Expert Opinion on Investigational Drugs, Volume 29, Issue 2 (2020)

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Expert Opinion on Investigational Drugs, Volume 29, Issue 2 (2020)

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NASH and NAFLD: Emerging drugs, therapeutic targets and translational and clinical challenges

Foreword

Introduction
NASH and NAFLD: emerging drugs, therapeutic targets and translational and clinical challenges
Naim Alkhouri
Page: 87
Published online: 29 Jan 2020
CitationforNASH and NAFLD: emerging drugs, therapeutic targets and translational and clinical challenges | Full Text | PDF (177.2 KB) | EPUB
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Editorial

Editorial
Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis: opportunities and challenges
Sander Lefere, Lindsey Devisscher & Frank Tacke
Pages: 89-92
Published online: 20 Jan 2020
First Page PreviewforTargeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis: opportunities and challenges | Full Text | References | PDF (517.6 KB) | EPUB
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Editorial
Effectiveness of lifestyle interventions in NAFLD (nonalcoholic fatty liver disease) – how are clinical trials affected?
Maurice Michel & Jörn M. Schattenberg
Pages: 93-97
Published online: 21 Jan 2020
First Page PreviewforEffectiveness of lifestyle interventions in NAFLD (nonalcoholic fatty liver disease) – how are clinical trials affected? | Full Text | References | PDF (548.9 KB) | EPUB
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Editorial
Thyromimetics as emerging therapeutic agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196)
Naim Alkhouri
Pages: 99-101
Published online: 25 Dec 2019
First Page PreviewforThyromimetics as emerging therapeutic agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196) | Full Text | References | PDF (436.3 KB) | EPUB
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Editorial
A role for IL-1 inhibitors in the treatment of non-alcoholic fatty liver disease (NAFLD)?
Herbert Tilg, Maria Effenberger & Timon E. Adolph
Pages: 103-106
Published online: 24 Oct 2019
First Page PreviewforA role for IL-1 inhibitors in the treatment of non-alcoholic fatty liver disease (NAFLD)? | Full Text | References | PDF (380.1 KB) | EPUB
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Editorial
Fatty liver disease and primary liver cancer: disease mechanisms, emerging therapies and the role of bariatric surgery
Luke V. Selby, Aslam Ejaz, Stacy A. Brethauer & Timothy M. Pawlik
Pages: 107-110
Published online: 27 Jan 2020
First Page PreviewforFatty liver disease and primary liver cancer: disease mechanisms, emerging therapies and the role of bariatric surgery | Full Text | References | PDF (497.2 KB) | EPUB
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Interview

Discussion
Prof Jörn Schattenberg sheds light on key treatment and diagnostic approaches to nonalcoholic steatohepatitis (NASH)
Jörn M. Schattenberg
Pages: 111-113
Published online: 03 Feb 2020
First Page PreviewforProf Jörn Schattenberg sheds light on key treatment and diagnostic approaches to nonalcoholic steatohepatitis (NASH) | Full Text | PDF (439.5 KB) | EPUB
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Discussion
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): prevalence, therapeutic innovations, and stumbling blocks for clinical development
Naim Alkhouri
Pages: 115-116
Published online: 03 Feb 2020
CitationforNonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): prevalence, therapeutic innovations, and stumbling blocks for clinical development | Full Text | PDF (265.9 KB) | EPUB
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Drug Evaluation

Article
Elafibranor: a potential drug for the treatment of nonalcoholic steatohepatitis (NASH)
Menso J. Westerouen Van Meeteren, Joost P.H. Drenth & Eric T.T.L. Tjwa
Pages: 117-123
Published online: 25 Sep 2019
AbstractforElafibranor: a potential drug for the treatment of nonalcoholic steatohepatitis (NASH) | Full Text | References | PDF (604.2 KB) | EPUB
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Article
Pegbelfermin (BMS-986036): an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitis
Cristy R.C. Verzijl, Ivo P. Van De Peppel, Dicky Struik & Johan W. Jonker
Pages: 125-133
Published online: 03 Jan 2020
AbstractforPegbelfermin (BMS-986036): an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitis | Full Text | References | PDF (984.5 KB) | EPUB
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Article
GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)
Naim Alkhouri, Eric Lawitz, Mazen Noureddin, Ralph DeFronzo & Gerald I. Shulman
Pages: 135-141
Published online: 19 Sep 2019
AbstractforGS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH) | Full Text | References | PDF (849.9 KB) | EPUB
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Review

Review
Multi-drug approaches to NASH: what’s in the development pipeline?
Michael P Johnston, Janisha Patel & Christopher D Byrne
Pages: 143-150
Published online: 23 Sep 2019
AbstractforMulti-drug approaches to NASH: what’s in the development pipeline? | Full Text | References | PDF (815 KB) | EPUB
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Review
The molecular basis for current targets of NASH therapies
Kamran Qureshi & Brent A. Neuschwander-Tetri
Pages: 151-161
Published online: 18 Dec 2019
AbstractforThe molecular basis for current targets of NASH therapies | Full Text | References | PDF (1,006.5 KB) | EPUB
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Review
Cyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH)
Daren R. Ure, Daniel J. Trepanier, Patrick R. Mayo & Robert T. Foster
Pages: 163-178
Published online: 23 Dec 2019
AbstractforCyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH) | Full Text | References | PDF (1.8 MB) | EPUB
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Review
Targeting the Wnt signaling pathway: the challenge of reducing scarring without affecting repair
Edward J. Jarman & Luke Boulter
Pages: 179-190
Published online: 23 Jan 2020
AbstractforTargeting the Wnt signaling pathway: the challenge of reducing scarring without affecting repair | Full Text | References | PDF (1.4 MB) | EPUB
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Review
NASH (nonalcoholic steatohepatitis), diabetes, and macrovascular disease: multiple chronic conditions and a potential treatment at the metabolic root
Jerry Colca
Pages: 191-196
Published online: 23 Jan 2020
AbstractforNASH (nonalcoholic steatohepatitis), diabetes, and macrovascular disease: multiple chronic conditions and a potential treatment at the metabolic root | Full Text | References | PDF (681.5 KB) | EPUB
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Review
Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?
Michael Ritchie, Ibrahim A. Hanouneh, Mazen Noureddin, Timothy Rolph & Naim Alkhouri
Pages: 197-204
Published online: 22 Jan 2020
AbstractforFibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)? | Full Text | References | PDF (680 KB) | EPUB
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Original Research

Article
Trends in pioglitazone use among U.S. adults with type 2 diabetes and suspected nonalcoholic fatty liver disease
Phuc Le, Alexander Chaitoff, Michael B. Rothberg, Arthur McCullough & Naim Alkhouri
Pages: 205-208
Published online: 24 Dec 2019
AbstractforTrends in pioglitazone use among U.S. adults with type 2 diabetes and suspected nonalcoholic fatty liver disease | Full Text | References | PDF (408.7 KB) | EPUB
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Article
Use of a bioengineered antioxidant in mouse models of metabolic syndrome
Deric M. Griffin, Brittany R. Bitner, Zachary Criss Ii, Daniela Marcano, Jacob M. Berlin, Thomas A. Kent, James M. Tour, Susan L. Samson & Robia G. Pautler
Pages: 209-219
Published online: 20 Jan 2020
AbstractforUse of a bioengineered antioxidant in mouse models of metabolic syndrome | Full Text | References | PDF (1.8 MB) | EPUB
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