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Volume 3, Issue 9

Expert Opinion on Drug Discovery

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Expert Opinion on Drug Discovery, Volume 3, Issue 9 (2008)

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Expert Opinion on Drug Discovery, Volume 3, Issue 9 (2008)

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Perspectives

Article

Oligonucleotidic therapeutics

Yoshitaka Isaka MD PhD, Enyu Imai MD PhD, Shiro Takahara MD PhD & Hiromi Rakugi MD PhD

Pages: 991-996

Published online: 21 Aug 2008

AbstractforOligonucleotidic therapeutics | Full Text | References | PDF (230.3 KB)

91 Views
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Reviews

Article

Recent progress in oligonucleotide therapeutics: antisense to aptamers

Douglas W Leaman PhD

Pages: 997-1009

Published online: 21 Aug 2008

AbstractforRecent progress in oligonucleotide therapeutics: antisense to aptamers | Full Text | References | PDF (292.6 KB)

171 Views
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Article

Virtual screening of chemical libraries for drug discovery

Darren VS Green

Pages: 1011-1026

Published online: 21 Aug 2008

AbstractforVirtual screening of chemical libraries for drug discovery | Full Text | References | PDF (547.8 KB)

236 Views
27 CrossRef citations
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Article

The potential of neuronal nicotinic acetylcholine receptor agonists for treating CNS conditions

Michael W Decker, Murali Gopalakrishnan & Michael D Meyer

Pages: 1027-1040

Published online: 21 Aug 2008

AbstractforThe potential of neuronal nicotinic acetylcholine receptor agonists for treating CNS conditions | Full Text | References | PDF (301.4 KB)

95 Views
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Article

Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases

Claire Bonfils, Donald R Walkinshaw, Jeffrey M Besterman, Xiang-Jiao Yang & Zuomei Li PhD

Pages: 1041-1065

Published online: 21 Aug 2008

AbstractforPharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases | Full Text | References | PDF (401.5 KB)

152 Views
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Article

Use of behavioural and long-term potentiation models in the development of memory-improving drugs

Arjan Blokland & Frank Boess

Pages: 1067-1080

Published online: 21 Aug 2008

AbstractforUse of behavioural and long-term potentiation models in the development of memory-improving drugs | Full Text | References | PDF (283.1 KB)

127 Views
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Article

Development and prospects for bispecific antibody-based therapeutics in cancer and other applications

Lawrence G Lum MD DSc & Zaid Al-Kadhimi

Pages: 1081-1097

Published online: 21 Aug 2008

AbstractforDevelopment and prospects for bispecific antibody-based therapeutics in cancer and other applications | Full Text | References | PDF (366.4 KB)

184 Views
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Article

New frontiers in assessing pain and analgesia in laboratory animals

Daniel N Cortright, David J Matson & Daniel C Broom

Pages: 1099-1108

Published online: 21 Aug 2008

AbstractforNew frontiers in assessing pain and analgesia in laboratory animals | Full Text | References | PDF (236.1 KB)

161 Views
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Article

Structural studies of taxol analogues for drug discovery

Wei-Shuo Fang & Shao-Rong Wang

Pages: 1109-1122

Published online: 21 Aug 2008

AbstractforStructural studies of taxol analogues for drug discovery | Full Text | References | PDF (1.2 MB)

143 Views
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Case History

Article

Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein–protein interaction

Michael D Wendt

Pages: 1123-1143

Published online: 21 Aug 2008

AbstractforDiscovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein–protein interaction | Full Text | References | PDF (1.9 MB)

772 Views
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Meeting Highlights

Article

Drug discovery paradigms: past, present, future – a centennial symposium of the American Society for Pharmacology and Experimental Therapeutics

6 April 2008, San Diego, USA

Icilio Cavero PhD & Harvey R Kaplan PhD

Pages: 1145-1154

Published online: 21 Aug 2008

AbstractforDrug discovery paradigms: past, present, future – a centennial symposium of the American Society for Pharmacology and Experimental Therapeutics | Full Text | References | PDF (240 KB)

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