Expert Opinion on Drug Discovery, Volume 16, Issue 1 (2021)

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Expert Opinion on Drug Discovery, Volume 16, Issue 1 (2021)

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Editorial

Editorial
Automated patch clamp in drug discovery: major breakthroughs and innovation in the last decade
Alison Obergrussberger, Søren Friis, Andrea Brüggemann & Niels Fertig
Pages: 1-5
Published online: 10 Jul 2020
First Page PreviewforAutomated patch clamp in drug discovery: major breakthroughs and innovation in the last decade | Full Text | References | PDF (475.7 KB) | EPUB
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Editorial
Pharmacological strategies to overcome treatment resistance in acute myeloid leukemia: increasing leukemic drug exposure by targeting the resistance factor SAMHD1 and the toxicity factor Top2β
Nikolas Herold
Pages: 7-11
Published online: 31 Aug 2020
First Page PreviewforPharmacological strategies to overcome treatment resistance in acute myeloid leukemia: increasing leukemic drug exposure by targeting the resistance factor SAMHD1 and the toxicity factor Top2β | Full Text | References | PDF (963.9 KB) | EPUB
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Drug Discovery Case History

Article
The preclinical discovery and development of rectal artesunate for the treatment of malaria in young children: a review of the evidence
Laís Pessanha de Carvalho, Andrea Kreidenweiss & Jana Held
Pages: 13-22
Published online: 14 Sep 2020
AbstractforThe preclinical discovery and development of rectal artesunate for the treatment of malaria in young children: a review of the evidence | Full Text | References | PDF (461.9 KB) | EPUB
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Perspective

A public-private partnership for the express development of antiviral leads: a perspective view
Anatoly Mayburd
Pages: 23-38
Published online: 02 Sep 2020
AbstractforA public-private partnership for the express development of antiviral leads: a perspective view | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Review

Metallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs
Damiano Cirri, Alessandro Pratesi, Tiziano Marzo & Luigi Messori
Pages: 39-46
Published online: 11 Sep 2020
AbstractforMetallo therapeutics for COVID-19. Exploiting metal-based compounds for the discovery of new antiviral drugs | Full Text | References | PDF (1.4 MB) | EPUB
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An update on dengue vaccine development, challenges, and future perspectives
Fakhriedzwan Idris, Donald Heng Rong Ting & Sylvie Alonso
Pages: 47-58
Published online: 25 Aug 2020
AbstractforAn update on dengue vaccine development, challenges, and future perspectives | Full Text | References | PDF (399.3 KB) | EPUB
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Phenotypic screening techniques for Cryptosporidium drug discovery
Melissa S. Love & Case W. McNamara
Pages: 59-74
Published online: 07 Sep 2020
AbstractforPhenotypic screening techniques for Cryptosporidium drug discovery | Full Text | References | PDF (891 KB) | EPUB
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Open Access
Challenges with matrix metalloproteinase inhibition and future drug discovery avenues
Thomas Fischer & Rainer Riedl
Pages: 75-88
Published online: 14 Sep 2020
AbstractforChallenges with matrix metalloproteinase inhibition and future drug discovery avenues | Full Text | References | PDF (3.2 MB) | EPUB
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Combining therapeutic vaccines with chemo- and immunotherapies in the treatment of cancer
Matthew D. Kerr, David A. McBride, Arun K. Chumber & Nisarg J. Shah
Pages: 89-99
Published online: 31 Aug 2020
AbstractforCombining therapeutic vaccines with chemo- and immunotherapies in the treatment of cancer | Full Text | References | PDF (829.4 KB) | EPUB
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Multi-targeted drug design strategies for the treatment of schizophrenia
Piotr Stępnicki, Magda Kondej, Oliwia Koszła, Justyna Żuk & Agnieszka A. Kaczor
Pages: 101-114
Published online: 11 Sep 2020
AbstractforMulti-targeted drug design strategies for the treatment of schizophrenia | Full Text | References | PDF (1.1 MB) | EPUB
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