Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 9 (2021)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 17, Issue 9 (2021)

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Editorial

Editorial
Evaluating the toxicity and therapeutic potential of ibogaine in the treatment of chronic opioid abuse
Matthias Luz & Deborah C. Mash
Pages: 1019-1022
Published online: 24 Jun 2021
First Page PreviewforEvaluating the toxicity and therapeutic potential of ibogaine in the treatment of chronic opioid abuse | Full Text | References | PDF (174.5 KB) | EPUB
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Drug Evaluation

Article
Assessing the pharmacokinetics of acalabrutinib in the treatment of chronic lymphocytic leukemia
Yi Miao, Wei Xu & Jianyong Li
Pages: 1023-1030
Published online: 28 Jul 2021
AbstractforAssessing the pharmacokinetics of acalabrutinib in the treatment of chronic lymphocytic leukemia | Full Text | References | PDF (1 MB) | EPUB
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Drug evaluation

Article
Evaluating pharmacokinetics of bempedoic acid in the treatment of hypercholesterolemia
Arrigo F.G. Cicero, Federica Fogacci & Ivan Cincione
Pages: 1031-1038
Published online: 15 Jul 2021
AbstractforEvaluating pharmacokinetics of bempedoic acid in the treatment of hypercholesterolemia | Full Text | References | PDF (564 KB) | EPUB
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Perspective

Article
Ceftriaxone and methicillin-susceptible staphylococcus aureus: a perspective from pharmacokinetics/pharmacodynamics studies
Joao Paulo Telles, Rodrigo Cuiabano Paes Leme, Michel Leandro Campos, Carmen Ito, Larissa Bail, Keite Da Silva Nogueira & Felipe Francisco Tuon
Pages: 1039-1048
Published online: 18 Aug 2021
AbstractforCeftriaxone and methicillin-susceptible staphylococcus aureus: a perspective from pharmacokinetics/pharmacodynamics studies | Full Text | References | PDF (2.6 MB) | EPUB
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Review

Genotyping HLA alleles to predict the development of Severe cutaneous adverse drug reactions (SCARs): state-of-the-art
Thawinee Jantararoungtong, Therdpong Tempark, Napatrupron Koomdee, Sadeep Medhasi & Chonlaphat Sukasem
Pages: 1049-1064
Published online: 08 Jul 2021
AbstractforGenotyping HLA alleles to predict the development of Severe cutaneous adverse drug reactions (SCARs): state-of-the-art | Full Text | References | PDF (10.1 MB) | EPUB
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Open Access
Cytotoxic activity of KRAS inhibitors in combination with chemotherapeutics
Gerhard Hamilton & Adelina Plangger
Pages: 1065-1074
Published online: 13 Aug 2021
AbstractforCytotoxic activity of KRAS inhibitors in combination with chemotherapeutics | Full Text | References | PDF (724.3 KB) | EPUB
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Understanding mechanisms of drug resistance in epilepsy and strategies for overcoming it
Krzysztof Łukawski & Stanisław J. Czuczwar
Pages: 1075-1090
Published online: 06 Aug 2021
AbstractforUnderstanding mechanisms of drug resistance in epilepsy and strategies for overcoming it | Full Text | References | PDF (562.1 KB) | EPUB
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Strategies for the prevention and treatment of bleeding in patients treated with dabigatran: an update
Ke Xu, Noel C. Chan & John W. Eikelboom
Pages: 1091-1102
Published online: 18 Aug 2021
AbstractforStrategies for the prevention and treatment of bleeding in patients treated with dabigatran: an update | Full Text | References | PDF (629 KB) | EPUB
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Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity
Lu Gaohua, Xiusheng Miao & Liu Dou
Pages: 1103-1124
Published online: 31 Jul 2021
AbstractforCrosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity | Full Text | References | PDF (4.2 MB) | EPUB
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Open Access
The impact of catha edulis (vahl) forssk. ex endl. (celestraceae) (khat) on pharmacokinetics of clinically used drugs
Eleni Aklillu & Ephrem Engidawork
Pages: 1125-1138
Published online: 30 Aug 2021
AbstractforThe impact of catha edulis (vahl) forssk. ex endl. (celestraceae) (khat) on pharmacokinetics of clinically used drugs | Full Text | References | PDF (862.1 KB) | EPUB
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Original Research

Article
Effect of oral semaglutide on the pharmacokinetics of thyroxine after dosing of levothyroxine and the influence of co-administered tablets on the pharmacokinetics of oral semaglutide in healthy subjects: an open-label, one-sequence crossover, single-center, multiple-dose, two-part trial
Camilla Hauge, Astrid Breitschaft, Marie-Louise Hartoft-Nielsen, Simon Jensen & Tine A. Bækdal
Pages: 1139-1148
Published online: 31 Aug 2021
AbstractforEffect of oral semaglutide on the pharmacokinetics of thyroxine after dosing of levothyroxine and the influence of co-administered tablets on the pharmacokinetics of oral semaglutide in healthy subjects: an open-label, one-sequence crossover, single-center, multiple-dose, two-part trial | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Original research

Article
Pharmacokinetic and pharmacodynamic evaluation of the new prolonged-release leuprorelin acetate microspheres for injection compared with Enantone® in healthy Chinese male volunteers
Huan Zhou, Jing Xie, Xingyu Zhu, Xiaoyi Li, Xiaohui Yu, Yong Zhang, Yue Su, Cuixia He, Minhui Zhu, Xiao li Li, Yuanyuan Liu, Juan Chen, Dongmei Cheng, Mengmeng Chen, Ying Wang, Qin Ge, Ling Fan, Ying Wang, ZhongHuan Shao, Bingyan Liu, Rongfang Shan, Xiangrong Dai, Hongju Wang & Huaxue Wang
Pages: 1149-1156
Published online: 10 Aug 2021
AbstractforPharmacokinetic and pharmacodynamic evaluation of the new prolonged-release leuprorelin acetate microspheres for injection compared with Enantone® in healthy Chinese male volunteers | Full Text | References | PDF (1.6 MB) | EPUB
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