong Hong, Aiqin Li & Gensheng Yang
Pages: 1027-1038
Published online: 06 Nov 2019
AbstractforDual functional matrix metalloproteinase-responsive curcumin-loaded nanoparticles for tumor-targeted treatment | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates
Wilson Poh, Nurlilah Ab Rahman, Yan Ostrovski, Josué Sznitman, Kevin Pethe & Say Chye Joachim Loo
Pages: 1039-1048
Published online: 06 Nov 2019
AbstractforActive pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 2043 Views
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Article
Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants
Li Gao, Qingshan Li, Jie Zhang, Yixin Huang, Lin Deng, Chenyang Li, Guangping Tai & Banfeng Ruan
Pages: 1049-1057
Published online: 06 Nov 2019
AbstractforLocal penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 1433 Views
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Article
(-)-Epigallocatechin-3-gallate encapsulated realgar nanoparticles exhibit enhanced anticancer therapeutic efficacy against acute promyelocytic leukemia
Wei Fang, Zhao Liang Peng, Ya Ji Dai, Dian Lei Wang, Peng Huang & He Ping Huang
Pages: 1058-1067
Published online: 18 Nov 2019
Abstractfor(-)-Epigallocatechin-3-gallate encapsulated realgar nanoparticles exhibit enhanced anticancer therapeutic efficacy against acute promyelocytic leukemia | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Redox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy
Fu Li, Zhao Huang, Huitong Chen, Lu Yan, Jin Li, Yue Su, Qian Zhang, Zhengye Huang & Yaxin Zheng
Pages: 1068-1079
Published online: 18 Nov 2019
AbstractforRedox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Co-delivery of plantamajoside and sorafenib by a multi-functional nanoparticle to combat the drug resistance of hepatocellular carcinoma through reprograming the tumor hypoxic microenvironment
Ying Zan, Zhijun Dai, Liang Liang, Yujiao Deng & Lei Dong
Pages: 1080-1091
Published online: 18 Nov 2019
AbstractforCo-delivery of plantamajoside and sorafenib by a multi-functional nanoparticle to combat the drug resistance of hepatocellular carcinoma through reprograming the tumor hypoxic microenvironment | Full Text | References | PDF (1.7 MB) | EPUB
  • 1783 Views
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Review Article

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery
Tao Liu, Xinxin Yu, Haipeng Yin & Jan P. Möschwitzer
Pages: 1092-1103
Published online: 18 Nov 2019
AbstractforAdvanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery | Full Text | References | PDF (1.2 MB) | EPUB
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Research Article

Article
Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation
Yujuan Mao, Xiaolan Chen, Bohui Xu, Yan Shen, Zixuan Ye, Birendra Chaurasiya, Li Liu, Yi Li, Xiaoling Xing & Daquan Chen
Pages: 1104-1114
Published online: 18 Nov 2019
AbstractforEprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 3311 Views
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Article
A novel adjuvant drug-device combination tissue scaffold for radical prostatectomy
Ketevan Paliashvili, Francesco Di Maggio, Hei Ming Kenneth Ho, Sanjayan Sathasivam, Hashim Ahmed & Richard M. Day
Pages: 1115-1124
Published online: 18 Nov 2019
AbstractforA novel adjuvant drug-device combination tissue scaffold for radical prostatectomy | Full Text | References | PDF (1.2 MB) | EPUB
  • 1064 Views
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Article
Novel mitochondrial targeting charge-reversal polysaccharide hybrid shell/core nanoparticles for prolonged systemic circulation and antitumor drug delivery
Lei Fang, Wei Zhang, Zhen Wang, Xinxin Fan, Ziting Cheng, Xiaoya Hou & Daquan Chen
Pages: 1125-1139
Published online: 18 Nov 2019
AbstractforNovel mitochondrial targeting charge-reversal polysaccharide hybrid shell/core nanoparticles for prolonged systemic circulation and antitumor drug delivery | Full Text | References | PDF (2.5 MB) | EPUB
  • 2449 Views
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RESEARCH ARTICLE

Article
Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway
Shahira F. El Menshawe, Mohamed M. Nafady, Heba M. Aboud, Rasha M. Kharshoum, Asmaa Mohammed M. Hussein Elkelawy & Doaa S. Hamad
Pages: 1140-1154
Published online: 18 Nov 2019
AbstractforTransdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Research Article

Article
Mechanisms of oral absorption improvement for insoluble drugs by the combination of phospholipid complex and SNEDDS
Yingpeng Tong, Qin Zhang, Wen Shi & Jianxin Wang
Pages: 1155-1166
Published online: 18 Nov 2019
AbstractforMechanisms of oral absorption improvement for insoluble drugs by the combination of phospholipid complex and SNEDDS | Full Text | References | PDF (1.4 MB) | EPUB
  • 2446 Views
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Article
Preparation and in vivo evaluation of a highly skin- and nail-permeable efinaconazole topical formulation for enhanced treatment of onychomycosis
Byung Chul Lee, Rudra Pangeni, Jungtae Na, Kyo-Tan Koo & Jin Woo Park
Pages: 1167-1177
Published online: 18 Nov 2019
AbstractforPreparation and in vivo evaluation of a highly skin- and nail-permeable efinaconazole topical formulation for enhanced treatment of onychomycosis | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3741 Views
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Article
Uniform-sized insulin-loaded PLGA microspheres for improved early-stage peri-implant bone regeneration
Xing Wang, Feng Qi, Helin Xing, Xiaoxuan Zhang, Chunxiang Lu, Jiajia Zheng & Xiuyun Ren
Pages: 1178-1190
Published online: 18 Nov 2019
AbstractforUniform-sized insulin-loaded PLGA microspheres for improved early-stage peri-implant bone regeneration | Full Text | References | PDF (2.2 MB) | EPUB
  • 1689 Views
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Article
Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution
Yunliang Guo, Xuyan Mao, Jing Zhang, Peng Sun, Haiyang Wang, Yue Zhang, Yingjuan Ma, Song Xu, Renjun Lv & Xueping Liu
Pages: 1191-1205
Published online: 18 Nov 2019
AbstractforOral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 2504 Views
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Review

Nanoparticles for antiparasitic drug delivery
Yuzhu Sun, Dongmei Chen, Yuanhu Pan, Wei Qu, Haihong Hao, Xu Wang, Zhenli Liu & Shuyu Xie
Pages: 1206-1221
Published online: 20 Nov 2019
AbstractforNanoparticles for antiparasitic drug delivery | Full Text | References | PDF (1.4 MB) | EPUB
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Research Article

Article
Optimized nonionic emulsifier for the efficient delivery of astaxanthin nanodispersions to retina: in vivo and ex vivo evaluations
Lei Xu, Haixiang Yu, Hongbin Sun, Xiang Yu & Ye Tao
Pages: 1222-1234
Published online: 21 Nov 2019
AbstractforOptimized nonionic emulsifier for the efficient delivery of astaxanthin nanodispersions to retina: in vivo and ex vivo evaluations | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1473 Views
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Article
Preparation and study of two kinds of ophthalmic nano-preparations of everolimus
Zhan Tang, Lina Yin, Yawen Zhang, Wenying Yu, Qiao Wang & Zhajun Zhan
Pages: 1235-1242
Published online: 21 Nov 2019
AbstractforPreparation and study of two kinds of ophthalmic nano-preparations of everolimus | Full Text | References | PDF (1.1 MB) | EPUB
  • 2103 Views
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Article
Enhancement of zaleplon oral bioavailability using optimized self-nano emulsifying drug delivery systems and its effect on sleep quality among a sample of psychiatric patients
Maha K. A. Khalifa, Hoda A. Salem, Seham M. Shawky, Heba A. Eassa & Asmaa M. Elaidy
Pages: 1243-1253
Published online: 21 Nov 2019
AbstractforEnhancement of zaleplon oral bioavailability using optimized self-nano emulsifying drug delivery systems and its effect on sleep quality among a sample of psychiatric patients | Full Text | References | PDF (1.4 MB) | EPUB
  • 2191 Views
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Article
Hybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy
Xiao Yuan, Yanlong Yin, Wang Zan, Xiyang Sun & Qian Yang
Pages: 1254-1264
Published online: 23 Nov 2019
AbstractforHybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy | Full Text | References | PDF (1.9 MB) | EPUB
  • 1988 Views
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Article
Development of dual-targeted nano-dandelion based on an oligomeric hyaluronic acid polymer targeting tumor-associated macrophages for combination therapy of non-small cell lung cancer
Bingjie Wang, Wei Zhang, Xiudi Zhou, Mengna Liu, Xiaoya Hou, Ziting Cheng & Daquan Chen
Pages: 1265-1279
Published online: 28 Nov 2019
AbstractforDevelopment of dual-targeted nano-dandelion based on an oligomeric hyaluronic acid polymer targeting tumor-associated macrophages for combination therapy of non-small cell lung cancer | Full Text | References | PDF (2.5 MB) | EPUB
  • 3606 Views
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Article
A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma
Tao Liu, Xidong Wu, Shaohua Chen, Peina Wu, Hong Han, Hongbin Zhang, Junzheng Li, Guanxue Li & Siyi Zhang
Pages: 1280-1291
Published online: 03 Dec 2019
AbstractforA cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma | Full Text | References | PDF (2.7 MB) | EPUB
  • 1223 Views
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Article
Synthesis and evaluation of polymeric micelle containing piperacillin/tazobactam for enhanced antibacterial activity
Milani Morteza, Salehi Roya, Hamishehkar Hamed, Zarebkohan Amir & Akbarzadeh Abolfazl
Pages: 1292-1299
Published online: 04 Dec 2019
AbstractforSynthesis and evaluation of polymeric micelle containing piperacillin/tazobactam for enhanced antibacterial activity | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 1811 Views
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Corrections

Correction
Correction
Page: 1300
Published online: 25 Mar 2019
CitationforCorrection | Full Text | PDF (163 KB) | EPUB
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Correction

Correction
Correction
Page: 1301
Published online: 09 Sep 2019
CitationforCorrection | Full Text | PDF (117.1 KB) | EPUB
  • 491 Views
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Corrections

Correction
Correction
Pages: 1302-1303
Published online: 26 Nov 2019
CitationforCorrection | Full Text | PDF (1 MB) | EPUB
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