Expert Opinion on Investigational Drugs, Volume 30, Issue 4 (2021)

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Expert Opinion on Investigational Drugs, Volume 30, Issue 4 (2021)

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Biliary tract cancers.

Foreword

Article
A foreword on biliary tract cancers: emerging treatments, drug targets, and fundamental knowledge gaps
Alessandro Rizzo & Giovanni Brandi
Page: 279
Published online: 14 Mar 2021
CitationforA foreword on biliary tract cancers: emerging treatments, drug targets, and fundamental knowledge gaps | Full Text | PDF (107.4 KB) | EPUB
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Editorial

Editorial
The impact of molecular profiling on cholangiocarcinoma clinical trials and experimental drugs
Qurat Ul Ain Riaz Sipra & Rachna Shroff
Pages: 281-284
Published online: 23 Nov 2020
First Page PreviewforThe impact of molecular profiling on cholangiocarcinoma clinical trials and experimental drugs | Full Text | References | PDF (1.7 MB) | EPUB
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Editorial
Key challenges for drugs in clinical development for cholangiocarcinoma
Bridget P. Keenan & R. Kate (Katie) Kelley
Pages: 285-290
Published online: 02 Feb 2021
First Page PreviewforKey challenges for drugs in clinical development for cholangiocarcinoma | Full Text | References | PDF (250.7 KB) | EPUB
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Interview

Susan Pandya on investigational treatment approaches to cholangiocarcinoma
Susan Pandya, MD
Pages: 291-293
Published online: 10 Dec 2020
First Page PreviewforSusan Pandya on investigational treatment approaches to cholangiocarcinoma | Full Text | PDF (245 KB) | EPUB
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Novel approaches for the management of biliary tract cancer: today and tomorrow
Alessandro Rizzo
Pages: 295-297
Published online: 17 Mar 2021
First Page PreviewforNovel approaches for the management of biliary tract cancer: today and tomorrow | Full Text | References | PDF (185.8 KB) | EPUB
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Surgical oncologist and liver cancer expert Dr. Tim Pawlik on the potential of pharmacological and surgical approaches in biliary tract cancer
Timothy M. Pawlik MD, MPH, PhD
Pages: 299-300
Published online: 14 Feb 2021
CitationforSurgical oncologist and liver cancer expert Dr. Tim Pawlik on the potential of pharmacological and surgical approaches in biliary tract cancer | Full Text | PDF (249.8 KB) | EPUB
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Drug Evaluation

Article
Ivosidenib: an investigational drug for the treatment of biliary tract cancers
Angelos Angelakas, Angela Lamarca, Richard a Hubner, Mairéad G McNamara & Juan W. Valle
Pages: 301-307
Published online: 26 Apr 2021
AbstractforIvosidenib: an investigational drug for the treatment of biliary tract cancers | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Infigratinib (BGJ398): an investigational agent for the treatment of FGFR-altered intrahepatic cholangiocarcinoma
Gehan Botrus, Puneet Raman, Thomas Oliver & Tanios Bekaii-Saab
Pages: 309-316
Published online: 04 Jan 2021
AbstractforInfigratinib (BGJ398): an investigational agent for the treatment of FGFR-altered intrahepatic cholangiocarcinoma | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Futibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives
Alessandro Rizzo, Angela Dalia Ricci & Giovanni Brandi
Pages: 317-324
Published online: 25 Oct 2020
AbstractforFutibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Nivolumab: an investigational agent for the treatment of biliary tract cancer
Alessandro Di Federico, Alessandro Rizzo, Angela Dalia Ricci, Giorgio Frega, Andrea Palloni, Simona Tavolari & Giovanni Brandi
Pages: 325-332
Published online: 23 Dec 2020
AbstractforNivolumab: an investigational agent for the treatment of biliary tract cancer | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Regorafenib, an investigational agent for the treatment of cholangiocarcinoma
Ibrahim Halil Sahin, Elaine Tan & Richard Kim
Pages: 333-341
Published online: 30 Dec 2020
AbstractforRegorafenib, an investigational agent for the treatment of cholangiocarcinoma | Full Text | References | PDF (1 MB) | EPUB
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Article
Durvalumab: an investigational anti-PD-L1 antibody for the treatment of biliary tract cancer
Alessandro Rizzo, Angela Dalia Ricci & Giovanni Brandi
Pages: 343-350
Published online: 09 Mar 2021
AbstractforDurvalumab: an investigational anti-PD-L1 antibody for the treatment of biliary tract cancer | Full Text | References | PDF (713.8 KB) | EPUB
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review

Immunotherapies in clinical development for biliary tract cancer
Arndt Vogel, Melanie Bathon & Anna Saborowski
Pages: 351-363
Published online: 31 Dec 2020
AbstractforImmunotherapies in clinical development for biliary tract cancer | Full Text | References | PDF (418 KB) | EPUB
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Perspective

Article
Cholangiocarcinoma: bridging the translational gap from preclinical to clinical development and implications for future therapy
Leonardo Baiocchi, Keisaku Sato, Burcin Ekser, Lindsey Kennedy, Heather Francis, Ludovica Ceci, Ilaria Lenci, Domenico Alvaro, Antonio Franchitto, Paolo Onori, Eugenio Gaudio, Chaodong Wu, Sanjukta Chakraborty, Shannon Glaser & Gianfranco Alpini
Pages: 365-375
Published online: 08 Dec 2020
AbstractforCholangiocarcinoma: bridging the translational gap from preclinical to clinical development and implications for future therapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 243 Views
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Review

Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic
Massimiliano Cadamuro, Alberto Lasagni, Angela Lamarca, Laura Fouassier, Maria Guido, Samantha Sarcognato, Enrico Gringeri, Umberto Cillo, Mario Strazzabosco, Jose JG Marin, Jesus M Banales & Luca Fabris
Pages: 377-388
Published online: 23 Feb 2021
AbstractforTargeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Experimental HER2- targeted therapies for biliary tract cancer
Alessandro Rizzo, Angela Dalia Ricci, Chiara Bonucci, Nastassja Tober, Andrea Palloni, Giorgio Frega & Giovanni Brandi
Pages: 389-399
Published online: 06 Dec 2020
AbstractforExperimental HER2- targeted therapies for biliary tract cancer | Full Text | References | PDF (2.2 MB) | EPUB
  • 412 Views
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Rare cancer, rare alteration: the case of NTRK fusions in biliary tract cancers
Alice Boilève, Loïc Verlingue, Antoine Hollebecque, Valérie Boige, Michel Ducreux & David Malka
Pages: 401-409
Published online: 24 Mar 2021
AbstractforRare cancer, rare alteration: the case of NTRK fusions in biliary tract cancers | Full Text | References | PDF (530.6 KB) | EPUB
  • 329 Views
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Angiogenesis in biliary tract cancer: targeting and therapeutic potential
Margherita Rimini & Andrea Casadei-Gardini
Pages: 411-418
Published online: 28 Mar 2021
AbstractforAngiogenesis in biliary tract cancer: targeting and therapeutic potential | Full Text | References | PDF (345.1 KB) | EPUB
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Cholangiocarcinoma: shedding light on the most promising drugs in clinical development
Amir A. Rahnemai-Azar & Timothy M. Pawlik
Pages: 419-427
Published online: 07 Mar 2021
AbstractforCholangiocarcinoma: shedding light on the most promising drugs in clinical development | Full Text | References | PDF (1.8 MB) | EPUB
  • 229 Views
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Targeting the tumor microenvironment in cholangiocarcinoma: implications for therapy
Juan Wang & Sumera Ilyas
Pages: 429-438
Published online: 28 Dec 2020
AbstractforTargeting the tumor microenvironment in cholangiocarcinoma: implications for therapy | Full Text | References | PDF (1.4 MB) | EPUB
  • 633 Views
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Developing models of cholangiocarcinoma to close the translational gap in cancer research
Scott H. Waddell & Luke Boulter
Pages: 439-450
Published online: 14 Feb 2021
AbstractforDeveloping models of cholangiocarcinoma to close the translational gap in cancer research | Full Text | References | PDF (4.2 MB) | EPUB
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Investigational PARP inhibitors for the treatment of biliary tract cancer: spotlight on preclinical and clinical studies
Rutika Mehta, Anthony C Wood, James Yu & Richard Kim
Pages: 451-461
Published online: 24 Mar 2021
AbstractforInvestigational PARP inhibitors for the treatment of biliary tract cancer: spotlight on preclinical and clinical studies | Full Text | References | PDF (1.3 MB) | EPUB
  • 463 Views
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Targeting FGFR in intrahepatic cholangiocarcinoma [iCCA]: leading the way for precision medicine in biliary tract cancer [BTC]?
Gabriella Aitcheson, Amit Mahipal & Binu V John
Pages: 463-477
Published online: 11 Apr 2021
AbstractforTargeting FGFR in intrahepatic cholangiocarcinoma [iCCA]: leading the way for precision medicine in biliary tract cancer [BTC]? | Full Text | References | PDF (3.6 MB) | EPUB
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