Expert Opinion on Drug Metabolism & Toxicology, Volume 7, Issue 12 (2011)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 7, Issue 12 (2011)

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Original Research

Article
A Phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers
Hae Won Lee, Mi-sun Lim, Sook Jin Seong, Joomi Lee, Jeonghyeon Park, Jeong Ju Seo, Hwi-yeol Yun, In-hwan Baek, Kwang-il Kwon (Professor) & Young-Ran Yoon (Associate Professor)
Pages: 1471-1479
Published online: 19 Nov 2011
AbstractforA Phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers | Full Text | References | PDF (309.5 KB)
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Reviews

Review Article
A review of the use of in silico methods to predict the chemistry of molecular initiating events related to drug toxicity
Claire M Ellison (Post-doctoral Researcher) BSc PhD, Steven J Enoch (Post-doctoral Researcher) BSc MSc PhD & Mark TD Cronin (Professor of Predictive Toxicology) BSc PhD
Pages: 1481-1495
Published online: 28 Oct 2011
AbstractforA review of the use of in silico methods to predict the chemistry of molecular initiating events related to drug toxicity | Full Text | References | PDF (592.7 KB)
  • 611 Views
  • 32 CrossRef citations
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Review Article
Computational methods for early predictive safety assessment from biological and chemical data
Florian Nigsch, Eugen Lounkine, Patrick McCarren, Ben Cornett, Meir Glick, Kamal Azzaoui, Laszlo Urban, Philippe Marc, Arne Müller, Florian Hahne, David J Heard & Jeremy L Jenkins
Pages: 1497-1511
Published online: 04 Nov 2011
AbstractforComputational methods for early predictive safety assessment from biological and chemical data | Full Text | References | PDF (752.7 KB)
  • 663 Views
  • 26 CrossRef citations
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Review Article
Improvements in the reliability of in vitro genotoxicity testing
David Kirkland (Professor)
Pages: 1513-1520
Published online: 19 Nov 2011
AbstractforImprovements in the reliability of in vitro genotoxicity testing | Full Text | References | PDF (384.3 KB)
  • 383 Views
  • 27 CrossRef citations
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Review Article
In vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem
Joshua G Yorgason MD, William Luxford (Associate) MD & Federico Kalinec (Head) PhD
Pages: 1521-1534
Published online: 14 Oct 2011
AbstractforIn vitro and in vivo models of drug ototoxicity: studying the mechanisms of a clinical problem | Full Text | References | PDF (439 KB)
  • 939 Views
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Review Article
The metabolic and toxicological considerations for mTOR inhibitors in the treatment of hepatocarcinoma
Francesca Ponziani, Veronica Ojetti, Annalisa Tortora, Luca Di Maurizio, Flaminia Purchiaroni & Antonio Gasbarrini
Pages: 1535-1546
Published online: 27 Oct 2011
AbstractforThe metabolic and toxicological considerations for mTOR inhibitors in the treatment of hepatocarcinoma | Full Text | References | PDF (270.8 KB)
  • 306 Views
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Review Article
Cytochrome P450 polymorphisms and drug-induced interstitial lung disease
Martin Schwaiblmair PhD, Werner Behr MD, Wolfgang Foerg & Thomas Berghaus MD
Pages: 1547-1560
Published online: 09 Nov 2011
AbstractforCytochrome P450 polymorphisms and drug-induced interstitial lung disease | Full Text | References | PDF (437.6 KB)
  • 320 Views
  • 2 CrossRef citations
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Drug Evaluations

Article
Linagliptin for the treatment of type 2 diabetes (pharmacokinetic evaluation)
André J Scheen (Professor)
Pages: 1561-1576
Published online: 25 Oct 2011
AbstractforLinagliptin for the treatment of type 2 diabetes (pharmacokinetic evaluation) | Full Text | References | PDF (307.2 KB)
  • 753 Views
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Article
Pharmacokinetic evaluation of roflumilast
Gezim Lahu PhD, Nassr Nassr MD & Andreas Hünnemeyer MD
Pages: 1577-1591
Published online: 08 Nov 2011
AbstractforPharmacokinetic evaluation of roflumilast | Full Text | References | PDF (352.5 KB)
  • 892 Views
  • 15 CrossRef citations
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Article
Pharmacokinetic evaluation of olopatadine for the treatment of allergic rhinitis and conjunctivitis
Andrew S Nickels MD, Vesselin Dimov (Assistant Professor) MD & Raoul Wolf (Professor) MD
Pages: 1593-1599
Published online: 28 Oct 2011
AbstractforPharmacokinetic evaluation of olopatadine for the treatment of allergic rhinitis and conjunctivitis | Full Text | References | PDF (228.6 KB)
  • 509 Views
  • 7 CrossRef citations
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Article
Pharmacokinetic evaluation of gemcitabine hydrochloride for the treatment of cervical cancer
Alfonso Dueñas-Gonzalez MD PhD, Jaime Coronel & Lucely Cetina
Pages: 1601-1612
Published online: 28 Sep 2011
AbstractforPharmacokinetic evaluation of gemcitabine hydrochloride for the treatment of cervical cancer | Full Text | References | PDF (267.2 KB)
  • 216 Views
  • 4 CrossRef citations
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