Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 8 (2021)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 8 (2021)

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Alternatives to Animal Models in Toxicology

Foreword

Article
Beyond animal models: implementing the 3Rs principles and improving pharmacological studies with new model systems
Elisa Giovannetti & Godefridus Peters
Pages: 867-868
Published online: 30 Jun 2021
CitationforBeyond animal models: implementing the 3Rs principles and improving pharmacological studies with new model systems | Full Text | References | PDF (155.7 KB) | EPUB
  • 123 Views
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Review

Overcoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance
Xiaomin Liang & Yurong Lai
Pages: 869-886
Published online: 15 Jun 2021
AbstractforOvercoming the shortcomings of the extended-clearance concept: a framework for developing a physiologically-based pharmacokinetic (PBPK) model to select drug candidates involving transporter-mediated clearance | Full Text | References | PDF (2.6 MB) | EPUB
  • 833 Views
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Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: strengths and weaknesses for hazard identification and risk characterization
Sarah D. Burnett, Alexander D Blanchette, Weihsueh A. Chiu & Ivan Rusyn
Pages: 887-902
Published online: 08 Mar 2021
AbstractforHuman induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: strengths and weaknesses for hazard identification and risk characterization | Full Text | References | PDF (2.9 MB) | EPUB
  • 728 Views
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High-throughput PBTK models for in vitro to in vivo extrapolation
Miyuki Breen, Caroline L Ring, Anna Kreutz, Michael-Rock Goldsmith & John F Wambaugh
Pages: 903-921
Published online: 15 Jun 2021
AbstractforHigh-throughput PBTK models for in vitro to in vivo extrapolation | Full Text | References | PDF (1.8 MB) | EPUB
  • 929 Views
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Novel test strategies for in vitro seizure liability assessment
Anke M. Tukker & Remco H. S. Westerink
Pages: 923-936
Published online: 17 Feb 2021
AbstractforNovel test strategies for in vitro seizure liability assessment | Full Text | References | PDF (982.1 KB) | EPUB
  • 2528 Views
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Open Access
Organotypic-liver slide culture systems to explore the role of extracellular vesicles in pancreatic cancer metastatic behavior and guide new therapeutic approaches
I Gede Putu Supadmanaba, Annalisa Comandatore, Luca Morelli, Elisa Giovannetti & Tonny Lagerweij
Pages: 937-946
Published online: 21 May 2021
AbstractforOrganotypic-liver slide culture systems to explore the role of extracellular vesicles in pancreatic cancer metastatic behavior and guide new therapeutic approaches | Full Text | References | PDF (2.3 MB) | EPUB
  • 433 Views
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Tumor grafted – chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation
Ana Katrina Mapanao, Pei Pei Che, Patrizia Sarogni, Peter Sminia, Elisa Giovannetti & Valerio Voliani
Pages: 947-968
Published online: 10 Feb 2021
AbstractforTumor grafted – chick chorioallantoic membrane as an alternative model for biological cancer research and conventional/nanomaterial-based theranostics evaluation | Full Text | References | PDF (7.5 MB) | EPUB
  • 4487 Views
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Open Access
Multi-organ-on-a-chip for pharmacokinetics and toxicokinetic study of drugs
Jong Hwan Sung
Pages: 969-986
Published online: 05 Apr 2021
AbstractforMulti-organ-on-a-chip for pharmacokinetics and toxicokinetic study of drugs | Full Text | References | PDF (2.4 MB) | EPUB
  • 950 Views
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Toward regulatory acceptance and improving the prediction confidence of in silico approaches: a case study of genotoxicity
Olga Tcheremenskaia & Romualdo Benigni
Pages: 987-1005
Published online: 21 Jun 2021
AbstractforToward regulatory acceptance and improving the prediction confidence of in silico approaches: a case study of genotoxicity | Full Text | References | PDF (1.2 MB) | EPUB
  • 234 Views
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Refining in vitro and in silico neurotoxicity approaches by accounting for interspecies and interindividual differences in toxicodynamics
Emma E.J. Kasteel & Remco H.S. Westerink
Pages: 1007-1017
Published online: 14 Feb 2021
AbstractforRefining in vitro and in silico neurotoxicity approaches by accounting for interspecies and interindividual differences in toxicodynamics | Full Text | References | PDF (462.2 KB) | EPUB
  • 2468 Views
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Open Access

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