Expert Opinion on Drug Metabolism & Toxicology, Volume 14, Issue 6 (2018)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 14, Issue 6 (2018)

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Original Research

Article
Influence of ethanol on the metabolism of alprazolam.
Zhibin Huang, Zhiru Xu, Hao Wang, ZQ Zhao & Yulan Rao
Pages: 551-559
Published online: 14 Jun 2018
AbstractforInfluence of ethanol on the metabolism of alprazolam. | Full Text | References | PDF (1.3 MB) | Supplemental
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Review

Review
Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication
Jeremiah D Momper & Sanjay K Nigam
Pages: 561-570
Published online: 04 Jun 2018
AbstractforDevelopmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication | Full Text | References | PDF (1.1 MB)
  • 371 Views
  • 12 CrossRef citations
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Review
Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activity
Harma Ellens, Zhou Meng, Sylvain J. Le Marchand & Joe Bentz
Pages: 571-584
Published online: 07 Jun 2018
AbstractforMechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activity | Full Text | References | PDF (1.4 MB)
  • 272 Views
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Review
Pediatric physiology in relation to the pharmacokinetics of monoclonal antibodies
Paul Malik & Andrea Edginton
Pages: 585-599
Published online: 04 Jun 2018
AbstractforPediatric physiology in relation to the pharmacokinetics of monoclonal antibodies | Full Text | References | PDF (1.4 MB)
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Review
Pharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold?
Gabriel Stillemans, Leila Belkhir, Dennis A. Hesselink, Vincent Haufroid & Laure Elens
Pages: 601-611
Published online: 28 May 2018
AbstractforPharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold? | Full Text | References | PDF (1 MB)
  • 175 Views
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Review
An update on efflux and uptake transporters as determinants of statin response
Karina Cunha e Rocha, Beatriz Maria Veloso Pereira & Alice Cristina Rodrigues
Pages: 613-624
Published online: 08 Jun 2018
AbstractforAn update on efflux and uptake transporters as determinants of statin response | Full Text | References | PDF (1.7 MB)
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Review
An update on the potential role of intestinal first-pass metabolism for the prediction of drug–drug interactions: the role of PBPK modeling
Saeed Alqahtani, Ishfaq Bukhari, Ahmed Albassam & Maha Alenazi
Pages: 625-634
Published online: 11 Jun 2018
AbstractforAn update on the potential role of intestinal first-pass metabolism for the prediction of drug–drug interactions: the role of PBPK modeling | Full Text | References | PDF (999 KB)
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Review
A current structural perspective on PXR and CAR in drug metabolism
Cameron D. Buchman, Sergio C. Chai & Taosheng Chen
Pages: 635-647
Published online: 30 May 2018
AbstractforA current structural perspective on PXR and CAR in drug metabolism | Full Text | References | PDF (1.7 MB)
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Drug Evaluation

Article
Pharmacokinetic and pharmacodynamic evaluation of daclatasvir, asunaprevir plus beclabuvir as a fixed-dose co-formulation for the treatment of hepatitis C
Isabella Esposito, Sebastián Marciano & Julieta Trinks
Pages: 649-657
Published online: 10 Jun 2018
AbstractforPharmacokinetic and pharmacodynamic evaluation of daclatasvir, asunaprevir plus beclabuvir as a fixed-dose co-formulation for the treatment of hepatitis C | Full Text | References | PDF (712.3 KB)
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