Expert Opinion on Investigational Drugs, Volume 31, Issue 10 (2022)

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Expert Opinion on Investigational Drugs, Volume 31, Issue 10 (2022)

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Drug Evaluation

Article
COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease
Marwan N. Sabbagh & Boris Decourt
Pages: 987-993
Published online: 01 Sep 2022
AbstractforCOR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease | Full Text | References | PDF (1.4 MB) | EPUB
  • 451 Views
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Perspective

Article
Failed clinical trials on COVID-19 acute respiratory distress syndrome in hospitalized patients: common oversights and streamlining the development of clinically effective therapeutics
Denise Battaglini, Fernanda Cruz, Chiara Robba, Paolo Pelosi & Patricia R.M. Rocco
Pages: 995-1015
Published online: 13 Sep 2022
AbstractforFailed clinical trials on COVID-19 acute respiratory distress syndrome in hospitalized patients: common oversights and streamlining the development of clinically effective therapeutics | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 153 Views
  • 3 CrossRef citations
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Review

Review
Postural orthostatic tachycardia syndrome: pathophysiology, management, and experimental therapies
Bharat Narasimhan, Devika Aggarwal, Priyanka Satish, Bharat Kantharia & Wilbert S. Aronow
Pages: 1017-1025
Published online: 11 Sep 2022
AbstractforPostural orthostatic tachycardia syndrome: pathophysiology, management, and experimental therapies | Full Text | References | PDF (1.9 MB) | EPUB
  • 773 Views
  • 1 CrossRef citations
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Review
Hypertrophic cardiomyopathy: an up-to-date snapshot of the clinical drug development pipeline
Juan Tamargo, María Tamargo & Ricardo Caballero
Pages: 1027-1052
Published online: 13 Sep 2022
AbstractforHypertrophic cardiomyopathy: an up-to-date snapshot of the clinical drug development pipeline | Full Text | References | PDF (3.8 MB) | EPUB
  • 378 Views
  • 1 CrossRef citations
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Review
New investigational agents for the treatment of major depressive disorder
Bartłomiej Pochwat, Anna Julia Krupa, Marcin Siwek & Bernadeta Szewczyk
Pages: 1053-1066
Published online: 24 Aug 2022
AbstractforNew investigational agents for the treatment of major depressive disorder | Full Text | References | PDF (2.2 MB) | EPUB
  • 408 Views
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Review
Investigational drugs in clinical trials for macular degeneration
Michael J Tolentino & Andrew J Tolentino
Pages: 1067-1085
Published online: 20 Sep 2022
AbstractforInvestigational drugs in clinical trials for macular degeneration | Full Text | References | PDF (3.5 MB) | EPUB
  • 5554 Views
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Open Access
Review
Investigational drugs for the treatment of kidney transplant rejection
Lukas K van Vugt, Maaike R Schagen, Annelies de Weerd, Marlies EJ Reinders, Brenda CM de Winter & Dennis A Hesselink
Pages: 1087-1100
Published online: 07 Oct 2022
AbstractforInvestigational drugs for the treatment of kidney transplant rejection | Full Text | References | PDF (2 MB) | EPUB
  • 3233 Views
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Open Access
Review
Seladelpar: an investigational drug for the treatment of early-stage primary biliary cholangitis (PBC)
Aaron Wetten, David Emrys Jeffreys Jones & Jessica Katharine Dyson
Pages: 1101-1107
Published online: 08 Oct 2022
AbstractforSeladelpar: an investigational drug for the treatment of early-stage primary biliary cholangitis (PBC) | Full Text | References | PDF (1.3 MB) | EPUB
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Open Access
Review
Emerging therapies for juvenile arthritis: agents in early clinical trials
Silvia Rosina, Gabriella Giancane & Nicolino Ruperto
Pages: 1109-1124
Published online: 08 Sep 2022
AbstractforEmerging therapies for juvenile arthritis: agents in early clinical trials | Full Text | References | PDF (428.1 KB) | EPUB
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Original Research

Article
Biosimilarity of HS-20090 to Denosumab in healthy Chinese subjects: a randomized, double-blinded, pharmacokinetics/pharmacodynamics study
Yaqi Lin, Heng Yang, Xiaoyan Yang, Can Guo, Shuang Yang, Guoping Yang, Qiong Wu, Chao Pan, Changan Sun, Chuan Li, Liangliang He, Jie Huang & Qi Pei
Pages: 1125-1132
Published online: 16 Sep 2022
AbstractforBiosimilarity of HS-20090 to Denosumab in healthy Chinese subjects: a randomized, double-blinded, pharmacokinetics/pharmacodynamics study | Full Text | References | PDF (1.3 MB) | EPUB
  • 210 Views
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Article
Pharmacokinetics, pharmacodynamics, safety, and immunogenicity of a biosimilar of denosumab (LY06006): a randomized, double-blind, single-dose, parallel-controlled clinical study in healthy Chinese subjects
Siyi Wang, Xiaoyan Yang, Jie Huang, Shuang Yang, Qian Wu, Honghui Chen, Shuting Wu, Changlin Dou, Guoping Yang & Yuxia Xiang
Pages: 1133-1142
Published online: 07 Sep 2022
AbstractforPharmacokinetics, pharmacodynamics, safety, and immunogenicity of a biosimilar of denosumab (LY06006): a randomized, double-blind, single-dose, parallel-controlled clinical study in healthy Chinese subjects | Full Text | References | PDF (1.1 MB) | EPUB
  • 256 Views
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