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Expert Opinion on Drug Metabolism & Toxicology
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Volume 10, Issue 10

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 10, Issue 10 (2014)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 10, Issue 10 (2014)

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Original Research

Article

Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity

Roslyn Thelingwani, Britta Bonn, Kelly Chibale & Collen Masimirembwa

Pages: 1313-1324

Published online: 15 Sep 2014

AbstractforPhysicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity | Full Text | References | PDF (502.7 KB)

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Article

Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences

Hua Sun, Huan Wang, Hongming Liu, Xingwang Zhang & Baojian Wu PhD

Pages: 1325-1336

Published online: 15 Sep 2014

AbstractforGlucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences | Full Text | References | PDF (687.8 KB)

300 Views
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Reviews

Review Article

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance

Oliver Bruhn PhD & Ingolf Cascorbi MD PhD

Pages: 1337-1354

Published online: 27 Aug 2014

AbstractforPolymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance | Full Text | References | PDF (554.6 KB)

1300 Views
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Review Article

Regional therapy in metastatic melanoma: an update on minimally invasive intraarterial isolated limb infusion and percutaneous hepatic perfusion

Omar M Rashid, Sarah Sloot & Jonathan S Zager (Director of Regional Therapies) MD FACS

Pages: 1355-1364

Published online: 01 Sep 2014

AbstractforRegional therapy in metastatic melanoma: an update on minimally invasive intraarterial isolated limb infusion and percutaneous hepatic perfusion | Full Text | References | PDF (239.2 KB)

226 Views
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Review Article

ADMET considerations when prescribing novel therapeutics to treat restless legs syndrome

Stefano de Biase MD, Giovanni Merlino MD PhD, Simone Lorenzut MD, Mariarosaria Valente MD & Gian Luigi Gigli (Professor, Director of Neurology) MD

Pages: 1365-1380

Published online: 22 Aug 2014

AbstractforADMET considerations when prescribing novel therapeutics to treat restless legs syndrome | Full Text | References | PDF (318.4 KB)

190 Views
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Review Article

Pharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches

Marzia Lecchi, Lidia D’Alonzo, Andrea Negro & Paolo Martelletti

Pages: 1381-1395

Published online: 15 Sep 2014

AbstractforPharmacokinetics and safety of a new aspirin formulation for the acute treatment of primary headaches | Full Text | References | PDF (329.6 KB)

488 Views
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Review Article

Some considerations on the predictions of pharmacokinetic alterations in subjects with liver disease

Martha Gonzalez, Laura Goracci, Gabriele Cruciani & Italo Poggesi

Pages: 1397-1408

Published online: 15 Sep 2014

AbstractforSome considerations on the predictions of pharmacokinetic alterations in subjects with liver disease | Full Text | References | PDF (599.8 KB) | Supplemental

410 Views
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Review Article

Noncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity

April K Marrone PhD, Frederick A Beland PhD & Igor P Pogribny MD PhD

Pages: 1409-1422

Published online: 29 Aug 2014

AbstractforNoncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity | Full Text | References | PDF (429.4 KB)

439 Views
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Drug Evaluations

Pharmacokinetic/pharmacodynamic evaluation of rasagiline mesylate for Parkinson’s disease

Thomas Müller MD

Pages: 1423-1432

Published online: 06 Sep 2014

AbstractforPharmacokinetic/pharmacodynamic evaluation of rasagiline mesylate for Parkinson’s disease | Full Text | References | PDF (363.5 KB)

513 Views
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Hydralazine–valproate: a repositioned drug combination for the epigenetic therapy of cancer

Alfonso Dueñas-Gonzalez, Jaime Coronel, Lucely Cetina MD, Aurora González-Fierro, Alma Chavez-Blanco & Lucia Taja-Chayeb

Pages: 1433-1444

Published online: 25 Aug 2014

AbstractforHydralazine–valproate: a repositioned drug combination for the epigenetic therapy of cancer | Full Text | References | PDF (326.3 KB)

505 Views
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Pharmacokinetic evaluation of treprostinil (oral) for the treatment of pulmonary arterial hypertension

Jennifer L Hellawell MD, Sanjeeb Bhattacharya MD & Harrison W Farber MD

Pages: 1445-1453

Published online: 10 Sep 2014

AbstractforPharmacokinetic evaluation of treprostinil (oral) for the treatment of pulmonary arterial hypertension | Full Text | References | PDF (415 KB)

323 Views
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Appendix

Correction

Erratum

Page: 1455

Published online: 05 Sep 2014

CitationforErratum | Full Text | PDF (28.8 KB)

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