Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 4 (2021)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 4 (2021)

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Editorial

Editorial
Analyzing FDA-approved drugs for compliance of pharmacokinetic principles: should there be a critical screening parameter in drug designing protocols?
Shelly Pathania & Pankaj Kumar Singh
Pages: 351-354
Published online: 29 Dec 2020
First Page PreviewforAnalyzing FDA-approved drugs for compliance of pharmacokinetic principles: should there be a critical screening parameter in drug designing protocols? | Full Text | References | PDF (269 KB) | EPUB
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Free Access

Perspective

Article
RRx-001, a downregulator of the CD47- SIRPα checkpoint pathway, does not cause anemia or thrombocytopenia
Bryan Oronsky, Pedro Cabrales, Scott Caroen, Xiaoning Guo, Curtis Scribner, Arnold Oronsky & Tony R. Reid
Pages: 355-357
Published online: 22 Jan 2021
AbstractforRRx-001, a downregulator of the CD47- SIRPα checkpoint pathway, does not cause anemia or thrombocytopenia | Full Text | References | PDF (252.9 KB) | EPUB
  • 291 Views
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Review

A narrative review of predictors for β-lactam antibiotic exposure during empirical treatment in critically ill patients
Alan Abdulla, Tim M.J. Ewoldt, Ilse M. Purmer, Anouk E. Muller, Diederik Gommers, Henrik Endeman & Birgit C.P. Koch
Pages: 359-368
Published online: 02 Feb 2021
AbstractforA narrative review of predictors for β-lactam antibiotic exposure during empirical treatment in critically ill patients | Full Text | References | PDF (1.4 MB) | EPUB
  • 2310 Views
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Open Access
ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?
Henrike Bruckmueller & Ingolf Cascorbi
Pages: 369-396
Published online: 02 Feb 2021
AbstractforABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding? | Full Text | References | PDF (692.9 KB) | EPUB
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Multi-factorial pharmacokinetic interactions: unraveling complexities in precision drug therapy
Baron Bechtold & John Clarke
Pages: 397-412
Published online: 20 Jan 2021
AbstractforMulti-factorial pharmacokinetic interactions: unraveling complexities in precision drug therapy | Full Text | References | PDF (1.3 MB) | EPUB
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The regulation of liver cytochrome P450 expression and activity by the brain serotonergic system in different experimental models
Ewa Bromek & Władysława Anna Daniel
Pages: 413-424
Published online: 18 Jan 2021
AbstractforThe regulation of liver cytochrome P450 expression and activity by the brain serotonergic system in different experimental models | Full Text | References | PDF (3.3 MB) | EPUB
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Circadian regulation of transporter expression and implications for drug disposition
Jiří Pácha, Kateřina Balounová & Matúš Soták
Pages: 425-439
Published online: 04 Jan 2021
AbstractforCircadian regulation of transporter expression and implications for drug disposition | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Xanthones as P-glycoprotein modulators and their impact on drug bioavailability
Vera Silva, Eva Gil-Martins, Bárbara Silva, Carolina Rocha-Pereira, Maria Emília Sousa, Fernando Remião & Renata Silva
Pages: 441-482
Published online: 20 Apr 2021
AbstractforXanthones as P-glycoprotein modulators and their impact on drug bioavailability | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Meta-analysis

Article
Sarcosine as an add-on treatment to antipsychotic medication for people with schizophrenia: a systematic review and meta-analysis of randomized controlled trials
Mattia Marchi, Giacomo Galli, Federica Maria Magarini, Giorgio Mattei & Gian Maria Galeazzi
Pages: 483-493
Published online: 16 Feb 2021
AbstractforSarcosine as an add-on treatment to antipsychotic medication for people with schizophrenia: a systematic review and meta-analysis of randomized controlled trials | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Original research

Article
Erythropoietin promoter polymorphism is associated with treatment efficacy and severe hematologic toxicity for platinum-based chemotherapy
Yi Zheng, Zheng Deng, Mimi Tang & Pei Cai
Pages: 495-502
Published online: 07 Feb 2021
AbstractforErythropoietin promoter polymorphism is associated with treatment efficacy and severe hematologic toxicity for platinum-based chemotherapy | Full Text | References | PDF (267.6 KB) | EPUB
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Original Research

Article
A phase I study of fluzoparib tablet formulation, an oral PARP inhibitor: effect of food on the pharmacokinetics and metabolism after oral dosing in healthy Chinese volunteers
Min Wu, Xiaojiao Li, Jixuan Sun, Hong Chen & Yanhua Ding
Pages: 503-508
Published online: 14 Feb 2021
AbstractforA phase I study of fluzoparib tablet formulation, an oral PARP inhibitor: effect of food on the pharmacokinetics and metabolism after oral dosing in healthy Chinese volunteers | Full Text | References | PDF (407.1 KB) | EPUB
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