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Volume 4, Issue 5

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 4, Issue 5 (2008)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 4, Issue 5 (2008)

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Reviews

Article

Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450

Eva Stjernschantz, Nico PE Vermeulen & Chris Oostenbrink

Pages: 513-527

Published online: 18 May 2008

AbstractforComputational prediction of drug binding and rationalisation of selectivity towards cytochromes P450 | Full Text | References | PDF (212.7 KB)

278 Views
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Review

Article

Interindividual variability in oral antidiabetic drug disposition and response: the role of drug transporter polymorphisms

Michael A Pacanowski PharmD MPH, Charles W Hopley MPH & Christina L Aquilante PharmD

Pages: 529-544

Published online: 18 May 2008

AbstractforInterindividual variability in oral antidiabetic drug disposition and response: the role of drug transporter polymorphisms | Full Text | References | PDF (1.4 MB)

301 Views
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Article

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs

Anne T Nies PhD, Matthias Schwab MD & Dietrich Keppler MD

Pages: 545-568

Published online: 18 May 2008

AbstractforInterplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs | Full Text | References | PDF (293.9 KB)

511 Views
105 CrossRef citations
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Article

Pharmacokinetic/pharmacodynamic modeling of cardiac toxicity in human acute overdoses: utility and limitations

Bruno Mégarbane MD PhD, Arsia Amir Aslani PhD, Nicolas Deye MD & Frédéric J Baud MD

Pages: 569-579

Published online: 18 May 2008

AbstractforPharmacokinetic/pharmacodynamic modeling of cardiac toxicity in human acute overdoses: utility and limitations | Full Text | References | PDF (210.4 KB)

267 Views
7 CrossRef citations
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Reviews

Article

Prediction of oral drug absorption in humans – from cultured cell lines and experimental animals

K-C Cheng, Cheng Li & Annette S Uss

Pages: 581-590

Published online: 18 May 2008

AbstractforPrediction of oral drug absorption in humans – from cultured cell lines and experimental animals | Full Text | References | PDF (184.5 KB)

836 Views
58 CrossRef citations
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Article

Studying cytochrome P450 kinetics in drug metabolism

Melissa A Kramer PhD & Timothy S Tracy PhD

Pages: 591-603

Published online: 18 May 2008

AbstractforStudying cytochrome P450 kinetics in drug metabolism | Full Text | References | PDF (181.2 KB)

469 Views
20 CrossRef citations
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Review

Article

In-vitro screening of the antiestrogenic activity of chemicals

José M Navas & Helmut Segner

Pages: 605-617

Published online: 18 May 2008

AbstractforIn-vitro screening of the antiestrogenic activity of chemicals | Full Text | References | PDF (481.1 KB)

74 Views
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Drug Evaluations

Article

Dexmedetomidine: sedation, analgesia and beyond

Constantinos Chrysostomou MD & Carol G Schmitt PharmD

Pages: 619-627

Published online: 18 May 2008

AbstractforDexmedetomidine: sedation, analgesia and beyond | Full Text | References | PDF (135.7 KB)

1013 Views
118 CrossRef citations
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Article

Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia

Edoardo Spina & Rocco Zoccali

Pages: 629-638

Published online: 18 May 2008

AbstractforSertindole: pharmacological and clinical profile and role in the treatment of schizophrenia | Full Text | References | PDF (131.1 KB)

153 Views
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Drug Evaluation

Article

Bortezomib in multiple myeloma

Evangelos Terpos, Maria Roussou & Meletios-Athanassios Dimopoulos

Pages: 639-654

Published online: 18 May 2008

AbstractforBortezomib in multiple myeloma | Full Text | References | PDF (540.7 KB)

275 Views
19 CrossRef citations
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Article

Ropinirole treatment for restless legs syndrome

Shilpa Chitnis MD PhD

Pages: 655-664

Published online: 18 May 2008

AbstractforRopinirole treatment for restless legs syndrome | Full Text | References | PDF (131.6 KB)

106 Views
6 CrossRef citations
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Expert Opinion on Drug Metabolism & Toxicology (Vol.4, Iss.5, 2008)

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