Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 4 (2012)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 4 (2012)

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Research Article

Article
Related articles
Page: 1
Published online: 21 Mar 2012
CitationforRelated articles | Full Text | PDF (121.6 KB)
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Editorial

Editorial
Application of advanced in silico methods for predictive modeling and information integration
Luis G Valerio Jr (Science and Research Staff)
Pages: 395-398
Published online: 21 Mar 2012
AbstractforApplication of advanced in silico methods for predictive modeling and information integration | Full Text | References | PDF (175.7 KB)
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Free Access

Original Research

Article
Assessment of pharmacokinetic proportionality of levofloxacin and cyclosporine over a 100-fold dose range in healthy human volunteers
Mi-sun Lim MD, Sook Jin Seong MD, Jeonghyeon Park MS, Jeong Ju Seo MS, Joomi Lee MS, Kyung-Sang Yu MD PhD, Hae Won Lee MD & Young-Ran Yoon MD PhD
Pages: 399-405
Published online: 09 Mar 2012
AbstractforAssessment of pharmacokinetic proportionality of levofloxacin and cyclosporine over a 100-fold dose range in healthy human volunteers | Full Text | References | PDF (333.5 KB)
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Reviews

Review Article
Alternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet?
Romualdo Benigni
Pages: 407-417
Published online: 23 Feb 2012
AbstractforAlternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet? | Full Text | References | PDF (281 KB)
  • 336 Views
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Review Article
Efflux transporters in the blood–brain interfaces – in vitro and in vivo methods and correlations
Péter Krajcsi (Chief Scientific Officer) PhD, Márton Jani (Head of Department) MSC, Beáta Tóth (Scientist) MSC, Franciska Erdő (Senior scientist) PhD, Emese Kis (Head of Laboratory) PhD, Erzsébet Beéry (Head of Laboratory) PhD & István Sziráki (Head of Laboratory) PhD
Pages: 419-431
Published online: 06 Mar 2012
AbstractforEfflux transporters in the blood–brain interfaces – in vitro and in vivo methods and correlations | Full Text | References | PDF (292.7 KB)
  • 404 Views
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Review Article
Renal drug–drug interactions: what we have learned and where we are going
Eve-Irene Lepist PhD & Adrian S Ray PhD
Pages: 433-448
Published online: 29 Feb 2012
AbstractforRenal drug–drug interactions: what we have learned and where we are going | Full Text | References | PDF (331.8 KB)
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Review Article
In vitro-to-in vivo predictions of drug–drug interactions involving multiple reversible inhibitors
Justin D Lutz PharmD & Nina Isoherranen MSc PhD
Pages: 449-466
Published online: 03 Mar 2012
AbstractforIn vitro-to-in vivo predictions of drug–drug interactions involving multiple reversible inhibitors | Full Text | References | PDF (557.4 KB)
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Review Article
Idiosyncratic reactions and metabolism of sulfur-containing drugs
Freddi I Zuniga PhD, Danmy Loi (Manager of Clinical Care Management Programs) PharmD, Kah Hiing John Ling (Director of Bioanalytical Chemistry) PhD & Diane D-S Tang-Liu PhD FAAPS FCP
Pages: 467-485
Published online: 07 Mar 2012
AbstractforIdiosyncratic reactions and metabolism of sulfur-containing drugs | Full Text | References | PDF (487.4 KB)
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Review Article
The role of aldehyde oxidase in drug metabolism
Enrico Garattini & Mineko Terao
Pages: 487-503
Published online: 16 Feb 2012
AbstractforThe role of aldehyde oxidase in drug metabolism | Full Text | References | PDF (349.1 KB)
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Drug Evaluations

Article
Pharmacokinetic evaluation of toremifene and its clinical implications for the treatment of osteoporosis
Luigi Gennari MD PhD, Daniela Merlotti MD, Konstantinos Stolakis MD & Ranuccio Nuti MD
Pages: 505-513
Published online: 23 Feb 2012
AbstractforPharmacokinetic evaluation of toremifene and its clinical implications for the treatment of osteoporosis | Full Text | References | PDF (228 KB)
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Article
Evaluation of colesevelam hydrochloride for the treatment of type 2 diabetes
Lisa M Younk (Clinical Research Specialist) BS & Stephen N Davis (Clinical Research Specialist) (Theodore E. Woodward Professor of Medicine, Chairman, Department of Medicine, University of Maryland School of Medicine, Physician-in-Chief) MBBS FRCP FACP
Pages: 515-525
Published online: 21 Mar 2012
AbstractforEvaluation of colesevelam hydrochloride for the treatment of type 2 diabetes | Full Text | References | PDF (247.1 KB)
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